bromodomain and PHD finger containing, 1 (BRPF1) - coding DNA reference sequence

(used for variant description)

(last modified January 26, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_001003694.1 in the BRPF1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_052955.1, covering BRPF1 transcript NM_001003694.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5060
                      cgtcgccgccgctgctgccgccgccgctgccacagcctt       c.-361

 .         .         .         .         .         .                g.5120
 tgccgccacggtctccgccgccgctgtcctcgcgctgcctctgggagcctccattgttcc       c.-301

 .         .         .         .         .         .                g.5180
 agcagcgcccggtcccgagaccgggcatcttgggggctcgcgaaacgggcggcggccgac       c.-241

 .         .         .         .         .         .                g.5240
 ggagttgagaccccagggcgccggcgggaccaggagcggcaggggtcagctcaggaatcc       c.-181

 .         .         .         .         .         .                g.5300
 cggggagccgggaccaaagcgtggggcggcagggggccggggtggcgaggtctacggtct       c.-121

 .         .         .         .         .         .                g.5360
 ccggagttggggctcccccttcccggcccgactttccccgccgacctccccaagtggggt       c.-61

 .         .         .         .         .          | 02            g.7412
 cggagccccggcgggcgcccccggcgatgagcccggactcgaggtggccg | atgtgacagc    c.-1

          .         .         .         .         .         .       g.7472
 ATGGGGGTGGACTTTGATGTGAAGACTTTCTGCCACAACTTGCGGGCGACTAAGCCACCA       c.60
 M  G  V  D  F  D  V  K  T  F  C  H  N  L  R  A  T  K  P  P         p.20

          .         .         .         .         .         .       g.7532
 TACGAGTGCCCGGTGGAGACCTGCCGAAAGGTCTACAAGAGTTACAGTGGTATTGAGTAC       c.120
 Y  E  C  P  V  E  T  C  R  K  V  Y  K  S  Y  S  G  I  E  Y         p.40

          .         .         .         .         .         .       g.7592
 CACCTGTACCACTATGACCACGACAACCCACCACCCCCACAACAAACTCCACTCCGCAAG       c.180
 H  L  Y  H  Y  D  H  D  N  P  P  P  P  Q  Q  T  P  L  R  K         p.60

          .         .         .         .         .         .       g.7652
 CACAAGAAAAAGGGGCGCCAGTCACGCCCAGCCAACAAGCAGTCACCCAGCCCCTCAGAG       c.240
 H  K  K  K  G  R  Q  S  R  P  A  N  K  Q  S  P  S  P  S  E         p.80

          .         .         .         .         .         .       g.7712
 GTCTCACAGTCACCAGGCCGTGAGGTGATGAGCTATGCACAGGCCCAGCGCATGGTGGAG       c.300
 V  S  Q  S  P  G  R  E  V  M  S  Y  A  Q  A  Q  R  M  V  E         p.100

          .         .         .         .         .         .       g.7772
 GTGGACTTGCATGGCCGCGTCCACCGCATCAGCATCTTTGACAACCTGGATGTGGTGTCA       c.360
 V  D  L  H  G  R  V  H  R  I  S  I  F  D  N  L  D  V  V  S         p.120

          .         .         .         .         .         .       g.7832
 GAGGATGAGGAAGCCCCCGAGGAGGCCCCTGAGAATGGCAGCAACAAGGAGAACACTGAG       c.420
 E  D  E  E  A  P  E  E  A  P  E  N  G  S  N  K  E  N  T  E         p.140

          .         .         .         .         .         .       g.7892
 ACACCAGCTGCTACTCCCAAGTCAGGCAAACATAAGAACAAGGAGAAGCGCAAGGACTCC       c.480
 T  P  A  A  T  P  K  S  G  K  H  K  N  K  E  K  R  K  D  S         p.160

          .         .         .         .         .         .       g.7952
 AACCATCACCACCACCACAATGTTTCTGCGAGCACCACTCCCAAGCTGCCAGAGGTGGTC       c.540
 N  H  H  H  H  H  N  V  S  A  S  T  T  P  K  L  P  E  V  V         p.180

          .         .         .         .         .          | 03    g.12271
 TATCGGGAGCTGGAACAGGACACCCCTGATGCCCCACCCCGGCCAACTTCCTATTACCG | G    c.600
 Y  R  E  L  E  Q  D  T  P  D  A  P  P  R  P  T  S  Y  Y  R  |      p.200

          .         .         .         .         .         .       g.12331
 TACATCGAGAAGTCTGCAGAGGAGCTGGACGAGGAAGTAGAGTATGACATGGACGAGGAG       c.660
 Y  I  E  K  S  A  E  E  L  D  E  E  V  E  Y  D  M  D  E  E         p.220

          .         .         .         .         .         .       g.12391
 GACTACATCTGGCTGGATATCATGAATGAGCGTCGGAAGACAGAGGGTGTAAGTCCCATC       c.720
 D  Y  I  W  L  D  I  M  N  E  R  R  K  T  E  G  V  S  P  I         p.240

          .         .         .         .         .         .       g.12451
 CCGCAGGAGATCTTTGAGTACCTAATGGACCGACTGGAGAAGGAGTCGTACTTTGAGAGT       c.780
 P  Q  E  I  F  E  Y  L  M  D  R  L  E  K  E  S  Y  F  E  S         p.260

          .         .         .         .         .         .       g.12511
 CATAATAAAGGCGACCCTAATGCGCTAGTGGACGAGGATGCTGTTTGCTGTATCTGCAAT       c.840
 H  N  K  G  D  P  N  A  L  V  D  E  D  A  V  C  C  I  C  N         p.280

          .         .         .         .         .         .       g.12571
 GATGGTGAGTGCCAGAACAGCAATGTCATCCTCTTCTGTGACATGTGCAACCTGGCCGTG       c.900
 D  G  E  C  Q  N  S  N  V  I  L  F  C  D  M  C  N  L  A  V         p.300

          .         .         .         .         .         .       g.12631
 CACCAGGAGTGCTACGGTGTCCCCTATATCCCTGAGGGCCAGTGGCTGTGCCGCCGTTGC       c.960
 H  Q  E  C  Y  G  V  P  Y  I  P  E  G  Q  W  L  C  R  R  C         p.320

          .         .         .         .         .         .       g.12691
 CTGCAGTCACCCTCTCGTGCTGTGGATTGTGCCCTGTGCCCCAACAAGGGCGGTGCCTTC       c.1020
 L  Q  S  P  S  R  A  V  D  C  A  L  C  P  N  K  G  G  A  F         p.340

          .         .         .         .         .         .       g.12751
 AAGCAGACAGATGACGGGCGCTGGGCCCATGTGGTGTGTGCCTTGTGGATCCCTGAGGTC       c.1080
 K  Q  T  D  D  G  R  W  A  H  V  V  C  A  L  W  I  P  E  V         p.360

          .         .         .         .         .         .       g.12811
 TGCTTCGCCAACACGGTCTTCCTAGAGCCTATTGACAGCATTGAGCACATCCCACCAGCT       c.1140
 C  F  A  N  T  V  F  L  E  P  I  D  S  I  E  H  I  P  P  A         p.380

          .         .         .         .         .         .       g.12871
 CGCTGGAAGCTCACCTGCTACATTTGCAAACAACGGGGCTCAGGGGCCTGCATCCAGTGC       c.1200
 R  W  K  L  T  C  Y  I  C  K  Q  R  G  S  G  A  C  I  Q  C         p.400

          .         .         .         .         .         .       g.12931
 CACAAGGCCAACTGTTACACAGCTTTCCATGTGACATGCGCCCAGCAGGCTGGCCTTTAC       c.1260
 H  K  A  N  C  Y  T  A  F  H  V  T  C  A  Q  Q  A  G  L  Y         p.420

          .         .         .         .         .         .       g.12991
 ATGAAGATGGAGCCTGTGCGGGAGACAGGCGCCAACGGCACCTCTTTCAGTGTCCGCAAG       c.1320
 M  K  M  E  P  V  R  E  T  G  A  N  G  T  S  F  S  V  R  K         p.440

          .         .         .         .         .         .       g.13051
 ACAGCCTACTGCGACATCCACACGCCTCCAGGTTCAGCACGCCGACTGCCTGCCCTGTCC       c.1380
 T  A  Y  C  D  I  H  T  P  P  G  S  A  R  R  L  P  A  L  S         p.460

          .         .         .         .         .         .       g.13111
 CACAGCGAGGGTGAGGAGGATGAAGATGAGGAGGAGGATGAGGGTAAGGGCTGGAGCTCA       c.1440
 H  S  E  G  E  E  D  E  D  E  E  E  D  E  G  K  G  W  S  S         p.480

          .         .         .         .         .         .       g.13171
 GAGAAAGTCAAGAAGGCCAAGGCCAAGTCCCGGATCAAAATGAAGAAGGCACGGAAGATC       c.1500
 E  K  V  K  K  A  K  A  K  S  R  I  K  M  K  K  A  R  K  I         p.500

          .         .         .         .         .          | 04    g.14051
 CTGGCAGAGAAGCGGGCAGCAGCACCTGTGGTGTCAGTGCCCTGCATCCCACCACACAG | G    c.1560
 L  A  E  K  R  A  A  A  P  V  V  S  V  P  C  I  P  P  H  R  |      p.520

          .         .         .         .         .         .       g.14111
 CTTAGTAAAATCACCAACCGCCTGACCATCCAAAGGAAGAGCCAGTTCATGCAGAGGCTG       c.1620
 L  S  K  I  T  N  R  L  T  I  Q  R  K  S  Q  F  M  Q  R  L         p.540

          .         .         .         .         .         .       g.14171
 CACAGCTACTGGACACTGAAGCGGCAGTCACGGAATGGGGTCCCATTGCTACGTCGCCTG       c.1680
 H  S  Y  W  T  L  K  R  Q  S  R  N  G  V  P  L  L  R  R  L         p.560

          .         .         .         .   | 05     .         .    g.14597
 CAGACACACCTGCAATCTCAGAGGAACTGTGACCAAGTTGGG | AGAGATTCTGAGGATAAG    c.1740
 Q  T  H  L  Q  S  Q  R  N  C  D  Q  V  G   | R  D  S  E  D  K      p.580

          .         .         .         .         .         .       g.14657
 AACTGGGCCCTTAAAGAACAGCTCAAGTCCTGGCAGCGGCTCCGGCATGACTTGGAGCGA       c.1800
 N  W  A  L  K  E  Q  L  K  S  W  Q  R  L  R  H  D  L  E  R         p.600

          .         .         .         .         .     | 06   .    g.15302
 GCTCGGCTGCTCGTGGAATTGATCCGCAAGCGGGAAAAACTCAAAAGGGAGACG | ATCAAG    c.1860
 A  R  L  L  V  E  L  I  R  K  R  E  K  L  K  R  E  T   | I  K      p.620

          .         .         .         .         .         .       g.15362
 GTTCAGCAGATTGCCATGGAGATGCAGCTGACTCCTTTCCTCATCCTCCTTCGCAAAACC       c.1920
 V  Q  Q  I  A  M  E  M  Q  L  T  P  F  L  I  L  L  R  K  T         p.640

          .         .         .         .         .         .       g.15422
 TTGGAGCAGCTCCAAGAGAAGGACACAGGCAACATCTTCAGCGAGCCGGTCCCTCTGTCT       c.1980
 L  E  Q  L  Q  E  K  D  T  G  N  I  F  S  E  P  V  P  L  S         p.660

          .         .  | 07      .         .         .         .    g.16254
 GAGGTAACCGAATTGGACGAA | GTACCTGACTACCTAGACCACATCAAAAAGCCCATGGAC    c.2040
 E  V  T  E  L  D  E   | V  P  D  Y  L  D  H  I  K  K  P  M  D      p.680

          .         .         .         .         .         .       g.16314
 TTTTTCACCATGAAGCAGAACTTGGAGGCTTACCGCTACCTGAATTTTGATGATTTTGAG       c.2100
 F  F  T  M  K  Q  N  L  E  A  Y  R  Y  L  N  F  D  D  F  E         p.700

          .         .         .         .         .         .       g.16374
 GAGGACTTCAACCTCATCGTCAGCAACTGCCTCAAGTATAACGCCAAGGACACCATCTTC       c.2160
 E  D  F  N  L  I  V  S  N  C  L  K  Y  N  A  K  D  T  I  F         p.720

          .         .         .         .         .         .       g.16434
 TACCGGGCAGCAGTGCGGCTTCGTGAGCAGGGTGGTGCTGTGCTCCGCCAGGCCCGGCGC       c.2220
 Y  R  A  A  V  R  L  R  E  Q  G  G  A  V  L  R  Q  A  R  R         p.740

          .         .         .         .         .         .       g.16494
 CAGGCAGAAAAAATGGGCATTGACTTTGAGACGGGCATGCATATCCCCCACAGCCTGGCT       c.2280
 Q  A  E  K  M  G  I  D  F  E  T  G  M  H  I  P  H  S  L  A         p.760

          .         .         .  | 08      .         .         .    g.16878
 GGAGATGAGGCCACACACCACACTGAAGATG | CAGCCGAGGAAGAGCGGCTGGTCTTGCTG    c.2340
 G  D  E  A  T  H  H  T  E  D  A |   A  E  E  E  R  L  V  L  L      p.780

          .         .         .         .         .         .       g.16938
 GAGAACCAGAAGCACCTGCCAGTGGAAGAACAGCTAAAGCTGCTTCTGGAGCGGCTGGAC       c.2400
 E  N  Q  K  H  L  P  V  E  E  Q  L  K  L  L  L  E  R  L  D         p.800

          .         .         .         .         .         .       g.16998
 GAAGTGAATGCCAGCAAGCAGAGTGTGGGCCGCTCACGGCGTGCAAAGATGATCAAGAAA       c.2460
 E  V  N  A  S  K  Q  S  V  G  R  S  R  R  A  K  M  I  K  K         p.820

          .         .         .         .         .         .       g.17058
 GAGATGACGGCACTGCGGCGGAAGCTTGCCCATCAGCGAGAGACGGGACGTGATGGCCCT       c.2520
 E  M  T  A  L  R  R  K  L  A  H  Q  R  E  T  G  R  D  G  P         p.840

          .         .         .         .         .         .       g.17118
 GAGCGGCATGGCCCCTCGAGCCGGGGTAGTCTGACACCCCACCCGGCAGCCTGTGACAAG       c.2580
 E  R  H  G  P  S  S  R  G  S  L  T  P  H  P  A  A  C  D  K         p.860

          .         .         .         .         .      | 09  .    g.17500
 GATGGGCAGACAGATAGTGCGGCAGAGGAGAGCAGCAGCCAGGAGACAAGCAAAG | GCCTG    c.2640
 D  G  Q  T  D  S  A  A  E  E  S  S  S  Q  E  T  S  K  G |   L      p.880

          .         .         .         .         .         .       g.17560
 GGTCCCAACATGTCCTCAACCCCCGCACATGAGGTGGGCAGGAGAACCTCAGTTCTGTTC       c.2700
 G  P  N  M  S  S  T  P  A  H  E  V  G  R  R  T  S  V  L  F         p.900

          .         .         .         .         .         .       g.17620
 TCCAAAAAGAACCCGAAGACAGCTGGACCGCCCAAGAGGCCGGGCCGGCCCCCCAAAAAC       c.2760
 S  K  K  N  P  K  T  A  G  P  P  K  R  P  G  R  P  P  K  N         p.920

          .         .         .         .         .         .       g.17680
 CGGGAGAGCCAGATGACCCCCAGCCACGGAGGCAGTCCTGTGGGGCCCCCCCAGCTCCCC       c.2820
 R  E  S  Q  M  T  P  S  H  G  G  S  P  V  G  P  P  Q  L  P         p.940

          .         .         .         .         .         .       g.17740
 ATCATGAGTTCCCTGCGTCAGCGCAAGCGGGGTAGGAGCCCCCGGCCCAGTTCGAGCTCA       c.2880
 I  M  S  S  L  R  Q  R  K  R  G  R  S  P  R  P  S  S  S  S         p.960

          .         .         .         . | 10       .         .    g.18299
 GACAGCGACAGTGATAAGTCCACAGAAGACCCCCCAATGG | ACTTACCAGCCAATGGCTTC    c.2940
 D  S  D  S  D  K  S  T  E  D  P  P  M  D |   L  P  A  N  G  F      p.980

          .         .         .         .         .         .       g.18359
 AGCGGTGGAAACCAACCAGTGAAGAAGAGTTTCTTGGTATACCGTAATGACTGCAGCCTT       c.3000
 S  G  G  N  Q  P  V  K  K  S  F  L  V  Y  R  N  D  C  S  L         p.1000

          .         .         .         .         .         .       g.18419
 CCCCGGAGCAGCTCAGACTCTGAGTCCAGCAGCAGTAGCAGTAGCAGCGCTGCTTCAGAC       c.3060
 P  R  S  S  S  D  S  E  S  S  S  S  S  S  S  S  A  A  S  D         p.1020

          | 11         .         .         .         .         .    g.18896
 CGGACCAG | CACAACGCCCTCAAAACAAGGCCGGGGCAAACCCTCCTTCTCTCGGGGCACT    c.3120
 R  T  S  |  T  T  P  S  K  Q  G  R  G  K  P  S  F  S  R  G  T      p.1040

          .         .         .         .         .         .       g.18956
 TTCCCAGAGGACAGCAGTGAGGATACCTCAGGCACTGAGAATGAGGCCTACTCCGTGGGC       c.3180
 F  P  E  D  S  S  E  D  T  S  G  T  E  N  E  A  Y  S  V  G         p.1060

          .         .      | 12  .         .         .         .    g.19118
 ACTGGCCGCGGCGTGGGCCACAGCA | TGGTAAGGAAGAGTCTGGGCCGGGGAGCTGGCTGG    c.3240
 T  G  R  G  V  G  H  S  M |   V  R  K  S  L  G  R  G  A  G  W      p.1080

          .         .         .         .         .         .       g.19178
 CTGTCAGAGGATGAGGACTCCCCGCTGGATGCTCTGGACCTCGTGTGGGCCAAATGCCGA       c.3300
 L  S  E  D  E  D  S  P  L  D  A  L  D  L  V  W  A  K  C  R         p.1100

          .         .     | 13   .         .         .         .    g.19607
 GGCTATCCATCATACCCAGCTCTG | ATCATTGATCCAAAGATGCCCCGAGAAGGTATGTTC    c.3360
 G  Y  P  S  Y  P  A  L   | I  I  D  P  K  M  P  R  E  G  M  F      p.1120

          .         .         .         .         .         .       g.19667
 CACCATGGGGTTCCCATCCCTGTGCCCCCACTGGAGGTGCTGAAACTTGGGGAGCAGATG       c.3420
 H  H  G  V  P  I  P  V  P  P  L  E  V  L  K  L  G  E  Q  M         p.1140

          .         .         .         .         .          | 14    g.20438
 ACCCAGGAAGCCCGAGAGCATCTCTACCTCGTCCTCTTCTTTGACAACAAACGAACCTG | G    c.3480
 T  Q  E  A  R  E  H  L  Y  L  V  L  F  F  D  N  K  R  T  W  |      p.1160

          .         .         .         .         .         .       g.20498
 CAGTGGCTGCCCAGGACCAAGCTGGTTCCTCTGGGTGTGAACCAGGACCTAGACAAGGAG       c.3540
 Q  W  L  P  R  T  K  L  V  P  L  G  V  N  Q  D  L  D  K  E         p.1180

          .         .         .         .         .         .       g.20558
 AAGATGCTGGAGGGCCGCAAGTCCAACATCCGCAAGTCAGTACAGATCGCCTACCACAGG       c.3600
 K  M  L  E  G  R  K  S  N  I  R  K  S  V  Q  I  A  Y  H  R         p.1200

          .         .         .         .         .         .       g.20618
 GCTCTGCAGCACCGCAGCAAGGTGCAAGGCGAGCAGAGCAGTGAGACCAGCGATAGTGAT       c.3660
 A  L  Q  H  R  S  K  V  Q  G  E  Q  S  S  E  T  S  D  S  D         p.1220

                                                                    g.20621
 TGA                                                                c.3663
 X                                                                  p.1220

          .         .         .         .         .         .       g.20681
 tactgctcaacacagcccaacctatagtgccctgtgacttctctcctcccctttgctcac       c.*60

          .         .         .         .         .         .       g.20741
 tgtcctggagtggcaccggcctctgcactgactcatttctggtcttggggccagtctcag       c.*120

          .         .         .         .         .         .       g.20801
 gggaagctgggtgggggaggtccctcctgccctaagtgcagctggactgtacagaacact       c.*180

          .         .         .         .         .         .       g.20861
 ccaagggccaatggcagttcagcgcaaggagagggagggcccacaggtcagaaaaagctc       c.*240

          .         .         .         .         .         .       g.20921
 cagagacctcacagcattgtagggcggggtggtgggccaaagttaggacactgcgtaaaa       c.*300

          .         .         .         .         .         .       g.20981
 caggccatcccaccacctctacctgctcatgccaggagaatccataactgcctagaggcc       c.*360

          .         .         .         .         .         .       g.21041
 tggggcccctaccggtcgtgaggtgagtgggcatctgtccagcctggaagaggggcacta       c.*420

          .         .         .         .         .         .       g.21101
 ggtgactccctcccctgctgttgtaaatactgtaattatcggagaatttaaattattctc       c.*480

          .         .         .         .         .         .       g.21161
 atttgtaactgcgtttccgggtcgcgccagagtcatttggtactaaaaaaaaaaaaaaaa       c.*540

          .         .         .         .         .         .       g.21221
 aagactgggggctgtccccatttcccttctctttcccatagattcccccacctttcaaac       c.*600

          .         .         .         .         .         .       g.21281
 tggtttgtatttatttcaaaggaagaaaatatattgattcttagaaaataaactgtcaat       c.*660

                                                                    g.21287
 ttagaa                                                             c.*666

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Bromodomain and PHD finger containing, 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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