BUB3 mitotic checkpoint protein (BUB3) - coding DNA reference sequence

(used for variant description)

(last modified September 5, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_004725.3 in the BUB3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_033794.1, covering BUB3 transcript NM_004725.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5002
                                                           ag       c.-241

 .         .         .         .         .         .                g.5062
 cggtttccctttgagccggaacaggatgactgggttgaccgatgctgggcagctgagcgg       c.-181

 .         .         .         .         .         .                g.5122
 accaatcggccccctagactgagacgttggcgtttgaaatcagccaatggcaggtctaca       c.-121

 .         .         .         .         .         .                g.5182
 ctggagcttcctctccgcctccttcgcctagcctgcgagtgttctgagggaagcaaggag       c.-61

 .         .         .         .         .         .                g.5242
 gcggcggcggccgcagcgagtggcgagtagtggaaacgttgcttctgaggggagcccaag       c.-1

  | 02       .         .         .         .         .         .    g.5734
  | ATGACCGGTTCTAACGAGTTCAAGCTGAACCAGCCACCCGAGGATGGCATCTCCTCCGTG    c.60
  | M  T  G  S  N  E  F  K  L  N  Q  P  P  E  D  G  I  S  S  V      p.20

          .         .         .         .         .         .       g.5794
 AAGTTCAGCCCCAACACCTCCCAGTTCCTGCTTGTCTCCTCCTGGGACACGTCCGTGCGT       c.120
 K  F  S  P  N  T  S  Q  F  L  L  V  S  S  W  D  T  S  V  R         p.40

          .         .         .         .         .         .       g.5854
 CTCTACGATGTGCCGGCCAACTCCATGCGGCTCAAGTACCAGCACACCGGCGCCGTCCTG       c.180
 L  Y  D  V  P  A  N  S  M  R  L  K  Y  Q  H  T  G  A  V  L         p.60

          .      | 03  .         .         .         .         .    g.6459
 GACTGCGCCTTCTAC | GATCCAACGCATGCCTGGAGTGGAGGACTAGATCATCAATTGAAA    c.240
 D  C  A  F  Y   | D  P  T  H  A  W  S  G  G  L  D  H  Q  L  K      p.80

          .         .      | 04  .         .         .         .    g.8520
 ATGCATGATTTGAACACTGATCAAG | AAAATCTTGTTGGGACCCATGATGCCCCTATCAGA    c.300
 M  H  D  L  N  T  D  Q  E |   N  L  V  G  T  H  D  A  P  I  R      p.100

          .         .         .         .         .         .       g.8580
 TGTGTTGAATACTGTCCAGAAGTGAATGTGATGGTCACTGGAAGTTGGGATCAGACAGTT       c.360
 C  V  E  Y  C  P  E  V  N  V  M  V  T  G  S  W  D  Q  T  V         p.120

          .         .         .         .         .        | 05.    g.11166
 AAACTGTGGGATCCCAGAACTCCTTGTAATGCTGGGACCTTCTCTCAGCCTGAAAAG | GTA    c.420
 K  L  W  D  P  R  T  P  C  N  A  G  T  F  S  Q  P  E  K   | V      p.140

          .         .         .         .         .         .       g.11226
 TATACCCTCTCAGTGTCTGGAGACCGGCTGATTGTGGGAACAGCAGGCCGCAGAGTGTTG       c.480
 Y  T  L  S  V  S  G  D  R  L  I  V  G  T  A  G  R  R  V  L         p.160

          .         .         .         .         .         .       g.11286
 GTGTGGGACTTACGGAACATGGGTTACGTGCAGCAGCGCAGGGAGTCCAGCCTGAAATAC       c.540
 V  W  D  L  R  N  M  G  Y  V  Q  Q  R  R  E  S  S  L  K  Y         p.180

          .         .         .       | 06 .         .         .    g.13016
 CAGACTCGCTGCATACGAGCGTTTCCAAACAAGCAG | GGTTATGTATTAAGCTCTATTGAA    c.600
 Q  T  R  C  I  R  A  F  P  N  K  Q   | G  Y  V  L  S  S  I  E      p.200

          .         .         .         .         .         .       g.13076
 GGCCGAGTGGCAGTTGAGTATTTGGACCCAAGCCCTGAGGTACAGAAGAAGAAGTATGCC       c.660
 G  R  V  A  V  E  Y  L  D  P  S  P  E  V  Q  K  K  K  Y  A         p.220

          .         .         .         .         .         .       g.13136
 TTCAAATGTCACAGACTAAAAGAAAATAATATTGAGCAGATTTACCCAGTCAATGCCATT       c.720
 F  K  C  H  R  L  K  E  N  N  I  E  Q  I  Y  P  V  N  A  I         p.240

          .         .         .     | 07   .         .         .    g.13394
 TCTTTTCACAATATCCACAATACATTTGCCACAG | GTGGTTCTGATGGCTTTGTAAATATT    c.780
 S  F  H  N  I  H  N  T  F  A  T  G |   G  S  D  G  F  V  N  I      p.260

          .         .         .         .         .         .       g.13454
 TGGGATCCATTTAACAAAAAGCGACTGTGCCAATTCCATCGGTACCCCACGAGCATCGCA       c.840
 W  D  P  F  N  K  K  R  L  C  Q  F  H  R  Y  P  T  S  I  A         p.280

          .         .         .         .         .         .       g.13514
 TCACTTGCCTTCAGTAATGATGGGACTACGCTTGCAATAGCGTCATCATATATGTATGAA       c.900
 S  L  A  F  S  N  D  G  T  T  L  A  I  A  S  S  Y  M  Y  E         p.300

          .         .         .         .         .         .       g.13574
 ATGGATGACACAGAACATCCTGAAGATGGTATCTTCATTCGCCAAGTGACAGATGCAGAA       c.960
 M  D  D  T  E  H  P  E  D  G  I  F  I  R  Q  V  T  D  A  E         p.320

          .  | 08      .                                            g.14625
 ACAAAACCCAA | GTCACCATGTACTTGA                                     c.987
 T  K  P  K  |  S  P  C  T  X                                       p.328

          .         .         .         .         .         .       g.14685
 caagatttcatttacttaagtgccatgttgatgataataaaacaattcgtactccccaat       c.*60

          .         .         .         .         .         .       g.14745
 ggtggatttattactattaaagaaaccagggaaaatattaattttaatattataacaacc       c.*120

          .         .         .         .         .         .       g.14805
 tgaaaataatggaaaagaggtttttgaatttttttttttaaataaacaccttcttaagtg       c.*180

          .         .         .         .         .         .       g.14865
 catgagatggtttgatggtttgctgcattaaaggtatttgggcaaacaaaattggagggc       c.*240

          .         .         .         .         .         .       g.14925
 aagtgactgcagttttgagaatcagttttgaccttgatgattttttgtttccactgtgga       c.*300

          .         .         .         .         .         .       g.14985
 aataaatgtttgtaaataagtgtaataaaaatccctttgcattctttctggaccttaaat       c.*360

          .         .         .         .         .         .       g.15045
 ggtagaggaaaaggctcgtgagccatttgtttcttttgctggttatagttgctaattcta       c.*420

          .         .         .         .         .         .       g.15105
 aagctgcttcagactgcttcatgaggaggttaatctacaattaaacaatatttcctcttg       c.*480

          .         .         .         .         .         .       g.15165
 gccgtccattattttctgaagcagatggttcatcatttcctgggctgttaaacaaagcga       c.*540

          .         .         .         .         .         .       g.15225
 ggttaaggttagactcttgggaatcagctagttttcaatcttattagggtgcagaaggaa       c.*600

          .         .         .         .         .         .       g.15285
 aactaataagaaaacctcctaatatcattttgtgactgtaaacaattatttattagcaaa       c.*660

          .         .         .         .         .         .       g.15345
 caattgatcccagaagggcaaattgtttgagtcagtaatgagctgagaaaagacagagca       c.*720

          .         .         .         .         .         .       g.15405
 tatctgtgtatttggaaaaataattgtaacgtaattgcagtgcatttagacaggcatcta       c.*780

          .         .         .         .         .         .       g.15465
 tttggacctgtttctatctctaaatgaatttttggaaacattaatgaggtttacatattt       c.*840

          .         .         .         .         .         .       g.15525
 ctctgacatttatatagttcttatgtccatttcagttgaccagccgctggtgattaaagt       c.*900

          .         .         .         .         .         .       g.15585
 taaaaagaaaaaaattatagtgagaatgagattcatttcaatgtaatgcactaaagcaga       c.*960

          .         .         .         .         .         .       g.15645
 acacgaacttagcttggcctattctaggtagttccaaatagtatttttgttgtcaaactt       c.*1020

          .         .         .         .         .         .       g.15705
 taaaatttatattaatttgcaaatgtatgtctctgagtaggacttggacctttcctgaga       c.*1080

          .         .         .         .         .         .       g.15765
 tttattttatccgtgatgtattttttttaattcttttgatacagagaagggtcttttttt       c.*1140

          .         .         .         .         .         .       g.15825
 ttttaagtatttcagtgaaaacttggtgtaagtctgaacccatcttttgaaatgtatttt       c.*1200

          .         .         .         .         .         .       g.15885
 cttcattgcaggtccacctaatcatcctgtgaaagtggtttctctatggaaagctttgtt       c.*1260

          .         .         .         .         .         .       g.15945
 tgcttcctacaaatacatgcttattccttaagggatgtgttagagttactgtggatttct       c.*1320

          .         .         .         .         .         .       g.16005
 ctgttttctgtcttacaagaaacttgtctatgtaccttaatactttgtttaggatgagga       c.*1380

          .         .         .         .         .         .       g.16065
 gtctttgtgtccctgtacagtagtctgacgtatttccccttctgtcccctagtaagccca       c.*1440

          .         .         .         .         .         .       g.16125
 gttgctgtatctgaacagtttgagctctttttgtaatatactctaaacctgttatttctg       c.*1500

          .         .         .                                     g.16160
 tgctaataaacgagatgcagaacccttgaatgttg                                c.*1535

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The BUB3 mitotic checkpoint protein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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