chromosome 10 open reading frame 11 (C10orf11) - coding DNA reference sequence

(used for variant description)

(last modified August 27, 2020)

This file was created to facilitate the description of sequence variants on transcript NM_032024.3 in the C10orf11 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000010.10, covering C10orf11 transcript NM_032024.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                               .         .         .                g.5035
                          gttgaagaaagaggatctggctgaaagacccgcaa       c.-181

 .         .         .         .         .         .                g.5095
 ctttcacttgttgagaacctttagccagcgccggcgtgcatgtgttttagttttattctt       c.-121

 .         .         .         .         .         .                g.5155
 tttcccttgcccccaaagccgtggagtacctgctgttgctctcatgcctcttgccaacag       c.-61

 .         .         .         .         .         .                g.5215
 tggcatctgctcagtgtagccatcaagaatttgaatgtcaatatctttgccttgaaatga       c.-1

          .         .         .         .        | 02.         .    g.258260
 ATGGAAAAGTATTTGTCACTCAGCGGCAATCATTCTTCAAATAAAAG | GTCACTGGAAGGA    c.60
 M  E  K  Y  L  S  L  S  G  N  H  S  S  N  K  R  |  S  L  E  G      p.20

          .         .         .         .         .         .       g.258320
 CTGAGCGCATTCAGGAGCCTGGAGGAACTCATCTTGGACAACAATCAGCTGGGGGACGAC       c.120
 L  S  A  F  R  S  L  E  E  L  I  L  D  N  N  Q  L  G  D  D         p.40

          .         .         .         .         .     | 03   .    g.269409
 CTTGTGTTGCCAGGGTTACCCAGACTGCATACCTTAACCCTCAACAAGAACCGA | ATCACT    c.180
 L  V  L  P  G  L  P  R  L  H  T  L  T  L  N  K  N  R   | I  T      p.60

          .         .         .         .         .         .       g.269469
 GATTTGGAGAACCTGCTGGATCACTTGGCAGAAGTGACACCAGCTCTGGAGTACCTCAGT       c.240
 D  L  E  N  L  L  D  H  L  A  E  V  T  P  A  L  E  Y  L  S         p.80

          .         .         .         .         .         .       g.269529
 CTGCTGGGCAACGTGGCCTGTCCCAACGAGCTGGTCAGCTTGGAAAAGGATGAGGAAGAC       c.300
 L  L  G  N  V  A  C  P  N  E  L  V  S  L  E  K  D  E  E  D         p.100

          .     | 04   .         .         .         .         .    g.280951
 TACAAGAGATACAG | ATGCTTTGTTCTGTACAAGCTGCCCAACTTGAAATTTCTGGATGCC    c.360
 Y  K  R  Y  R  |  C  F  V  L  Y  K  L  P  N  L  K  F  L  D  A      p.120

          .         .         .         .         .         .       g.281011
 CAGAAAGTAACCAGACAAGAACGAGAGGAGGCGTTGGTCAGAGGAGTCTTCATGAAGGTG       c.420
 Q  K  V  T  R  Q  E  R  E  E  A  L  V  R  G  V  F  M  K  V         p.140

          .   | 05     .         .         .         .         .    g.546688
 GTGAAGCCCAAG | GCTTCTAGTGAGGACGTTGCCAGCTCCCCGGAGCGCCACTACACGCCC    c.480
 V  K  P  K   | A  S  S  E  D  V  A  S  S  P  E  R  H  Y  T  P      p.160

          .         .         .        | 06.         .         .    g.779471
 TTGCCTTCTGCTTCCAGGGAACTCACCAGTCACCAAG | GTGTCCTGGGGAAGTGTCGCTAC    c.540
 L  P  S  A  S  R  E  L  T  S  H  Q  G |   V  L  G  K  C  R  Y      p.180

          .         .         .         .         .                 g.779528
 GTTTACTATGGGAAAAACTCAGAGGGCAACAGGTTTATCCGAGATGACCAGCTCTGA          c.597
 V  Y  Y  G  K  N  S  E  G  N  R  F  I  R  D  D  Q  L  X            p.198

          .         .         .         .         .         .       g.779588
 agccaacttctgtataccttcacccatttcatgaaaataaaatcaaaagggaaatcaaaa       c.*60

          .         .                                               g.779612
 ataaagaaaacgctaaagaaaaaa                                           c.*84

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Chromosome 10 open reading frame 11 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.