chromosome 14 open reading frame 39 (C14orf39) - coding DNA reference sequence

(used for variant description)

(last modified February 4, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_174978.2 in the C14orf39 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000014.8, covering C14orf39 transcript NM_174978.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           ccggggaccgtttgtagttaggatccgctgtggcgtcctgagtggagttt       c.-61

 .         .         .         .         .         .  | 02          g.5968
 gggaccccagggagggagggtgtgggcgttcgggtccagaggagctgtttag | tatccaag    c.-1

          .         .         .         .          | 03        .    g.6120
 ATGAATGACAGCCTGTTTGTCAGTTTGGACAGACTTTTGCTAGAATTTG | TCTTCCAGTAT    c.60
 M  N  D  S  L  F  V  S  L  D  R  L  L  L  E  F  V |   F  Q  Y      p.20

          .         .         .         .       | 04 .         .    g.7243
 GAGCAAGACATAAGTACTAAAGAAGAGATGATTCAAAGAATTAATA | AATGCTGTGAAGAT    c.120
 E  Q  D  I  S  T  K  E  E  M  I  Q  R  I  N  K |   C  C  E  D      p.40

          .         .         .         .         .         .       g.7303
 ATTAAGGAAAACAAAGTAACTATTTGTAGGATACACGAAACTATAAATGCAACAGATGAG       c.180
 I  K  E  N  K  V  T  I  C  R  I  H  E  T  I  N  A  T  D  E         p.60

          .         .         .         .         .    | 05    .    g.12664
 GAAATTGATCATTACTGTAAACATAGTGAGGAGATTAAAGACAACTGTAGAAA | CTGGAAG    c.240
 E  I  D  H  Y  C  K  H  S  E  E  I  K  D  N  C  R  N  |  W  K      p.80

          .         .         .         .         .         .       g.12724
 CCAACATGTGATGTTTTTCGTAAACATGAAGATTATATGCAGGACCAATTTACTGTTTAT       c.300
 P  T  C  D  V  F  R  K  H  E  D  Y  M  Q  D  Q  F  T  V  Y         p.100

          .         .    | 06    .         .         .         .    g.19344
 CAAGGAACTGTTGAAAAAGACAA | AGAAATGTATCATGATTATATATGTCAGTATAAAGAA    c.360
 Q  G  T  V  E  K  D  K  |  E  M  Y  H  D  Y  I  C  Q  Y  K  E      p.120

          .         .         .         .         .         .       g.19404
 GTTTTGAAGCAGTACCAACTAAAATACTCAGAAACACCCTTTTCACGTGAATATTATGAG       c.420
 V  L  K  Q  Y  Q  L  K  Y  S  E  T  P  F  S  R  E  Y  Y  E         p.140

          .         .         .         .         .         .       g.19464
 AAGAAAAGAGAACATGAAGAAATTCAAAGCAGAGTGTTGGCATGTACTGAACAATTAAAA       c.480
 K  K  R  E  H  E  E  I  Q  S  R  V  L  A  C  T  E  Q  L  K         p.160

          .         .         .  | 07      .         .         .    g.19616
 ATGAATGAAACAATTTTTATGAAATTTCGAG | TGCCTGCTCCCTTTCCATCACTTACTAAA    c.540
 M  N  E  T  I  F  M  K  F  R  V |   P  A  P  F  P  S  L  T  K      p.180

          .     | 08   .         .         .         .         .    g.21439
 TGGACTTTAAACAT | TGTTAATTTGAGATGTGAAACACAAGATATTCTTAAACATGCCAGC    c.600
 W  T  L  N  I  |  V  N  L  R  C  E  T  Q  D  I  L  K  H  A  S      p.200

          .         .         .         .         .         .       g.21499
 AATCTTACCAAAAGTTCATCCGAATTGAAGAAAGAAGTAGATGAAATGGAAATAGAAATT       c.660
 N  L  T  K  S  S  S  E  L  K  K  E  V  D  E  M  E  I  E  I         p.220

          .      | 09  .         .         .         .         .    g.22555
 AATTATTTAAACCAG | CAGATATCTAGGCATAATGAAACTAAGGCTCTTTCAGAAACTCTG    c.720
 N  Y  L  N  Q   | Q  I  S  R  H  N  E  T  K  A  L  S  E  T  L      p.240

          .         .         .         .        | 10.         .    g.24015
 GAAGAAAAGAACAAAAATACAGAAAACAGAAAAGAACTGAAAGAAAG | AATTTTTGGAAAA    c.780
 E  E  K  N  K  N  T  E  N  R  K  E  L  K  E  R  |  I  F  G  K      p.260

          .         .         .         .         .         .       g.24075
 GATGAGCATGTACTTACATTGAATAAAACTCAAAGCAGTCAATTATTTCTTCCTTATGAA       c.840
 D  E  H  V  L  T  L  N  K  T  Q  S  S  Q  L  F  L  P  Y  E         p.280

          .         .         .         .         .      | 11  .    g.24996
 TCTCAGAAATTAGTAAGACCAATAAAGATGCATTCTTCAGAACCAAGAGTTGCAG | ATATA    c.900
 S  Q  K  L  V  R  P  I  K  M  H  S  S  E  P  R  V  A  D |   I      p.300

          .         .         .         .         .         .       g.25056
 AAAGAAGAAAGTTCTGCGAAGCAGTCAAAGCTTGCCAATATTGACTTTAGACAAAAAGAA       c.960
 K  E  E  S  S  A  K  Q  S  K  L  A  N  I  D  F  R  Q  K  E         p.320

          .   | 12     .         .         .         .         .    g.29501
 AATGATACACAG | ATATTTAATGACTCTGCTGTGGATAACCATTCAAAATGTTCACATATT    c.1020
 N  D  T  Q   | I  F  N  D  S  A  V  D  N  H  S  K  C  S  H  I      p.340

          .         .         .         | 13         .         .    g.29656
 ACGACTATCACAAGTTCACAAAAGTTTATGCAAGTCAG | ATTGTTAACCCCACAGAAACAA    c.1080
 T  T  I  T  S  S  Q  K  F  M  Q  V  R  |  L  L  T  P  Q  K  Q      p.360

          .         .         .        | 14.         .         .    g.32330
 TCAAATTCCAATCAGTGGTCGGAAAAAGGGGATAAAG | ATGCTGAGTATGGAGATAAAGGG    c.1140
 S  N  S  N  Q  W  S  E  K  G  D  K  D |   A  E  Y  G  D  K  G      p.380

          .         .         .          | 15        .         .    g.33972
 ACAGTAAGACAAGTAAGAGAATCAAAATGTACTTCACAA | GCTATATATACTGAACATTTT    c.1200
 T  V  R  Q  V  R  E  S  K  C  T  S  Q   | A  I  Y  T  E  H  F      p.400

          .         .         .         .         .         .       g.34032
 GGGAAGTCAGTAGAAAATGATAGTGATGAAGTAGAAGAGAGAGCTGAGAATTTTCCACGA       c.1260
 G  K  S  V  E  N  D  S  D  E  V  E  E  R  A  E  N  F  P  R         p.420

          .         .         .         .         .         .       g.34092
 ACGTCTGAAATTCCTATATTTTTAGGAACTCCCAAAGCTGTGAAAGCACCTGAGTCATTG       c.1320
 T  S  E  I  P  I  F  L  G  T  P  K  A  V  K  A  P  E  S  L         p.440

          .         .         .         | 16         .         .    g.35923
 GAGAAAATAAAATTCCCTAAAACCCCCCCGTTCGAAAT | TAACAGAAATAGAAATGCAGTA    c.1380
 E  K  I  K  F  P  K  T  P  P  F  E  I  |  N  R  N  R  N  A  V      p.460

          .         .         .         .         .         .       g.35983
 CCTGAAGTTCAAACAGAAAAGGAATCCCCTGGACTTTCTTTTCTTATGAGTTATACTTCT       c.1440
 P  E  V  Q  T  E  K  E  S  P  G  L  S  F  L  M  S  Y  T  S         p.480

          .         .         .         .         .         .       g.36043
 AGATCACCTGGATTGAATTTATTTGATTCTTCTGTATTTGATACAGAAATCTCATCAGAT       c.1500
 R  S  P  G  L  N  L  F  D  S  S  V  F  D  T  E  I  S  S  D         p.500

     | 17    .         .         .         .         .         .    g.48972
 CAG | TTTAATGAACATTATTCTGCAAGAAATCTAAATCCTCTGTCATCAGAGCAAGAGATT    c.1560
 Q   | F  N  E  H  Y  S  A  R  N  L  N  P  L  S  S  E  Q  E  I      p.520

   | 18      .         .         .         .         .         .    g.54058
 G | GAAACTTACTTGAGAAGCCAGAAGGAGAAGATGGCTTTACATTTTCTTTTCCATCAGAC    c.1620
 G |   N  L  L  E  K  P  E  G  E  D  G  F  T  F  S  F  P  S  D      p.540

          .         .         .         .         .         .       g.54118
 ACTTCAACTCATACATTTGGAGCTGGAAAAGATGATTTTAGTTTTCCATTTTCATTTGGA       c.1680
 T  S  T  H  T  F  G  A  G  K  D  D  F  S  F  P  F  S  F  G         p.560

          .         .         .         .         .         .       g.54178
 CAGGGTCAAAATTCAATACCTTCTTCTTCTTTAAAAGGTTTTTCATCTTCCTCACAAAAT       c.1740
 Q  G  Q  N  S  I  P  S  S  S  L  K  G  F  S  S  S  S  Q  N         p.580

          .         .                                               g.54202
 ACAACACAGTTTACTTTTTTTTGA                                           c.1764
 T  T  Q  F  T  F  F  X                                             p.587

          .         .         .         .         .         .       g.54262
 gctagtcattaattccttaaattattttactgttctgtgttcatgagggcataaatttac       c.*60

          .         .         .         .         .         .       g.54322
 attattgcttaaaacatgaagactgctttcttttattgattaaagcagtaatgtttacat       c.*120

          .         .         .         .         .         .       g.54382
 tatttgattatatttattgaaatattgaaatactgaatattttgggttttgtgtgtgcta       c.*180

          .         .         .         .         .         .       g.54442
 ttaactaatcattatttattttggttttgattttgcgagccgtggtcaggtagaactttt       c.*240

          .         .         .         .         .         .       g.54502
 attaatcttaatagaatttgatgcttttttcattactctttatttaaatattaagcctgc       c.*300

          .         .         .         .         .         .       g.54562
 ttctccttggaacctaaggtttttttctggaagtattgttggtactttgataagaacaag       c.*360

          .         .         .         .         .         .       g.54622
 aactgcagtagtaactccagagttagtgctgaagcgtactttagctactaaaaatttcta       c.*420

          .         .         .         .         .         .       g.54682
 ttaaaattattgggtttcacttctgcttcactatgtagtatacagagtggtactgtaata       c.*480

          .         .         .         .         .         .       g.54742
 ataatttcaaataatttatgttaataacaaaatctgtgttattttcttctaatataacac       c.*540

          .         .         .         .         .         .       g.54802
 atggtacaattctaattttatgagttatgctaatgctttcaatggctaaaaattaaatgt       c.*600

          .         .         .         .         .         .       g.54862
 aaagggcaagagtaatttctgaaaattggattgttgtatcagtggtgatcctgttaatat       c.*660

          .         .         .         .         .         .       g.54922
 tcttttttgcttaaatattttttgaagaacatttacaattttgtctccttcaataacaaa       c.*720

          .         .         .         .         .         .       g.54982
 aatttcttctttatgttttgtgttcagtatttgtcaattaattatatagcttaagtgaag       c.*780

          .         .         .         .         .         .       g.55042
 atatttaagatttgatgaacttctgtaaacattttgctcaatatcattgtattttgtgct       c.*840

          .         .         .         .                           g.55091
 ttgtaaattagctgtactgagttaccaagtaataaagggtttgactcca                  c.*889

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Chromosome 14 open reading frame 39 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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