chromosome 2 open reading frame 69 (C2orf69) - coding DNA reference sequence

(used for variant description)

(last modified June 12, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_153689.5 in the C2orf69 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000002.11, covering C2orf69 transcript NM_153689.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5003
                                                          ctt       c.-181

 .         .         .         .         .         .                g.5063
 cctttccttacgcacgctgcgcgcggacgtcggcctctgacgtcgtcgcctcagcgccgg       c.-121

 .         .         .         .         .         .                g.5123
 ctcccggccgggccgcggccgccgaccgttgagccgccggctgagccgcctgctgaagtc       c.-61

 .         .         .         .         .         .                g.5183
 cctccctcaggaacccctccgccaccctccacctccgaaccgctctcgcggcggcgaccc       c.-1

          .         .         .         .         .         .       g.5243
 ATGTGGGGGTTCAGGCTCCTGCGGTCGCCGCCGTTGCTGCTCCTGCTGCCGCAGCTCGGA       c.60
 M  W  G  F  R  L  L  R  S  P  P  L  L  L  L  L  P  Q  L  G         p.20

          .         .         .         .         .         .       g.5303
 ATCGGAAACGCCTCGTCCTGCTCTCAGGCCAGAACCATGAACCCGGGCGGCAGCGGCGGC       c.120
 I  G  N  A  S  S  C  S  Q  A  R  T  M  N  P  G  G  S  G  G         p.40

          .         .         .         .         .         .       g.5363
 GCGCGATGCTCCCTCTCGGCCGAGGTGCGCCGCCGTCAGTGCCTGCAGCTTTCCACCGTG       c.180
 A  R  C  S  L  S  A  E  V  R  R  R  Q  C  L  Q  L  S  T  V         p.60

          .         .         .         .         .         .       g.5423
 CCTGGAGCCGATCCGCAGCGCAGCAACGAATTGCTCCTGTTGGCGGCGGCCGGGGAGGGA       c.240
 P  G  A  D  P  Q  R  S  N  E  L  L  L  L  A  A  A  G  E  G         p.80

          .         .         .         .         .         .       g.5483
 CTGGAGCGGCAGGACCTCCCCGGGGACCCAGCGAAGGAGGAGCCGCAGCCGCCGCCCCAG       c.300
 L  E  R  Q  D  L  P  G  D  P  A  K  E  E  P  Q  P  P  P  Q         p.100

          .         .         .    | 02    .         .         .    g.18833
 CATCACGTCCTCTATTTCCCTGGGGATGTGCAG | AATTACCATGAAATTATGACTCGTCAT    c.360
 H  H  V  L  Y  F  P  G  D  V  Q   | N  Y  H  E  I  M  T  R  H      p.120

          .         .         .         .         .         .       g.18893
 CCTGAGAATTATCAATGGGAAAACTGGAGTCTAGAAAATGTTGCTACCATTTTAGCCCAC       c.420
 P  E  N  Y  Q  W  E  N  W  S  L  E  N  V  A  T  I  L  A  H         p.140

          .         .         .         .         .         .       g.18953
 CGGTTCCCCAATAGTTATATTTGGGTGATAAAATGTTCCCGAATGCATTTGCACAAATTC       c.480
 R  F  P  N  S  Y  I  W  V  I  K  C  S  R  M  H  L  H  K  F         p.160

          .         .         .         .         .         .       g.19013
 AGCTGCTATGACAATTTTGTGAAAAGTAACATGTTTGGTGCCCCAGAACACAATACTGAC       c.540
 S  C  Y  D  N  F  V  K  S  N  M  F  G  A  P  E  H  N  T  D         p.180

          .         .         .         .         .         .       g.19073
 TTTGGAGCTTTTAAGCACCTTTATATGTTATTAGTTAATGCTTTTAATTTAAGTCAGAAT       c.600
 F  G  A  F  K  H  L  Y  M  L  L  V  N  A  F  N  L  S  Q  N         p.200

          .         .         .         .         .         .       g.19133
 AGTTTATCAAAGAAAAGTTTGAATGTTTGGAATAAGGACTCCATAGCATCTAACTGTAGA       c.660
 S  L  S  K  K  S  L  N  V  W  N  K  D  S  I  A  S  N  C  R         p.220

          .         .         .         .         .         .       g.19193
 TCCAGTCCTTCTCATACTACGAATGGTTGCCAGGGAGAAAAAGTGAGGACCTGTGAAAAA       c.720
 S  S  P  S  H  T  T  N  G  C  Q  G  E  K  V  R  T  C  E  K         p.240

          .         .         .         .         .         .       g.19253
 TCTGATGAGTCTGCCATGAGTTTTTATCCACCATCACTAAATGACGCATCTTTTACTTTG       c.780
 S  D  E  S  A  M  S  F  Y  P  P  S  L  N  D  A  S  F  T  L         p.260

          .         .         .         .         .         .       g.19313
 ATTGGATTCAGTAAAGGTTGTGTTGTTTTGAATCAGTTGCTTTTTGAATTGAAAGAAGCC       c.840
 I  G  F  S  K  G  C  V  V  L  N  Q  L  L  F  E  L  K  E  A         p.280

          .         .         .         .         .         .       g.19373
 AAGAAAGACAAGAACATAGATGCTTTTATCAAAAGCATAAGAACAATGTATTGGCTGGAT       c.900
 K  K  D  K  N  I  D  A  F  I  K  S  I  R  T  M  Y  W  L  D         p.300

          .         .         .         .         .         .       g.19433
 GGTGGTCATTCTGGAGGAAGCAATACTTGGGTTACTTATCCAGAAGTCTTGAAAGAATTT       c.960
 G  G  H  S  G  G  S  N  T  W  V  T  Y  P  E  V  L  K  E  F         p.320

          .         .         .         .         .         .       g.19493
 GCACAAACAGGAATTATCGTTCACACTCATGTAACACCTTACCAAGTACGTGATCCAATG       c.1020
 A  Q  T  G  I  I  V  H  T  H  V  T  P  Y  Q  V  R  D  P  M         p.340

          .         .         .         .         .         .       g.19553
 AGATCTTGGATTGGAAAGGAGCACAAGAAATTTGTTCAGATACTTGGGGATCTTGGTATG       c.1080
 R  S  W  I  G  K  E  H  K  K  F  V  Q  I  L  G  D  L  G  M         p.360

          .         .         .         .         .         .       g.19613
 CAGGTGACTAGCCAAATTCATTTTACAAAGGAAGCTCCTTCCATAGAGAATCACTTCAGG       c.1140
 Q  V  T  S  Q  I  H  F  T  K  E  A  P  S  I  E  N  H  F  R         p.380

          .                                                         g.19631
 GTTCATGAAGTATTTTGA                                                 c.1158
 V  H  E  V  F  X                                                   p.385

          .         .         .         .         .         .       g.19691
 gattacaggtatattaatgaacttgttcagtggaagaacataagcacttttgagtgttat       c.*60

          .         .         .         .         .         .       g.19751
 aaattcagataatgggatgtaattcatagctgcattgtcagttttggggtatggggggaa       c.*120

          .         .         .         .         .         .       g.19811
 gcacacattcctaaaatgtgagtgtaatgtgcaatagtattttttgcttgtgaatgtgag       c.*180

          .         .         .         .         .         .       g.19871
 cagttattaatttggattgagttagaattagttaatttgaaatctaacaaggtggtttgt       c.*240

          .         .         .         .         .         .       g.19931
 aataatgctgaggagatataagacccttaaaatgaaagttacaacattgttcttataaaa       c.*300

          .         .         .         .         .         .       g.19991
 ggtaactaaaattgttactgttggaaataactgattttctgagtaatgttttaaactaat       c.*360

          .         .         .         .         .         .       g.20051
 ttggtgacattttaacagtaattagctattttgagtggaaatattttcatttctcttcaa       c.*420

          .         .         .         .         .         .       g.20111
 acaaaagcaaaggtacgatgctgttttctatcattttggaataactgcaccctgcctttt       c.*480

          .         .         .         .         .         .       g.20171
 gtgtttttgtaaactccttgactcattctttcatgtgtcaccaagtacttttctcatgag       c.*540

          .         .         .         .         .         .       g.20231
 agtcaacatatatttgtttccaaatgtccacaagtgtacaatagtgtaaaggtggttttt       c.*600

          .         .         .         .         .         .       g.20291
 aaaaacatagccaggtgtggtggcacgtgcctttagttccagctactcaggaggctaagg       c.*660

          .         .         .         .         .         .       g.20351
 caggaggattgcttgagcccaggctgtgtggttcaccataattgtgtttgtgactagcta       c.*720

          .         .         .         .         .         .       g.20411
 ctgcactccaacctgggcaacatagtgggacttcatctctaaaacaaaacaaaacaaaat       c.*780

          .         .         .         .         .         .       g.20471
 tacacttaagcactattgtttaatttttaattgtcagtttatcattattttgggtaagac       c.*840

          .         .         .         .         .         .       g.20531
 attctggggtttcttgaatcttgtccaaaaaccagttgttttggaaaattgctttaaatt       c.*900

          .         .         .         .         .         .       g.20591
 gagcatatttatgtatattggataaaaatgtactacagagcaaatttcaaatttttcatt       c.*960

          .         .         .         .         .         .       g.20651
 atatcagtctttttgaaaggatcaacttggataaaataaatatataatgctctatttgtt       c.*1020

          .         .         .         .         .         .       g.20711
 agagctctattaaaaaggaaacagattccatagatctaagtcaatgtttctccagaagca       c.*1080

          .         .         .         .         .         .       g.20771
 tgattttgtctgccaaaagaaaatagctctctttggccaaaatgcaaaattacattgcta       c.*1140

          .         .         .         .         .         .       g.20831
 taagaaaagttacaagggaaagtttgaagacacaaatgatttaattttggctcaaaaact       c.*1200

          .         .         .         .         .         .       g.20891
 gaatttgcttaacactgctacataatttgggtgaagtttccttctgcccgtttttcttga       c.*1260

          .         .         .         .         .         .       g.20951
 cctagataaatacactttgagaaatccagatctaataaatgtcaaccaacattgacattg       c.*1320

          .         .         .         .         .         .       g.21011
 taattgggtgattacaataaaaggtgagcagtttgttgtttattaataattagcttttgc       c.*1380

          .         .         .         .         .         .       g.21071
 aggtaatgaaatagcagggaagtaacatgctgctttaggactaaaaaaaaaaaaaaaaaa       c.*1440

          .         .         .         .         .         .       g.21131
 aagacactgaagcttaataccttaatgacccagaagacctagatttataaagccatatag       c.*1500

          .         .         .         .         .         .       g.21191
 aataaaaatgttaatttcttggtttcttcccagaattatattttaatgactccataaata       c.*1560

          .         .         .         .         .         .       g.21251
 cattccaaatattcagagattcatgagaaaggattcttaacaaatgtttaaaaataacat       c.*1620

          .         .         .         .         .         .       g.21311
 ttctttttggtgttttaacacttaattttataaactgcagaacagcatctctaaatggct       c.*1680

          .         .         .         .         .         .       g.21371
 ttttttttttttttaaagacaaagtagtattatgttgcttcagtttctttaaatacctcg       c.*1740

          .         .         .         .         .         .       g.21431
 tttcttttgagaccaaaaattcccatcaaggaaataaatcagcctgattttaacatttta       c.*1800

          .         .         .         .         .         .       g.21491
 catattacattgcctttaagcactatgattggatggctttttttctatttgtttaataat       c.*1860

          .         .         .         .         .         .       g.21551
 ccttggctaaattcacatgtatctaaaggaaaatagctgagttactgaattctataaggg       c.*1920

          .         .         .         .         .         .       g.21611
 gaagaaaaagcatttattttcacatgattaactgaaatggaaaagtaagacatttagcag       c.*1980

          .         .         .         .         .         .       g.21671
 aataattcatttaaaaataattttaaaaaatcagacatatttaaaaatctaggttgtcta       c.*2040

          .         .         .         .         .         .       g.21731
 tccagtatgtgaatgcttaattataattgttacatgttgaatgggtattaagagtaagtc       c.*2100

          .         .         .         .         .         .       g.21791
 accaggtacacaaaactgccatcatagcaaaatgagacagtgttgaaaagacaaaatatt       c.*2160

          .         .         .         .         .         .       g.21851
 ttctggaatgaaaatatattcaagttgatccatattcagatgttttctgtttaatacttc       c.*2220

          .         .         .         .         .         .       g.21911
 agattggtcctttgtccacatttgtttaaaacttattgtaatgttaatttacacttttgg       c.*2280

          .         .         .         .         .         .       g.21971
 attgtgcctttgtcatgagttgagaaaagtagtcctacaaataatgtgaaagttgttacc       c.*2340

          .         .         .         .                           g.22018
 accacagcatgaatgtataattgtattaaaattgatcatccacagaa                    c.*2387

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Chromosome 2 open reading frame 69 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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