chromosome 9 open reading frame 84 (C9orf84) - coding DNA reference sequence

(used for variant description)

(last modified September 27, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_173521.3 in the C9orf84 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000009.11, covering C9orf84 transcript NM_173521.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5015
                                              aattctaaagaagaa       c.-121

 .         .         .         .         .         .                g.5075
 agtgcttcaagaaggaagtagtagtccaatgtgttgggctcctgttaaaagctcaagtta       c.-61

 .         .         .         .       | 02 .         .             g.7505
 tgtgaggatagtgagttgaccattagcttgactaaat | tctcagctgtttcagttccggga    c.-1

          .         .         .         .         .         .       g.7565
 ATGACAGATACCTCAGTCTTGGACCAATGGAAAGCAAGTTTCTTTGTGGAGGATTTCCTT       c.60
 M  T  D  T  S  V  L  D  Q  W  K  A  S  F  F  V  E  D  F  L         p.20

       | 03  .         .         .         .         .         .    g.12579
 GAGAA | AAAAACAATTACAAGAATGGTGACCCAGATTAATTGTGAATTTGAGGAAGTTGTT    c.120
 E  K  |  K  T  I  T  R  M  V  T  Q  I  N  C  E  F  E  E  V  V      p.40

          .         .         .         .         .         .       g.12639
 CCAAGTTCAAATCCAGACTCCCAAATTGAAGTAGAGGAGGTCAGTTTATACACCCACATG       c.180
 P  S  S  N  P  D  S  Q  I  E  V  E  E  V  S  L  Y  T  H  M         p.60

          .         .         .         .         .         .       g.12699
 GACTACAATGAAGTCTTTACCCCTGTCAGTTGTTTAGAAAAATGTTCAGCACTTCAAAAC       c.240
 D  Y  N  E  V  F  T  P  V  S  C  L  E  K  C  S  A  L  Q  N         p.80

          . | 04       .         .         .         .         .    g.29701
 CAGAACCAAG | ATTTATTTATTGATGATAAAGGAATACTTTTTGTAAGTAGTAGAAAACAC    c.300
 Q  N  Q  D |   L  F  I  D  D  K  G  I  L  F  V  S  S  R  K  H      p.100

          .         .         .         .         .         .       g.29761
 CTACCAACTTTGCCTACTCTCTTGAGTAGACTAAAACTGTTTTTGGTAAAGGATCCTCTT       c.360
 L  P  T  L  P  T  L  L  S  R  L  K  L  F  L  V  K  D  P  L         p.120

          .         .         .         .     | 05   .         .    g.30320
 TTAGATTTCAAAGGACAGATCTTCACAGAAGCTAATTTTTCCAG | GGAATGTTTCTCTCTT    c.420
 L  D  F  K  G  Q  I  F  T  E  A  N  F  S  R  |  E  C  F  S  L      p.140

          .         .         .         .         .         .       g.30380
 CAAGAAACTTTGGAAGCTTTTGTGAAAGAAGATTTTTGTATGGATAAAGTGAACTTTTGT       c.480
 Q  E  T  L  E  A  F  V  K  E  D  F  C  M  D  K  V  N  F  C         p.160

          .         .         .       | 06 .         .         .    g.32045
 CAAGAGAAACTAGAAGATACAATATGTTTAAATGAG | CCGTCAAGTTTTCTTATTGAGTAT    c.540
 Q  E  K  L  E  D  T  I  C  L  N  E   | P  S  S  F  L  I  E  Y      p.180

          .         .         .         .         .         .       g.32105
 GAATTCTTAATACCTCCAAGCCTCAAACCAGAAATTGATATTCCATCACTCTCAGAACTG       c.600
 E  F  L  I  P  P  S  L  K  P  E  I  D  I  P  S  L  S  E  L         p.200

          .         .         .         .         .         .       g.32165
 AAGGAGTTATTAAACCCAGTGCCAGAAATAATAAACTATGTAGATGAAAAGGAAAAGCTT       c.660
 K  E  L  L  N  P  V  P  E  I  I  N  Y  V  D  E  K  E  K  L         p.220

          . | 07       .         .         .         .         .    g.40350
 TTTGAAAGAG | ATCTTACTAACAAGCATGGAATTGAGGATATCGGGGATATAAAATTCAGC    c.720
 F  E  R  D |   L  T  N  K  H  G  I  E  D  I  G  D  I  K  F  S      p.240

          .         .         .         .         .         | 08    g.42159
 TCCACAGAGATTTTGACCATTCAAAGCCAGAGTGAACCAGAAGAGTGCAGTAAACCAG | GA    c.780
 S  T  E  I  L  T  I  Q  S  Q  S  E  P  E  E  C  S  K  P  G |       p.260

          .         .         .         .         .         .       g.42219
 GAGTTAGAAATGCCACTAACTCCTCTATTCCTAACATGCCAACATTCTTCAGTGAATTCA       c.840
 E  L  E  M  P  L  T  P  L  F  L  T  C  Q  H  S  S  V  N  S         p.280

          .         .         .         .        | 09.         .    g.46942
 TTACGTACAGAACTTCAGACATTTCCATTATCTCCGGTTTGTAAAAT | TAATTTGCTTACT    c.900
 L  R  T  E  L  Q  T  F  P  L  S  P  V  C  K  I  |  N  L  L  T      p.300

          .         .         .         .         .         .       g.47002
 GCTGAAGAATCAGCTAATGAATACTACATGATGTGGCAATTAGAAAGATGTAGAAGCCCT       c.960
 A  E  E  S  A  N  E  Y  Y  M  M  W  Q  L  E  R  C  R  S  P         p.320

          .         .   | 10     .         .         .         .    g.50015
 TTGAACCCATTTTTGCTTACAG | TGCCAAGAATTCAAGAGCCCCACAGCCAATATTCAGTT    c.1020
 L  N  P  F  L  L  T  V |   P  R  I  Q  E  P  H  S  Q  Y  S  V      p.340

          .         .         .         .         .         .       g.50075
 ACAGATTTGAAAAAGATATTTTCTGTTAAAGAAGAAAGCCTTGTGATTAATCTGGAAAAG       c.1080
 T  D  L  K  K  I  F  S  V  K  E  E  S  L  V  I  N  L  E  K         p.360

          .         .         .         .         .         .       g.50135
 GCAGAGTGGTGGAAACAAGCAGGACTAAATCTGAAAATGATGGAAACATTGGAACATCTG       c.1140
 A  E  W  W  K  Q  A  G  L  N  L  K  M  M  E  T  L  E  H  L         p.380

          .         .         .         .         .         .       g.50195
 AATACATATTTATGTCATGATAATTTGTCTTCTAATGACACTAAAATTGAGATATTTTTG       c.1200
 N  T  Y  L  C  H  D  N  L  S  S  N  D  T  K  I  E  I  F  L         p.400

          .         .      | 11  .         .         .         .    g.60485
 CCTACGAAAGTGCTTCAATTAGAAT | CATGTCTAGAACATAAAAGTCATTCTTCACCTATT    c.1260
 P  T  K  V  L  Q  L  E  S |   C  L  E  H  K  S  H  S  S  P  I      p.420

          .         .         .         .         .         .       g.60545
 GCACTTATTGATGAAAAATCTACAAATGCTCATTTATCACTTCCACAAAAGAGTCCATCT       c.1320
 A  L  I  D  E  K  S  T  N  A  H  L  S  L  P  Q  K  S  P  S         p.440

          .         .         .         .         .         .       g.60605
 CTGGCAAAAGAAGTACCAGATCTATGTTTTTCTGATGACTATTTCTCTGATAAAGGAGCA       c.1380
 L  A  K  E  V  P  D  L  C  F  S  D  D  Y  F  S  D  K  G  A         p.460

          .         .         .         .         .         .       g.60665
 GCAAAAGAAGAAAAACCAAAGAATGACCAAGAACCAGTAAACAGAATAATCCAAAAGAAA       c.1440
 A  K  E  E  K  P  K  N  D  Q  E  P  V  N  R  I  I  Q  K  K         p.480

          .         .         .         .         .         .       g.60725
 GAAAATAACGATCACTTTGAACTTGACTGCACAGGACCATCTATTAAATCACCTTCCTCT       c.1500
 E  N  N  D  H  F  E  L  D  C  T  G  P  S  I  K  S  P  S  S         p.500

          .         .         .         .         .         .       g.60785
 TCAATAATTAAAAAAGCATCTTTTGAACATGGCAAAAAACAAGAGAATGATTTGGACCTT       c.1560
 S  I  I  K  K  A  S  F  E  H  G  K  K  Q  E  N  D  L  D  L         p.520

          .         .         .         .         .         .       g.60845
 TTGAGCGACTTTATTATGCTGCGAAATAAATATAAGACTTGCACCTCAAAGACTGAAGTC       c.1620
 L  S  D  F  I  M  L  R  N  K  Y  K  T  C  T  S  K  T  E  V         p.540

          .         .   | 12     .         .         .         .    g.64626
 ACAAACAGTGATGAAAAACATG | ATAAAGAAGCATGTTCTTTGACACTTCAAGAAGAAAGT    c.1680
 T  N  S  D  E  K  H  D |   K  E  A  C  S  L  T  L  Q  E  E  S      p.560

          .         .         .         .         .         .       g.64686
 CCTATTGTTCATATTAATAAAACCCTGGAGGAAATAAATCAGGAAAGGGGAACAGATAGT       c.1740
 P  I  V  H  I  N  K  T  L  E  E  I  N  Q  E  R  G  T  D  S         p.580

          .         .   | 13     .         .         .         .    g.65952
 GTCATTGAAATTCAAGCGTCAG | ATAGCCAGTGCCAAGCATTTTGCCTCCTCGAAGCAGCA    c.1800
 V  I  E  I  Q  A  S  D |   S  Q  C  Q  A  F  C  L  L  E  A  A      p.600

          .         .         .         .         .         .       g.66012
 GCTTCTCCTATCTTAAAAAACCTTGTATCCTTGTGTACCCTCCCTACTGCTAATTGGAAA       c.1860
 A  S  P  I  L  K  N  L  V  S  L  C  T  L  P  T  A  N  W  K         p.620

          .         .         .         .         .         .       g.66072
 TTTGCCACTGTTATTTTTGACCAAACAAGGTTTCTCTTAAAGGAACAAGAAAAAGTAGTA       c.1920
 F  A  T  V  I  F  D  Q  T  R  F  L  L  K  E  Q  E  K  V  V         p.640

          .          | 14        .         .         .         .    g.70252
 AGTGATGCTGTTCGCCAAG | GTACAATTGATGAAAGAGAAATGACTTTCAAGCATGCCGCT    c.1980
 S  D  A  V  R  Q  G |   T  I  D  E  R  E  M  T  F  K  H  A  A      p.660

          .         .         .         .         .         .       g.70312
 CTCTTACATCTTCTGGTAACAATTAGAGATGTCCTTTTAACATGCAGCTTGGACACAGCA       c.2040
 L  L  H  L  L  V  T  I  R  D  V  L  L  T  C  S  L  D  T  A         p.680

      | 15   .         .         .         .         .         .    g.73932
 TTGG | GATATTTGTCGAAGGCAAAAGATATCTACAACAGCATTTTAGGCCCCTATTTGGGT    c.2100
 L  G |   Y  L  S  K  A  K  D  I  Y  N  S  I  L  G  P  Y  L  G      p.700

          .         .         .         .         .         .       g.73992
 GACATTTGGAGACAGCTGGAGATTGTACAGTTTATTAGGGGGAAAAAGCCTGAAACCAAC       c.2160
 D  I  W  R  Q  L  E  I  V  Q  F  I  R  G  K  K  P  E  T  N         p.720

          .         .         .         .         .         .       g.74052
 TACAAGATACAAGAATTGCAATGTCAGATACTAAGTTGGATGCAAAGTCAACAGCAAATT       c.2220
 Y  K  I  Q  E  L  Q  C  Q  I  L  S  W  M  Q  S  Q  Q  Q  I         p.740

     | 16    .         .         .         .         .         .    g.75384
 AAG | GTACTGATTATAATAAGAATGGACTCAGACGGTGAAAAACATTTTCTCATTAAAATT    c.2280
 K   | V  L  I  I  I  R  M  D  S  D  G  E  K  H  F  L  I  K  I      p.760

          .       | 17 .         .         .         .         .    g.80619
 CTTAACAAAATAGAAG | GTTTAACACTGACTGTCCTTCATTCAAATGAAAGAAAAGATTTT    c.2340
 L  N  K  I  E  G |   L  T  L  T  V  L  H  S  N  E  R  K  D  F      p.780

          .         .       | 18 .         .         .         .    g.81787
 CTGGAATCTGAAGGTGTTTTAAGGGG | TACAAGTTCCTGTGTAGTTGTACATAATCAATAT    c.2400
 L  E  S  E  G  V  L  R  G  |  T  S  S  C  V  V  V  H  N  Q  Y      p.800

          .         .         .         .         .         .       g.81847
 ATTGGAGCAGATTTCCCCTGGAGTAATTTCTCATTTGTGGTGGAATACAATTATGTGGAA       c.2460
 I  G  A  D  F  P  W  S  N  F  S  F  V  V  E  Y  N  Y  V  E         p.820

          .         .         .         .         .         .       g.81907
 GACTCTTGTTGGACTAAACACTGCAAAGAGTTGAATATTCCTTACATGGCCTTTAAAGTG       c.2520
 D  S  C  W  T  K  H  C  K  E  L  N  I  P  Y  M  A  F  K  V         p.840

          .         .      | 19  .         .         .         .    g.83170
 ATTCTTCCAGACACAGTTTTAGAAA | GAAGCACCTTGCTGGATAGATTTGGAGGTTTTCTT    c.2580
 I  L  P  D  T  V  L  E  R |   S  T  L  L  D  R  F  G  G  F  L      p.860

          .         .         .         .         .         .       g.83230
 TTGGAAATTCAGATTCCATATGTGTTTTTTGCATCTGAAGGACTTCTTAATACTCCAGAC       c.2640
 L  E  I  Q  I  P  Y  V  F  F  A  S  E  G  L  L  N  T  P  D         p.880

          .         .    | 20    .         .         .         .    g.84544
 ATACTTCAGCTGCTAGAATCCAA | CTATAACATCTCACTAGTAGAGAGAGGCTGCAGTGAG    c.2700
 I  L  Q  L  L  E  S  N  |  Y  N  I  S  L  V  E  R  G  C  S  E      p.900

          .         .         .         .         .         .       g.84604
 TCATTGAAACTCTTTGGAAGTTCAGAGTGTTATGTAGTGGTGACAATTGATGAACACACT       c.2760
 S  L  K  L  F  G  S  S  E  C  Y  V  V  V  T  I  D  E  H  T         p.920

          .      | 21  .         .         .         .         .    g.86318
 GCCATAATTTTGCAG | GATCTAGAAGAATTGAATTATGAGAAGGCATCAGACAATATCATT    c.2820
 A  I  I  L  Q   | D  L  E  E  L  N  Y  E  K  A  S  D  N  I  I      p.940

          .         .         .         .         .         .       g.86378
 ATGAGGCTGATGGCATTATCATTACAGTACAGATATTGTTGGATAATTTTATATACCAAA       c.2880
 M  R  L  M  A  L  S  L  Q  Y  R  Y  C  W  I  I  L  Y  T  K         p.960

          .        | 22.         .         .         .         .    g.88495
 GAAACATTAAATTCAGA | GTATCTGCTTACAGAAAAGACACTTCATCACCTAGCACTGATT    c.2940
 E  T  L  N  S  E  |  Y  L  L  T  E  K  T  L  H  H  L  A  L  I      p.980

          .         .         .         .         .  | 23      .    g.94146
 TATGCAGCTTTGGTTTCATTTGGGCTAAACTCTGAAGAACTGGATGTAAAG | CTTATAATT    c.3000
 Y  A  A  L  V  S  F  G  L  N  S  E  E  L  D  V  K   | L  I  I      p.1000

          .         .         .         .         .         .       g.94206
 GCCCCAGGAGTAGAAGCAACTGCCTTGATAATTCGACAAATTGCTGACCACAGTTTAATG       c.3060
 A  P  G  V  E  A  T  A  L  I  I  R  Q  I  A  D  H  S  L  M         p.1020

          .         .         .         .         .         .       g.94266
 ACCTCAAAGAGAGATCCTCATGAATGGTTGGATAAATCCTGGCTTAAAGTTTCACCATCT       c.3120
 T  S  K  R  D  P  H  E  W  L  D  K  S  W  L  K  V  S  P  S         p.1040

     | 24    .         .         .         .         .         .    g.94608
 GAG | GAAGAAATGTACTTACTTGATTTTCCATGTATTAACCCATTGGTGGCTCAGCTCATG    c.3180
 E   | E  E  M  Y  L  L  D  F  P  C  I  N  P  L  V  A  Q  L  M      p.1060

          .         .         .         .         .         .       g.94668
 CTAAATAAAGGACCTTCACTGCATTGGATATTATTAGCAACTCTGTGTCAACTTCAGGAA       c.3240
 L  N  K  G  P  S  L  H  W  I  L  L  A  T  L  C  Q  L  Q  E         p.1080

          .         .         .    | 25    .         .         .    g.96015
 CTCCTACCTGAAGTCCCAGAAAAAGTGTTAAAG | CATTTTTGTAGCATCACTTCCCTATTC    c.3300
 L  L  P  E  V  P  E  K  V  L  K   | H  F  C  S  I  T  S  L  F      p.1100

          .         .         .         .         .         .       g.96075
 AAGATTGGTTCTTCTTCCATAACAAAATCACCGCAAATTTCGTCACCTCAGGAAAATAGG       c.3360
 K  I  G  S  S  S  I  T  K  S  P  Q  I  S  S  P  Q  E  N  R         p.1120

          .         .         .         .         .         .       g.96135
 AATCAGATTAGTACCTTGTCTTCTCAAAGTTCAGCTTCTGATTTAGACTCTGTCATTCAA       c.3420
 N  Q  I  S  T  L  S  S  Q  S  S  A  S  D  L  D  S  V  I  Q         p.1140

          .         .         .         .         .         .       g.96195
 GAACATAATGAATATTATCAGTATTTAGGATTAGGAGAGACAGTGCAGGAAGACAAAACC       c.3480
 E  H  N  E  Y  Y  Q  Y  L  G  L  G  E  T  V  Q  E  D  K  T         p.1160

          .         .         .         .         .         .       g.96255
 ACCATTTTGAATGACAACTCTTCCATTATGGAACTAAAAGAAATCTCAAGTTTTTTACCA       c.3540
 T  I  L  N  D  N  S  S  I  M  E  L  K  E  I  S  S  F  L  P         p.1180

          .         .         .         .         .         .       g.96315
 CCTGTGACTTCATACAATCAGACCAGCTACTGGAAAGACTCCAGCTGTAAATCTAATATA       c.3600
 P  V  T  S  Y  N  Q  T  S  Y  W  K  D  S  S  C  K  S  N  I         p.1200

          .         .         .         .         .         .       g.96375
 GGGCAGAATACTCCTTTTCTAATTAATATAGAATCAAGGAGACCGGCTTATAACTCCTTT       c.3660
 G  Q  N  T  P  F  L  I  N  I  E  S  R  R  P  A  Y  N  S  F         p.1220

          .         .         .         .         .         .       g.96435
 CTAAACCACAGTGATTCAGAGTCAGATGTCTTTTCTTTGGGTCTAACACAAATGAACTGT       c.3720
 L  N  H  S  D  S  E  S  D  V  F  S  L  G  L  T  Q  M  N  C         p.1240

          .         .         .         .         .         .       g.96495
 GAAACTATAAAATCACCAACTGACACTCAGAAGAGAGTGTCAGTTGTCCCCCGTTTTATA       c.3780
 E  T  I  K  S  P  T  D  T  Q  K  R  V  S  V  V  P  R  F  I         p.1260

          .         .         .         .         .         .       g.96555
 AATTCTCAGAAAAGGAGAACACATGAAGCAAAAGGTTTCATAAATAAAGATGTATCGGAC       c.3840
 N  S  Q  K  R  R  T  H  E  A  K  G  F  I  N  K  D  V  S  D         p.1280

          .         .         .         .         .         .       g.96615
 CCTATCTTTTCACTAGAGGGCACTCAATCTCCTCTTCATTGGAACTTTAAGAAAAATATA       c.3900
 P  I  F  S  L  E  G  T  Q  S  P  L  H  W  N  F  K  K  N  I         p.1300

          .         .         .         .         .         .       g.96675
 TGGGAACAAGAGAATCACCCGTTCAACTTACAATATGGTGCACAGCAGACTGCATGTAAC       c.3960
 W  E  Q  E  N  H  P  F  N  L  Q  Y  G  A  Q  Q  T  A  C  N         p.1320

          .         .         .         .         .         .       g.96735
 AAATTGTACTCTCAGAAAGGTAATTTATTCACTGATCAGCAAAAATGTCTATCAGATGAG       c.4020
 K  L  Y  S  Q  K  G  N  L  F  T  D  Q  Q  K  C  L  S  D  E         p.1340

          .         .         .         .         .         .       g.96795
 TCTGAAGGCCTCACATGTGAAAGTTCAAAAGATGAGACTTTCTGGAGAGAATTACCATCT       c.4080
 S  E  G  L  T  C  E  S  S  K  D  E  T  F  W  R  E  L  P  S         p.1360

          .         .         .         .         .         .       g.96855
 GTCCCCAGTTTGGATTTATTTCGTGCTTCTGATTCTAATGCAAATCAAAAAGAATTCAAC       c.4140
 V  P  S  L  D  L  F  R  A  S  D  S  N  A  N  Q  K  E  F  N         p.1380

          .         .         .         .         .         .       g.96915
 AGCCTTTATTTCTACCAAAGAGCTGGAAAAAGTTTAGGACAGAAAAGGCACCATGAATCT       c.4200
 S  L  Y  F  Y  Q  R  A  G  K  S  L  G  Q  K  R  H  H  E  S         p.1400

          .         .         .     | 26   .         .         .    g.101655
 TCATTTAACTCAGGAGACAAGGAATCATTAACAG | GTTTTATGTGCTCACAACTACCACAA    c.4260
 S  F  N  S  G  D  K  E  S  L  T  G |   F  M  C  S  Q  L  P  Q      p.1420

          .         .         .         .         .         .       g.101715
 TTCAAAAAACGACGTCTAGCATATGAAAAAGTCCCTGGTAGAGTTGATGGGCAGACTCGG       c.4320
 F  K  K  R  R  L  A  Y  E  K  V  P  G  R  V  D  G  Q  T  R         p.1440

          .                                                         g.101730
 CTGAGGTTTTTTTGA                                                    c.4335
 L  R  F  F  X                                                      p.1444

          .         .         .         .         .         .       g.101790
 aggaggagaagagcaatgttacatgccatattccactgtttttgatgctaatccactagc       c.*60

          .         .         .         .         .         .       g.101850
 gcaattatttagatttgctcatacactaaagaaaacacaattgttcatatatgtctcagt       c.*120

          .         .                                               g.101879
 atttctgtattaaatattcataatatgta                                      c.*149

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Chromosome 9 open reading frame 84 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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