calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E) - coding DNA reference sequence

(used for variant description)

(last modified October 28, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000721.3 in the CACNA1E gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_050616.1, covering CACNA1E transcript NM_000721.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5015
                                              tttagattcaacagt       c.-181

 .         .         .         .         .         .                g.5075
 tcacagcggcgggctgctgctgctgcctctccgaagagctcgcggagctccccagaggcg       c.-121

 .         .         .         .         .         .                g.5135
 gtggtccccgtgcttgtctggatgcggctctgagtctccgtgtgtctttctgcttgttgc       c.-61

 .         .         .         .         .         .                g.5195
 tgtgtgcgggtgttcggccgcgatcacctttgtgtgtcttctgtctgtttaaacctcagg       c.-1

          .         .         .         .         .         .       g.5255
 ATGGCTCGCTTCGGGGAGGCGGTGGTCGCCAGGCCAGGGTCCGGCGATGGAGACTCGGAC       c.60
 M  A  R  F  G  E  A  V  V  A  R  P  G  S  G  D  G  D  S  D         p.20

          .         .         .         .         .         .       g.5315
 CAGAGCAGGAACCGGCAAGGAACCCCCGTGCCGGCCTCGGGGCAGGCGGCCGCCTACAAG       c.120
 Q  S  R  N  R  Q  G  T  P  V  P  A  S  G  Q  A  A  A  Y  K         p.40

          .         .         .         .         .         .       g.5375
 CAGACGAAAGCACAGAGGGCGCGGACTATGGCTTTGTACAACCCCATTCCCGTCCGGCAG       c.180
 Q  T  K  A  Q  R  A  R  T  M  A  L  Y  N  P  I  P  V  R  Q         p.60

          .         .         .         .         .         .       g.5435
 AACTGTTTCACCGTCAACAGATCCCTGTTCATCTTCGGAGAAGATAACATTGTCAGGAAA       c.240
 N  C  F  T  V  N  R  S  L  F  I  F  G  E  D  N  I  V  R  K         p.80

          .         .       | 02 .         .         .         .    g.31961
 TATGCCAAGAAGCTCATCGATTGGCC | GCCATTTGAGTACATGATCCTGGCCACCATCATT    c.300
 Y  A  K  K  L  I  D  W  P  |  P  F  E  Y  M  I  L  A  T  I  I      p.100

          .         .         .         .         .         .       g.32021
 GCCAACTGCATCGTCCTGGCCCTGGAGCAGCATCTTCCTGAGGATGACAAGACCCCCATG       c.360
 A  N  C  I  V  L  A  L  E  Q  H  L  P  E  D  D  K  T  P  M         p.120

          .   | 03     .         .         .         .         .    g.32869
 TCCCGAAGACTG | GAGAAGACAGAACCTTATTTCATTGGGATCTTTTGCTTTGAAGCTGGG    c.420
 S  R  R  L   | E  K  T  E  P  Y  F  I  G  I  F  C  F  E  A  G      p.140

          .         .         .         .         .         .       g.32929
 ATCAAAATTGTGGCCCTGGGGTTCATCTTCCATAAGGGCTCTTACCTCCGCAATGGCTGG       c.480
 I  K  I  V  A  L  G  F  I  F  H  K  G  S  Y  L  R  N  G  W         p.160

          .         .         .   | 04     .         .         .    g.99244
 AATGTCATGGACTTCATCGTGGTCCTCAGTGG | CATCCTGGCCACTGCAGGAACCCACTTC    c.540
 N  V  M  D  F  I  V  V  L  S  G  |  I  L  A  T  A  G  T  H  F      p.180

          .         .         .         .         .         .       g.99304
 AATACTCACGTGGACCTGAGGACCCTCCGGGCTGTGCGTGTCCTGCGGCCTTTGAAGCTC       c.600
 N  T  H  V  D  L  R  T  L  R  A  V  R  V  L  R  P  L  K  L         p.200

          .       | 05 .         .         .         .         .    g.100566
 GTGTCAGGGATACCTA | GCCTGCAGATTGTGTTGAAGTCCATCATGAAGGCCATGGTACCT    c.660
 V  S  G  I  P  S |   L  Q  I  V  L  K  S  I  M  K  A  M  V  P      p.220

          .         .         .         .         .         .       g.100626
 CTTCTGCAGATTGGCCTTCTGCTCTTCTTTGCCATCCTGATGTTTGCTATCATTGGTTTG       c.720
 L  L  Q  I  G  L  L  L  F  F  A  I  L  M  F  A  I  I  G  L         p.240

          .         .         .         .          | 06        .    g.102056
 GAGTTCTACAGTGGCAAGTTACATCGAGCATGCTTCATGAACAATTCAG | GTATTCTAGAA    c.780
 E  F  Y  S  G  K  L  H  R  A  C  F  M  N  N  S  G |   I  L  E      p.260

          .         .         .         .         .         .       g.102116
 GGATTTGACCCCCCTCACCCATGTGGTGTGCAGGGCTGCCCAGCTGGTTATGAATGCAAG       c.840
 G  F  D  P  P  H  P  C  G  V  Q  G  C  P  A  G  Y  E  C  K         p.280

          .         .         .         .         .         .       g.102176
 GACTGGATCGGCCCCAATGATGGGATCACCCAGTTTGATAACATCCTTTTTGCTGTGCTG       c.900
 D  W  I  G  P  N  D  G  I  T  Q  F  D  N  I  L  F  A  V  L         p.300

          .         .         .         .         .  | 07      .    g.172797
 ACTGTCTTCCAGTGCATCACCATGGAAGGGTGGACCACTGTGCTGTACAAT | ACCAATGAT    c.960
 T  V  F  Q  C  I  T  M  E  G  W  T  T  V  L  Y  N   | T  N  D      p.320

          .         .         .         .         .         .       g.172857
 GCCTTAGGAGCCACCTGGAATTGGCTGTACTTCATCCCCCTCATCATCATTGGATCCTTC       c.1020
 A  L  G  A  T  W  N  W  L  Y  F  I  P  L  I  I  I  G  S  F         p.340

          .         .         .      | 08  .         .         .    g.232429
 TTTGTTCTCAACCTAGTCCTGGGAGTGCTTTCCGG | GGAATTTGCCAAAGAGAGAGAGAGA    c.1080
 F  V  L  N  L  V  L  G  V  L  S  G  |  E  F  A  K  E  R  E  R      p.360

          .         .         .         .         .         .       g.232489
 GTGGAGAACCGAAGGGCTTTCATGAAGCTGCGGCGCCAGCAGCAGATTGAGCGTGAGCTG       c.1140
 V  E  N  R  R  A  F  M  K  L  R  R  Q  Q  Q  I  E  R  E  L         p.380

          .         .         .  | 09      .         .         .    g.236817
 AATGGCTACCGTGCCTGGATAGACAAAGCAG | AGGAAGTCATGCTCGCTGAAGAAAATAAA    c.1200
 N  G  Y  R  A  W  I  D  K  A  E |   E  V  M  L  A  E  E  N  K      p.400

          .         .      | 10  .         .         .         .    g.237525
 AATGCTGGAACATCCGCCTTAGAAG | TGCTTCGAAGGGCAACCATCAAGAGGAGCCGGACA    c.1260
 N  A  G  T  S  A  L  E  V |   L  R  R  A  T  I  K  R  S  R  T      p.420

          .         .         .         .         .      | 11  .    g.238548
 GAGGCCATGACTCGAGACTCCAGTGATGAGCACTGTGTTGATATCTCCTCTGTGG | GCACA    c.1320
 E  A  M  T  R  D  S  S  D  E  H  C  V  D  I  S  S  V  G |   T      p.440

          .         .         .         .         .         .       g.238608
 CCTCTGGCCCGAGCCAGTATCAAAAGTGCAAAGGTAGACGGGGTCTCTTATTTCCGGCAC       c.1380
 P  L  A  R  A  S  I  K  S  A  K  V  D  G  V  S  Y  F  R  H         p.460

          .         .         .         .         .         .       g.238668
 AAGGAAAGGCTTCTGCGCATCTCCATTCGCCACATGGTTAAATCCCAGGTGTTTTACTGG       c.1440
 K  E  R  L  L  R  I  S  I  R  H  M  V  K  S  Q  V  F  Y  W         p.480

          .         .         .         .         .         .       g.238728
 ATTGTGCTGAGCCTTGTGGCACTCAACACTGCCTGTGTGGCCATTGTCCATCACAACCAG       c.1500
 I  V  L  S  L  V  A  L  N  T  A  C  V  A  I  V  H  H  N  Q         p.500

          .         .      | 12  .         .         .         .    g.239540
 CCCCAGTGGCTCACCCACCTCCTCT | ACTATGCAGAATTTCTGTTTCTGGGACTCTTCCTC    c.1560
 P  Q  W  L  T  H  L  L  Y |   Y  A  E  F  L  F  L  G  L  F  L      p.520

          .         .         .         .         .         .       g.239600
 TTGGAGATGTCCCTGAAGATGTATGGCATGGGGCCTCGCCTTTATTTTCACTCTTCATTC       c.1620
 L  E  M  S  L  K  M  Y  G  M  G  P  R  L  Y  F  H  S  S  F         p.540

          .         | 13         .         .         .         .    g.241243
 AACTGCTTTGATTTTGGG | GTCACAGTGGGCAGTATCTTTGAAGTGGTCTGGGCAATCTTC    c.1680
 N  C  F  D  F  G   | V  T  V  G  S  I  F  E  V  V  W  A  I  F      p.560

          .         .         .         .         .         .       g.241303
 AGACCTGGTACGTCTTTTGGAATCAGTGTCTTGCGAGCCCTCCGGCTTCTAAGAATATTT       c.1740
 R  P  G  T  S  F  G  I  S  V  L  R  A  L  R  L  L  R  I  F         p.580

          .  | 14      .         .         .         .         .    g.241705
 AAAATAACCAA | GTATTGGGCTTCCCTACGGAATTTGGTGGTCTCCTTGATGAGCTCAATG    c.1800
 K  I  T  K  |  Y  W  A  S  L  R  N  L  V  V  S  L  M  S  S  M      p.600

          .         .         .         .         .         .       g.241765
 AAGTCTATCATCAGTTTGCTTTTCCTCCTCTTCCTCTTCATCGTTGTCTTTGCTCTCCTA       c.1860
 K  S  I  I  S  L  L  F  L  L  F  L  F  I  V  V  F  A  L  L         p.620

          .         .    | 15    .         .         .         .    g.242270
 GGAATGCAGTTATTTGGAGGCAG | GTTTAACTTTAATGATGGGACTCCTTCGGCAAATTTT    c.1920
 G  M  Q  L  F  G  G  R  |  F  N  F  N  D  G  T  P  S  A  N  F      p.640

          .         .         .       | 16 .         .         .    g.243232
 GATACCTTCCCTGCAGCCATCATGACTGTGTTCCAG | ATCCTGACGGGTGAGGACTGGAAT    c.1980
 D  T  F  P  A  A  I  M  T  V  F  Q   | I  L  T  G  E  D  W  N      p.660

          .         .         .         .         .         .       g.243292
 GAGGTGATGTACAATGGGATCCGCTCCCAGGGTGGGGTCAGCTCAGGCATGTGGTCTGCC       c.2040
 E  V  M  Y  N  G  I  R  S  Q  G  G  V  S  S  G  M  W  S  A         p.680

          .         .         .     | 17   .         .         .    g.245946
 ATCTACTTCATTGTGCTCACCTTGTTTGGCAACT | ACACGCTACTGAATGTGTTCTTGGCT    c.2100
 I  Y  F  I  V  L  T  L  F  G  N  Y |   T  L  L  N  V  F  L  A      p.700

          .         .         .         .   | 18     .         .    g.247533
 ATCGCTGTGGATAATCTCGCCAACGCCCAGGAACTGACCAAG | GATGAACAGGAGGAAGAA    c.2160
 I  A  V  D  N  L  A  N  A  Q  E  L  T  K   | D  E  Q  E  E  E      p.720

          .         .         .         .         .         .       g.247593
 GAGGCCTTCAACCAGAAACATGCACTGCAGAAGGCCAAGGAGGTCAGCCCGATGTCTGCA       c.2220
 E  A  F  N  Q  K  H  A  L  Q  K  A  K  E  V  S  P  M  S  A         p.740

          .         . | 19       .         .         .         .    g.252665
 CCCAACATGCCTTCGATCGA | AAGAGACAGAAGGAGAAGACACCACATGTCGATGTGGGAG    c.2280
 P  N  M  P  S  I  E  |  R  D  R  R  R  R  H  H  M  S  M  W  E      p.760

          .        | 20.         .         .         .         .    g.253877
 CCACGCAGCAGCCACCT | GAGGGAGCGGAGGCGCCGGCACCACATGTCCGTGTGGGAGCAG    c.2340
 P  R  S  S  H  L  |  R  E  R  R  R  R  H  H  M  S  V  W  E  Q      p.780

          .         .         .         .         .         .       g.253937
 CGTACCAGCCAGCTGAGGAAGCACATGCAGATGTCCAGCCAGGAGGCCCTCAACAGAGAG       c.2400
 R  T  S  Q  L  R  K  H  M  Q  M  S  S  Q  E  A  L  N  R  E         p.800

          .         .         .         .         .         .       g.253997
 GAGGCGCCGACCATGAACCCGCTCAACCCCCTCAACCCGCTCAGCTCCCTCAACCCGCTC       c.2460
 E  A  P  T  M  N  P  L  N  P  L  N  P  L  S  S  L  N  P  L         p.820

          .         .         .         .         .         .       g.254057
 AATGCCCACCCCAGCCTTTATCGGCGACCCAGGGCCATTGAGGGCCTGGCCCTGGGCCTG       c.2520
 N  A  H  P  S  L  Y  R  R  P  R  A  I  E  G  L  A  L  G  L         p.840

          .         .         .         .         .         .       g.254117
 GCCCTGGAGAAGTTCGAGGAGGAGCGCATCAGCCGTGGGGGGTCCCTCAAGGGGGATGGA       c.2580
 A  L  E  K  F  E  E  E  R  I  S  R  G  G  S  L  K  G  D  G         p.860

          .         .         .         .         .         .       g.254177
 GGGGACCGATCCAGTGCCCTGGACAACCAGAGGACCCCTTTGTCCCTGGGCCAGCGGGAG       c.2640
 G  D  R  S  S  A  L  D  N  Q  R  T  P  L  S  L  G  Q  R  E         p.880

          .         .         .         .         .         .       g.254237
 CCACCATGGCTGGCCAGGCCCTGTCATGGAAACTGTGACCCGACTCAGCAGGAGGCAGGG       c.2700
 P  P  W  L  A  R  P  C  H  G  N  C  D  P  T  Q  Q  E  A  G         p.900

          .         .         .         .         .         .       g.254297
 GGAGGAGAGGCTGTGGTGACCTTTGAGGACCGGGCCAGGCACAGGCAGAGCCAACGGCGC       c.2760
 G  G  E  A  V  V  T  F  E  D  R  A  R  H  R  Q  S  Q  R  R         p.920

          .         .         .         .         .         .       g.254357
 AGCCGGCATCGCCGCGTCAGGACAGAAGGCAAGGAGTCCTCTTCAGCCTCCCGGAGCAGG       c.2820
 S  R  H  R  R  V  R  T  E  G  K  E  S  S  S  A  S  R  S  R         p.940

          .         .         .         .         .         .       g.254417
 TCTGCCAGCCAGGAACGCAGTCTGGATGAAGCCATGCCCACTGAAGGGGAGAAGGACCAT       c.2880
 S  A  S  Q  E  R  S  L  D  E  A  M  P  T  E  G  E  K  D  H         p.960

          .         .         .         .         .         .       g.254477
 GAGCTCAGGGGCAACCATGGTGCCAAGGAGCCAACGATCCAAGAAGAGAGAGCCCAGGAT       c.2940
 E  L  R  G  N  H  G  A  K  E  P  T  I  Q  E  E  R  A  Q  D         p.980

          | 21         .         .         .         .         .    g.254939
 TTAAGGAG | GACCAACAGTCTGATGGTGTCCAGAGGCTCCGGGCTGGCAGGAGGCCTTGAT    c.3000
 L  R  R  |  T  N  S  L  M  V  S  R  G  S  G  L  A  G  G  L  D      p.1000

          .         .         .         .         .         .       g.254999
 GAGGCTGACACCCCCCTAGTCCTGCCCCATCCTGAGCTGGAAGTGGGGAAGCACGTGGTG       c.3060
 E  A  D  T  P  L  V  L  P  H  P  E  L  E  V  G  K  H  V  V         p.1020

          .         .         .         .         .         .       g.255059
 CTGACGGAGCAGGAGCCAGAAGGCAGCAGTGAGCAGGCCCTGCTGGGGAATGTGCAGCTA       c.3120
 L  T  E  Q  E  P  E  G  S  S  E  Q  A  L  L  G  N  V  Q  L         p.1040

          .         .         .         .         .         .       g.255119
 GACATGGGCCGGGTCATCAGCCAGAGCGAGCCTGACCTCTCCTGCATCACGGCCAACACG       c.3180
 D  M  G  R  V  I  S  Q  S  E  P  D  L  S  C  I  T  A  N  T         p.1060

          .         .         .         .         .         .       g.255179
 GACAAGGCCACCACCGAGAGCACCAGCGTCACCGTCGCCATCCCCGACGTGGACCCCTTG       c.3240
 D  K  A  T  T  E  S  T  S  V  T  V  A  I  P  D  V  D  P  L         p.1080

          .         .   | 22     .         .         .         .    g.257763
 GTGGACTCAACCGTGGTGCACA | TTAGCAACAAGACGGATGGGGAAGCCAGTCCCTTGAAG    c.3300
 V  D  S  T  V  V  H  I |   S  N  K  T  D  G  E  A  S  P  L  K      p.1100

          .         .         .         .         .         .       g.257823
 GAGGCAGAGATCAGAGAGGATGAGGAGGAGGTGGAGAAGAAGAAGCAGAAGAAGGAGAAG       c.3360
 E  A  E  I  R  E  D  E  E  E  V  E  K  K  K  Q  K  K  E  K         p.1120

          .         .         .         .         .         .       g.257883
 CGTGAGACAGGCAAAGCCATGGTGCCCCACAGCTCAATGTTCATCTTCAGCACCACCAAC       c.3420
 R  E  T  G  K  A  M  V  P  H  S  S  M  F  I  F  S  T  T  N         p.1140

    | 23     .         .         .         .         .         .    g.259033
 CC | GATCCGGAGGGCCTGCCACTACATCGTGAACCTGCGCTACTTTGAGATGTGCATCCTC    c.3480
 P  |  I  R  R  A  C  H  Y  I  V  N  L  R  Y  F  E  M  C  I  L      p.1160

          .         .         .         .         .         .       g.259093
 CTGGTGATTGCAGCCAGCAGCATCGCCCTGGCGGCAGAGGACCCCGTCCTGACCAACTCG       c.3540
 L  V  I  A  A  S  S  I  A  L  A  A  E  D  P  V  L  T  N  S         p.1180

          .   | 24     .         .         .         .         .    g.259865
 GAGCGCAACAAA | GTCCTGAGGTATTTTGACTATGTGTTCACGGGCGTGTTCACCTTTGAG    c.3600
 E  R  N  K   | V  L  R  Y  F  D  Y  V  F  T  G  V  F  T  F  E      p.1200

          .   | 25     .         .         .         .         .    g.260645
 ATGGTTATAAAG | ATGATAGACCAAGGCTTGATCCTGCAGGATGGGTCCTACTTCCGAGAC    c.3660
 M  V  I  K   | M  I  D  Q  G  L  I  L  Q  D  G  S  Y  F  R  D      p.1220

          .         .         .         .         .          | 26    g.271927
 TTGTGGAACATCCTGGACTTTGTGGTGGTCGTTGGCGCATTGGTGGCCTTTGCTCTGGC | G    c.3720
 L  W  N  I  L  D  F  V  V  V  V  G  A  L  V  A  F  A  L  A  |      p.1240

          .  | 27      .         .         .         .         .    g.273642
 AACGCTTTGGG | AACCAACAAAGGACGGGACATCAAGACCATCAAGTCTCTGCGGGTGCTC    c.3780
 N  A  L  G  |  T  N  K  G  R  D  I  K  T  I  K  S  L  R  V  L      p.1260

          .         .         .         .         | 28         .    g.276699
 CGAGTTCTAAGGCCACTGAAAACCATCAAGCGCTTGCCCAAGCTCAAG | GCCGTCTTCGAC    c.3840
 R  V  L  R  P  L  K  T  I  K  R  L  P  K  L  K   | A  V  F  D      p.1280

          .         .         .         .         .         .       g.276759
 TGCGTAGTGACCTCCTTGAAGAATGTCTTCAACATACTCATTGTGTACAAGCTCTTCATG       c.3900
 C  V  V  T  S  L  K  N  V  F  N  I  L  I  V  Y  K  L  F  M         p.1300

          .         .         .         .         .         .       g.276819
 TTCATCTTTGCTGTCATCGCAGTTCAGCTCTTCAAGGGAAAGTTCTTTTATTGCACGGAC       c.3960
 F  I  F  A  V  I  A  V  Q  L  F  K  G  K  F  F  Y  C  T  D         p.1320

          .         .          | 29        .         .         .    g.277437
 AGTTCCAAGGACACAGAGAAGGAGTGCAT | AGGCAACTATGTAGATCATGAGAAAAACAAG    c.4020
 S  S  K  D  T  E  K  E  C  I  |  G  N  Y  V  D  H  E  K  N  K      p.1340

          .         .         .         .         .         .       g.277497
 ATGGAGGTGAAGGGCCGGGAATGGAAGCGCCATGAATTCCACTACGACAACATTATCTGG       c.4080
 M  E  V  K  G  R  E  W  K  R  H  E  F  H  Y  D  N  I  I  W         p.1360

          .         .         .         .        | 30.         .    g.278388
 GCCCTGCTGACCCTCTTCACCGTCTCCACAGGGGAAGGATGGCCTCA | AGTTCTGCAGCAC    c.4140
 A  L  L  T  L  F  T  V  S  T  G  E  G  W  P  Q  |  V  L  Q  H      p.1380

          .         .         .         .         .         .       g.278448
 TCTGTAGATGTGACAGAGGAAGACCGAGGCCCAAGCCGCAGCAACCGCATGGAGATGTCT       c.4200
 S  V  D  V  T  E  E  D  R  G  P  S  R  S  N  R  M  E  M  S         p.1400

          .         .         .         .         .         .       g.278508
 ATCTTTTATGTAGTCTACTTTGTGGTCTTCCCCTTCTTCTTTGTCAATATCTTTGTGGCT       c.4260
 I  F  Y  V  V  Y  F  V  V  F  P  F  F  F  V  N  I  F  V  A         p.1420

          .         .         .         .         .         .       g.278568
 CTCATCATCATCACCTTCCAGGAGCAAGGGGATAAGATGATGGAGGAGTGCAGCCTGGAG       c.4320
 L  I  I  I  T  F  Q  E  Q  G  D  K  M  M  E  E  C  S  L  E         p.1440

           | 31        .         .         .         .         .    g.279448
 AAGAATGAG | AGGGCGTGCATCGACTTCGCCATCAGCGCCAAACCTCTCACCCGCTACATG    c.4380
 K  N  E   | R  A  C  I  D  F  A  I  S  A  K  P  L  T  R  Y  M      p.1460

          .         .         .         .         .         .       g.279508
 CCGCAGAACAGACACACCTTCCAGTACCGCGTGTGGCACTTTGTGGTGTCTCCGTCCTTT       c.4440
 P  Q  N  R  H  T  F  Q  Y  R  V  W  H  F  V  V  S  P  S  F         p.1480

          .         .         .         .         .     | 32   .    g.280214
 GAGTACACCATTATGGCCATGATCGCCTTGAATACTGTTGTGCTGATGATGAAG | TATTAT    c.4500
 E  Y  T  I  M  A  M  I  A  L  N  T  V  V  L  M  M  K   | Y  Y      p.1500

          .         .         .         .         .         .       g.280274
 TCTGCTCCCTGTACCTATGAGCTGGCCCTGAAGTACCTGAATATCGCCTTCACCATGGTG       c.4560
 S  A  P  C  T  Y  E  L  A  L  K  Y  L  N  I  A  F  T  M  V         p.1520

          .         .         .         .      | 33  .         .    g.284039
 TTTTCCCTGGAATGTGTCCTGAAGGTCATCGCTTTTGGCTTTTTG | AACTATTTCCGAGAC    c.4620
 F  S  L  E  C  V  L  K  V  I  A  F  G  F  L   | N  Y  F  R  D      p.1540

          .         .         .         .         .         .       g.284099
 ACCTGGAATATCTTTGACTTCATCACCGTGATTGGCAGTATCACAGAAATTATCCTGACA       c.4680
 T  W  N  I  F  D  F  I  T  V  I  G  S  I  T  E  I  I  L  T         p.1560

           | 34        .         .         .         .         .    g.284907
 GACAGCAAG | CTGGTGAACACCAGTGGCTTCAATATGAGCTTTCTGAAGCTCTTCCGAGCT    c.4740
 D  S  K   | L  V  N  T  S  G  F  N  M  S  F  L  K  L  F  R  A      p.1580

          .         .         .         .         .         .       g.284967
 GCCCGCCTCATAAAGCTCCTGCGTCAGGGCTATACCATACGCATTTTGCTGTGGACCTTT       c.4800
 A  R  L  I  K  L  L  R  Q  G  Y  T  I  R  I  L  L  W  T  F         p.1600

          .      | 35  .         .         .         .         .    g.288041
 GTGCAGTCCTTTAAG | GCCCTCCCTTATGTCTGCCTTTTAATTGCCATGCTTTTCTTCATT    c.4860
 V  Q  S  F  K   | A  L  P  Y  V  C  L  L  I  A  M  L  F  F  I      p.1620

          .         .  | 36      .         .         .         .    g.292782
 TATGCCATCATTGGGATGCAG | GTATTTGGAAACATAAAATTAGACGAGGAGAGTCACATC    c.4920
 Y  A  I  I  G  M  Q   | V  F  G  N  I  K  L  D  E  E  S  H  I      p.1640

          .         .         .         .         .    | 37    .    g.293523
 AACCGGCACAACAACTTCCGGAGTTTCTTTGGGTCCCTAATGCTACTCTTCAG | GAGTGCC    c.4980
 N  R  H  N  N  F  R  S  F  F  G  S  L  M  L  L  F  R  |  S  A      p.1660

          .         .         .         .         .         .       g.293583
 ACAGGTGAGGCCTGGCAGGAGATTATGCTGTCATGCCTTGGGGAGAAGGGCTGTGAGCCT       c.5040
 T  G  E  A  W  Q  E  I  M  L  S  C  L  G  E  K  G  C  E  P         p.1680

          .         .         .         .         .         .       g.293643
 GACACCACCGCACCATCAGGGCAGAACGAGAACGAACGCTGCGGCACCGATCTGGCCTAC       c.5100
 D  T  T  A  P  S  G  Q  N  E  N  E  R  C  G  T  D  L  A  Y         p.1700

          .         .         .          | 38        .         .    g.297572
 GTGTACTTTGTCTCCTTCATCTTCTTCTGCTCCTTCTTG | ATGCTCAACCTGTTTGTGGCC    c.5160
 V  Y  F  V  S  F  I  F  F  C  S  F  L   | M  L  N  L  F  V  A      p.1720

          .         .         .         .         .         .       g.297632
 GTCATCATGGACAACTTTGAGTACCTGACTCGGGACTCCTCCATCCTGGGGCCTCACCAC       c.5220
 V  I  M  D  N  F  E  Y  L  T  R  D  S  S  I  L  G  P  H  H         p.1740

          .         .         .         .        | 39.         .    g.302890
 TTGGACGAGTTTGTCCGCGTCTGGGCAGAATATGACCGAGCAGCATG | TGGCCGCATCCAT    c.5280
 L  D  E  F  V  R  V  W  A  E  Y  D  R  A  A  C  |  G  R  I  H      p.1760

          .         .         .         .         .         .       g.302950
 TACACTGAGATGTATGAAATGCTGACTCTCATGTCACCTCCGCTAGGCCTCGGCAAGAGA       c.5340
 Y  T  E  M  Y  E  M  L  T  L  M  S  P  P  L  G  L  G  K  R         p.1780

          .         .     | 40   .         .         .         .    g.305165
 TGTCCCTCCAAAGTGGCATATAAG | AGGTTGGTCCTGATGAACATGCCAGTAGCTGAGGAC    c.5400
 C  P  S  K  V  A  Y  K   | R  L  V  L  M  N  M  P  V  A  E  D      p.1800

          .         .         .         .         .         .       g.305225
 ATGACGGTCCACTTCACCTCCACACTTATGGCTCTGATCCGGACAGCTCTGGACATTAAA       c.5460
 M  T  V  H  F  T  S  T  L  M  A  L  I  R  T  A  L  D  I  K         p.1820

          . | 41       .         .         .         .         .    g.306161
 ATTGCCAAAG | GTGGTGCAGACAGGCAGCAGCTAGACTCAGAGCTACAAAAGGAGACCCTA    c.5520
 I  A  K  G |   G  A  D  R  Q  Q  L  D  S  E  L  Q  K  E  T  L      p.1840

          .         .         .         .         .         | 42    g.306770
 GCCATCTGGCCTCACCTATCCCAGAAGATGCTGGATCTGCTTGTGCCCATGCCCAAAG | CC    c.5580
 A  I  W  P  H  L  S  Q  K  M  L  D  L  L  V  P  M  P  K  A |       p.1860

          .         .         .         .         .         .       g.306830
 TCTGACCTGACTGTGGGCAAAATCTATGCAGCAATGATGATCATGGACTACTATAAGCAG       c.5640
 S  D  L  T  V  G  K  I  Y  A  A  M  M  I  M  D  Y  Y  K  Q         p.1880

          .         .         .          | 43        .         .    g.307184
 AGTAAGGTGAAGAAGCAGAGGCAGCAGCTGGAGGAACAG | AAAAATGCCCCCATGTTCCAG    c.5700
 S  K  V  K  K  Q  R  Q  Q  L  E  E  Q   | K  N  A  P  M  F  Q      p.1900

          .         .         .         .         .         .       g.307244
 CGCATGGAGCCTTCATCTCTGCCTCAGGAGATCATTGCTAATGCCAAAGCCCTGCCTTAC       c.5760
 R  M  E  P  S  S  L  P  Q  E  I  I  A  N  A  K  A  L  P  Y         p.1920

          .         .       | 44 .         .         .         .    g.311929
 CTCCAGCAGGACCCCGTTTCAGGCCT | GAGTGGCCGGAGTGGATACCCTTCGATGAGTCCA    c.5820
 L  Q  Q  D  P  V  S  G  L  |  S  G  R  S  G  Y  P  S  M  S  P      p.1940

          .         .         .         .         .         .       g.311989
 CTCTCTCCCCAGGATATATTCCAGTTGGCTTGTATGGACCCCGCCGATGACGGACAGTTC       c.5880
 L  S  P  Q  D  I  F  Q  L  A  C  M  D  P  A  D  D  G  Q  F         p.1960

          .         | 45         .         .         .         .    g.316356
 CAAGAACGGCAGTCTCTG | GTGGTGACAGACCCTAGCTCCATGAGACGTTCATTTTCCACT    c.5940
 Q  E  R  Q  S  L   | V  V  T  D  P  S  S  M  R  R  S  F  S  T      p.1980

          .         .         .         .         .         .       g.316416
 ATTCGGGATAAGCGTTCAAATTCCTCGTGGTTGGAGGAATTCTCCATGGAGCGAAGCAGT       c.6000
 I  R  D  K  R  S  N  S  S  W  L  E  E  F  S  M  E  R  S  S         p.2000

          .         .         .         .         .         .       g.316476
 GAAAATACCTACAAGTCCCGTCGCCGGAGTTACCACTCCTCCTTGCGGCTGTCAGCCCAC       c.6060
 E  N  T  Y  K  S  R  R  R  S  Y  H  S  S  L  R  L  S  A  H         p.2020

          .          | 46        .         .         .         .    g.318159
 CGCCTGAACTCTGATTCAG | GCCACAAGTCTGACACTCACCGCTCAGGGGGCAGGGAGCGG    c.6120
 R  L  N  S  D  S  G |   H  K  S  D  T  H  R  S  G  G  R  E  R      p.2040

          .         .         .         .         .         .       g.318219
 GGACGATCAAAAGAGCGAAAGCATCTTCTCTCTCCTGATGTCTCCCGCTGCAATTCAGAA       c.6180
 G  R  S  K  E  R  K  H  L  L  S  P  D  V  S  R  C  N  S  E         p.2060

          .         .         .         .         .         .       g.318279
 GAGCGAGGGACCCAGGCTGACTGGGAGTCCCCAGAGCGCCGTCAATCCAGGTCACCCAGT       c.6240
 E  R  G  T  Q  A  D  W  E  S  P  E  R  R  Q  S  R  S  P  S         p.2080

          .         .         . | 47       .         .         .    g.319772
 GAGGGCAGGTCACAGACGCCCAACAGACAG | GGCACAGGTTCCCTAAGTGAGAGCTCCATC    c.6300
 E  G  R  S  Q  T  P  N  R  Q   | G  T  G  S  L  S  E  S  S  I      p.2100

          .         .         .         .         .         .       g.319832
 CCCTCTGTCTCTGACACCAGCACCCCAAGAAGAAGTCGTCGGCAGCTCCCACCCGTCCCG       c.6360
 P  S  V  S  D  T  S  T  P  R  R  S  R  R  Q  L  P  P  V  P         p.2120

          .         .         .         .         .         .       g.319892
 CCAAAGCCCCGGCCCCTCCTTTCCTACAGCTCCCTGATTCGACACGCGGGCAGCATCTCT       c.6420
 P  K  P  R  P  L  L  S  Y  S  S  L  I  R  H  A  G  S  I  S         p.2140

          .         .         .         .         .         .       g.319952
 CCACCTGCTGATGGAAGCGAGGAGGGCTCCCCGCTGACCTCCCAAGCTCTGGAGAGCAAC       c.6480
 P  P  A  D  G  S  E  E  G  S  P  L  T  S  Q  A  L  E  S  N         p.2160

          .         .         .         .         .         .       g.320012
 AATGCTTGCCTGACCGAGTCTTCCAACTCTCCGCACCCCCAGCAGAGCCAACATGCCTCC       c.6540
 N  A  C  L  T  E  S  S  N  S  P  H  P  Q  Q  S  Q  H  A  S         p.2180

          .         .         .         .         .         .       g.320072
 CCACAGCGCTACATCTCCGAGCCCTACTTGGCCCTGCACGAAGACTCCCACGCCTCAGAC       c.6600
 P  Q  R  Y  I  S  E  P  Y  L  A  L  H  E  D  S  H  A  S  D         p.2200

          .         .         .         .         .         .       g.320132
 TGTGGTGAGGAGGAGACGCTCACTTTCGAAGCAGCCGTGGCTACTAGCCTGGGCCGTTCC       c.6660
 C  G  E  E  E  T  L  T  F  E  A  A  V  A  T  S  L  G  R  S         p.2220

          .         .         .         .         .         .       g.320192
 AACACCATCGGCTCAGCCCCACCCCTGCGGCATAGCTGGCAGATGCCCAACGGGCACTAT       c.6720
 N  T  I  G  S  A  P  P  L  R  H  S  W  Q  M  P  N  G  H  Y         p.2240

          .         .         .         .         .         .       g.320252
 CGGCGGCGGAGGCGCGGGGGGCCTGGGCCAGGCATGATGTGTGGGGCTGTCAACAACCTG       c.6780
 R  R  R  R  R  G  G  P  G  P  G  M  M  C  G  A  V  N  N  L         p.2260

          .         .         .                                     g.320285
 CTAAGTGACACGGAAGAAGATGACAAATGCTAG                                  c.6813
 L  S  D  T  E  E  D  D  K  C  X                                    p.2270

          .         .         .         .         .         .       g.320345
 aggctgctcccccctccgatgcatgctcttctctcacatggagaaaaccaagacagaatt       c.*60

          .         .         .         .         .         .       g.320405
 gggaagccagtgcggcccgggggggaggaagagggaaaaggaagatggaaggacaccatg       c.*120

          .         .         .         .         .         .       g.320465
 cattatcagagaagaggaagtaaaggacaatcagaacaccagtcaaacccaccaaattgc       c.*180

          .         .         .         .         .         .       g.320525
 tttattcccctttgcaagatgggcactgccatagttctgcctctttgctggggaaagaaa       c.*240

          .         .         .         .         .         .       g.320585
 ccaggaacgtggagggttattactgcgggagaagggacacgaggatggctttgcttcccc       c.*300

          .         .         .         .         .         .       g.320645
 ttgccccttcccacttttctaaaagctgtggagggatctagctggcctatgtctacactc       c.*360

          .         .         .         .         .         .       g.320705
 agtgccctgagaagcctggaagactttctggctcttaactggggagtagtggagaccata       c.*420

          .         .         .         .         .         .       g.320765
 ggagaggactctcctccctcaccagctcttacgcctcagccagcaccactgccaccaggg       c.*480

          .         .         .         .         .         .       g.320825
 caactgcagcagcatctcatgcataaccctgtggcttgcttcccccagggcagcacaggc       c.*540

          .         .         .         .         .         .       g.320885
 taagtcaggaacatcggatgccagggagggaggagaaagccgaagcgaaaggggtcaggg       c.*600

          .         .         .         .         .         .       g.320945
 tgctgaggcaacagcagcaagggctggtctggacaagaaaagccatagcccggcagcccc       c.*660

          .         .         .         .         .         .       g.321005
 taccatgagggagacagagaaacagaactggtggtgctggggggtatagccccccatcct       c.*720

          .         .         .         .         .         .       g.321065
 tgaggcctgtcacccacacagtaggtgctgagagttaggacaggtcaggaagtcccccag       c.*780

          .         .         .         .         .         .       g.321125
 ggtccacaaaggtgcctgaggctctggtaagggtgaagataaaagtatttaacaaccgct       c.*840

          .         .         .         .         .         .       g.321185
 atggcatcaatgtaagtggagtttggtcctagtgccggagcccatgctattccaggcatt       c.*900

          .         .         .         .         .         .       g.321245
 ggctctttagatgccagtcatgggggaaccctgagggtgtgggtagagtagcaggggcca       c.*960

          .         .         .         .         .         .       g.321305
 cctaagagattaaaaacagtctgttttccaaccagtgtggaagcaattaaatatgcgtaa       c.*1020

          .         .         .         .         .         .       g.321365
 cagtgctacggccacaccagcacctcctggctgaaggtcagcccacactctggtccatga       c.*1080

          .         .         .         .         .         .       g.321425
 ggcagcaaggccagtgctgtgccaagcccggtaaggccaagtgccgaggcccagccttcc       c.*1140

          .         .         .         .         .         .       g.321485
 ctgccactcctctgagagggcagaacacacatatccaagtaggctacccaccactgggta       c.*1200

          .         .         .         .         .         .       g.321545
 gggatttctgtaaagatgggaaaggctgatagattgaaataagcttctgtgaaagtctgg       c.*1260

          .         .         .         .         .         .       g.321605
 atttactgaggacctcccctgaggagggaccgttgggaccgcagattctgcagctggtgt       c.*1320

          .         .         .         .         .         .       g.321665
 ggggttcaggtcagtttgtcaggatgctttaaggtgattagtaaatatacctcagcttag       c.*1380

          .         .         .         .         .         .       g.321725
 acttgggctgctccttctagcaaagcaggctccagtggggcctcatcatacaggatgaca       c.*1440

          .         .         .         .         .         .       g.321785
 agactggggccctgttcaccttgaacatgcccctgggccaagatggggcttcacccctcc       c.*1500

          .         .         .         .         .         .       g.321845
 ccagagtaagagctggggctgacagtcccaccctgtcattcctaatagcccaaacgcaga       c.*1560

          .         .         .         .         .         .       g.321905
 agcactgagcaagagagccctttcttgccaagccagtgctcttttggtatatggcataca       c.*1620

          .         .         .         .         .         .       g.321965
 gctccattggaggggacacatcactggctttatctggtggaaatgtacctttcccttaag       c.*1680

          .         .         .         .         .         .       g.322025
 ttcctccttagtgccatcacagcaggtgaatgggtgccctacggggccctccttccccca       c.*1740

          .         .         .         .         .         .       g.322085
 ccaggaacagatggaacctgccacccaggatcctgatctgccctgcactgagcactcagt       c.*1800

          .         .         .         .         .         .       g.322145
 ggataaacactcctccagcccagacacactcctcctcttgggcaggagcaatccagagtt       c.*1860

          .         .         .         .         .         .       g.322205
 gttatttttcttagaaggagcctcttttccctctattttttaaattgaaatataatagct       c.*1920

          .         .         .         .         .         .       g.322265
 gcatcagccctgaaaagccaaattcaaccacatggctggagaatcatttgtcatggcccc       c.*1980

          .         .         .         .         .         .       g.322325
 gccttctcttctgatactaatggagcttcatgacccacggtcagcccccaaaccaaagtt       c.*2040

          .         .         .         .         .         .       g.322385
 gtcccaacagaggaggccagtgaggcagagacagagctctcccactctcagaccctcttt       c.*2100

          .         .         .         .         .         .       g.322445
 tgtcttcattttcctctcccacttagcacatgtgtgcttgagggtggctgggaatgtgat       c.*2160

          .         .         .         .         .         .       g.322505
 atacagcaccctgatcctaacaggtgtgattgttacgtaagacgctgatactgggccttg       c.*2220

          .         .         .         .         .         .       g.322565
 tattgcttttaaagtttcctctgctcagcatcatttcatgccaaagtgctgctatgggct       c.*2280

          .         .         .         .         .         .       g.322625
 gctttgtgtgcacaaaattgctttttccacctcggaaatgcagctttccctagggggagg       c.*2340

          .         .         .         .         .         .       g.322685
 cctacaacaggacgaccattctgagccagtgagtctattgcatggtgttttgagaaaggg       c.*2400

          .         .         .         .         .         .       g.322745
 aattttagtgacaccttatgccatttcaagaggagaaatgcaggctggcagagcaatttc       c.*2460

          .         .         .         .         .         .       g.322805
 cagaaatggaatttgcctgcaaatagtataaacaacactaaatttactgtgccaggaaat       c.*2520

          .         .         .         .         .         .       g.322865
 cttcctgaactccttgaactcatacacacaggtatttgagtcctgaataaagtgttggaa       c.*2580

          .         .         .         .         .         .       g.322925
 agcactgcagatgcggtcacctgactgaccacctgggttttctattaccagtgaatttct       c.*2640

          .         .         .         .         .         .       g.322985
 tttattcaccttcccttgaccaagaaattgggtttcttttccctcagcctgcacttactc       c.*2700

          .         .         .         .         .         .       g.323045
 ttctattaagaccagaaaataaaataattttccgttgagtcacaaactcatcatcttgtt       c.*2760

          .         .         .         .         .         .       g.323105
 tggtgttctgctgcctctgaacaaaagtgaatgccagccttcccttgctgggtgtcagag       c.*2820

          .         .         .         .         .         .       g.323165
 tctgcctcccttgaaaagaggcccctgtagaccccaacacctattcttttctctggttaa       c.*2880

          .         .         .         .         .         .       g.323225
 ttacagcagcatctgagaaattccatgcaaaagaagactacaaccagtgtttcagatata       c.*2940

          .         .         .         .         .         .       g.323285
 ccacaagatcaaatttgggcactggtggtccacctcagaagactcttgagtcatatattc       c.*3000

          .         .         .         .         .         .       g.323345
 agtttctcttgctaatatatgactcgtcttcaccatctcctcaaaacaagagcaaagcca       c.*3060

          .         .         .         .         .         .       g.323405
 agatagaggaaggtaaaaggaggaggaaaggaaaccaaggcagggagatgttctaagtag       c.*3120

          .         .         .         .         .         .       g.323465
 gtttgcatttagttacccctcatttcacttaaggctccagacagactccaggtagggaat       c.*3180

          .         .         .         .         .         .       g.323525
 gcatgctgtctctttctctgtgtctgtctccccatctcctagaggacagagtgccagcga       c.*3240

          .         .         .         .         .         .       g.323585
 cctctggacaggggcagggctccagccaaggtgcccctgagccagggtcaacatagaatt       c.*3300

          .         .         .         .         .         .       g.323645
 tcctgccccgtgaagggctggcaccagctagcatccccttggctccacatgagtcatgaa       c.*3360

          .         .         .         .         .         .       g.323705
 cacaattgtcagtgggggtctctgctgctcttctggctgaagaatctgtttttcttctgg       c.*3420

          .         .         .         .         .         .       g.323765
 gcttcacttgtagttcctattcaatgtctccatagggcactgagatcaccaagaacatta       c.*3480

          .         .         .         .         .         .       g.323825
 cccagaagctgaagtccaaatgttctagattttgacctctcttgactctggggccacaaa       c.*3540

          .         .         .         .         .         .       g.323885
 gagaaggccccataatccacctctcagccagtatctcccttctttgcacagattcctccc       c.*3600

          .         .         .         .         .         .       g.323945
 aaccccatagagcctatgtggtgagcatgagggtcgtcttccctctgttctcccatccca       c.*3660

          .         .         .         .         .         .       g.324005
 gcctctgttttgctgcatgttagcgctgatccagctcctgagatggttaattccacccaa       c.*3720

          .         .         .         .         .         .       g.324065
 tccaagcttatttgcttgcctgactgactccaccactctctcagctatgggggaatattg       c.*3780

          .         .         .         .         .         .       g.324125
 cattctaatgaaatagggtttggaactcacctggtgctcctcgcaagacaactgacacaa       c.*3840

          .         .         .         .         .         .       g.324185
 ggtgtagggtgtgggggtggacaaaatgcccacctactggataaaagctcactgcaggaa       c.*3900

          .         .         .         .         .         .       g.324245
 aatgaggtctcctggcataatgcaacaaaaatctcatataattttgatttttaaaaagtt       c.*3960

          .         .         .         .         .         .       g.324305
 gttctcaatttttcattacatcctacttctcagccctctggatgtttcatttttttggac       c.*4020

          .         .         .         .         .         .       g.324365
 aaagtgtttctttagtggttggggccagggacaggttgagggatatttctcggctcattt       c.*4080

          .         .         .         .         .         .       g.324425
 ataagatataaatattatgaggttgtatgtaaagaaagggcaaacgtacagcagaagggg       c.*4140

          .         .         .         .         .         .       g.324485
 agcaaatagctacctttcaaggattttgagatttgaaggttaaggaatttttactgctat       c.*4200

          .         .         .         .         .         .       g.324545
 ttttgttcatcagtttcatgtctgttatgttttgagatcctcagaggcctagggttagcg       c.*4260

          .         .         .         .         .         .       g.324605
 tataccaagaatcctggtgagaggcgttgccatgccttggggtgaattcttccccactag       c.*4320

          .         .         .         .         .         .       g.324665
 ctctctcacccagcctacaagtccttctctcatagatcccagagcaatgggcaccgtcca       c.*4380

          .         .         .         .         .         .       g.324725
 ggaggtacaggagaggactttatgatgcaggaaagaaggaagaagtgggtcccttgcaag       c.*4440

          .         .         .         .         .         .       g.324785
 tggccagacagggaatgatggtttgactccagaaatcaggaatcaggttcaggtttggat       c.*4500

          .         .         .         .         .         .       g.324845
 aacttctctttaaaatatctccacattgagactcttattttaacaaaatccaaacaaaat       c.*4560

          .         .         .         .         .         .       g.324905
 taactcagggcttgtgacctaacctttgtaagaaggtgatcaaagagatcctacattaat       c.*4620

          .         .         .         .         .         .       g.324965
 aagcactgcctgtagcaccagctttgtctttttgtcttttgttgtttctttcctgaacca       c.*4680

          .         .         .         .         .         .       g.325025
 ccctgtacatcatagccaggtctaccccaaatagagcagcagctgatggcttctctgctg       c.*4740

          .         .         .         .         .         .       g.325085
 tctgtggagggagggctcggctgcagacctatggtgttttgtcagctgttaggtgctaca       c.*4800

          .         .         .         .         .         .       g.325145
 gcccacccagtcagagtacatagacatagcgctttaagggacaaaggacaaacagaacta       c.*4860

          .         .         .         .         .         .       g.325205
 tctttgctttccggaggccatctttttctttccttgaatcctttctgctttaaacttctg       c.*4920

          .         .         .         .         .         .       g.325265
 aggtttatgcatcccagagaggtcacaccaagccaaagagaaaaaattcatagattgtcc       c.*4980

          .         .         .         .         .         .       g.325325
 cagcctacccaaagggcctgaaaagcctctctaaacaaaactcaagatagctgagaagta       c.*5040

          .         .         .         .         .         .       g.325385
 tgaatggggttcacagcaaagtccaattgatggcttttgaggctgggacacccccaaact       c.*5100

          .         .         .         .         .         .       g.325445
 gcccttctgtttttgtagttttgctttcttccacccaccctctctccgcatgctgtaagt       c.*5160

          .         .         .         .         .         .       g.325505
 taggggagttagtatcttgaacttctaaatgcaaaaggagattttataataagccatgct       c.*5220

          .         .         .         .         .         .       g.325565
 acctgtaaatacattattgaggtttgcatttttatttttggaggtatgaaagagttgagt       c.*5280

          .         .         .         .         .         .       g.325625
 agaccaagtcaaaagaggtgtggggatttatgtttatttttatttgtttggggttgtttg       c.*5340

          .         .         .         .         .         .       g.325685
 gttggtggctgggtttcttgtaacagacctattctggaatagcaaagaaggataccttgg       c.*5400

          .         .         .         .         .         .       g.325745
 tgatctgcaatgtttctgaatctgtttctctttaggaagtgattgccatcaaatttagtg       c.*5460

          .         .         .         .         .         .       g.325805
 atatgatatttgagtcaaaaatctgaggttatagtaccagctgtcttttctctctggtct       c.*5520

          .         .         .         .         .         .       g.325865
 cctttttgtcgtctttctctttctgtctaaattggcctctgtcttttcctaaggacttaa       c.*5580

          .         .         .         .         .         .       g.325925
 aatataacccaaattaatgaagaactgccccaaaacttcagtgaaagccaaggaggtaca       c.*5640

          .         .         .         .         .         .       g.325985
 gaattttttcaggacatctttaaccaatacaaaatttatgtcttaagaagataattttta       c.*5700

          .         .         .         .         .         .       g.326045
 caatagtgtagtaatctgataaatgaaaactattggaagtcaatagttttttatattcca       c.*5760

          .         .         .         .         .         .       g.326105
 gctttctgtattcaaacttgtgccttcagcaagcatctcttcactttctttcccttgtca       c.*5820

          .         .         .         .         .         .       g.326165
 attgaaacatgaatgtttggctaactcatgatgtaaagtgtctgttaagttaataataca       c.*5880

          .         .         .         .         .         .       g.326225
 taatttaaagcacttagtctccacaaagcaatttagaaaaatcttcacttgttagatccc       c.*5940

          .         .         .         .         .         .       g.326285
 atgaagtacctatgaaattctcagcattgctataagcatttgattttttttaaggaaact       c.*6000

          .         .         .         .         .         .       g.326345
 tcctgtttaatggaatctgaatccaagatttgctttaatttcactctattcttcccattt       c.*6060

          .         .         .         .         .         .       g.326405
 tcccttattcttcttgttgtctctctaattaaaaaaaaaaaaaacctaggcttttttttt       c.*6120

          .         .         .         .         .         .       g.326465
 tctatccagaaagttgggttttcatgatctgagcttccttatgtctccttctctttgtgc       c.*6180

          .         .         .         .         .         .       g.326525
 aaacttaaaccagtcatagattgtcacccagacatattctccaacccagcattggaaatc       c.*6240

          .         .         .         .         .         .       g.326585
 tgaacgaatcttttctctttttgtcctacaagtttgtcagagatgagaatggattgctgt       c.*6300

          .         .         .         .         .         .       g.326645
 ctacattctacaaccagaccctagactttataccaggctgtgccacttcctcttcacttc       c.*6360

          .         .         .         .         .         .       g.326705
 actcagaggatggccccaaaactgaaaaggaaatgaaataatcaaatataccaaatccga       c.*6420

          .         .         .         .         .         .       g.326765
 atttgactttatttgatgactcaatattttccttccagtactctaatttttttttatggc       c.*6480

          .         .         .         .         .         .       g.326825
 aatggcctatatggcacaagaaccaccacttaaagcaaatctgttgaacatttttataag       c.*6540

          .         .         .         .         .         .       g.326885
 ggatgagcaagaaaaacacactccaaaattttaaagtgccattaatcaatttttaagaat       c.*6600

          .         .         .         .         .         .       g.326945
 aaaggtaatatgaaatgagggctaaacaatgtaatataactgccagttaaggtagacagt       c.*6660

          .         .         .         .         .         .       g.327005
 agttgtggtcttagttacatttgatatggagttgtgtaatattaagcagatcccagtgga       c.*6720

          .         .         .         .         .         .       g.327065
 gttagtaaaaacataggtattgagttttaatggctaccaattgggatatatacttagcct       c.*6780

          .         .         .         .         .         .       g.327125
 gcaggctgaactttagtcagtgtttttctatcatgttgttttgtgaacaagtcaaaattt       c.*6840

          .         .         .         .         .         .       g.327185
 atacaaagctaccctaagtgctgcaattgcagaggaacttgcctcttcgtgatattagag       c.*6900

          .         .         .         .         .         .       g.327245
 ggcagtccaactccgctcaaactgagtccaagatttgaattcatccagaaaaacaaatgg       c.*6960

          .         .         .         .         .         .       g.327305
 aggagaaaagcctaatgcaccacatgtgtttggcatttcatggctgggacaatggagtag       c.*7020

          .         .         .         .         .         .       g.327365
 agggtaggaagacaagctgtagaacaaaagcaaagtgaggtagaaagtaacaggtcccag       c.*7080

          .         .         .         .         .         .       g.327425
 acgaggacagacttagagatgtgtaaccttggatcctctttttcacttagaatatgggta       c.*7140

          .         .         .         .         .         .       g.327485
 aacttcttagcacaagactggattaagagaagttctttctgttaaactcacctagggtag       c.*7200

          .         .         .         .         .         .       g.327545
 tggctttgaaggcctcagaggattaatagattcccaaaattttcttccagacctgggaga       c.*7260

          .         .         .         .         .         .       g.327605
 tggagagaaagaggttcttgctttaaagcggctcgaagacaatctttatgacttcagcaa       c.*7320

          .         .         .         .         .         .       g.327665
 ctcttcaacatagtagcaccaataaaggagagattatgttaacttcctagtggtgagaat       c.*7380

          .         .         .         .         .         .       g.327725
 accatgggatgggagaagggccagtgagtgggatgggaatgagcttcatcaggaacagat       c.*7440

          .         .         .         .         .         .       g.327785
 ttcagactctgcagggtgcaccggttctagcctcaaataacaacattgcaaggaggtgga       c.*7500

          .         .         .         .         .         .       g.327845
 ctacagggtccacaccctctgtccttcggggcccatggtcaggccattccctctttgttt       c.*7560

          .         .         .         .         .         .       g.327905
 tgctcctagaggatgagcatgtaagatgagatcaggagggaaattgggtgctctgcctca       c.*7620

          .         .         .         .         .         .       g.327965
 ggctgttaaaatgctgctacctgcattctaaaacgtgcaagtcatgccccacaagacacc       c.*7680

          .         .         .         .         .         .       g.328025
 tccttagggcagcatccactgtggtgtgccagcctgacacccctgcagtcacggtgtttg       c.*7740

          .         .         .         .         .         .       g.328085
 aatggcagctgatgctggcccacccagagtatcggtgcatctctcctaaagccacagttc       c.*7800

          .         .         .         .         .         .       g.328145
 agcactgcatgttgaccaggcggatatcctataatatagatgctcgtttggatccaaaag       c.*7860

          .         .         .         .         .         .       g.328205
 gaaaaccattaaaaataaaagaaagatgaaaaactttaatgttttgggggggataaaaga       c.*7920

          .         .         .                                     g.328235
 aaagaataaataaaaccttgttgtaaagaa                                     c.*7950

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Calcium channel, voltage-dependent, R type, alpha 1E subunit protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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