calcium channel, voltage-dependent, beta 2 subunit (CACNB2) - coding DNA reference sequence

(used for variant description)

(last modified January 27, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_000724.3 in the CACNB2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016195.1, covering CACNB2 transcript NM_000724.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.124993
                                              agcaaatcagatatg       c.-601

 .         .         .         .         .         .                g.125053
 cccaaaacgttacagaggtaacagtgaatccaggatgctgctgtcagcctgtgcattgtg       c.-541

 .         .         .         .         .         .                g.125113
 aagaaggcaatcataggcgagcagccgcgggagcaggaacagcagcgtgctaagaagcag       c.-481

 .         .         .         .         .         .                g.125173
 tcacataaacagcagcaggagtaggcctcctgcttttcaaaagcagagtactgcagggtc       c.-421

 .         .         .         .         .         .                g.125233
 gcgaaatgcaagacactcagatgtttgaaaatctcccgagttgagaatggctactgtaaa       c.-361

 .         .         .         .         .         .                g.125293
 agcgtcaccaagaaactctgacgatctggacagtcctaactctgtgttagcaatacttac       c.-301

 .         .         .         .         .         .                g.125353
 ttccggaaaattaatgctacttcttgtagatttttgcaaataggaaacccccttgaagaa       c.-241

 .         .         .         .         .         .                g.125413
 gatctcaaattacgccccccacccccaaaaaaagacaaacaggggagaacaaagttttgg       c.-181

 .         .         .         .         .         .                g.125473
 catgcctgcaggaacggtggcttttttagaaactacctaggaggcagaagctaagtgatt       c.-121

 .         .         .         .         .         .                g.125533
 tgctcatgcctcttacctgggagtagaaggtgggaagaaatggaccgaggctgtgacgag       c.-61

 .         .         .         .         .         .                g.125593
 aagacaaggcacagtgcagcttggtgaagccacacgctgactgcgttctgccccctcttc       c.-1

          .         .         .         .         | 02         .    g.266259
 ATGCAGTGCTGCGGGCTGGTGCATCGCCGGCGAGTACGGGTGTCCTAT | GGTTCGGCAGAC    c.60
 M  Q  C  C  G  L  V  H  R  R  R  V  R  V  S  Y   | G  S  A  D      p.20

          .         .         .         .         .         .       g.266319
 TCCTACACTAGCCGTCCATCCGATTCCGATGTATCTCTGGAGGAGGACCGGGAGGCAGTG       c.120
 S  Y  T  S  R  P  S  D  S  D  V  S  L  E  E  D  R  E  A  V         p.40

          .         .         .         .         | 03         .    g.362690
 CGCAGAGAAGCGGAGCGGCAGGCCCAGGCACAGTTGGAAAAAGCAAAG | ACAAAGCCCGTT    c.180
 R  R  E  A  E  R  Q  A  Q  A  Q  L  E  K  A  K   | T  K  P  V      p.60

          .         .         .         .         .         .       g.362750
 GCATTTGCGGTTCGGACAAATGTCAGCTACAGTGCGGCCCATGAAGATGATGTTCCAGTG       c.240
 A  F  A  V  R  T  N  V  S  Y  S  A  A  H  E  D  D  V  P  V         p.80

          .         .         .         .         .  | 04      .    g.365144
 CCTGGCATGGCCATCTCATTCGAAGCAAAAGATTTTCTGCATGTTAAGGAA | AAATTTAAC    c.300
 P  G  M  A  I  S  F  E  A  K  D  F  L  H  V  K  E   | K  F  N      p.100

          .         .         .         .         .         .       g.365204
 AATGACTGGTGGATAGGGCGATTGGTAAAAGAAGGCTGTGAAATCGGATTCATTCCAAGC       c.360
 N  D  W  W  I  G  R  L  V  K  E  G  C  E  I  G  F  I  P  S         p.120

          .         .         .         .         .         .       g.365264
 CCAGTCAAACTAGAAAACATGAGGCTGCAGCATGAACAGAGAGCCAAGCAAGGGAAATTC       c.420
 P  V  K  L  E  N  M  R  L  Q  H  E  Q  R  A  K  Q  G  K  F         p.140

          | 05         .         .         .         .         .    g.370846
 TACTCCAG | TAAATCAGGAGGAAATTCATCATCCAGTTTGGGTGACATAGTACCTAGTTCC    c.480
 Y  S  S  |  K  S  G  G  N  S  S  S  S  L  G  D  I  V  P  S  S      p.160

          .         .      | 06  .         .         .         .    g.378594
 AGAAAATCAACACCTCCATCATCTG | CTATAGACATAGATGCTACTGGCTTAGATGCAGAA    c.540
 R  K  S  T  P  P  S  S  A |   I  D  I  D  A  T  G  L  D  A  E      p.180

          .         .         .         .         .         .       g.378654
 GAAAATGATATTCCAGCAAACCACCGCTCCCCTAAACCCAGTGCAAACAGTGTAACGTCA       c.600
 E  N  D  I  P  A  N  H  R  S  P  K  P  S  A  N  S  V  T  S         p.200

          .         .         .          | 07        .         .    g.382680
 CCCCACTCCAAAGAGAAAAGAATGCCCTTCTTTAAGAAG | ACAGAGCACACTCCTCCGTAT    c.660
 P  H  S  K  E  K  R  M  P  F  F  K  K   | T  E  H  T  P  P  Y      p.220

          .         .         .         .         .         .       g.382740
 GATGTGGTACCTTCCATGCGACCAGTGGTCCTAGTGGGCCCTTCTCTGAAGGGCTACGAG       c.720
 D  V  V  P  S  M  R  P  V  V  L  V  G  P  S  L  K  G  Y  E         p.240

  | 08       .         .         .         .         .          | 09 g.391912
  | GTCACAGATATGATGCAAAAAGCGCTGTTTGATTTTTTAAAACACAGATTTGAAGGGCG | G c.780
  | V  T  D  M  M  Q  K  A  L  F  D  F  L  K  H  R  F  E  G  R  |   p.260

          .         .         .         .         .         .       g.391972
 ATATCCATCACAAGGGTCACCGCTGACATCTCGCTTGCCAAACGCTCGGTATTAAACAAT       c.840
 I  S  I  T  R  V  T  A  D  I  S  L  A  K  R  S  V  L  N  N         p.280

          .         .         .         .          | 10        .    g.398410
 CCCAGTAAGCACGCAATAATAGAAAGATCCAACACAAGGTCAAGCTTAG | CGGAAGTTCAG    c.900
 P  S  K  H  A  I  I  E  R  S  N  T  R  S  S  L  A |   E  V  Q      p.300

          .         .         .         .         .         .       g.398470
 AGTGAAATCGAAAGGATTTTTGAACTTGCAAGAACATTGCAGTTGGTGGTCCTTGACGCG       c.960
 S  E  I  E  R  I  F  E  L  A  R  T  L  Q  L  V  V  L  D  A         p.320

          .         .         .         .         .         .       g.398530
 GATACAATTAATCATCCAGCTCAACTCAGTAAAACCTCCTTGGCCCCTATTATAGTATAT       c.1020
 D  T  I  N  H  P  A  Q  L  S  K  T  S  L  A  P  I  I  V  Y         p.340

          .         .  | 11      .         .         .         .    g.400463
 GTAAAGATTTCTTCTCCTAAG | GTTTTACAAAGGTTAATAAAATCTCGAGGGAAATCTCAA    c.1080
 V  K  I  S  S  P  K   | V  L  Q  R  L  I  K  S  R  G  K  S  Q      p.360

          .         .         .         .         .        | 12.    g.402506
 GCTAAACACCTCAACGTCCAGATGGTAGCAGCTGATAAACTGGCTCAGTGTCCTCCA | GAG    c.1140
 A  K  H  L  N  V  Q  M  V  A  A  D  K  L  A  Q  C  P  P   | E      p.380

          .         .         .         .         .         .       g.402566
 CTGTTCGATGTGATCTTGGATGAGAACCAGCTTGAGGATGCCTGTGAGCACCTTGCCGAC       c.1200
 L  F  D  V  I  L  D  E  N  Q  L  E  D  A  C  E  H  L  A  D         p.400

          .         .         .         .         .         .       g.402626
 TATCTGGAGGCCTACTGGAAGGCCACCCATCCTCCCAGCAGTAGCCTCCCCAACCCTCTC       c.1260
 Y  L  E  A  Y  W  K  A  T  H  P  P  S  S  S  L  P  N  P  L         p.420

          .         .         .         .         .         .       g.402686
 CTTAGCCGTACATTAGCCACTTCAAGTCTGCCTCTTAGCCCCACCCTAGCCTCTAATTCA       c.1320
 L  S  R  T  L  A  T  S  S  L  P  L  S  P  T  L  A  S  N  S         p.440

     | 13    .         .         .         .         .         .    g.403610
 CAG | GGTTCTCAAGGTGATCAGAGGACTGATCGCTCCGCTCCTATCCGTTCTGCTTCCCAA    c.1380
 Q   | G  S  Q  G  D  Q  R  T  D  R  S  A  P  I  R  S  A  S  Q      p.460

          .         .         .         .         .         .       g.403670
 GCTGAAGAAGAACCTAGTGTGGAACCAGTCAAGAAATCCCAGCACCGCTCTTCCTCCTCA       c.1440
 A  E  E  E  P  S  V  E  P  V  K  K  S  Q  H  R  S  S  S  S         p.480

          .         .         .         .         .         .       g.403730
 GCCCCACACCACAACCATCGCAGTGGGACAAGTCGCGGCCTCTCCAGGCAAGAGACATTT       c.1500
 A  P  H  H  N  H  R  S  G  T  S  R  G  L  S  R  Q  E  T  F         p.500

          .         .         .         .         .         .       g.403790
 GACTCGGAAACCCAGGAGAGTCGAGACTCTGCCTACGTAGAGCCAAAGGAAGATTATTCC       c.1560
 D  S  E  T  Q  E  S  R  D  S  A  Y  V  E  P  K  E  D  Y  S         p.520

          .         .         .         .         .         .       g.403850
 CATGACCACGTGGACCACTATGCCTCACACCGTGACCACAACCACAGAGACGAGACCCAC       c.1620
 H  D  H  V  D  H  Y  A  S  H  R  D  H  N  H  R  D  E  T  H         p.540

          .         .         .         .         .         .       g.403910
 GGGAGCAGTGACCACAGACACAGGGAGTCCCGGCACCGTTCCCGGGACGTGGATCGAGAG       c.1680
 G  S  S  D  H  R  H  R  E  S  R  H  R  S  R  D  V  D  R  E         p.560

          .         .         .         .         .         .       g.403970
 CAGGACCACAACGAGTGCAACAAGCAGCGCAGCCGTCATAAATCCAAGGATCGCTACTGT       c.1740
 Q  D  H  N  E  C  N  K  Q  R  S  R  H  K  S  K  D  R  Y  C         p.580

          .         .         .         .         .         .       g.404030
 GAAAAGGATGGAGAAGTGATATCAAAAAAACGGAATGAGGCTGGGGAGTGGAACAGGGAT       c.1800
 E  K  D  G  E  V  I  S  K  K  R  N  E  A  G  E  W  N  R  D         p.600

          .                                                         g.404048
 GTTTACATCCGCCAATGA                                                 c.1818
 V  Y  I  R  Q  X                                                   p.605

          .         .         .         .         .         .       g.404108
 gttttgcccgtttgtgtttttttttttttttttttgaagtcttgtataactaacagcatc       c.*60

          .         .         .         .         .         .       g.404168
 cccaaaacaaagtctttggggtctacactgcaatcatatgtgatctgtcttgtaatattt       c.*120

          .         .         .         .         .         .       g.404228
 tgtattattgctgttgcttgaatagcaatagcatggatagagtattgagatactttttct       c.*180

          .         .         .         .         .         .       g.404288
 tttgtaagtgctacataaattggcctggtatggctgcagtcctccggttgcatactggac       c.*240

          .         .         .         .         .         .       g.404348
 tcttcaaaaactgttttgggtagctgccacttgaacaaaatctgttgccacccaggtgat       c.*300

          .         .         .         .         .         .       g.404408
 gttagtgttttaagaaatgtagttgatgtatccaacaagccagaatcagcacagataaaa       c.*360

          .         .         .         .         .         .       g.404468
 agtggaatttcttgtttctccagatttttaatacgttaatacgcaggcatctgatttgca       c.*420

          .         .         .         .         .         .       g.404528
 tattcattcatggaccactgtttcttgcttgtacctctggctgactaaatttggggacag       c.*480

          .         .         .         .         .         .       g.404588
 attcagtcttgccttacacaaaggggatcataaagttagaatctattttctatgtactag       c.*540

          .         .         .         .         .         .       g.404648
 tactgtgtactgtatagacagtttgtaaatgttatttctgcaaacaaacaccttcttatt       c.*600

          .         .         .         .         .         .       g.404708
 atatatataatatatatatatatcagtttgatcacactattttagagtcttaatgccaag       c.*660

          .         .         .         .         .         .       g.404768
 tcagcagatttgctttatgaattacagggactagaaatgcccacattcaggaaatttgta       c.*720

          .         .         .         .         .         .       g.404828
 ataacattgtctagacacctatcctcattctagtagaaagtgtgtacatactgtaaatat       c.*780

          .         .         .         .         .         .       g.404888
 gtgtgattgcttgacttgaaaaggtttgaattctgaatgttataccatccttgtaagtaa       c.*840

          .         .         .         .         .         .       g.404948
 gtttgtaatttccaccataaattatggtaaatataaaactccagaggttgttctactcca       c.*900

          .         .         .         .         .         .       g.405008
 tacagttcacactgattgtgacacattcttagtagctagtgtctgttctagtcactgcac       c.*960

          .         .         .         .         .         .       g.405068
 tggagtctacgagccggaactcgctatatgcacgtgtgtgtgtccgtatgtaagaaagtg       c.*1020

          .         .         .         .         .         .       g.405128
 tgcaccgagtgactgaatggttgagatgaattggaatgctgaagactaacgaagaaacta       c.*1080

          .         .         .         .         .         .       g.405188
 gagactgatatcgagcattctgcccacctcgctctgtatttaattaattgtgctatatgt       c.*1140

          .         .         .         .         .         .       g.405248
 tgctttaacaacccattgagcagtcagggaatgtgagtaagcttgctgccaaaggtaact       c.*1200

          .         .         .         .         .         .       g.405308
 aggaaagcattcatctgctgcctccttgtttttgctcctagagagtgaaaatacaggcaa       c.*1260

          .         .         .         .         .         .       g.405368
 ttttactgtgagtgtttcactggaaatgtacaatctttgtgtgttagagtatttgtttta       c.*1320

          .         .         .         .         .         .       g.405428
 gtaagaaatgtttacacagcttgtggaattatttcgtgggaaaataaatttttataactt       c.*1380

          .         .         .         .         .         .       g.405488
 ctcccacttcaatttctaaccttgcctattgttcctgttgtttgtttacctcccagttac       c.*1440

          .         .         .         .         .         .       g.405548
 ctaccattcctccccaccaccgactccagcaggttcactgtctgtcagaacccagaagtg       c.*1500

          .         .         .         .         .         .       g.405608
 cttcttataaccaaagtttctgttcttcagaagaaatcagggcaaaatggggtgacttga       c.*1560

          .         .         .         .         .         .       g.405668
 agtgaataaaatgttaagaatattatcctacataagacatgtacacagaaggggaacctt       c.*1620

          .         .         .         .         .         .       g.405728
 gaagacattatctccatgcctcaattacactgctgtaagaagcttacaatgtcatcatgt       c.*1680

          .         .         .         .         .         .       g.405788
 ttaaggctaagaccttttccgtgtctcaagtgtatattttgtccagttataactggatgg       c.*1740

          .         .         .         .         .         .       g.405848
 taagacagtattaagagtgcaagtacctggcacttgaagtttgtcccaggaaaatgcctg       c.*1800

          .         .         .         .         .         .       g.405908
 tgtataattacctaacttcagatctgcacattaacttatttaacaaaataaatcagccgg       c.*1860

          .         .         .         .         .         .       g.405968
 gcgcagtggctcatgcctgtaatcccagcaatttgggaggctgaggagggtggatcacct       c.*1920

          .         .         .         .         .         .       g.406028
 gaggtcaggagttcaagaccagcctggccaacgtggcgaaaccccgtctctactaaaaag       c.*1980

          .         .         .         .         .                 g.406083
 ataaaaaattagccaggtgtggtggtgcacacctgtaatcccagctacttgggag            c.*2035

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Calcium channel, voltage-dependent, beta 2 subunit protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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