calcium channel, voltage-dependent, gamma subunit 2 (CACNG2) - coding DNA reference sequence

(used for variant description)

(last modified November 14, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_006078.3 in the CACNG2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_031861.1, covering CACNG2 transcript NM_006078.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5009
                                                    gtacttgca       c.-61

 .         .         .         .         .         .                g.5069
 ccctcacacacactctcccgagaaccagaagtcggttgggtgtttatataatgaagaatt       c.-1

          .         .         .         .         .         .       g.5129
 ATGGGGCTGTTTGATCGAGGTGTTCAAATGCTTTTAACCACCGTTGGTGCTTTCGCTGCC       c.60
 M  G  L  F  D  R  G  V  Q  M  L  L  T  T  V  G  A  F  A  A         p.20

          .         .         .         .         .         .       g.5189
 TTCAGCCTGATGACCATAGCTGTGGGAACCGACTATTGGCTCTACTCCAGAGGGGTTTGC       c.120
 F  S  L  M  T  I  A  V  G  T  D  Y  W  L  Y  S  R  G  V  C         p.40

          .         .         .         .         .         .       g.5249
 AAGACCAAAAGTGTCAGTGAGAATGAAACCAGCAAAAAGAACGAGGAAGTTATGACCCAT       c.180
 K  T  K  S  V  S  E  N  E  T  S  K  K  N  E  E  V  M  T  H         p.60

          .         .         .  | 02      .         .         .    g.120124
 TCCGGATTATGGAGAACCTGCTGCCTAGAAG | GGAATTTCAAAGGTCTGTGCAAGCAAATT    c.240
 S  G  L  W  R  T  C  C  L  E  G |   N  F  K  G  L  C  K  Q  I      p.80

          .         .         .         .         .      | 03  .    g.141155
 GATCACTTCCCAGAGGATGCAGATTACGAAGCTGACACAGCAGAATATTTCCTCC | GGGCC    c.300
 D  H  F  P  E  D  A  D  Y  E  A  D  T  A  E  Y  F  L  R |   A      p.100

          .         .         .         .         .         .       g.141215
 GTGAGGGCCTCCAGCATTTTCCCAATCCTGAGTGTGATTCTGCTTTTCATGGGTGGCCTC       c.360
 V  R  A  S  S  I  F  P  I  L  S  V  I  L  L  F  M  G  G  L         p.120

          .         .         .         .         .         .       g.141275
 TGCATCGCAGCCAGCGAGTTCTACAAAACTCGACACAACATCATCCTGAGTGCCGGCATC       c.420
 C  I  A  A  S  E  F  Y  K  T  R  H  N  I  I  L  S  A  G  I         p.140

          .       | 04 .         .         .         .         .    g.142801
 TTCTTCGTGTCTGCAG | GTCTGAGTAACATCATTGGCATCATAGTGTACATATCTGCCAAT    c.480
 F  F  V  S  A  G |   L  S  N  I  I  G  I  I  V  Y  I  S  A  N      p.160

          .         .         .         .         .         .       g.142861
 GCCGGAGACCCCTCCAAGAGCGACTCCAAAAAGAATAGTTACTCATACGGCTGGTCCTTC       c.540
 A  G  D  P  S  K  S  D  S  K  K  N  S  Y  S  Y  G  W  S  F         p.180

          .         .         .         .         .         .       g.142921
 TACTTCGGGGCCCTGTCCTTCATCATCGCCGAGATGGTCGGGGTGCTGGCGGTGCACATG       c.600
 Y  F  G  A  L  S  F  I  I  A  E  M  V  G  V  L  A  V  H  M         p.200

          .         .         .         .         .         .       g.142981
 TTTATCGACCGGCACAAACAGCTGCGGGCCACGGCCCGCGCCACGGACTACCTCCAGGCC       c.660
 F  I  D  R  H  K  Q  L  R  A  T  A  R  A  T  D  Y  L  Q  A         p.220

          .         .         .         .         .         .       g.143041
 TCTGCCATCACCCGCATCCCCAGCTACCGCTACCGCTACCAGCGCCGCAGCCGCTCCAGC       c.720
 S  A  I  T  R  I  P  S  Y  R  Y  R  Y  Q  R  R  S  R  S  S         p.240

          .         .         .         .         .         .       g.143101
 TCGCGCTCCACGGAGCCCTCACACTCCAGGGACGCCTCCCCCGTGGGCATCAAGGGCTTC       c.780
 S  R  S  T  E  P  S  H  S  R  D  A  S  P  V  G  I  K  G  F         p.260

          .         .         .         .         .         .       g.143161
 AACACCCTGCCGTCCACGGAGATCTCCATGTACACGCTCAGCAGGGACCCCCTGAAGGCC       c.840
 N  T  L  P  S  T  E  I  S  M  Y  T  L  S  R  D  P  L  K  A         p.280

          .         .         .         .         .         .       g.143221
 GCCACCACGCCCACCGCCACCTACAACTCCGACAGGGATAACAGCTTCCTCCAGGTTCAC       c.900
 A  T  T  P  T  A  T  Y  N  S  D  R  D  N  S  F  L  Q  V  H         p.300

          .         .         .         .         .         .       g.143281
 AACTGTATCCAGAAGGAGAACAAGGACTCTCTCCACTCCAACACAGCCAACCGCCGGACC       c.960
 N  C  I  Q  K  E  N  K  D  S  L  H  S  N  T  A  N  R  R  T         p.320

          .                                                         g.143293
 ACCCCCGTATAA                                                       c.972
 T  P  V  X                                                         p.323

          .         .         .         .         .         .       g.143353
 agaccgcgggcctcgccagaagaccgcgggaggagggcgcggtccccgggggcggggcgg       c.*60

          .         .         .         .         .         .       g.143413
 ggcggggagacccagaccctccgctgggagaccttccaaaagcaaaaacaaaaaacaaaa       c.*120

          .         .         .         .         .         .       g.143473
 aaaacaaaaaaacaaaaaacaaaaaaacacacacacacaaaaaaagagaaaaaacataac       c.*180

          .         .         .         .         .         .       g.143533
 aagtaaattttaaaaaaaagaacaaaatataagaggaacaaagaagcaaaacaacaggaa       c.*240

          .         .         .         .         .         .       g.143593
 atgtgggaaaatataaacgagggaagaaaacaaactttaaaaaaaagcgagagggataaa       c.*300

          .         .         .         .         .         .       g.143653
 aaattaaaaatagaaaataaatctaaaagaaaatgcatgatttcccatgtaccattattt       c.*360

          .         .         .         .         .         .       g.143713
 taacatttaataaaaatcaatttaaatgaaaaaataaaagggaaccaagataacattaaa       c.*420

          .         .         .         .         .         .       g.143773
 gcaaaaaaaaaaaaaatgagaacagaaaggaaaggggatgtcctttgtatttttcagggt       c.*480

          .         .         .         .         .         .       g.143833
 ttatgttactttttttttttttttttaactcggggagagttacttttctgttccctttaa       c.*540

          .         .         .         .         .         .       g.143893
 cccccagcgggccctgcctccctgggagattggggggcgagactcaggggccctggggcc       c.*600

          .         .         .         .         .         .       g.143953
 aggtgagcctgcagtcactgccaggtccctggagcccctgggtgggtgccccaggaactc       c.*660

          .         .         .         .         .         .       g.144013
 caggaaggctcagagctcgagccggctccgcccagcattgatggggcaatcgtaggcctc       c.*720

          .         .         .         .         .         .       g.144073
 caggtgaccgagcccttgtccctcctctccgttagggtgcctggaggggggtacacttgg       c.*780

          .         .         .         .         .         .       g.144133
 ggcttgcctggccccaggttcccagtccttaatgctccttaacccactgtgatgacttcc       c.*840

          .         .         .         .         .         .       g.144193
 taggccttgaggaaagggaaggagaggggaggctgccggtggcttaccaagatgccggaa       c.*900

          .         .         .         .         .         .       g.144253
 accccggaatcctcagggtgagcctcttggggtcatgtccccaagctcctgtccttgggg       c.*960

          .         .         .         .         .         .       g.144313
 tcaggagatgccacccccccccccgggggacatgaaacagctctccctcctcacccctca       c.*1020

          .         .         .         .         .         .       g.144373
 cctcagggccacctgatgaccctggggcgatggtggaccccctgactcataagcccccca       c.*1080

          .         .         .         .         .         .       g.144433
 gtcccctgggaagggggttcattgaccctttgggggtccttggactcactgatgccccct       c.*1140

          .         .         .         .         .         .       g.144493
 tggggcccagcgggttcaacaatgacactgcaaaaaggcttctttttacaaaagaaaaag       c.*1200

          .         .         .         .         .         .       g.144553
 gaaaaacaagtggtgatttttttttaataaaaaaaccacagactataaataaatgtaaat       c.*1260

          .         .         .         .         .         .       g.144613
 acaaaataagtggatttacttgcaagaaaatcagatagtatttttcttttaattcttttc       c.*1320

          .         .         .         .         .         .       g.144673
 cagctttaaactgtgaaaacaaaaaatggggcggggtgggggacttaaactttagcaggg       c.*1380

          .         .         .         .         .         .       g.144733
 aacttgtaaagaaaaaaaaaacagaaaacgaatatacaaatccatttacaaaaacaaagc       c.*1440

          .         .         .         .         .         .       g.144793
 aaaaccgttgtgagaggtgagagctgggcttgaaggttggagggagtagcggaaggtccc       c.*1500

          .         .         .         .         .         .       g.144853
 agtgagctgcagggggtctctgtgatggaaaggtggcttcctcagacaaggaaggtgctg       c.*1560

          .         .         .         .         .         .       g.144913
 cgaatgggggaagacagaatccaacaaagaaagagaccacacaccccacacgcacacagg       c.*1620

          .         .         .         .         .         .       g.144973
 cacgttcacacacacatacacagtccacttagcccagcactgcagtcactcacagggaca       c.*1680

          .         .         .         .         .         .       g.145033
 cactcagtctcaacccttccatcccatacacggccaggggcgtggctcaaaggaaattga       c.*1740

          .         .         .         .         .         .       g.145093
 ctcatgccctccaaagccatggacgacaacaactccacactggcctttgtgttcattcac       c.*1800

          .         .         .         .         .         .       g.145153
 aacctcccaacagagcatacacatgaacacacacatgcacacatacccacacacgcacac       c.*1860

          .         .         .         .         .         .       g.145213
 atacccacacacacacacacaccactcgcatgcatgggaagggcacccgtctagaatcca       c.*1920

          .         .         .         .         .         .       g.145273
 ggactggattccggaattccttgctgcatggcctctctgggccttaattttccccccatg       c.*1980

          .         .         .         .         .         .       g.145333
 taagcatgtggattgacccagagaagcactaaaggcccattcttgctctatgtatctgtg       c.*2040

          .         .         .         .         .         .       g.145393
 acttaagatctgccacctgccccgaggatatgccagggatgaccaggacagctgccacca       c.*2100

          .         .         .         .         .         .       g.145453
 agcccccaggctcatcatcagtcagcctctcagacacacacacacacacacaccatatac       c.*2160

          .         .         .         .         .         .       g.145513
 ctcctcactgtgctccccgaacacctgcccccacatccaatgtcaaagcaaaaatacaca       c.*2220

          .         .         .         .         .         .       g.145573
 catgtgagcaaacataaagctgttcaggcaaagaggggaaagacgcaggggtccccaaag       c.*2280

          .         .         .         .         .         .       g.145633
 cccttcttcactttgtgtccccttgctgcgatcatggagagttaaagaggcttccttggg       c.*2340

          .         .         .         .         .         .       g.145693
 agaagagctctgccaccagggcttccccagtgtctttgggggtctgtgaaaaagaggatc       c.*2400

          .         .         .         .         .         .       g.145753
 ctctgaggtttactgggagggctcaaggctgagggaatggagaggaaaattttagcagtt       c.*2460

          .         .         .         .         .         .       g.145813
 ccatcccagtgtaaggaccaaccccaaaagttaaacttgcaccacagactaaaggtcaag       c.*2520

          .         .         .         .         .         .       g.145873
 ggcatcctgtgtttctcccctttcttccccagagtgacaagggccagttcagactgacag       c.*2580

          .         .         .         .         .         .       g.145933
 aaatccaacagctttcctgagctggaaatttcagaacagtctgcaagttactcccaggtg       c.*2640

          .         .         .         .         .         .       g.145993
 actgaaggtcaaggtgaggcccccctgcctctgcctgcgagtctcccccggtttgcattt       c.*2700

          .         .         .         .         .         .       g.146053
 ttcttgacaccggcatttcctgaggttgagctctctggggagttctagagaatggctagt       c.*2760

          .         .         .         .         .         .       g.146113
 aaggctttttgagcttgcacatctcacctgcctttcctgtcttttgcctgggaaaggaaa       c.*2820

          .         .         .         .         .         .       g.146173
 gttattttcccaggtcagcaaggggcagaacatcggccagcccagcccagaagtacaggg       c.*2880

          .         .         .         .         .         .       g.146233
 ggaggtcatgggccctggggcagaacaatgggagacaattcaaggtgtggtaacaacaac       c.*2940

          .         .         .         .         .         .       g.146293
 caagttgccctcagtctgggcagaaactgaactctacccctctcccaccccaatcttgcc       c.*3000

          .         .         .         .         .         .       g.146353
 cgccatcccaccagattccagacctaaagggatcaaggatgagagcgaagggagaaggga       c.*3060

          .         .         .         .         .         .       g.146413
 gggtccccaagaaaaccgcacccaagcgagcactgtctgaagagaaaaactagctccagt       c.*3120

          .         .         .         .         .         .       g.146473
 tctccgaattctggcagagcgtctgggaaggcgatcagtgcttctttccatggcgcaagg       c.*3180

          .         .         .         .         .         .       g.146533
 cctgggttctgggtgtgcttgaagaaagccactggggtgtggggtgacatcgccatggct       c.*3240

          .         .         .         .         .         .       g.146593
 gagaaggggctagggggtccggagggaaggagccaggaccggaactgcaagggcgttgct       c.*3300

          .         .         .         .         .         .       g.146653
 gcccaggggtgtggatgattgctcatgtccagctcagaccagttcaagaaactaacctcc       c.*3360

          .         .         .         .         .         .       g.146713
 atttattttcttggtgagtcctttttttttttttcagactgttaacagaaaaaaaatttt       c.*3420

          .         .         .         .         .         .       g.146773
 aaaaagcagaaaactgaaaaaaaaaatcctggtacatgaaataaagatttttttttttta       c.*3480

                                                                    g.146775
 ta                                                                 c.*3482

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Calcium channel, voltage-dependent, gamma subunit 2 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 12
©2004-2014 Leiden University Medical Center