calcium/calmodulin-dependent protein kinase II alpha (CAMK2A) - coding DNA reference sequence

(used for variant description)

(last modified July 6, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_015981.3 in the CAMK2A gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_047040.1, covering CAMK2A transcript NM_015981.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5035
                          ggttgccatggggacctggatgctgacgaaggctc       c.-181

 .         .         .         .         .         .                g.5095
 gcgaggctgtgagcagccacagtgccctgctcagaagccccgggctcgtcagtcaaaccg       c.-121

 .         .         .         .         .         .                g.5155
 gttctctgtttgcactcggcagcacgggcaggcaagtggtccctaggttcgggagcagag       c.-61

 .         .         .         .         .         .                g.5215
 cagcagcgcctcagtcctggtcccccagtcccaagcctcacctgcctgcccagcgccagg       c.-1

          .         .         .         .         .         .       g.5275
 ATGGCCACCATCACCTGCACCCGCTTCACGGAAGAGTACCAGCTCTTCGAGGAATTGGGC       c.60
 M  A  T  I  T  C  T  R  F  T  E  E  Y  Q  L  F  E  E  L  G         p.20

    | 02     .         .         .         .         .         .    g.21739
 AA | GGGAGCCTTCTCGGTGGTGCGAAGGTGTGTGAAGGTGCTGGCTGGCCAGGAGTATGCT    c.120
 K  |  G  A  F  S  V  V  R  R  C  V  K  V  L  A  G  Q  E  Y  A      p.40

          .         .         .        | 03.         .         .    g.29848
 GCCAAGATCATCAACACAAAGAAGCTGTCAGCCAGAG | ACCATCAGAAGCTGGAGCGTGAA    c.180
 A  K  I  I  N  T  K  K  L  S  A  R  D |   H  Q  K  L  E  R  E      p.60

          .         .         .        | 04.         .         .    g.37246
 GCCCGCATCTGCCGCCTGCTGAAGCACCCCAACATCG | TCCGACTACATGACAGCATCTCA    c.240
 A  R  I  C  R  L  L  K  H  P  N  I  V |   R  L  H  D  S  I  S      p.80

          .         .         .   | 05     .         .         .    g.38037
 GAGGAGGGACACCACTACCTGATCTTCGACCT | GGTCACTGGTGGGGAACTGTTTGAAGAT    c.300
 E  E  G  H  H  Y  L  I  F  D  L  |  V  T  G  G  E  L  F  E  D      p.100

          .         .         .         | 06         .         .    g.38217
 ATCGTGGCCCGGGAGTATTACAGTGAGGCGGATGCCAG | TCACTGTATCCAGCAGATCCTG    c.360
 I  V  A  R  E  Y  Y  S  E  A  D  A  S  |  H  C  I  Q  Q  I  L      p.120

          .         .         .         .         .  | 07      .    g.41303
 GAGGCTGTGCTGCACTGCCACCAGATGGGGGTGGTGCACCGGGACCTGAAG | CCTGAGAAT    c.420
 E  A  V  L  H  C  H  Q  M  G  V  V  H  R  D  L  K   | P  E  N      p.140

          .         .         .         .         .         .       g.41363
 CTGTTGCTGGCCTCCAAGCTCAAGGGTGCCGCAGTGAAGCTGGCAGACTTTGGCCTGGCC       c.480
 L  L  L  A  S  K  L  K  G  A  A  V  K  L  A  D  F  G  L  A         p.160

          .         .         .     | 08   .         .         .    g.42801
 ATAGAGGTGGAGGGGGAGCAGCAGGCATGGTTTG | GGTTTGCAGGGACTCCTGGATATCTC    c.540
 I  E  V  E  G  E  Q  Q  A  W  F  G |   F  A  G  T  P  G  Y  L      p.180

          .         .         .         .         .         | 09    g.42998
 TCCCCAGAAGTGCTGCGGAAGGACCCGTACGGGAAGCCTGTGGACCTGTGGGCTTGTG | GG    c.600
 S  P  E  V  L  R  K  D  P  Y  G  K  P  V  D  L  W  A  C  G |       p.200

          .         .         .         .         .         .       g.43058
 GTCATCCTGTACATCCTGCTGGTTGGGTACCCCCCGTTCTGGGATGAGGACCAGCACCGC       c.660
 V  I  L  Y  I  L  L  V  G  Y  P  P  F  W  D  E  D  Q  H  R         p.220

          .         .         .    | 10    .         .         .    g.44057
 CTGTACCAGCAGATCAAAGCCGGCGCCTATGAT | TTCCCATCGCCGGAATGGGACACTGTC    c.720
 L  Y  Q  Q  I  K  A  G  A  Y  D   | F  P  S  P  E  W  D  T  V      p.240

          .         .         .         .         .         .       g.44117
 ACCCCGGAAGCCAAGGATCTGATCAATAAGATGCTGACCATTAACCCATCCAAACGCATC       c.780
 T  P  E  A  K  D  L  I  N  K  M  L  T  I  N  P  S  K  R  I         p.260

          .         .         .       | 11 .         .         .    g.44555
 ACAGCTGCCGAAGCCCTTAAGCACCCCTGGATCTCG | CACCGCTCCACCGTGGCATCCTGC    c.840
 T  A  A  E  A  L  K  H  P  W  I  S   | H  R  S  T  V  A  S  C      p.280

          .         .         .         .         .         .       g.44615
 ATGCACAGACAGGAGACCGTGGACTGCCTGAAGAAGTTCAATGCCAGGAGGAAACTGAAG       c.900
 M  H  R  Q  E  T  V  D  C  L  K  K  F  N  A  R  R  K  L  K         p.300

  | 12       .         .         .         .    | 13    .         . g.49656
  | GGAGCCATTCTCACCACGATGCTGGCCACCAGGAACTTCTCCG | GAGGGAAGAGTGGGGGA c.960
  | G  A  I  L  T  T  M  L  A  T  R  N  F  S  G |   G  K  S  G  G   p.320

          .         .     | 14   .         .         .        | 15. g.56095
 AACAAGAAGAGCGATGGTGTGAAG | AAAAGAAAGTCCAGTTCCAGCGTTCAGTTAATG | GAA c.1020
 N  K  K  S  D  G  V  K   | K  R  K  S  S  S  S  V  Q  L  M   | E   p.340

          .         .         .         .       | 16 .         .    g.63474
 TCCTCAGAGAGCACCAACACCACCATCGAGGATGAAGACACCAAAG | TGCGGAAACAGGAA    c.1080
 S  S  E  S  T  N  T  T  I  E  D  E  D  T  K  V |   R  K  Q  E      p.360

          .         .         .         .         .         .       g.63534
 ATTATAAAAGTGACAGAGCAGCTGATTGAAGCCATAAGCAATGGAGATTTTGAGTCCTAC       c.1140
 I  I  K  V  T  E  Q  L  I  E  A  I  S  N  G  D  F  E  S  Y         p.380

    | 17     .         .         .         .         .         .    g.66612
 AC | GAAGATGTGCGACCCTGGCATGACAGCCTTCGAACCTGAGGCCCTGGGGAACCTGGTT    c.1200
 T  |  K  M  C  D  P  G  M  T  A  F  E  P  E  A  L  G  N  L  V      p.400

          .         .         .        | 18.         .         .    g.71646
 GAGGGCCTGGACTTCCATCGATTCTATTTTGAAAACC | TGTGGTCCCGGAACAGCAAGCCC    c.1260
 E  G  L  D  F  H  R  F  Y  F  E  N  L |   W  S  R  N  S  K  P      p.420

          .         .         .         .         .         .       g.71706
 GTGCACACCACCATCCTGAATCCCCACATCCACCTGATGGGCGACGAGTCAGCCTGCATC       c.1320
 V  H  T  T  I  L  N  P  H  I  H  L  M  G  D  E  S  A  C  I         p.440

          .         .         .         .         .         .       g.71766
 GCCTACATCCGCATCACGCAGTACCTGGACGCTGGCGGCATCCCACGCACCGCCCAGTCG       c.1380
 A  Y  I  R  I  T  Q  Y  L  D  A  G  G  I  P  R  T  A  Q  S         p.460

          .         .         .         .         .         .       g.71826
 GAGGAGACCCGTGTCTGGCACCGCCGGGATGGCAAATGGCAGATCGTCCACTTCCACAGA       c.1440
 E  E  T  R  V  W  H  R  R  D  G  K  W  Q  I  V  H  F  H  R         p.480

          .         .       | 19 .                                  g.72161
 TCTGGGGCGCCCTCCGTCCTGCCCCA | CTGA                                  c.1470
 S  G  A  P  S  V  L  P  H  |  X                                    p.489

          .         .         .         .         .         .       g.72221
 gggaccaggctggggtcgctgcgttgctgtgccgcagagatccactctgtccgtggagtg       c.*60

          .         .         .         .         .         .       g.72281
 gagctgctggttctcccaggtggattttgctggaattctcccatgtcatcaccccaccac       c.*120

          .         .         .         .         .         .       g.72341
 cgtcacttctgtacctgcatcaagaaaacctgcttgttcacaaaagtcatcgcaacttca       c.*180

          .         .         .         .         .         .       g.72401
 gagcgaacggccacatctccccacctctcacccccaccctctcccctgccaggctggggc       c.*240

          .         .         .         .         .         .       g.72461
 ttcctcaggcatgggtgtccacagcactggccccctctccccagcctcagctgctgtccg       c.*300

          .         .         .         .         .         .       g.72521
 cctgatctgtcttgggctgtaggctagaatgcccgggctggtgcccaccaggggctgggg       c.*360

          .         .         .         .         .         .       g.72581
 agaaggaggggtggcatgatgaggaaggcagcatccgtccgtccctctcccagacctctc       c.*420

          .         .         .         .         .         .       g.72641
 ctcttccagtgtccccggggaagggcagatgacactcccttccccctaagccaaccgcac       c.*480

          .         .         .         .         .         .       g.72701
 tgaaggagtggggagaagagcatacgccaggagcctcctgcctcaaagtgctcccctaag       c.*540

          .         .         .         .         .         .       g.72761
 tcttcttcctcctgtgctgacctcagggtggtctgacccttccctcggtgtgggggatgt       c.*600

          .         .         .         .         .         .       g.72821
 ggccctctcaggtgcccctacttgctttctgcttccttctggtgaagtccacctccaaca       c.*660

          .         .         .         .         .         .       g.72881
 ttaacctgcccaccccacccccgtcatccctggagaattccagctttgtcgtatctcaga       c.*720

          .         .         .         .         .         .       g.72941
 gagggaatctaattgtttttggggggcaaaagaaagcaacgtttaggtatcacttctact       c.*780

          .         .         .         .         .         .       g.73001
 tggaccgcatgcctttttatagccaaatttctgtgtatttcgtaaatggatttcgcgtta       c.*840

          .         .         .         .         .         .       g.73061
 atggatatttatgtaataactagacttctcagattattgtgagaagggtcaggttggaag       c.*900

          .         .         .         .         .         .       g.73121
 gggtgtaggaagaggggtgaggggtagtttttttctgttctagttttttttttttttttt       c.*960

          .         .         .         .         .         .       g.73181
 gtcatctctgaggtggaccttgtcacctgtggttattggggccaaggtggactcagctcc       c.*1020

          .         .         .         .         .         .       g.73241
 ggggagaagggcctctctgccatttcggtcccaaggtgagctgacacaggcgttcctttt       c.*1080

          .         .         .         .         .         .       g.73301
 gggactgtggaagcatcagatgccagcactgactcaggaacagcaagtcagggcagagag       c.*1140

          .         .         .         .         .         .       g.73361
 gaggagggaggctgtcaggatggaaatacctggacttttctttgcttccctcgcaaactg       c.*1200

          .         .         .         .         .         .       g.73421
 gggtcttctctaccgaacttcccaggatttcatctcaccatatctgtgtgccgcccccag       c.*1260

          .         .         .         .         .         .       g.73481
 caccccccacccacctctggggggcccgtgagcgtgtgtcttcattgcctctctcccctt       c.*1320

          .         .         .         .         .         .       g.73541
 ggcgtctgatgaccacagcaaagcactgggaatttctactcttcatgcctcatcctgcag       c.*1380

          .         .         .         .         .         .       g.73601
 cctcgggttcgcattctctctttcttttcctctttccctctttccctgggattgactctg       c.*1440

          .         .         .         .         .         .       g.73661
 agtggaataccttggcacatccactaggatctactgtctgcactgttttctttgcatgac       c.*1500

          .         .         .         .         .         .       g.73721
 tttatacgcagtaagtatgttgaaaacaaacaaaaagaagaaaacactcaacaaaaccaa       c.*1560

          .         .         .         .         .         .       g.73781
 tctacatgttttggactaaaaaaaaaaatagaggttgtattctcagtgtccgactcggaa       c.*1620

          .         .         .         .         .         .       g.73841
 ttatgttgctgcctctctgtgcttttggcctctgtgtggccgtgttttgccagcatgaga       c.*1680

          .         .         .         .         .         .       g.73901
 tactgtcccctctggaggattttaggggaggaagagccacgtccccagggattggaggag       c.*1740

          .         .         .         .         .         .       g.73961
 gctccggtaccctcgaccctcctgggtgttggttggagcagaactggtgaggatgtttga       c.*1800

          .         .         .         .         .         .       g.74021
 tccgagattttctgagctctccccaatcaccagctgtctgctgggttcttttctcaagtc       c.*1860

          .         .         .         .         .         .       g.74081
 ctgctgcccaggcccaggtgagacaggcaacgccaggtctgcaggccaggagagatgctg       c.*1920

          .         .         .         .         .         .       g.74141
 cccaggcctcctggtttccaagctggtccatcactggcctctgtccttggcagagacctt       c.*1980

          .         .         .         .         .         .       g.74201
 gctgcccaggcccaggggcaggctcttggcctgccccaggcccagagggcttcccagtaa       c.*2040

          .         .         .         .         .         .       g.74261
 ggcccagtgatcccattatcccaggggcaaaaccacctgtccccttttgagctgccagtt       c.*2100

          .         .         .         .         .         .       g.74321
 ccctacagccatccccagtcaagggtgagggtgtggccttcaccaggggctgctgtaatt       c.*2160

          .         .         .         .         .         .       g.74381
 accgagcaaggtctgagctcttcttcagcctcagttccctcattggttaaaagggttctt       c.*2220

          .         .         .         .         .         .       g.74441
 tgttcccatccagccgatgaaggagcaaacgtctggctatgtgaagcctaatttacctgc       c.*2280

          .         .         .         .         .         .       g.74501
 aggaactggcagggatagtcactggctggactcctgtttacttctagacctggtcaggct       c.*2340

          .         .         .         .         .         .       g.74561
 ccatcccctcccccacctgcccctgattcccctcgtcggtgcctgtcaactgcttttcag       c.*2400

          .         .         .         .         .         .       g.74621
 cagtggactgcaggggaaagagcagtgatttggggtgagtaggcttcaattcccagctct       c.*2460

          .         .         .         .         .         .       g.74681
 gaccagacttgctgtgtgaccttgggcaagttcctttccctctttggagcttggtttccc       c.*2520

          .         .         .         .         .         .       g.74741
 tgccagaggaaactgagctggaggagcctgaggtcctgcctttcattggctgacacacct       c.*2580

          .         .         .         .         .         .       g.74801
 cctgtccactgtgtcactctccaagtgccagagaagtggaggcagatcgctaccccaggc       c.*2640

          .         .         .         .         .         .       g.74861
 tgagatggcccccactgtgaaggccacgcctgtgggtgggcagccacctggtgccaccac       c.*2700

          .         .         .         .         .         .       g.74921
 agggcaccagggatgatcctgatgtggcaggcaggggagactcacagaaaaatctgccca       c.*2760

          .         .         .         .         .         .       g.74981
 gagcctaccctcaccagacaaactctgtgctcctccaaaacatcctttagatgcaaaata       c.*2820

          .         .         .         .         .         .       g.75041
 ataataataataataataaataaataaataaaaatccaaacccaagtcaaaaccttggct       c.*2880

          .         .         .         .         .         .       g.75101
 ccagcatgaaaacacgtttacaggaaagtgttctcctgggtttgtgcccaccatggtgcg       c.*2940

          .         .         .         .         .         .       g.75161
 aatcctgacccaaggcctcctgtctcccttcaaagggagacccttttgggggatgagttt       c.*3000

          .         .         .         .         .         .       g.75221
 gccagactccccgtgctggtttctttgttactatttgtttggggttttgttttagttctt       c.*3060

          .         .         .         .         .         .       g.75281
 tttttttttcttttcttttttaaaaatatgtggctgtgaacttgaatgaacactgctcaa       c.*3120

          .         .         .         .         .         .       g.75341
 actttctgctattggggggggcgggtgggatgggaagaaggggcgtttgttttattcttg       c.*3180

          .         .         .                                     g.75380
 gtgttttcagtgcaataaatagctacaaacttctgtgca                            c.*3219

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Calcium/calmodulin-dependent protein kinase II alpha protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 19
©2004-2017 Leiden University Medical Center