carbohydrate kinase domain containing (CARKD) - coding DNA reference sequence

(used for variant description)

(last modified December 29, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_018210.3 in the CARKD gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000013.10, covering CARKD transcript NM_018210.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5155
                              aatccggaatgctgcccgatggccctgggtc       c.-61

 .         .         .         .         .         .                g.5215
 ctcgctgtggggcaatccgggcttgcagacgaggtaaggtcgattccatttggcccgggg       c.-1

          .         .         .         .         .         .       g.5275
 ATGGTCACACGCGCGGGGGCCGGAACTGCCGTCGCCGGCGCGGTCGTTGTCGCATTGCTC       c.60
 M  V  T  R  A  G  A  G  T  A  V  A  G  A  V  V  V  A  L  L         p.20

          .         .         .         . | 02       .         .    g.11776
 TCGGCCGCACTCGCGCTGTACGGGCCGCCACTGGACGCAG | TTTTAGAAAGAGCGTTTTCG    c.120
 S  A  A  L  A  L  Y  G  P  P  L  D  A  V |   L  E  R  A  F  S      p.40

          .         .         .         .         .         .       g.11836
 CTACGTAAAGCACATTCGATAAAGGATATGGAAAATACTTTGCAGCTGGTGAGAAATATC       c.180
 L  R  K  A  H  S  I  K  D  M  E  N  T  L  Q  L  V  R  N  I         p.60

          .         .         .         .         .         .       g.11896
 ATACCTCCTCTGTCTTCCACAAAGCACAAAGGGCAAGATGGAAGAATAGGCGTAGTTGGA       c.240
 I  P  P  L  S  S  T  K  H  K  G  Q  D  G  R  I  G  V  V  G         p.80

          .  | 03      .         .         .         .        | 04. g.14733
 GGCTGTCAGGA | GTACACTGGAGCCCCATATTTTGCAGCAATCTCAGCTCTCAAAGTG | GGC c.300
 G  C  Q  E  |  Y  T  G  A  P  Y  F  A  A  I  S  A  L  K  V   | G   p.100

          .         .         .         .         .         .       g.14793
 GCAGACTTGTCCCACGTGTTCTGTGCCAGTGCGGCCGCACCTGTGATTAAGGCCTACAGC       c.360
 A  D  L  S  H  V  F  C  A  S  A  A  A  P  V  I  K  A  Y  S         p.120

          .         .       | 05 .         .         .         .    g.17013
 CCGGAGCTGATCGTCCACCCAGTTCT | TGACAGCCCCAATGCTGTTCATGAGGTGGAGAAG    c.420
 P  E  L  I  V  H  P  V  L  |  D  S  P  N  A  V  H  E  V  E  K      p.140

          .         .         .         .         .         .       g.17073
 TGGCTGCCCCGGCTGCATGCTCTTGTCGTAGGACCTGGCTTGGGTAGAGATGATGCGCTT       c.480
 W  L  P  R  L  H  A  L  V  V  G  P  G  L  G  R  D  D  A  L         p.160

          .      | 06  .         .         .         .         .    g.24130
 CTCAGAAATGTCCAG | GGCATTTTGGAAGTGTCAAAGGCCAGGGACATCCCTGTTGTCATC    c.540
 L  R  N  V  Q   | G  I  L  E  V  S  K  A  R  D  I  P  V  V  I      p.180

        | 07 .         .         .         .         .         .    g.24266
 GACGCG | GATGGCCTGTGGCTGGTCGCTCAGCAGCCGGCCCTCATCCATGGCTACCGGAAG    c.600
 D  A   | D  G  L  W  L  V  A  Q  Q  P  A  L  I  H  G  Y  R  K      p.200

          .         .         .         .         .  | 08      .    g.25017
 GCTGTGCTCACTCCCAACCACGTGGAGTTCAGCAGACTGTATGACGCTGTG | CTCAGAGGC    c.660
 A  V  L  T  P  N  H  V  E  F  S  R  L  Y  D  A  V   | L  R  G      p.220

          .         .         .         .         .         .       g.25077
 CCTATGGACAGCGATGACAGCCATGGATCTGTGCTAAGACTCAGCCAAGCCCTGGGCAAC       c.720
 P  M  D  S  D  D  S  H  G  S  V  L  R  L  S  Q  A  L  G  N         p.240

          .         .         .         .         .   | 09     .    g.26677
 GTGACGGTGGTCCAGAAAGGAGAGCGCGACATCCTCTCCAACGGCCAGCAGG | TGCTTGTG    c.780
 V  T  V  V  Q  K  G  E  R  D  I  L  S  N  G  Q  Q  V |   L  V      p.260

          .         .         .         .         .         .       g.26737
 TGCAGCCAGGAAGGCAGCAGCCGCAGGTGTGGAGGGCAAGGGGACCTCCTGTCGGGCTCC       c.840
 C  S  Q  E  G  S  S  R  R  C  G  G  Q  G  D  L  L  S  G  S         p.280

          .         .         .         .         .    | 10    .    g.27789
 CTGGGCGTCCTGGTACACTGGGCGCTCCTTGCTGGACCACAGAAAACAAATGG | GGGCATA    c.900
 L  G  V  L  V  H  W  A  L  L  A  G  P  Q  K  T  N  G  |  G  I      p.300

          .         .         .         .         .         .       g.27849
 TCAGACTTGAAATTGACAATTTGGGGTCCTGAGATTGAAACAGGAGTCAAAACCAGAGCC       c.960
 S  D  L  K  L  T  I  W  G  P  E  I  E  T  G  V  K  T  R  A         p.320

          .         .         .         .         .         .       g.27909
 CAGGGTAGCTGCGGCCCCCGGACCACGACGCCCACTTCCCCACACCTCCTGCTGTCCCCC       c.1020
 Q  G  S  C  G  P  R  T  T  T  P  T  S  P  H  L  L  L  S  P         p.340

          .         .         .         .         .         .       g.27969
 TCTCCGCAGGTCCAGCCCTCTCCTGGTGGCCGCGTTTGGCGCCTGCTCTCTCACCAGGCA       c.1080
 S  P  Q  V  Q  P  S  P  G  G  R  V  W  R  L  L  S  H  Q  A         p.360

          .         .         .         .         .         .       g.28029
 GTGCAACCACCAAGCCTTCCAGAAGCACGGTCGCTCCACCACCACCTCCGACATGATCGC       c.1140
 V  Q  P  P  S  L  P  E  A  R  S  L  H  H  H  L  R  H  D  R         p.380

          .         .         .                                     g.28062
 CGAGGTGGGGGCCGCCTTCAGCAAGCTCTTTGA                                  c.1173
 R  G  G  G  R  L  Q  Q  A  L  X                                    p.390

          .         .         .         .         .         .       g.28122
 aacctgagcccgcgcagaccagaagtaaacaggcaccttggacgggggagagcgtgtgtg       c.*60

          .         .         .         .         .         .       g.28182
 tgatgggaaaatccggacccacgcgtgtgctgaaggcgtacggtgcttgccagattttca       c.*120

          .         .         .         .         .         .       g.28242
 acttgagcataaattggttgccattgagaatttaagaatctggaatattgcagcttttgg       c.*180

          .         .         .         .         .         .       g.28302
 ttaaacttaatgcatggttggagatgttatggcgacactaaacaaagtattcctgaactt       c.*240

          .         .         .         .         .         .       g.28362
 tccttagctccttggtagtaactgggaagacagaaatgaagaaaatcacatgagaatgaa       c.*300

          .         .         .         .         .         .       g.28422
 gaattctttagcagctcaacagagtttctcggcctgctcccagatcggcgaagtttctac       c.*360

          .         .         .         .         .         .       g.28482
 ttgttactctctctgccggcgcccttcgttcctcctctgcttcccttccctagtctttcc       c.*420

          .         .         .         .         .         .       g.28542
 tccggcagggagctgggcaggggtccccgggtgtctccctgagtcccgactgcactgact       c.*480

          .         .         .         .         .         .       g.28602
 gggtccatcagagggctgcttcgttctccagctcatcttcttttaaagtggtgactagct       c.*540

          .         .         .         .         .         .       g.28662
 tggtggtatctggctgctggtgtttggcttattgacatactccagggtaatcaatgatga       c.*600

          .         .         .         .         .         .       g.28722
 ctttgtttggaaacccttttggaggcaccatgggaacagaaggaaacatgagtgacgctg       c.*660

          .         .         .         .         .         .       g.28782
 acccttgagtgtgtgggtggggagctctgagacgcctcctgtcccacgctctccggtgtc       c.*720

          .         .         .         .         .         .       g.28842
 cgtgtctacacaggggtccccatgatacccaccggccccagcagggcagaccggaccggg       c.*780

          .         .         .         .         .         .       g.28902
 gacgggcacggtgaagggctgcagcctggggtctgacgtggcccctagtgctgtctcagg       c.*840

          .         .         .         .         .         .       g.28962
 agaaggctctggaggacttgaggcatgctgggcctggtgcagtgatggcgctaaggagac       c.*900

          .         .         .         .         .         .       g.29022
 ccggggaaagacagtatcgtggtcacgtatgcttaggaagcagcacagccgtgtccttag       c.*960

          .         .         .         .         .         .       g.29082
 ggatgttcgcgtccagtaaagacactggtaactgcggtttcagccaacactcttcatggc       c.*1020

          .         .         .         .         .         .       g.29142
 agtgtcgacctcgggttagcttctgttgtctttgtggatggttttcctggagcggcctga       c.*1080

          .         .         .         .         .         .       g.29202
 cgttgacgtgttctctggtcccatgtcttagcggggcatggtacggtttcgtgcctgacg       c.*1140

          .         .         .         .         .         .       g.29262
 cgtgcattagggtgttctcttatactttcagtagcatctttccacagcaagggccaaacc       c.*1200

          .         .         .         .         .         .       g.29322
 ctcctggttcccttcagagtctttttggcctgatgatgactcttgagtgataccctgtga       c.*1260

          .         .         .         .         .         .       g.29382
 tgcagacatgccccagatggattctactttctttaaaactagggactttcaagattaaaa       c.*1320

          .         .         .         .         .         .       g.29442
 aaaagattgtcactactaatttgacgcctaacttcagaagcttcactgtctacatgtgaa       c.*1380

          .         .         .         .         .         .       g.29502
 cttttccagaaaaactgtgccatggacatttttcctctggggaattaacatctaaattct       c.*1440

          .         .         .                                     g.29537
 ggtaactattaaaagacagatctggttaatttaaa                                c.*1475

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Carbohydrate kinase domain containing protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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