caspase 1, apoptosis-related cysteine peptidase (CASP1) - coding DNA reference sequence

(used for variant description)

(last modified June 29, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_033292.3 in the CASP1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029124.1, covering CASP1 transcript NM_033292.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5017
                 atactttcagtttcagtcacacaagaagggaggagagaaaagcc       c.-1

         | 02.         .         .         .         .         .    g.5709
 ATGGCCG | ACAAGGTCCTGAAGGAGAAGAGAAAGCTGTTTATCCGTTCCATGGGTGAAGGT    c.60
 M  A  D |   K  V  L  K  E  K  R  K  L  F  I  R  S  M  G  E  G      p.20

          .         .         .         .         .         .       g.5769
 ACAATAAATGGCTTACTGGATGAATTATTACAGACAAGGGTGCTGAACAAGGAAGAGATG       c.120
 T  I  N  G  L  L  D  E  L  L  Q  T  R  V  L  N  K  E  E  M         p.40

          .         .         .         .         .         .       g.5829
 GAGAAAGTAAAACGTGAAAATGCTACAGTTATGGATAAGACCCGAGCTTTGATTGACTCC       c.180
 E  K  V  K  R  E  N  A  T  V  M  D  K  T  R  A  L  I  D  S         p.60

          .         .         .         .         .         .       g.5889
 GTTATTCCGAAAGGGGCACAGGCATGCCAAATTTGCATCACATACATTTGTGAAGAAGAC       c.240
 V  I  P  K  G  A  Q  A  C  Q  I  C  I  T  Y  I  C  E  E  D         p.80

          .         .         .     | 03   .         .         .    g.7030
 AGTTACCTGGCAGGGACGCTGGGACTCTCAGCAG | ATCAAACATCTGGAAATTACCTTAAT    c.300
 S  Y  L  A  G  T  L  G  L  S  A  D |   Q  T  S  G  N  Y  L  N      p.100

          .         .         .        | 04.         .         .    g.8873
 ATGCAAGACTCTCAAGGAGTACTTTCTTCCTTTCCAG | CTCCTCAGGCAGTGCAGGACAAC    c.360
 M  Q  D  S  Q  G  V  L  S  S  F  P  A |   P  Q  A  V  Q  D  N      p.120

          .         .         .         .         .         .       g.8933
 CCAGCTATGCCCACATCCTCAGGCTCAGAAGGGAATGTCAAGCTTTGCTCCCTAGAAGAA       c.420
 P  A  M  P  T  S  S  G  S  E  G  N  V  K  L  C  S  L  E  E         p.140

          .         .         .    | 05    .         .         .    g.9654
 GCTCAAAGGATATGGAAACAAAAGTCGGCAGAG | ATTTATCCAATAATGGACAAGTCAAGC    c.480
 A  Q  R  I  W  K  Q  K  S  A  E   | I  Y  P  I  M  D  K  S  S      p.160

          .         .         .         .         .         .       g.9714
 CGCACACGTCTTGCTCTCATTATCTGCAATGAAGAATTTGACAGTATTCCTAGAAGAACT       c.540
 R  T  R  L  A  L  I  I  C  N  E  E  F  D  S  I  P  R  R  T         p.180

          .         .         .         .         .         .       g.9774
 GGAGCTGAGGTTGACATCACAGGCATGACAATGCTGCTACAAAATCTGGGGTACAGCGTA       c.600
 G  A  E  V  D  I  T  G  M  T  M  L  L  Q  N  L  G  Y  S  V         p.200

          .         .        | 06.         .         .         .    g.10264
 GATGTGAAAAAAAATCTCACTGCTTCG | GACATGACTACAGAGCTGGAGGCATTTGCACAC    c.660
 D  V  K  K  N  L  T  A  S   | D  M  T  T  E  L  E  A  F  A  H      p.220

          .         .         .         .         .         .       g.10324
 CGCCCAGAGCACAAGACCTCTGACAGCACGTTCCTGGTGTTCATGTCTCATGGTATTCGG       c.720
 R  P  E  H  K  T  S  D  S  T  F  L  V  F  M  S  H  G  I  R         p.240

          .         .         .         .         .         .       g.10384
 GAAGGCATTTGTGGGAAGAAACACTCTGAGCAAGTCCCAGATATACTACAACTCAATGCA       c.780
 E  G  I  C  G  K  K  H  S  E  Q  V  P  D  I  L  Q  L  N  A         p.260

          .         .         .         .         .         .       g.10444
 ATCTTTAACATGTTGAATACCAAGAACTGCCCAAGTTTGAAGGACAAACCGAAGGTGATC       c.840
 I  F  N  M  L  N  T  K  N  C  P  S  L  K  D  K  P  K  V  I         p.280

          .         .   | 07     .         .         .         .    g.10901
 ATCATCCAGGCCTGCCGTGGTG | ACAGCCCTGGTGTGGTGTGGTTTAAAGATTCAGTAGGA    c.900
 I  I  Q  A  C  R  G  D |   S  P  G  V  V  W  F  K  D  S  V  G      p.300

          .         .         .         .         .         .       g.10961
 GTTTCTGGAAACCTATCTTTACCAACTACAGAAGAGTTTGAGGATGATGCTATTAAGAAA       c.960
 V  S  G  N  L  S  L  P  T  T  E  E  F  E  D  D  A  I  K  K         p.320

          .         .         .         .       | 08 .         .    g.13193
 GCCCACATAGAGAAGGATTTTATCGCTTTCTGCTCTTCCACACCAG | ATAATGTTTCTTGG    c.1020
 A  H  I  E  K  D  F  I  A  F  C  S  S  T  P  D |   N  V  S  W      p.340

          .         .         .         .         .         .       g.13253
 AGACATCCCACAATGGGCTCTGTTTTTATTGGAAGACTCATTGAACATATGCAAGAATAT       c.1080
 R  H  P  T  M  G  S  V  F  I  G  R  L  I  E  H  M  Q  E  Y         p.360

          .         .         .       | 09 .         .         .    g.13798
 GCCTGTTCCTGTGATGTGGAGGAAATTTTCCGCAAG | GTTCGATTTTCATTTGAGCAGCCA    c.1140
 A  C  S  C  D  V  E  E  I  F  R  K   | V  R  F  S  F  E  Q  P      p.380

          .         .         .         .         .         .       g.13858
 GATGGTAGAGCGCAGATGCCCACCACTGAAAGAGTGACTTTGACAAGATGTTTCTACCTC       c.1200
 D  G  R  A  Q  M  P  T  T  E  R  V  T  L  T  R  C  F  Y  L         p.400

          .                                                     g.13873
 TTCCCAGGACATTAA |                                                 c.1216
 F  P  G  H  X                                                   p.404

          .         .         .   | 10     .         .         .    g.14558
 aataaggaaactgtatgaatgtctgtgggcag | gaagtgaagagatccttctgtaaaggtt    c.*60

          .         .         .         .         .         .       g.14618
 tttggaattatgtctgctgaataataaacttttttgaaataataaatctggtagaaaaat       c.*120

                                                                    g.14623
 gaaaa                                                              c.*125

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Caspase 1, apoptosis-related cysteine peptidase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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