caspase 2, apoptosis-related cysteine peptidase (CASP2) - coding DNA reference sequence

(used for variant description)

(last modified November 26, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_032982.3 in the CASP2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000007.13, covering CASP2 transcript NM_032982.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5001
                                                            c       c.-241

 .         .         .         .         .         .                g.5061
 ttttgtctgtccgccgagcaccccacttcaccccattggaccgcgcggccgccgctagag       c.-181

 .         .         .         .         .         .                g.5121
 ctctgcgcctgcgcacgcaccgggccggggactgggtggcctggtgtgtgggcgcggcag       c.-121

 .         .         .         .         .         .                g.5181
 ggcgcaggcgcaggcgcagtgtgcgtccgcgtctgaggggagggatgtgggggaagcgac       c.-61

 .         .         .         .         .         .                g.5241
 ggcccccggtttgtttgggctgtgggcggtgcgcagcggagagcccgggaaaagcgggaa       c.-1

          .         .         .         .         .         .       g.5301
 ATGGCGGCGCCGAGCGCGGGGTCTTGGTCCACCTTCCAGCACAAGGAGCTGATGGCCGCT       c.60
 M  A  A  P  S  A  G  S  W  S  T  F  Q  H  K  E  L  M  A  A         p.20

          .     | 02   .         .         .         .         .    g.8371
 GACAGGGGACGCAG | GATATTGGGAGTGTGTGGCATGCATCCTCATCATCAGGAAACTCTA    c.120
 D  R  G  R  R  |  I  L  G  V  C  G  M  H  P  H  H  Q  E  T  L      p.40

          .         .         .         .         .         .       g.8431
 AAAAAGAACCGAGTGGTGCTAGCCAAACAGCTGTTGTTGAGCGAATTGTTAGAACATCTT       c.180
 K  K  N  R  V  V  L  A  K  Q  L  L  L  S  E  L  L  E  H  L         p.60

          .         .         .         .      | 03  .         .    g.9100
 CTGGAGAAGGACATCATCACCTTGGAAATGAGGGAGCTCATCCAG | GCCAAAGTGGGCAGT    c.240
 L  E  K  D  I  I  T  L  E  M  R  E  L  I  Q   | A  K  V  G  S      p.80

          .         .         .         .         .         .       g.9160
 TTCAGCCAGAATGTGGAACTCCTCAACTTGCTGCCTAAGAGGGGTCCCCAAGCTTTTGAT       c.300
 F  S  Q  N  V  E  L  L  N  L  L  P  K  R  G  P  Q  A  F  D         p.100

          .         .         .         .         .         .       g.9220
 GCCTTCTGTGAAGCACTGAGGGAGACCAAGCAAGGCCACCTGGAGGATATGTTGCTCACC       c.360
 A  F  C  E  A  L  R  E  T  K  Q  G  H  L  E  D  M  L  L  T         p.120

          .         .         .    | 04    .         .         .    g.9429
 ACCCTTTCTGGGCTTCAGCATGTACTCCCACCG | TTGAGCTGTGACTACGACTTGAGTCTC    c.420
 T  L  S  G  L  Q  H  V  L  P  P   | L  S  C  D  Y  D  L  S  L      p.140

          .         .         .         .         .      | 05  .    g.11020
 CCTTTTCCGGTGTGTGAGTCCTGTCCCCTTTACAAGAAGCTCCGCCTGTCGACAG | ATACT    c.480
 P  F  P  V  C  E  S  C  P  L  Y  K  K  L  R  L  S  T  D |   T      p.160

          .         .         .         .         .         .       g.11080
 GTGGAACACTCCCTAGACAATAAAGATGGTCCTGTCTGCCTTCAGGTGAAGCCTTGCACT       c.540
 V  E  H  S  L  D  N  K  D  G  P  V  C  L  Q  V  K  P  C  T         p.180

          .         .         . | 06       .         .         .    g.11412
 CCTGAATTTTATCAAACACACTTCCAGCTG | GCATATAGGTTGCAGTCTCGGCCTCGTGGC    c.600
 P  E  F  Y  Q  T  H  F  Q  L   | A  Y  R  L  Q  S  R  P  R  G      p.200

          .         .         .         .         .         .       g.11472
 CTAGCACTGGTGTTGAGCAATGTGCACTTCACTGGAGAGAAAGAACTGGAATTTCGCTCT       c.660
 L  A  L  V  L  S  N  V  H  F  T  G  E  K  E  L  E  F  R  S         p.220

          .         .         .         .         .         .       g.11532
 GGAGGGGATGTGGACCACAGTACTCTAGTCACCCTCTTCAAGCTTTTGGGCTATGACGTC       c.720
 G  G  D  V  D  H  S  T  L  V  T  L  F  K  L  L  G  Y  D  V         p.240

          .         .        | 07.         .         .         .    g.16741
 CATGTTCTATGTGACCAGACTGCACAG | GAAATGCAAGAGAAACTGCAGAATTTTGCACAG    c.780
 H  V  L  C  D  Q  T  A  Q   | E  M  Q  E  K  L  Q  N  F  A  Q      p.260

          .         .         .         .         .         .       g.16801
 TTACCTGCACACCGAGTCACGGACTCCTGCATCGTGGCACTCCTCTCGCATGGTGTGGAG       c.840
 L  P  A  H  R  V  T  D  S  C  I  V  A  L  L  S  H  G  V  E         p.280

          .         .         .       | 08 .         .         .    g.17013
 GGCGCCATCTATGGTGTGGATGGGAAACTGCTCCAG | CTCCAAGAGGTTTTTCAGCTCTTT    c.900
 G  A  I  Y  G  V  D  G  K  L  L  Q   | L  Q  E  V  F  Q  L  F      p.300

          .         .         .         .         .         .       g.17073
 GACAACGCCAACTGCCCAAGCCTACAGAACAAACCAAAAATGTTCTTCATCCAGGCCTGC       c.960
 D  N  A  N  C  P  S  L  Q  N  K  P  K  M  F  F  I  Q  A  C         p.320

         | 09.         .         .         .         .         .    g.20622
 CGTGGAG | ATGAGACTGATCGTGGGGTTGACCAACAAGATGGAAAGAACCACGCAGGATCC    c.1020
 R  G  D |   E  T  D  R  G  V  D  Q  Q  D  G  K  N  H  A  G  S      p.340

          .         .         .         .         .         .       g.20682
 CCTGGGTGCGAGGAGAGTGATGCCGGTAAAGAAAAGTTGCCGAAGATGAGACTGCCCACG       c.1080
 P  G  C  E  E  S  D  A  G  K  E  K  L  P  K  M  R  L  P  T         p.360

          .         .         .        | 10.         .         .    g.21482
 CGCTCAGACATGATATGCGGCTATGCCTGCCTCAAAG | GGACTGCCGCCATGCGGAACACC    c.1140
 R  S  D  M  I  C  G  Y  A  C  L  K  G |   T  A  A  M  R  N  T      p.380

          .         .         .         .         .         .       g.21542
 AAACGAGGTTCCTGGTACATCGAGGCTCTTGCTCAAGTGTTTTCTGAGCGGGCTTGTGAT       c.1200
 K  R  G  S  W  Y  I  E  A  L  A  Q  V  F  S  E  R  A  C  D         p.400

          .         .        | 11.         .         .         .    g.21758
 ATGCACGTGGCCGACATGCTGGTTAAG | GTGAACGCACTTATCAAGGATCGGGAAGGTTAT    c.1260
 M  H  V  A  D  M  L  V  K   | V  N  A  L  I  K  D  R  E  G  Y      p.420

          .         .         .         .         .         .       g.21818
 GCTCCTGGCACAGAATTCCACCGGTGCAAGGAGATGTCTGAATACTGCAGCACTCTGTGC       c.1320
 A  P  G  T  E  F  H  R  C  K  E  M  S  E  Y  C  S  T  L  C         p.440

          .         .         .                                     g.21857
 CGCCACCTCTACCTGTTCCCAGGACACCCTCCCACATGA                            c.1359
 R  H  L  Y  L  F  P  G  H  P  P  T  X                              p.452

          .         .         .         .         .         .       g.21917
 tgtcacctccccatcatccacgccaagtggaagccactggaccacaggaggtgtgataga       c.*60

          .         .         .         .         .         .       g.21977
 gcctttgatcttcaggatgcacggtttctgttctgccccctcagggatgtgggaatctcc       c.*120

          .         .         .         .         .         .       g.22037
 cagacttgtttcctgtgcccatcatctctgcctttgagtgtgggactccaggccagctcc       c.*180

          .         .         .         .         .         .       g.22097
 ttttctgtgaagccctttgcctgtagagccagccttggttggacctattgccaggaatgt       c.*240

          .         .         .         .         .         .       g.22157
 ttcagctgcagttgaagagcctgacaagtgaagttgtaaacacagtgtggttatggggag       c.*300

          .         .         .         .         .         .       g.22217
 agggcatataaattccccatatttgtgttcagttccagcttttgtagatggcactttagt       c.*360

          .         .         .         .         .         .       g.22277
 gattgcttttattacattagttaagatgtctgagagaccatctcctatcttttatttcat       c.*420

          .         .         .         .         .         .       g.22337
 tcatatcctccgccctttttgtcctagagtgagagtttggaaggtgtccaaatttaatgt       c.*480

          .         .         .         .         .         .       g.22397
 agacattatcttttggctctgaagaagcaaacatgactagagacgcaccttgctgcagtg       c.*540

          .         .         .         .         .         .       g.22457
 tccagaagcggcctgtgcgttcccttcagtactgcagcgccacccagtggaaggacactc       c.*600

          .         .         .         .         .         .       g.22517
 ttggctcgtttgggctcaaggcaccgcagcctgtcagccaacattgccttgcatttgtac       c.*660

          .         .         .         .         .         .       g.22577
 cttattgatctttgcccatggaagtctcaaagatctttcgttggttgtttctctgagctt       c.*720

          .         .         .         .         .         .       g.22637
 tgttactgaaatgagcctcgtggggagcatcagagaaggccaggaagaatggtgtgtttc       c.*780

          .         .         .         .         .         .       g.22697
 cctagactctgtaaccacctctctgtctttttccttcctgagaaacgtccatctctctcc       c.*840

          .         .         .         .         .         .       g.22757
 cttactattcccactttcattcaatcaacctgcacttcatatctagatttctagaaaagc       c.*900

          .         .         .         .         .         .       g.22817
 ttcctagcttatctccctgcttcatatctctcccttctttaccttcatttcatcctgttg       c.*960

          .         .         .         .         .         .       g.22877
 gctgctgccaccaaatctgtctagaatcctgctttacaggatcatgtaaatgctcaaaga       c.*1020

          .         .         .         .         .         .       g.22937
 tgtaatgtagttctttgttcctgctttctctttcagtattaaactctcctttgatattat       c.*1080

          .         .         .         .         .         .       g.22997
 gtggcttttatttcagtgccatacatgttattgttttcaacctagaaacctttatccctg       c.*1140

          .         .         .         .         .         .       g.23057
 cttatctgaaacttcccaacttccctgttctttaagactttttttttttttttttttttt       c.*1200

          .         .         .         .         .         .       g.23117
 tttgagacagagtctcgctctgtcgcccaggctggagggcagtggcacgatctcagctca       c.*1260

          .         .         .         .         .         .       g.23177
 ctgcaagctccaactcccgggttcacgccattctcctgcctcagccttccaagtagctgg       c.*1320

          .         .         .         .         .         .       g.23237
 gactacaggtgcccgccaccgtgcccggctaatttttttgtatttttagtagagacaggg       c.*1380

          .         .         .         .         .         .       g.23297
 tttcaccatgttagccgggatggtcttgatctcctgacctcatgatccacccacctcagc       c.*1440

          .         .         .         .         .         .       g.23357
 ctcccaaagtgttgggattacaggcgtgagccactgcgcccgggcaagacctttttttaa       c.*1500

          .         .         .         .         .         .       g.23417
 aaaaaaaaaaaaaaaaacttccattctttcttcctccagtctgttctcacataacagagt       c.*1560

          .         .         .         .         .         .       g.23477
 agttttggtttttaattttttttggttgtttgctgttttttgttttttaaggtgagttct       c.*1620

          .         .         .         .         .         .       g.23537
 cactatgtttctcagactggtctcgaactcctggcctcaagccatcttcccgcctcagcc       c.*1680

          .         .         .         .         .         .       g.23597
 tctcaaatagctgggcttacaggcatgagccaccacacctggccaggatttggttgttta       c.*1740

          .         .         .         .         .         .       g.23657
 aatataaatctgatcacccccctgcttagaacccttctgctttctattacccctcattta       c.*1800

          .         .         .         .         .         .       g.23717
 aaatgtaaactcttcaccttggtttatgagaactggttcttgccttccccttgaacctca       c.*1860

          .         .         .         .         .         .       g.23777
 ttaaatggtgatttcttgctaagctccagcccgagtggtctcctctcagcttctaatttt       c.*1920

          .         .         .         .         .         .       g.23837
 gtgctctttcctgcccttttcctgggccttctcagctctccacccccaccactcttgact       c.*1980

          .         .         .         .         .         .       g.23897
 caggtggtgtccttcttcctcaagtcttgacaattcccgggcccttcagtccctgagcag       c.*2040

          .         .         .         .         .         .       g.23957
 tctacttctgtgtctgtcaccacatcttgtcttttcccctcattgcatttattgcagttt       c.*2100

          .         .         .         .         .         .       g.24017
 atatatatgctacttttacttgttcatttctgtctcccctaccaggctgtaaatgagggc       c.*2160

          .         .         .         .         .         .       g.24077
 agaaaccttgtttgttttattcaccatcatgtaccaagtgcttggcacatagtgggcctt       c.*2220

          .         .         .         .         .         .       g.24137
 cattaaatgtttgttgaataaaagagggaagaaggcaagccaaccttagctacaatccta       c.*2280

          .         .         .         .         .         .       g.24197
 ccttttgataaaatgttccttttgacaatatacacggattattatttgtactttgttttt       c.*2340

          .         .         .         .         .         .       g.24257
 ccatgtgttttgcttttatccactggcatttttagctccttgaagacatatcatgtgtga       c.*2400

          .         .         .         .         .         .       g.24317
 gataacttccttcacatctcccatggtccctagcaaaatgctaggcctgtagtagtcaag       c.*2460

          .         .         .         .         .         .       g.24377
 gtgctcaataaatatttgtttgggtggtttgtgagccttgctgccaagtcctgcctttgg       c.*2520

          .         .         .         .         .         .       g.24437
 gtcgacatagtatggaagtatttgagagagagaacctttccactcccactgccaggattt       c.*2580

          .         .         .         .                           g.24482
 tgtattgccatcgggtgccaaataaatgctcatatttattactga                      c.*2625

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Caspase 2, apoptosis-related cysteine peptidase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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