calcium-sensing receptor (CASR) - coding DNA reference sequence

(used for variant description)

(last modified May 9, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_000388.3 in the CASR gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_009058.1, covering CASR transcript NM_000388.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5012
                                                 caacaggcacct       c.-361

 .         .         .         .         .         .                g.5072
 ggctgcagccaggaaggaccgcacgccctttcgcgcaggagagtggaaggagggagctgt       c.-301

 .         .         .         .         .         .        | 02    g.75267
 ttgccagcaccgaggtcttgcggcacaggcaacgcttgacctgagtcttgcagaatga | aa    c.-241

 .         .         .         .         .         .                g.75327
 ggcatcacaggaggcctctgcatgatgtggcttccaaagactcaaggaccacccacatta       c.-181

 .         .         .         .         .         .                g.75387
 caagtctggattgaggaaggcagaaatggagattcaaacaccacgtcttctattatttta       c.-121

 .         .         .         .         .         .                g.75447
 ttaatcaatctgtagacatgtgtccccactgcagggagtgaactgctccaagggagaaac       c.-61

 .         .         .         .         .         .                g.75507
 ttctgggagcctccaaactcctagctgtctcatcccttgccctggagagacggcagaacc       c.-1

          .         .         .         .         .         .       g.75567
 ATGGCATTTTATAGCTGCTGCTGGGTCCTCTTGGCACTCACCTGGCACACCTCTGCCTAC       c.60
 M  A  F  Y  S  C  C  W  V  L  L  A  L  T  W  H  T  S  A  Y         p.20

          .         .         .         .         .         .       g.75627
 GGGCCAGACCAGCGAGCCCAAAAGAAGGGGGACATTATCCTTGGGGGGCTCTTTCCTATT       c.120
 G  P  D  Q  R  A  Q  K  K  G  D  I  I  L  G  G  L  F  P  I         p.40

          .         .         .         .         .         .       g.75687
 CATTTTGGAGTAGCAGCTAAAGATCAAGATCTCAAATCAAGGCCGGAGTCTGTGGAATGT       c.180
 H  F  G  V  A  A  K  D  Q  D  L  K  S  R  P  E  S  V  E  C         p.60

       | 03  .         .         .         .         .         .    g.78453
 ATCAG | GTATAATTTCCGTGGGTTTCGCTGGTTACAGGCTATGATATTTGCCATAGAGGAG    c.240
 I  R  |  Y  N  F  R  G  F  R  W  L  Q  A  M  I  F  A  I  E  E      p.80

          .         .         .         .         .         .       g.78513
 ATAAACAGCAGCCCAGCCCTTCTTCCCAACTTGACGCTGGGATACAGGATATTTGACACT       c.300
 I  N  S  S  P  A  L  L  P  N  L  T  L  G  Y  R  I  F  D  T         p.100

          .         .         .         .         .         .       g.78573
 TGCAACACCGTTTCTAAGGCCTTGGAAGCCACCCTGAGTTTTGTTGCTCAAAACAAAATT       c.360
 C  N  T  V  S  K  A  L  E  A  T  L  S  F  V  A  Q  N  K  I         p.120

          .         .         .         .         .         .       g.78633
 GATTCTTTGAACCTTGATGAGTTCTGCAACTGCTCAGAGCACATTCCCTCTACGATTGCT       c.420
 D  S  L  N  L  D  E  F  C  N  C  S  E  H  I  P  S  T  I  A         p.140

          .         .         .         .         .         .       g.78693
 GTGGTGGGAGCAACTGGCTCAGGCGTCTCCACGGCAGTGGCAAATCTGCTGGGGCTCTTC       c.480
 V  V  G  A  T  G  S  G  V  S  T  A  V  A  N  L  L  G  L  F         p.160

          .   | 04     .         .         .         .         .    g.82893
 TACATTCCCCAG | GTCAGTTATGCCTCCTCCAGCAGACTCCTCAGCAACAAGAATCAATTC    c.540
 Y  I  P  Q   | V  S  Y  A  S  S  S  R  L  L  S  N  K  N  Q  F      p.180

          .         .         .         .         .         .       g.82953
 AAGTCTTTCCTCCGAACCATCCCCAATGATGAGCACCAGGCCACTGCCATGGCAGACATC       c.600
 K  S  F  L  R  T  I  P  N  D  E  H  Q  A  T  A  M  A  D  I         p.200

          .         .         .         .         .         .       g.83013
 ATCGAGTATTTCCGCTGGAACTGGGTGGGCACAATTGCAGCTGATGACGACTATGGGCGG       c.660
 I  E  Y  F  R  W  N  W  V  G  T  I  A  A  D  D  D  Y  G  R         p.220

          .         .         .         .         .         .       g.83073
 CCGGGGATTGAGAAATTCCGAGAGGAAGCTGAGGAAAGGGATATCTGCATCGACTTCAGT       c.720
 P  G  I  E  K  F  R  E  E  A  E  E  R  D  I  C  I  D  F  S         p.240

          .         .         .         .         .         .       g.83133
 GAACTCATCTCCCAGTACTCTGATGAGGAAGAGATCCAGCATGTGGTAGAGGTGATTCAA       c.780
 E  L  I  S  Q  Y  S  D  E  E  E  I  Q  H  V  V  E  V  I  Q         p.260

          .         .         .         .         .         .       g.83193
 AATTCCACGGCCAAAGTCATCGTGGTTTTCTCCAGTGGCCCAGATCTTGAGCCCCTCATC       c.840
 N  S  T  A  K  V  I  V  V  F  S  S  G  P  D  L  E  P  L  I         p.280

          .         .         .         .         .         .       g.83253
 AAGGAGATTGTCCGGCGCAATATCACGGGCAAGATCTGGCTGGCCAGCGAGGCCTGGGCC       c.900
 K  E  I  V  R  R  N  I  T  G  K  I  W  L  A  S  E  A  W  A         p.300

          .         .         .         .         .         .       g.83313
 AGCTCCTCCCTGATCGCCATGCCTCAGTACTTCCACGTGGTTGGCGGCACCATTGGATTC       c.960
 S  S  S  L  I  A  M  P  Q  Y  F  H  V  V  G  G  T  I  G  F         p.320

          .         .         .         .         .         .       g.83373
 GCTCTGAAGGCTGGGCAGATCCCAGGCTTCCGGGAATTCCTGAAGAAGGTCCATCCCAGG       c.1020
 A  L  K  A  G  Q  I  P  G  F  R  E  F  L  K  K  V  H  P  R         p.340

          .         .         .         .         .         .       g.83433
 AAGTCTGTCCACAATGGTTTTGCCAAGGAGTTTTGGGAAGAAACATTTAACTGCCACCTC       c.1080
 K  S  V  H  N  G  F  A  K  E  F  W  E  E  T  F  N  C  H  L         p.360

          .         .         .         .         .         .       g.83493
 CAAGAAGGTGCAAAAGGACCTTTACCTGTGGACACCTTTCTGAGAGGTCACGAAGAAAGT       c.1140
 Q  E  G  A  K  G  P  L  P  V  D  T  F  L  R  G  H  E  E  S         p.380

          .         .         .         .         .         .       g.83553
 GGCGACAGGTTTAGCAACAGCTCGACAGCCTTCCGACCCCTCTGTACAGGGGATGAGAAC       c.1200
 G  D  R  F  S  N  S  S  T  A  F  R  P  L  C  T  G  D  E  N         p.400

          .         .         .         .         .         .       g.83613
 ATCAGCAGTGTCGAGACCCCTTACATAGATTACACGCATTTACGGATATCCTACAATGTG       c.1260
 I  S  S  V  E  T  P  Y  I  D  Y  T  H  L  R  I  S  Y  N  V         p.420

          .         .         .         .         .         .       g.83673
 TACTTAGCAGTCTACTCCATTGCCCACGCCTTGCAAGATATATATACCTGCTTACCTGGG       c.1320
 Y  L  A  V  Y  S  I  A  H  A  L  Q  D  I  Y  T  C  L  P  G         p.440

          .         .         .         .         .        | 05.    g.97132
 AGAGGGCTCTTCACCAATGGCTCCTGTGCAGACATCAAGAAAGTTGAGGCGTGGCAG | GTC    c.1380
 R  G  L  F  T  N  G  S  C  A  D  I  K  K  V  E  A  W  Q   | V      p.460

          .         .         .         .         .         .       g.97192
 CTGAAGCACCTACGGCATCTAAACTTTACAAACAATATGGGGGAGCAGGTGACCTTTGAT       c.1440
 L  K  H  L  R  H  L  N  F  T  N  N  M  G  E  Q  V  T  F  D         p.480

          .         .         .         .         .         .       g.97252
 GAGTGTGGTGACCTGGTGGGGAACTATTCCATCATCAACTGGCACCTCTCCCCAGAGGAT       c.1500
 E  C  G  D  L  V  G  N  Y  S  I  I  N  W  H  L  S  P  E  D         p.500

          .         .         .         .         .         .       g.97312
 GGCTCCATCGTGTTTAAGGAAGTCGGGTATTACAACGTCTATGCCAAGAAGGGAGAAAGA       c.1560
 G  S  I  V  F  K  E  V  G  Y  Y  N  V  Y  A  K  K  G  E  R         p.520

          .         .         .         .         | 06         .    g.103442
 CTCTTCATCAACGAGGAGAAAATCCTGTGGAGTGGGTTCTCCAGGGAG | GTGCCCTTCTCC    c.1620
 L  F  I  N  E  E  K  I  L  W  S  G  F  S  R  E   | V  P  F  S      p.540

          .         .         .         .         .         .       g.103502
 AACTGCAGCCGAGACTGCCTGGCAGGGACCAGGAAAGGGATCATTGAGGGGGAGCCCACC       c.1680
 N  C  S  R  D  C  L  A  G  T  R  K  G  I  I  E  G  E  P  T         p.560

          .         .         .         .         .   | 07     .    g.105012
 TGCTGCTTTGAGTGTGTGGAGTGTCCTGATGGGGAGTATAGTGATGAGACAG | ATGCCAGT    c.1740
 C  C  F  E  C  V  E  C  P  D  G  E  Y  S  D  E  T  D |   A  S      p.580

          .         .         .         .         .         .       g.105072
 GCCTGTAACAAGTGCCCAGATGACTTCTGGTCCAATGAGAACCACACCTCCTGCATTGCC       c.1800
 A  C  N  K  C  P  D  D  F  W  S  N  E  N  H  T  S  C  I  A         p.600

          .         .         .         .         .         .       g.105132
 AAGGAGATCGAGTTTCTGTCGTGGACGGAGCCCTTTGGGATCGCACTCACCCTCTTTGCC       c.1860
 K  E  I  E  F  L  S  W  T  E  P  F  G  I  A  L  T  L  F  A         p.620

          .         .         .         .         .         .       g.105192
 GTGCTGGGCATTTTCCTGACAGCCTTTGTGCTGGGTGTGTTTATCAAGTTCCGCAACACA       c.1920
 V  L  G  I  F  L  T  A  F  V  L  G  V  F  I  K  F  R  N  T         p.640

          .         .         .         .         .         .       g.105252
 CCCATTGTCAAGGCCACCAACCGAGAGCTCTCCTACCTCCTCCTCTTCTCCCTGCTCTGC       c.1980
 P  I  V  K  A  T  N  R  E  L  S  Y  L  L  L  F  S  L  L  C         p.660

          .         .         .         .         .         .       g.105312
 TGCTTCTCCAGCTCCCTGTTCTTCATCGGGGAGCCCCAGGACTGGACGTGCCGCCTGCGC       c.2040
 C  F  S  S  S  L  F  F  I  G  E  P  Q  D  W  T  C  R  L  R         p.680

          .         .         .         .         .         .       g.105372
 CAGCCGGCCTTTGGCATCAGCTTCGTGCTCTGCATCTCATGCATCCTGGTGAAAACCAAC       c.2100
 Q  P  A  F  G  I  S  F  V  L  C  I  S  C  I  L  V  K  T  N         p.700

          .         .         .         .         .         .       g.105432
 CGTGTCCTCCTGGTGTTTGAGGCCAAGATCCCCACCAGCTTCCACCGCAAGTGGTGGGGG       c.2160
 R  V  L  L  V  F  E  A  K  I  P  T  S  F  H  R  K  W  W  G         p.720

          .         .         .         .         .         .       g.105492
 CTCAACCTGCAGTTCCTGCTGGTTTTCCTCTGCACCTTCATGCAGATTGTCATCTGTGTG       c.2220
 L  N  L  Q  F  L  L  V  F  L  C  T  F  M  Q  I  V  I  C  V         p.740

          .         .         .         .         .         .       g.105552
 ATCTGGCTCTACACCGCGCCCCCCTCAAGCTACCGCAACCAGGAGCTGGAGGATGAGATC       c.2280
 I  W  L  Y  T  A  P  P  S  S  Y  R  N  Q  E  L  E  D  E  I         p.760

          .         .         .         .         .         .       g.105612
 ATCTTCATCACGTGCCACGAGGGCTCCCTCATGGCCCTGGGCTTCCTGATCGGCTACACC       c.2340
 I  F  I  T  C  H  E  G  S  L  M  A  L  G  F  L  I  G  Y  T         p.780

          .         .         .         .         .         .       g.105672
 TGCCTGCTGGCTGCCATCTGCTTCTTCTTTGCCTTCAAGTCCCGGAAGCTGCCGGAGAAC       c.2400
 C  L  L  A  A  I  C  F  F  F  A  F  K  S  R  K  L  P  E  N         p.800

          .         .         .         .         .         .       g.105732
 TTCAATGAAGCCAAGTTCATCACCTTCAGCATGCTCATCTTCTTCATCGTCTGGATCTCC       c.2460
 F  N  E  A  K  F  I  T  F  S  M  L  I  F  F  I  V  W  I  S         p.820

          .         .         .         .         .         .       g.105792
 TTCATTCCAGCCTATGCCAGCACCTATGGCAAGTTTGTCTCTGCCGTAGAGGTGATTGCC       c.2520
 F  I  P  A  Y  A  S  T  Y  G  K  F  V  S  A  V  E  V  I  A         p.840

          .         .         .         .         .         .       g.105852
 ATCCTGGCAGCCAGCTTTGGCTTGCTGGCGTGCATCTTCTTCAACAAGATCTACATCATT       c.2580
 I  L  A  A  S  F  G  L  L  A  C  I  F  F  N  K  I  Y  I  I         p.860

          .         .         .         .         .         .       g.105912
 CTCTTCAAGCCATCCCGCAACACCATCGAGGAGGTGCGTTGCAGCACCGCAGCTCACGCT       c.2640
 L  F  K  P  S  R  N  T  I  E  E  V  R  C  S  T  A  A  H  A         p.880

          .         .         .         .         .         .       g.105972
 TTCAAGGTGGCTGCCCGGGCCACGCTGCGCCGCAGCAACGTCTCCCGCAAGCGGTCCAGC       c.2700
 F  K  V  A  A  R  A  T  L  R  R  S  N  V  S  R  K  R  S  S         p.900

          .         .         .         .         .         .       g.106032
 AGCCTTGGAGGCTCCACGGGATCCACCCCCTCCTCCTCCATCAGCAGCAAGAGCAACAGC       c.2760
 S  L  G  G  S  T  G  S  T  P  S  S  S  I  S  S  K  S  N  S         p.920

          .         .         .         .         .         .       g.106092
 GAAGACCCATTCCCACAGCCCGAGAGGCAGAAGCAGCAGCAGCCGCTGGCCCTAACCCAG       c.2820
 E  D  P  F  P  Q  P  E  R  Q  K  Q  Q  Q  P  L  A  L  T  Q         p.940

          .         .         .         .         .         .       g.106152
 CAAGAGCAGCAGCAGCAGCCCCTGACCCTCCCACAGCAGCAACGATCTCAGCAGCAGCCC       c.2880
 Q  E  Q  Q  Q  Q  P  L  T  L  P  Q  Q  Q  R  S  Q  Q  Q  P         p.960

          .         .         .         .         .         .       g.106212
 AGATGCAAGCAGAAGGTCATCTTTGGCAGCGGCACGGTCACCTTCTCACTGAGCTTTGAT       c.2940
 R  C  K  Q  K  V  I  F  G  S  G  T  V  T  F  S  L  S  F  D         p.980

          .         .         .         .         .         .       g.106272
 GAGCCTCAGAAGAACGCCATGGCCCACAGGAATTCTACGCACCAGAACTCCCTGGAGGCC       c.3000
 E  P  Q  K  N  A  M  A  H  R  N  S  T  H  Q  N  S  L  E  A         p.1000

          .         .         .         .         .         .       g.106332
 CAGAAAAGCAGCGATACGCTGACCCGACACCAGCCATTACTCCCGCTGCAGTGCGGGGAA       c.3060
 Q  K  S  S  D  T  L  T  R  H  Q  P  L  L  P  L  Q  C  G  E         p.1020

          .         .         .         .         .         .       g.106392
 ACGGACTTAGATCTGACCGTCCAGGAAACAGGTCTGCAAGGACCTGTGGGTGGAGACCAG       c.3120
 T  D  L  D  L  T  V  Q  E  T  G  L  Q  G  P  V  G  G  D  Q         p.1040

          .         .         .         .         .         .       g.106452
 CGGCCAGAGGTGGAGGACCCTGAAGAGTTGTCCCCAGCACTTGTAGTGTCCAGTTCACAG       c.3180
 R  P  E  V  E  D  P  E  E  L  S  P  A  L  V  V  S  S  S  Q         p.1060

          .         .         .         .         .                 g.106509
 AGCTTTGTCATCAGTGGTGGAGGCAGCACTGTTACAGAAAACGTAGTGAATTCATAA          c.3237
 S  F  V  I  S  G  G  G  S  T  V  T  E  N  V  V  N  S  X            p.1078

          .         .         .         .         .         .       g.106569
 aatggaaggagaagactgggctagggagaatgcagagaggtttcttggggtcccagggaa       c.*60

          .         .         .         .         .         .       g.106629
 gaggaatcgccccagactcctttcctctgaggaagaagggataatagacacatcaaatgc       c.*120

          .         .         .         .         .         .       g.106689
 cccgaatttagtcacaccatcttaaatgacagtgaattgacccatgttccctttaaaatt       c.*180

          .         .         .         .         .         .       g.106749
 aaaaaaaagaagagccttgtgtttctgtggttgcatttgtcaaagcattgagatctccac       c.*240

          .         .         .         .         .         .       g.106809
 ggtcagatttgctgttcacccacatctaatgtctcttcctctgttctatcccacccaaca       c.*300

          .         .         .         .         .         .       g.106869
 gctcagagatgaaactatggctttaaactaccctccagagtgtgcagactgatgggacat       c.*360

          .         .         .         .         .         .       g.106929
 caaatttgccaccactagagctgagagtctgaaagacagaatgtcaccagtcctgcccaa       c.*420

          .         .         .         .         .         .       g.106989
 tgccttgacaacagactgaattttaaatgttcacaacataaggagaatgtatctcctcct       c.*480

          .         .         .         .         .         .       g.107049
 atttatgaaaaccatatgatattttgtctcctacctgctgctgctattatgtaacatcca       c.*540

          .         .         .         .         .         .       g.107109
 gaaggtttgcacccctcctataccatatgtctgcttctgtccaggacatgatactgatgc       c.*600

          .         .         .         .         .         .       g.107169
 catgtttagattccaggatcacaagaatcacctcaaattgttaggaagggactgcataaa       c.*660

          .         .         .         .         .         .       g.107229
 ccaatgagctgtatctgtaattaatattcctatatgtagctttatccttaggaaaatgct       c.*720

          .         .         .         .         .         .       g.107289
 tctgttgtaatagtccatggacaatataaactgaaaaatgtcagtctggtttatataagg       c.*780

          .         .         .         .         .         .       g.107349
 cagtattattgagctctatttccccaccccactatcctcactcccataagctaagcctta       c.*840

          .         .         .         .         .         .       g.107409
 tgtgagccccttcagggactcaagggtccagaagtccctcccatctctaccccaaagaat       c.*900

          .         .         .         .         .         .       g.107469
 tcctgaagccagatccaccctatccctgtacagagtaagttctcaattattggcctgcta       c.*960

          .         .         .         .         .         .       g.107529
 atagctgctagggtaggaaagcgtggttccaagaaagatccaccctcaaatgtcagagct       c.*1020

          .         .         .         .         .         .       g.107589
 atgttccctccagcagtggtattaatactgccggtcacccaggctctggagccagagaga       c.*1080

          .         .         .         .         .         .       g.107649
 cagaccggggttcaagccatggcttcgtcatttgcaagctgagtgactgtaggcagggaa       c.*1140

          .         .         .         .         .         .       g.107709
 ccttaacctctctaagccacagcttcttcatctttaaaataaggataataatcattcttt       c.*1200

          .         .         .         .         .         .       g.107769
 cccctcagagctcttatgtggattaaacgagataatgtatataaagtactttagcctggt       c.*1260

          .         .         .         .                           g.107815
 acctagcacacaataagcattcaataaatattagttaatattatta                     c.*1306

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Calcium-sensing receptor protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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