cystathionine-beta-synthase (CBS) - coding DNA reference sequence

(used for variant description)

(last modified August 28, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_000071.2 in the CBS gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008938.1, covering CBS transcript NM_000071.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5005
                                                        acatt       c.-241

 .         .         .         .         .         .                g.5065
 ggccggcgccggcctccgcccccgcctctccgccaatcaccgcccgcctgctcccctcgc       c.-181

 .         .         .         .         .         .                g.5125
 cgtgggtccccgcgaggccgccaccccggggtcgccgtctccgcctcgccgcagtcgggg       c.-121

 .         .         .         .      | 02  .         .             g.7613
 cagccgctcgcccctcttttccatgtatccgtccag | gatcccatgacagattctgttgtc    c.-61

 .         .         .         .         .         .  | 03          g.8737
 acgtctccttacagagtttgagcggtgctgaactgtcagcaccatctgtccg | gtcccagc    c.-1

          .         .         .         .         .         .       g.8797
 ATGCCTTCTGAGACCCCCCAGGCAGAAGTGGGGCCCACAGGCTGCCCCCACCGCTCAGGG       c.60
 M  P  S  E  T  P  Q  A  E  V  G  P  T  G  C  P  H  R  S  G         p.20

          .         .         .         .         .         .       g.8857
 CCACACTCGGCGAAGGGGAGCCTGGAGAAGGGGTCCCCAGAGGATAAGGAAGCCAAGGAG       c.120
 P  H  S  A  K  G  S  L  E  K  G  S  P  E  D  K  E  A  K  E         p.40

          .         .         .         .         .         .       g.8917
 CCCCTGTGGATCCGGCCCGATGCTCCGAGCAGGTGCACCTGGCAGCTGGGCCGGCCTGCC       c.180
 P  L  W  I  R  P  D  A  P  S  R  C  T  W  Q  L  G  R  P  A         p.60

          .         .          | 04        .         .         .    g.12346
 TCCGAGTCCCCACATCACCACACTGCCCC | GGCAAAATCTCCAAAAATCTTGCCAGATATT    c.240
 S  E  S  P  H  H  H  T  A  P  |  A  K  S  P  K  I  L  P  D  I      p.80

          .         .         .         .         .         .       g.12406
 CTGAAGAAAATCGGGGACACCCCTATGGTCAGAATCAACAAGATTGGGAAGAAGTTCGGC       c.300
 L  K  K  I  G  D  T  P  M  V  R  I  N  K  I  G  K  K  F  G         p.100

          .       | 05 .         .         .         .         .    g.14597
 CTGAAGTGTGAGCTCT | TGGCCAAGTGTGAGTTCTTCAACGCGGGCGGGAGCGTGAAGGAC    c.360
 L  K  C  E  L  L |   A  K  C  E  F  F  N  A  G  G  S  V  K  D      p.120

          .         .         .         .         .         .       g.14657
 CGCATCAGCCTGCGGATGATTGAGGATGCTGAGCGCGACGGGACGCTGAAGCCCGGGGAC       c.420
 R  I  S  L  R  M  I  E  D  A  E  R  D  G  T  L  K  P  G  D         p.140

          .         .         .  | 06      .         .         .    g.15264
 ACGATTATCGAGCCGACATCCGGGAACACCG | GGATCGGGCTGGCCCTGGCTGCGGCAGTG    c.480
 T  I  I  E  P  T  S  G  N  T  G |   I  G  L  A  L  A  A  A  V      p.160

          .         .         .         .         .  | 07      .    g.15418
 AGGGGCTATCGCTGCATCATCGTGATGCCAGAGAAGATGAGCTCCGAGAAG | GTGGACGTG    c.540
 R  G  Y  R  C  I  I  V  M  P  E  K  M  S  S  E  K   | V  D  V      p.180

          .         .         .         .         .         .       g.15478
 CTGCGGGCACTGGGGGCTGAGATTGTGAGGACGCCCACCAATGCCAGGTTCGACTCCCCG       c.600
 L  R  A  L  G  A  E  I  V  R  T  P  T  N  A  R  F  D  S  P         p.200

          .         .         .         .         .         .       g.15538
 GAGTCACACGTGGGGGTGGCCTGGCGGCTGAAGAACGAAATCCCCAATTCTCACATCCTA       c.660
 E  S  H  V  G  V  A  W  R  L  K  N  E  I  P  N  S  H  I  L         p.220

        | 08 .         .         .         .         .         .    g.15712
 GACCAG | TACCGCAACGCCAGCAACCCCCTGGCTCACTACGACACCACCGCTGATGAGATC    c.720
 D  Q   | Y  R  N  A  S  N  P  L  A  H  Y  D  T  T  A  D  E  I      p.240

          .       | 09 .         .         .         .         .    g.16983
 CTGCAGCAGTGTGATG | GGAAGCTGGACATGCTGGTGGCTTCAGTGGGCACGGGCGGCACC    c.780
 L  Q  Q  C  D  G |   K  L  D  M  L  V  A  S  V  G  T  G  G  T      p.260

          .         .         .         .         | 10         .    g.17864
 ATCACGGGCATTGCCAGGAAGCTGAAGGAGAAGTGTCCTGGATGCAGG | ATCATTGGGGTG    c.840
 I  T  G  I  A  R  K  L  K  E  K  C  P  G  C  R   | I  I  G  V      p.280

          .         .         .         .         .         .       g.17924
 GATCCCGAAGGGTCCATCCTCGCAGAGCCGGAGGAGCTGAACCAGACGGAGCAGACAACC       c.900
 D  P  E  G  S  I  L  A  E  P  E  E  L  N  Q  T  E  Q  T  T         p.300

          .         .         .         .         .     | 11   .    g.18541
 TACGAGGTGGAAGGGATCGGCTACGACTTCATCCCCACGGTGCTGGACAGGACG | GTGGTG    c.960
 Y  E  V  E  G  I  G  Y  D  F  I  P  T  V  L  D  R  T   | V  V      p.320

          .         .         .         .         .         .       g.18601
 GACAAGTGGTTCAAGAGCAACGATGAGGAGGCGTTCACCTTTGCCCGCATGCTGATCGCG       c.1020
 D  K  W  F  K  S  N  D  E  E  A  F  T  F  A  R  M  L  I  A         p.340

          .          | 12        .         .         .         .    g.20425
 CAAGAGGGGCTGCTGTGCG | GTGGCAGTGCTGGCAGCACGGTGGCGGTGGCCGTGAAGGCC    c.1080
 Q  E  G  L  L  C  G |   G  S  A  G  S  T  V  A  V  A  V  K  A      p.360

          .         .         .         .         .         .       g.20485
 GCGCAGGAGCTGCAGGAGGGCCAGCGCTGCGTGGTCATTCTGCCCGACTCAGTGCGGAAC       c.1140
 A  Q  E  L  Q  E  G  Q  R  C  V  V  I  L  P  D  S  V  R  N         p.380

       | 13  .         .         .         .         .         .    g.21682
 TACAT | GACCAAGTTCCTGAGCGACAGGTGGATGCTGCAGAAGGGCTTTCTGAAGGAGGAG    c.1200
 Y  M  |  T  K  F  L  S  D  R  W  M  L  Q  K  G  F  L  K  E  E      p.400

          .         .    | 14    .         .         .         .    g.21999
 GACCTCACGGAGAAGAAGCCCTG | GTGGTGGCACCTCCGTGTTCAGGAGCTGGGCCTGTCA    c.1260
 D  L  T  E  K  K  P  W  |  W  W  H  L  R  V  Q  E  L  G  L  S      p.420

          .         .         .         .         .         .       g.22059
 GCCCCGCTGACCGTGCTCCCGACCATCACCTGTGGGCACACCATCGAGATCCTCCGGGAG       c.1320
 A  P  L  T  V  L  P  T  I  T  C  G  H  T  I  E  I  L  R  E         p.440

          .         .         .         | 15         .         .    g.22699
 AAGGGCTTCGACCAGGCGCCCGTGGTGGATGAGGCGGG | GGTAATCCTGGGAATGGTGACG    c.1380
 K  G  F  D  Q  A  P  V  V  D  E  A  G  |  V  I  L  G  M  V  T      p.460

          .         .         .         .         .         .       g.22759
 CTTGGGAACATGCTCTCGTCCCTGCTTGCCGGGAAGGTGCAGCCGTCAGACCAAGTTGGC       c.1440
 L  G  N  M  L  S  S  L  L  A  G  K  V  Q  P  S  D  Q  V  G         p.480

          .         .        | 16.         .         .         .    g.24076
 AAAGTCATCTACAAGCAGTTCAAACAG | ATCCGCCTCACGGACACGCTGGGCAGGCTCTCG    c.1500
 K  V  I  Y  K  Q  F  K  Q   | I  R  L  T  D  T  L  G  R  L  S      p.500

          .         .         .         .         .   | 17     .    g.26955
 CACATCCTGGAGATGGACCACTTCGCCCTGGTGGTGCACGAGCAGATCCAGT | ACCACAGC    c.1560
 H  I  L  E  M  D  H  F  A  L  V  V  H  E  Q  I  Q  Y |   H  S      p.520

          .         .         .         .         .         .       g.27015
 ACCGGGAAGTCCAGTCAGCGGCAGATGGTGTTCGGGGTGGTCACCGCCATTGACTTGCTG       c.1620
 T  G  K  S  S  Q  R  Q  M  V  F  G  V  V  T  A  I  D  L  L         p.540

          .         .         .                                     g.27051
 AACTTCGTGGCCGCCCAGGAGCGGGACCAGAAGTGA                               c.1656
 N  F  V  A  A  Q  E  R  D  Q  K  X                                 p.551

          .         .         .         .         .         .       g.27111
 agtccggagcgctgggcggtgcggagcgggcccgccacccttgcccacttctccttcgct       c.*60

          .         .         .         .         .         .       g.27171
 ttcctgagccctaaacacacgcgtgattggtaactgcctggcctggcaccgttatccctg       c.*120

          .         .         .         .         .         .       g.27231
 cacacggcacagagcatccgtctcccctcgttaacacatggcttcctaaatggccctgtt       c.*180

          .         .         .         .         .         .       g.27291
 tacggcctatgagatgaaatatgtgattttctctaatgtaacttcctcttaggatgtttc       c.*240

          .         .         .         .         .         .       g.27351
 accaaggaaatattgagagagaagtcggccaggtaggatgaacacaggcaatgactgcgc       c.*300

          .         .         .         .         .         .       g.27411
 agagtggattaaaggcaaaagagagaagagtccaggaaggggcggggagaagcctgggtg       c.*360

          .         .         .         .         .         .       g.27471
 gctcagcatcctccacgggctgcgccgtctgctcggggctgagctggcgggagcagtttg       c.*420

          .         .         .         .         .         .       g.27531
 cgtgtttgggttttttaattgagatgaaattcaaataacctaaaaatcaatcacttgaaa       c.*480

          .         .         .         .         .         .       g.27591
 gtgaacaatcagcggcatttagtacatccagaaagttgtgtaggcaccacctctgtcacg       c.*540

          .         .         .         .         .         .       g.27651
 ttctggaacattctgtcatcaccccgtgaagcaatcatttcccctcccgtcttcctcctc       c.*600

          .         .         .         .         .         .       g.27711
 ccctggcaactgctgatcgactttgtgtctctgttgtctaaaataggttttccctgttct       c.*660

          .         .                                               g.27740
 ggacatttcatataaatggaatcacacaa                                      c.*689

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cystathionine-beta-synthase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

Powered by LOVD v.3.0 Build 13
©2004-2015 Leiden University Medical Center