collagen and calcium binding EGF domains 1 (CCBE1) - coding DNA reference sequence

(used for variant description)

(last modified April 20, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_133459.3 in the CCBE1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016990.1, covering CCBE1 transcript NM_133459.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   cggccgcgga       c.-61

 .         .         .         .         .         .                g.5070
 ggagcaggacgcttggtccggacggagctcggcgctgggaagaagccgggagcttccctg       c.-1

          .         .         .         .         .         .       g.5130
 ATGGTGCCGCCGCCTCCGAGCCGGGGAGGAGCTGCCAGGGGCCAGCTGGGCAGGAGCCTG       c.60
 M  V  P  P  P  P  S  R  G  G  A  A  R  G  Q  L  G  R  S  L         p.20

          .         .         .         .         .         .       g.5190
 GGTCCGCTGCTGCTGCTCCTGGCGTTGGGACACACGTGGACCTACAGAGAGGAGCCGGAG       c.120
 G  P  L  L  L  L  L  A  L  G  H  T  W  T  Y  R  E  E  P  E         p.40

          .  | 02      .         .         .         .         .    g.5752
 GACGGCGACAG | AGAAATCTGCTCAGAGAGCAAAATCGCGACGACTAAATACCCGTGTCTG    c.180
 D  G  D  R  |  E  I  C  S  E  S  K  I  A  T  T  K  Y  P  C  L      p.60

          .         .         .   | 03     .         .         .    g.222202
 AAGTCTTCAGGCGAGCTCACCACATGCTACAG | GAAAAAGTGCTGCAAAGGATATAAATTT    c.240
 K  S  S  G  E  L  T  T  C  Y  R  |  K  K  C  C  K  G  Y  K  F      p.80

          .         .      | 04  .         .         .         .    g.232840
 GTTCTTGGACAATGCATCCCAGAAG | ATTACGACGTTTGTGCCGAGGCTCCCTGTGAACAG    c.300
 V  L  G  Q  C  I  P  E  D |   Y  D  V  C  A  E  A  P  C  E  Q      p.100

          .         .         .         .         .         .       g.232900
 CAGTGCACGGACAACTTTGGCCGAGTGCTGTGTACTTGTTATCCGGGATACCGATATGAC       c.360
 Q  C  T  D  N  F  G  R  V  L  C  T  C  Y  P  G  Y  R  Y  D         p.120

          .         .         .         . | 05       .         .    g.235541
 CGGGAGAGACACCGGAAGCGGGAGAAGCCATACTGTCTGG | ATATTGATGAGTGTGCCAGC    c.420
 R  E  R  H  R  K  R  E  K  P  Y  C  L  D |   I  D  E  C  A  S      p.140

          .         .         .         .         .         .       g.235601
 AGCAATGGGACGCTGTGTGCCCACATCTGCATCAATACCTTGGGCAGCTACCGCTGCGAG       c.480
 S  N  G  T  L  C  A  H  I  C  I  N  T  L  G  S  Y  R  C  E         p.160

          .         .         .         .         .         .       g.235661
 TGCCGGGAAGGCTACATCCGGGAAGATGATGGGAAGACATGTACCAGGGGAGACAAATAT       c.540
 C  R  E  G  Y  I  R  E  D  D  G  K  T  C  T  R  G  D  K  Y         p.180

          .    | 06    .         .         .         .         .    g.247508
 CCCAATGACACTG | GCCATGAGAAGTCTGAGAACATGGTGAAAGCCGGAACTTGCTGTGCC    c.600
 P  N  D  T  G |   H  E  K  S  E  N  M  V  K  A  G  T  C  C  A      p.200

          .         .         .         .         .     | 07   .    g.254315
 ACATGCAAGGAGTTCTACCAGATGAAGCAGACCGTGCTGCAGCTGAAGCAAAAG | ATTGCT    c.660
 T  C  K  E  F  Y  Q  M  K  Q  T  V  L  Q  L  K  Q  K   | I  A      p.220

          .         .         .         .         .         .       g.254375
 CTGCTCCCCAACAATGCAGCTGACCTGGGCAAGTATATCACTGGTGACAAGGTGCTGGCC       c.720
 L  L  P  N  N  A  A  D  L  G  K  Y  I  T  G  D  K  V  L  A         p.240

          .         .         .         .         .      | 08  .    g.262601
 TCAAACACCTACCTTCCAGGACCTCCTGGCCTGCCTGGGGGCCAGGGCCCTCCCG | GCTCA    c.780
 S  N  T  Y  L  P  G  P  P  G  L  P  G  G  Q  G  P  P  G |   S      p.260

          .         .         .         .         .         .       g.262661
 CCAGGACCAAAGGGAAGCCCAGGCTTCCCCGGTATGCCAGGCCCTCCTGGGCAGCCCGGC       c.840
 P  G  P  K  G  S  P  G  F  P  G  M  P  G  P  P  G  Q  P  G         p.280

          .         .         .         .         .         .       g.262721
 CCACGGGGCTCAATGGGACCCATGGGACCATCTCCTGATCTGTCCCACATTAAGCAAGGC       c.900
 P  R  G  S  M  G  P  M  G  P  S  P  D  L  S  H  I  K  Q  G         p.300

          .      | 09  .         .         .         .  | 10      . g.264275
 CGGAGGGGCCCTGTG | GGTCCACCAGGGGCACCAGGAAGAGATGGTTCTAAG | GGGGAGAGA c.960
 R  R  G  P  V   | G  P  P  G  A  P  G  R  D  G  S  K   | G  E  R   p.320

          .         .        | 11.         .         .         .    g.266304
 GGAGCGCCTGGGCCCAGAGGGTCTCCA | GGACCCCCTGGTTCTTTCGACTTCCTGCTACTT    c.1020
 G  A  P  G  P  R  G  S  P   | G  P  P  G  S  F  D  F  L  L  L      p.340

          .         .         .         .         .         .       g.266364
 ATGCTGGCTGACATCCGCAATGACATCACTGAGCTGCAGGAAAAGGTGTTCGGGCACCGG       c.1080
 M  L  A  D  I  R  N  D  I  T  E  L  Q  E  K  V  F  G  H  R         p.360

          .         .         .         .         .         .       g.266424
 ACTCACTCTTCAGCAGAGGAGTTCCCTTTACCTCAGGAATTTCCCAGCTACCCAGAAGCC       c.1140
 T  H  S  S  A  E  E  F  P  L  P  Q  E  F  P  S  Y  P  E  A         p.380

          .         .         .         .         .         .       g.266484
 ATGGACCTGGGCTCTGGAGATGACCATCCAAGAAGAACTGAGACAAGAGACTTGAGAGCC       c.1200
 M  D  L  G  S  G  D  D  H  P  R  R  T  E  T  R  D  L  R  A         p.400

          .         .                                               g.266505
 CCCAGAGACTTCTACCCATAG                                              c.1221
 P  R  D  F  Y  P  X                                                p.406

          .         .         .         .         .         .       g.266565
 cacatcccaacaccgtcacgccaaaggaagagaaagatcaactcacctgcagttaaacca       c.*60

          .         .         .         .         .         .       g.266625
 tctaaagagaagaaagaccactggagacctagaaaacatacatttttctcttctcttctc       c.*120

          .         .         .         .         .         .       g.266685
 ctgacgtctctccactcctcttcttccaaatacgatgctattttcagagtcccctcctag       c.*180

          .         .         .         .         .         .       g.266745
 gcctgcagacatgagggagtgaatgattgatttacctgcttctcactaagagtccattgg       c.*240

          .         .         .         .         .         .       g.266805
 ggtggtttgcattgtaacttttcttttacatcctatttttccaggaactttggatttaag       c.*300

          .         .         .         .         .         .       g.266865
 tactctcacagtgtcttaaatcataaattcttgaagttaaatttggcagagtatcaaaag       c.*360

          .         .         .         .         .         .       g.266925
 ggggaaaatgacaaagtgagctctaagaaaatgtgaggctacttctaagatgtgtgttca       c.*420

          .         .         .         .         .         .       g.266985
 caatagaccataactcctctagtatcaaaattggggctcttcagttaaaaaggggtgggg       c.*480

          .         .         .         .         .         .       g.267045
 aggacaaacgtgtcgatgtgctttggtggagaattttttccttgtgcttctagtagactt       c.*540

          .         .         .         .         .         .       g.267105
 taaatattgtatccctttgtcaaaccttgtttcccaaattcaattaaagagaggagagaa       c.*600

          .         .         .         .         .         .       g.267165
 ttgaatggcgtttagagaagatagaaaagaatcacagtcatatatttactgttatataga       c.*660

          .         .         .         .         .         .       g.267225
 ttgccacattctaaaattcaaatacggtgcttaaggtttcatgccatgcttatctgtaag       c.*720

          .         .         .         .         .         .       g.267285
 tatcctatttagggaagaagattaaactctcttttcaaaaaaacaaagtgaaatgcctgg       c.*780

          .         .         .         .         .         .       g.267345
 attcacattaaaacaatgggctctcgtttgctataatattttaaagctgtttaatcaaca       c.*840

          .         .         .         .         .         .       g.267405
 gtggagtctgctctataaatatagattatttgttcaataaactggctgagcttagagaga       c.*900

          .         .         .         .         .         .       g.267465
 ggtgcagaattcctggttctgagcaggtgcccagaaggtaccattaggtgccatgatcca       c.*960

          .         .         .         .         .         .       g.267525
 ggctgaaccaatatacagtggggctgaagtctgcaaggaggttgctggcttgggctgacc       c.*1020

          .         .         .         .         .         .       g.267585
 tcactaatgccatcagcagcggtaggtaaattttttctccttgggtattacaagtttttg       c.*1080

          .         .         .         .         .         .       g.267645
 tctggagccaaccaagcttgccaccaacatattgagagtaatacactattgaaagttatc       c.*1140

          .         .         .         .         .         .       g.267705
 ttggatggggagaaaaaaaaatagtggttttccttgtttgcaaaaacttccttcctattc       c.*1200

          .         .         .         .         .         .       g.267765
 tcattttttcttaattttctttaatttagtccaagttccagttcttttaggccttctctt       c.*1260

          .         .         .         .         .         .       g.267825
 tgatttattttcccctgcatgtgagaagcagttcagaaaaaggtctatatctccacctcc       c.*1320

          .         .         .         .         .         .       g.267885
 tagtgagttagagtgttttctcagagcacctctgggtggcaaagggaagcatgttcctgc       c.*1380

          .         .         .         .         .         .       g.267945
 caaggtttgctgtggattcagaagcaccaggagcaagagaccagaaggatgatctgctcc       c.*1440

          .         .         .         .         .         .       g.268005
 tttgtaacgttgttgagggccctcttgtttccaatgagcagcttataggttactcacagt       c.*1500

          .         .         .         .         .         .       g.268065
 ccactttctcactggacacacaaagtggctctttatctacctttgcgggagattttcact       c.*1560

          .         .         .         .         .         .       g.268125
 ctcctgcaaatgatcgttctcacactcatattagctcatgttggaatttcccatcctgcc       c.*1620

          .         .         .         .         .         .       g.268185
 atgtcctttcccatttctttttggcttttttgcctccaccttttagcccacatcatttaa       c.*1680

          .         .         .         .         .         .       g.268245
 ctccactactgtgaaagcttgcttaaagaaaatccctcttggccgggtgtggtagcccac       c.*1740

          .         .         .         .         .         .       g.268305
 gcctctaatcccagcactttgggaggctgaggcggggagatcacaaggtcaggagatcga       c.*1800

          .         .         .         .         .         .       g.268365
 gaccagcctgaccaacatggtgaaaccctgtctctactaaaaatacaaaaattagctggg       c.*1860

          .         .         .         .         .         .       g.268425
 cgtgttggcacacacctgtaatcccagctactcaggaggctgaggcaggagaattacttt       c.*1920

          .         .         .         .         .         .       g.268485
 aacctgcggggggagcctagattgcgctactgcactccagcctaggcaacagagggagac       c.*1980

          .         .         .         .         .         .       g.268545
 tctgtctcattaaaaaaaaaaaaaaaaaaaaaaaaaggccgggcttggtggctcatgcct       c.*2040

          .         .         .         .         .         .       g.268605
 gtaatcccagcactttgggaggccgaggcgggcggatcacgaggtcaggagatcgagacc       c.*2100

          .         .         .         .         .         .       g.268665
 acagtgaaaccctgtctctactaaaaacacaaaaaattagtcgggcgtggtggtgggcgc       c.*2160

          .         .         .         .         .         .       g.268725
 ctgtggtcccagctgctcgggaggctgaggcaggagaatggcgtgaacctgggaggcgga       c.*2220

          .         .         .         .         .         .       g.268785
 gcttgcgctgagccgagatcgtgccactgcactccagcctgggcgacagagcgagactct       c.*2280

          .         .         .         .         .         .       g.268845
 gtctcaaaaaaaaaaaaatatcccttttgttgtgtttgaatgccacctttcagtcttctt       c.*2340

          .         .         .         .         .         .       g.268905
 ccttaagaatgttaggaaggggctttgcaaacctctagtggcaacagtcttccttccctt       c.*2400

          .         .         .         .         .         .       g.268965
 cttcctaccacgttggaaatgcaggactcatgtcagtcagcatgtgaccgagtctttcat       c.*2460

          .         .         .         .         .         .       g.269025
 gaacactttgctcctctatgtctcatttatgcaaaattcctggtgactctccactaacat       c.*2520

          .         .         .         .         .         .       g.269085
 ttttaaagtgaaagcaaactttcactttaaaaaaagtgagcgagaggatcccttgagccc       c.*2580

          .         .         .         .         .         .       g.269145
 aggagttcaaggccagtctgggcaacatagcaagaccccatccctaaaaaaaaaaaaata       c.*2640

          .         .         .         .         .         .       g.269205
 agttttattaaatgtggcactttcccctagaagggcagtaaccccaggaaccagtctgcc       c.*2700

          .         .         .         .         .         .       g.269265
 tcttttcgaataaaggagactttttaaaaagaaaaaatttctttttagggtggggtgctc       c.*2760

          .         .         .         .         .         .       g.269325
 tttatctagcatctttccttcctccttctctctgcaaaattcaacattcatgacagaggg       c.*2820

          .         .         .         .         .         .       g.269385
 ccacaccaaccacgggtttatagagagaggaactgaacagctgttgattcccatctggaa       c.*2880

          .         .         .         .         .         .       g.269445
 tatatttaatgtttgcctgcttgtggagcatggtatttaaagggtgtggatggatgaatg       c.*2940

          .         .         .         .         .         .       g.269505
 tttaaaaaaaaacacacaaaactatgcacaagctgtatgagagatggctaggtccatcta       c.*3000

          .         .         .         .         .         .       g.269565
 tgattttttttaaaagaagaattttaataccttttctttgacagtgaactgtatttagaa       c.*3060

          .         .         .         .         .         .       g.269625
 atatgatctttattgtgaaatgctcataaaatgcaaccaaactgcatgtttggccatagg       c.*3120

          .         .         .         .         .         .       g.269685
 ctagaataatatattaaaagaattaatggaaagtagtattgtctgggtttcatgaaacta       c.*3180

          .         .         .         .         .         .       g.269745
 ttccagataatattctccagcaaaacttatggtaacctgtattttataatgtcaatctgc       c.*3240

          .         .         .         .         .         .       g.269805
 tggaccaagttaatttagaaaataatttttaatcctcagattttcaaaacttggactact       c.*3300

          .         .         .         .         .         .       g.269865
 gcaagactgatatgtactttttatgcccaaatcatatttttcaaagataggacatcataa       c.*3360

          .         .         .         .         .         .       g.269925
 ggcatcattatttctaatgtatcttttaactagatagaaaaagctttactgtctaaacag       c.*3420

          .         .         .         .         .         .       g.269985
 gacttctgctcaaaacctaatgggaaagctatttctggggtaagatttgtaacagtgctt       c.*3480

          .         .         .         .         .         .       g.270045
 ctaggtcatttcatgttttatagggaaaaagatctttgtacacctcctcaacctgttagt       c.*3540

          .         .         .         .         .         .       g.270105
 agaaatgttgacttcgattttttgcaccctcttcacaggacctcataagttgcctctgtt       c.*3600

          .         .         .         .         .         .       g.270165
 cttggaaagcaatgggaataaaaatatgctgttgaaaatagtgcatggggccaggcacag       c.*3660

          .         .         .         .         .         .       g.270225
 tggttatgcctgtaatcccaacactttgggaggctgaggcgggcgcatcatgaggtcagg       c.*3720

          .         .         .         .         .         .       g.270285
 agatcaagaccatcctgaccaacacgtggtgaaaccccatctctactaaaataaataaaa       c.*3780

          .         .         .         .         .         .       g.270345
 aaaaaaattagccaggcgtggtggtgcacgcctgtagtctcagctactcgggaagctgag       c.*3840

          .         .         .         .         .         .       g.270405
 acacaagaattgcttgaacccgggaggtggaggttgcagtgagccaagattgcgccactg       c.*3900

          .         .         .         .         .         .       g.270465
 cactccagcctggctacagagtgagactccgtctcgaaaaaagaaaatagtacatggagg       c.*3960

          .         .         .         .         .         .       g.270525
 gcatgcattttagtttaggaaacccccctcccttcccagttccagagggagaaattataa       c.*4020

          .         .         .         .         .         .       g.270585
 gctatactgtgccaaaagtgagtggggctgcagagagaatggtgccttttctcaccttct       c.*4080

          .         .         .         .         .         .       g.270645
 gagttaatgcccgacatctgccattggattcattgaccaaaggaagtcatttctactgta       c.*4140

          .         .         .         .         .         .       g.270705
 taaactcaggagtatcatagcccaacaagtaaataataaatgttcattggttttggaagg       c.*4200

          .         .         .         .         .         .       g.270765
 aaggaaaggtgagtattaccccaccaaataccagcgaagagcaccctggctttggccatc       c.*4260

          .         .         .         .         .         .       g.270825
 tttccaaggttcataattgctgtgggcctggtgagccctgttcccaggtatgcaagggag       c.*4320

          .         .         .         .         .         .       g.270885
 ggcttctccaggccagacatttctgtaggttttcaggtagcaactcccccatcatatttt       c.*4380

          .         .         .         .         .         .       g.270945
 gggtgtcattccccactctctctccccacttctcagcctgtgccccagaaacaaccacag       c.*4440

          .         .         .         .         .         .       g.271005
 cagcctcattctgcagacttaacatctgtcaaataaccttcctgaaaaggaaagttattg       c.*4500

          .         .         .         .         .         .       g.271065
 gaggaatccaggccaaacaacaagtagaatagagccatctaaagttattaataatgagtt       c.*4560

          .         .         .         .         .         .       g.271125
 cagggaaatagatgaattttttcctggcatagtcaatatttatatctcacaacaagtcaa       c.*4620

          .         .         .         .         .         .       g.271185
 aaataattttccatttggaaaacaaaacacaccatgactgtaattgttaaggcatataat       c.*4680

          .         .         .         .         .         .       g.271245
 catgaacttcacatgctccctcaacaaacgttactgctctagggaaatcatagaaaagga       c.*4740

          .         .         .         .         .         .       g.271305
 ccctcttactccccaggggatcaaagcaagtccccttaggaatttcatgtgtgccgtggg       c.*4800

          .         .         .         .         .         .       g.271365
 tctgtttttatttcacagtgactagtcatatactggagtagctctgttgttcattatttg       c.*4860

          .         .         .         .         .         .       g.271425
 taacaggtccatgtaacagtcaagttagcattcaagcaattatggatgtgatactatgat       c.*4920

          .         .         .         .                           g.271474
 gtacttttgttatgattgtatatgcttaataacaaagttatttttctta                  c.*4969

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Collagen and calcium binding EGF domains 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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