coiled-coil domain containing 22 (CCDC22) - coding DNA reference sequence

(used for variant description)

(last modified September 4, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_014008.3 in the CCDC22 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_021311.1, covering CCDC22 transcript NM_014008.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5050
           ctcacatccggcatgcgccgtgctcgctcacagaactacactttccaact       c.-121

 .         .         .         .         .         .                g.5110
 ctccccacacgacccgtgacactctgtggaccgcgagcacggagcagggtttctacagct       c.-61

 .         .         .         .         .         .                g.5170
 gctccccactttctcggacccggtcctggacccagcccccgactccgacacggctccacc       c.-1

          .         .         .         .         . | 02       .    g.6636
 ATGGAGGAGGCGGACCGAATCCTCATCCATTCGCTGCGCCAGGCCGGCAC | GGCAGTTCCT    c.60
 M  E  E  A  D  R  I  L  I  H  S  L  R  Q  A  G  T  |  A  V  P      p.20

          .         .         .         .         .         .       g.6696
 CCAGATGTGCAGACCTTGCGCGCCTTCACCACTGAGCTGGTTGTAGAGGCTGTGGTCCGC       c.120
 P  D  V  Q  T  L  R  A  F  T  T  E  L  V  V  E  A  V  V  R         p.40

          .         .         .         .         .         .       g.6756
 TGCCTGCGTGTGATCAACCCTGCGGTGGGCTCTGGCCTCAGCCCTCTGCTGCCTCTTGCC       c.180
 C  L  R  V  I  N  P  A  V  G  S  G  L  S  P  L  L  P  L  A         p.60

          .         .         .         .         | 03         .    g.11567
 ATGTCTGCCCGGTTCCGCCTGGCCATGAGCCTGGCTCAGGCCTGCATG | GACCTGGGCTAT    c.240
 M  S  A  R  F  R  L  A  M  S  L  A  Q  A  C  M   | D  L  G  Y      p.80

          .         .         .         .         .         .       g.11627
 CCCTTGGAGCTTGGCTATCAGAACTTCCTCTACCCCAGTGAGCCTGACCTCCGAGACCTG       c.300
 P  L  E  L  G  Y  Q  N  F  L  Y  P  S  E  P  D  L  R  D  L         p.100

          .         .         .         .         .         .       g.11687
 CTTCTCTTCTTGGCTGAGCGTCTGCCCACCGATGCCTCTGAGGATGCAGACCAGCCTGCA       c.360
 L  L  F  L  A  E  R  L  P  T  D  A  S  E  D  A  D  Q  P  A         p.120

   | 04      .         .         .         .         .         .    g.12484
 G | GTGACTCAGCTATTCTCCTCCGGGCCATTGGGAGCCAAATTCGGGACCAGCTGGCACTG    c.420
 G |   D  S  A  I  L  L  R  A  I  G  S  Q  I  R  D  Q  L  A  L      p.140

          .         .         .         .         | 05         .    g.12669
 CCTTGGGTCCCGCCCCACCTTCGCACTCCCAAGCTGCAGCACCTCCAG | GGCTCGGCCCTC    c.480
 P  W  V  P  P  H  L  R  T  P  K  L  Q  H  L  Q   | G  S  A  L      p.160

          .         .         .         .         .      | 06  .    g.12828
 CAGAAGCCTTTCCATGCCAGCAGGCTGGTCGTGCCAGAATTGAGTTCCAGAGGTG | AGCCA    c.540
 Q  K  P  F  H  A  S  R  L  V  V  P  E  L  S  S  R  G  E |   P      p.180

          .         .         .         .         .         .       g.12888
 CGGGAGTTCCAGGCGAGTCCCCTGCTGCTTCCAGTCCCTACCCAGGTGCCTCAGCCTGTT       c.600
 R  E  F  Q  A  S  P  L  L  L  P  V  P  T  Q  V  P  Q  P  V         p.200

          .         .         .         .         .         .       g.12948
 GGAAGGGTGGCCTCGCTCCTCGAACACCATGCCCTGCAGCTCTGCCAGCAGACGGGCCGG       c.660
 G  R  V  A  S  L  L  E  H  H  A  L  Q  L  C  Q  Q  T  G  R         p.220

          .         .         .         .         .     | 07   .    g.16271
 GACCGGCCAGGGGATGAGGACTGGGTCCACCGGACATCCCGCCTCCCACCCCAG | GAGGAC    c.720
 D  R  P  G  D  E  D  W  V  H  R  T  S  R  L  P  P  Q   | E  D      p.240

          .         .         .         .         .         .       g.16331
 ACACGGGCTCAGCGGCAGCGGCTGCAGAAGCAACTGACTGAGCATCTGCGCCAAAGCTGG       c.780
 T  R  A  Q  R  Q  R  L  Q  K  Q  L  T  E  H  L  R  Q  S  W         p.260

          .         .         .         .         .         .       g.16391
 GGCCTGCTTGGGGCCCCCATACAAGCCCGGGACCTGGGAGAACTGCTGCAGGCCTGGGGT       c.840
 G  L  L  G  A  P  I  Q  A  R  D  L  G  E  L  L  Q  A  W  G         p.280

          .         .         .         .         .         .       g.16451
 GCTGGGGCCAAGACTGGTGCTCCTAAGGGCTCCCGCTTCACGCACTCAGAGAAGTTCACC       c.900
 A  G  A  K  T  G  A  P  K  G  S  R  F  T  H  S  E  K  F  T         p.300

           | 08        .         .         .         .         .    g.17081
 TTCCATCTG | GAGCCCCAGGCCCAGGCCACTCAGGTGTCAGATGTGCCAGCCACCTCCCGG    c.960
 F  H  L   | E  P  Q  A  Q  A  T  Q  V  S  D  V  P  A  T  S  R      p.320

          .   | 09     .         .         .         .         .    g.17231
 CGGCCTGAACAG | GTCACGTGGGCAGCTCAGGAACAGGAGCTCGAGTCCCTTCGGGAGCAG    c.1020
 R  P  E  Q   | V  T  W  A  A  Q  E  Q  E  L  E  S  L  R  E  Q      p.340

          .         .         .         .         .         .       g.17291
 CTGGAAGGAGTGAACCGCAGCATTGAGGAGGTTGAGGCCGACATGAAGACCCTGGGCGTC       c.1080
 L  E  G  V  N  R  S  I  E  E  V  E  A  D  M  K  T  L  G  V         p.360

          .   | 10     .         .         .         .         .    g.17773
 AGCTTTGTGCAG | GCAGAGTCTGAGTGCCGGCACAGCAAGCTCAGTACAGCAGAGCGTGAG    c.1140
 S  F  V  Q   | A  E  S  E  C  R  H  S  K  L  S  T  A  E  R  E      p.380

          .         .         .         .         .         .       g.17833
 CAGGCCCTGCGCCTGAAGAGCCGCGCGGTGGAGCTGCTGCCCGATGGGACTGCCAACCTT       c.1200
 Q  A  L  R  L  K  S  R  A  V  E  L  L  P  D  G  T  A  N  L         p.400

          .   | 11     .         .         .         .         .    g.17989
 GCCAAGCTGCAG | CTTGTGGTGGAGAATAGTGCCCAGCGGGTCATCCACTTGGCGGGTCAG    c.1260
 A  K  L  Q   | L  V  V  E  N  S  A  Q  R  V  I  H  L  A  G  Q      p.420

          .         .         .         .         .         .       g.18049
 TGGGAGAAGCACCGGGTCCCACTCCTCGCTGAGTACCGCCACCTCCGAAAGCTGCAGGAT       c.1320
 W  E  K  H  R  V  P  L  L  A  E  Y  R  H  L  R  K  L  Q  D         p.440

           | 12        .         .         .         .         .    g.18218
 TGCAGAGAG | CTGGAATCTTCTCGACGGCTGGCAGAGATCCAAGAACTGCACCAGAGTGTC    c.1380
 C  R  E   | L  E  S  S  R  R  L  A  E  I  Q  E  L  H  Q  S  V      p.460

          .         .         .         .         .  | 13      .    g.18360
 CGGGCGGCTGCTGAAGAGGCCCGCAGGAAGGAGGAGGTCTATAAGCAGCTG | ATGTCAGAG    c.1440
 R  A  A  A  E  E  A  R  R  K  E  E  V  Y  K  Q  L   | M  S  E      p.480

          .         .         .         .         .         .       g.18420
 CTGGAGACTCTGCCCAGAGATGTGTCCCGGCTGGCCTACACCCAGCGCATCCTGGAGATC       c.1500
 L  E  T  L  P  R  D  V  S  R  L  A  Y  T  Q  R  I  L  E  I         p.500

          .         .         .          | 14        .         .    g.18722
 GTGGGCAACATCCGGAAGCAGAAGGAAGAGATCACCAAG | ATCTTGTCTGATACGAAGGAG    c.1560
 V  G  N  I  R  K  Q  K  E  E  I  T  K   | I  L  S  D  T  K  E      p.520

          .         .         .         .         .         .       g.18782
 CTTCAGAAGGAAATCAACTCCCTATCTGGGAAGCTGGACCGGACGTTTGCGGTGACTGAT       c.1620
 L  Q  K  E  I  N  S  L  S  G  K  L  D  R  T  F  A  V  T  D         p.540

          .      | 15  .         .         .         .         .    g.19088
 GAGCTTGTGTTCAAG | GATGCCAAGAAGGACGATGCTGTTCGGAAGGCCTATAAGTATCTA    c.1680
 E  L  V  F  K   | D  A  K  K  D  D  A  V  R  K  A  Y  K  Y  L      p.560

          .      | 16  .         .         .         .         .    g.19230
 GCTGCTCTGCACGAG | AACTGCAGCCAGCTCATCCAGACCATCGAGGACACAGGCACCATC    c.1740
 A  A  L  H  E   | N  C  S  Q  L  I  Q  T  I  E  D  T  G  T  I      p.580

          .         .         . | 17       .         .         .    g.19712
 ATGCGGGAGGTTCGAGACCTCGAGGAGCAG | ATCGAGACAGAGCTGGGCAAGAAGACCCTC    c.1800
 M  R  E  V  R  D  L  E  E  Q   | I  E  T  E  L  G  K  K  T  L      p.600

          .         .         .         .         .         .       g.19772
 AGCAACCTGGAGAAGATCCGGGAGGACTACCGAGCCCTCCGCCAGGAGAACGCTGGCCTC       c.1860
 S  N  L  E  K  I  R  E  D  Y  R  A  L  R  Q  E  N  A  G  L         p.620

          .         .                                               g.19796
 CTAGGCCGGGTCCGGGAGGCCTGA                                           c.1884
 L  G  R  V  R  E  A  X                                             p.627

          .         .         .         .         .         .       g.19856
 ggagccgccggcagaggtctctccccagcctcaggcagggatttggggtgctggaggcag       c.*60

          .         .         .         .         .         .       g.19916
 tggccaagcacatgccctagctacttcctccgctgtccagttcctcctgctgcggccttg       c.*120

          .         .         .         .         .         .       g.19976
 gacccagacccctgcccactgaccgcaacccttatatggggtgatagtccagcatgtggg       c.*180

          .         .         .         .         .         .       g.20036
 gagctcggctgcagtttattggggacggtactgtgggttgggggccttggatcccaaata       c.*240

          .         .                                               g.20061
 aatgagtagttcctctgcagtctaa                                          c.*265

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Coiled-coil domain containing 22 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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