coiled-coil domain containing 40 (CCDC40) - coding DNA reference sequence

(used for variant description)

(last modified August 20, 2012)


This file was created to facilitate the description of sequence variants on transcript NM_017950.3 in the CCDC40 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering CCDC40 transcript NM_017950.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5031
                              ggatgttgacagcgtcgcctagcaacgggaa       c.-1

          .         .          | 02        .         .         .    g.6522
 ATGGCGGAACCGGGCGGCGCGGCGGGCCG | GTCCCATCCGGAAGATGGATCGGCTTCTGAG    c.60
 M  A  E  P  G  G  A  A  G  R  |  S  H  P  E  D  G  S  A  S  E      p.20

          .         .         .    | 03    .         .         .    g.8207
 GGAGAGAAGGAAGGGAATAATGAAAGCCACATG | GTGTCACCACCAGAGAAGGATGATGGC    c.120
 G  E  K  E  G  N  N  E  S  H  M   | V  S  P  P  E  K  D  D  G      p.40

          .         .         .         .         .         .       g.8267
 CAGAAAGGTGAAGAAGCTGTCGGTAGCACAGAGCATCCTGAGGAAGTCACAACCCAAGCG       c.180
 Q  K  G  E  E  A  V  G  S  T  E  H  P  E  E  V  T  T  Q  A         p.60

          .         .         .         .         .         .       g.8327
 GAAGCTGCAATTGAAGAGGGGGAGGTGGAGACAGAAGGGGAAGCAGCAGTGGAAGGGGAA       c.240
 E  A  A  I  E  E  G  E  V  E  T  E  G  E  A  A  V  E  G  E         p.80

          .         .         .         .         .         .       g.8387
 GAGGAGGCTGTGTCCTATGGAGATGCTGAAAGCGAAGAGGAATATTACTATACAGAAACT       c.300
 E  E  A  V  S  Y  G  D  A  E  S  E  E  E  Y  Y  Y  T  E  T         p.100

          .         .         .         .         .         .       g.8447
 TCATCCCCGGAAGGGCAAATCAGTGCTGCAGATACGACTTACCCGTATTTCAGTCCTCCT       c.360
 S  S  P  E  G  Q  I  S  A  A  D  T  T  Y  P  Y  F  S  P  P         p.120

          .         .         .         .         .         .       g.8507
 CAGGAACTGCCTGGAGAGGAGGCATACGATAGTGTTAGCGGGGAGGCTGGTCTCCAAGGC       c.420
 Q  E  L  P  G  E  E  A  Y  D  S  V  S  G  E  A  G  L  Q  G         p.140

          .         .         .         .         .         .       g.8567
 TTCCAGCAAGAGGCCACCGGTCCACCAGAATCCAGAGAAAGGAGGGTCACCTCCCCAGAG       c.480
 F  Q  Q  E  A  T  G  P  P  E  S  R  E  R  R  V  T  S  P  E         p.160

          .         .         .         .         .         .       g.8627
 CCATCCCACGGAGTCTTAGGCCCGTCGGAGCAAATGGGCCAGGTCACCTCTGGGCCAGCA       c.540
 P  S  H  G  V  L  G  P  S  E  Q  M  G  Q  V  T  S  G  P  A         p.180

          .   | 04     .         .         .         .         .    g.15695
 GTGGGCAGATTG | ACAGGATCCACAGAGGAGCCCCAGGGGCAGGTGCTCCCAATGGGCGTC    c.600
 V  G  R  L   | T  G  S  T  E  E  P  Q  G  Q  V  L  P  M  G  V      p.200

          .         .         .         .         .         .       g.15755
 CAGCACCGCTTCCGGCTGAGCCACGGGAGCGACATCGAGTCCTCAGACCTGGAGGAGTTC       c.660
 Q  H  R  F  R  L  S  H  G  S  D  I  E  S  S  D  L  E  E  F         p.220

          .       | 05 .         .         .         .         .    g.16995
 GTCTCGCAGGAGCCAG | TGATCCCCCCAGGGGTGCCCGATGCCCACCCCAGGGAAGGAGAC    c.720
 V  S  Q  E  P  V |   I  P  P  G  V  P  D  A  H  P  R  E  G  D      p.240

          .         .         .         .         .         .       g.17055
 CTGCCAGTGTTCCAGGACCAGATCCAGCAGCCCAGCACCGAGGAGGGGGCCATGGCAGAG       c.780
 L  P  V  F  Q  D  Q  I  Q  Q  P  S  T  E  E  G  A  M  A  E         p.260

          .         .         .         .         .         .       g.17115
 AGAGTGGAGTCCGAGGGGAGTGACGAGGAAGCAGAAGACGAAGGGTCCCAGCTGGTGGTT       c.840
 R  V  E  S  E  G  S  D  E  E  A  E  D  E  G  S  Q  L  V  V         p.280

          .      | 06  .         .         .         .         .    g.18319
 TTGGACCCAGACCAC | CCCCTGATGGTAAGATTCCAGGCTGCCCTGAAGAACTACCTGAAC    c.900
 L  D  P  D  H   | P  L  M  V  R  F  Q  A  A  L  K  N  Y  L  N      p.300

          .         .         .          | 07        .         .    g.18453
 CGACAGATCGAAAAGTTGAAGCTGGACCTCCAAGAGCTG | GTTGTGGCTACCAAGCAGAGC    c.960
 R  Q  I  E  K  L  K  L  D  L  Q  E  L   | V  V  A  T  K  Q  S      p.320

          .         .         .         .         .         .       g.18513
 CGAGCCCAGCGGCAGGAGCTGGGGGTGAATCTCTATGAGGTGCAGCAGCACCTGGTACAC       c.1020
 R  A  Q  R  Q  E  L  G  V  N  L  Y  E  V  Q  Q  H  L  V  H         p.340

          .         .         .         .         .         .       g.18573
 CTGCAGAAGCTGCTGGAGAAGAGTCACGACCGCCACGCAATGGCCTCGAGCGAGCGCAGG       c.1080
 L  Q  K  L  L  E  K  S  H  D  R  H  A  M  A  S  S  E  R  R         p.360

          .         .         .         .         .         .       g.18633
 CAGAAGGAGGAGGAGCTGCAGGCCGCCCGCGCTCTCTACACCAAGACCTGCGCAGCCGCC       c.1140
 Q  K  E  E  E  L  Q  A  A  R  A  L  Y  T  K  T  C  A  A  A         p.380

          .          | 08        .         .         .         .    g.26903
 AACGAGGAGCGCAAAAAGT | TGGCGGCTCTGCAGACTGAGATGGAGAACTTGGCCCTGCAT    c.1200
 N  E  E  R  K  K  L |   A  A  L  Q  T  E  M  E  N  L  A  L  H      p.400

          .         .         .         .         .         .       g.26963
 CTCTTCTACATGCAGAACATCGACCAGGACATGCGTGACGACATCCGCGTGATGACACAA       c.1260
 L  F  Y  M  Q  N  I  D  Q  D  M  R  D  D  I  R  V  M  T  Q         p.420

          .         .         .         .         .        | 09.    g.27229
 GTGGTAAAGAAGGCCGAGACGGAGAGGATCCGGGCAGAAATCGAGAAGAAAAAGCAG | GAC    c.1320
 V  V  K  K  A  E  T  E  R  I  R  A  E  I  E  K  K  K  Q   | D      p.440

          .         .         .         .         .         .       g.27289
 CTGTATGTGGACCAGCTCACCACTCGAGCCCAGCAACTGGAAGAAGACATTGCCCTGTTT       c.1380
 L  Y  V  D  Q  L  T  T  R  A  Q  Q  L  E  E  D  I  A  L  F         p.460

          .         .         .         .         .         .       g.27349
 GAGGCTCAGTACTTGGCCCAAGCTGAGGACACCCGGATTTTAAGGAAAGCAGTGAGTGAG       c.1440
 E  A  Q  Y  L  A  Q  A  E  D  T  R  I  L  R  K  A  V  S  E         p.480

  | 10       .         .         .         .         .         .    g.33913
  | GCCTGCACCGAGATCGACGCCATCAGCGTGGAGAAGAGGCGCATCATGCAGCAATGGGCC    c.1500
  | A  C  T  E  I  D  A  I  S  V  E  K  R  R  I  M  Q  Q  W  A      p.500

          .         .         .         .         .         .       g.33973
 AGCAGCCTGGTGGGCATGAAGCACCGCGACGAGGCGCACAGGGCGGTGCTGGAGGCGCTC       c.1560
 S  S  L  V  G  M  K  H  R  D  E  A  H  R  A  V  L  E  A  L         p.520

    | 11     .         .         .         .         .         .    g.49972
 AG | AGGATGCCAGCATCAAGCCAAATCCACCGACGGCGAGATTGAGGCCTATAAGAAATCC    c.1620
 R  |  G  C  Q  H  Q  A  K  S  T  D  G  E  I  E  A  Y  K  K  S      p.540

          .         .         .         .         .         .       g.50032
 ATCATGAAGGAGGAAGAAAAGAACGAGAAGCTGGCGAGCATCCTGAACCGGACAGAGACG       c.1680
 I  M  K  E  E  E  K  N  E  K  L  A  S  I  L  N  R  T  E  T         p.560

          .         .         .         .         .         .       g.50092
 GAAGCCACACTGCTGCAGAAGCTCACCACCCAGTGCCTGACCAAGCAGGTGGCCCTGCAG       c.1740
 E  A  T  L  L  Q  K  L  T  T  Q  C  L  T  K  Q  V  A  L  Q         p.580

          .         .         .         .         .         .       g.50152
 AGCCAGTTCAATACCTACAGGCTCACCCTGCAGGACACAGAGGATGCCCTCAGCCAGGAC       c.1800
 S  Q  F  N  T  Y  R  L  T  L  Q  D  T  E  D  A  L  S  Q  D         p.600

        | 12 .         .         .         .         .         .    g.50298
 CAGCTG | GAACAAATGATACTCACGGAGGAGTTGCAGGCCATCCGCCAAGCCATCCAGGGC    c.1860
 Q  L   | E  Q  M  I  L  T  E  E  L  Q  A  I  R  Q  A  I  Q  G      p.620

          .         .         .         .         .         .       g.50358
 GAGCTGGAGCTCAGGAGGAAGACGGATGCTGCCATCCGGGAGAAGCTGCAGGAGCACATG       c.1920
 E  L  E  L  R  R  K  T  D  A  A  I  R  E  K  L  Q  E  H  M         p.640

          .         .         .         .         .         .       g.50418
 ACCTCCAACAAGACCACCAAATACTTCAACCAGCTCATCCTGAGGCTGCAGAAGGAGAAG       c.1980
 T  S  N  K  T  T  K  Y  F  N  Q  L  I  L  R  L  Q  K  E  K         p.660

           | 13        .         .         .         .         .    g.53162
 ACCAACATG | ATGACACATCTTTCCAAAATCAACGGTGACATTGCCCAGACCACCCTGGAC    c.2040
 T  N  M   | M  T  H  L  S  K  I  N  G  D  I  A  Q  T  T  L  D      p.680

          .         .         .         .         .         .       g.53222
 ATCACACACACCAGCAGCAGGCTGGACGCACACCAGAAGACCCTGGTGGAGCTGGACCAG       c.2100
 I  T  H  T  S  S  R  L  D  A  H  Q  K  T  L  V  E  L  D  Q         p.700

          .         .         .         .         .         .       g.53282
 GACGTGAAGAAAGTCAACGAGCTCATCACCAACAGCCAGAGCGAGATCTCCCGGCGCACG       c.2160
 D  V  K  K  V  N  E  L  I  T  N  S  Q  S  E  I  S  R  R  T         p.720

          .         .         .         .         .         .       g.53342
 ATCCTGATCGAGAGGAAGCAAGGGCTCATCAACTTCCTCAACAAGCAGCTGGAGCGGATG       c.2220
 I  L  I  E  R  K  Q  G  L  I  N  F  L  N  K  Q  L  E  R  M         p.740

          .      | 14  .         .         .         .         .    g.54416
 GTCTCCGAGCTGGGG | GGGGAAGAAGTGGGGCCCCTGGAGCTTGAAATCAAAAGGCTGAGC    c.2280
 V  S  E  L  G   | G  E  E  V  G  P  L  E  L  E  I  K  R  L  S      p.760

          .         .         .         .         .         .       g.54476
 AAGCTGATCGACGAGCACGATGGCAAGGCGGTCCAGGCCCAGGTGACCTGGCTGCGCCTG       c.2340
 K  L  I  D  E  H  D  G  K  A  V  Q  A  Q  V  T  W  L  R  L         p.780

          .         .         .         .         .         .       g.54536
 CAGCAGGAGATGGTCAAGGTGACACAGGAGCAGGAGGAGCAGCTGGCCTCCCTGGACGCA       c.2400
 Q  Q  E  M  V  K  V  T  Q  E  Q  E  E  Q  L  A  S  L  D  A         p.800

          .         .         .         .          | 15        .    g.55986
 TCCAAGAAGGAGCTCCACATCATGGAGCAGAAGAAACTACGAGTAGAAA | GCAAGATTGAG    c.2460
 S  K  K  E  L  H  I  M  E  Q  K  K  L  R  V  E  S |   K  I  E      p.820

          .         .         .         .         .         .       g.56046
 CAGGAGAAGAAGGAGCAGAAGGAGATCGAGCACCACATGAAGGACCTGGACAACGACCTG       c.2520
 Q  E  K  K  E  Q  K  E  I  E  H  H  M  K  D  L  D  N  D  L         p.840

          .         .         .         .         .         .       g.56106
 AAGAAGCTCAACATGTTGATGAATAAAAACCGGTGCAGCTCGGAGGAGCTGGAGCAGAAC       c.2580
 K  K  L  N  M  L  M  N  K  N  R  C  S  S  E  E  L  E  Q  N         p.860

          .         .         .          | 16        .         .    g.56400
 AACCGGGTGACAGAGAATGAGTTCGTGCGCTCGCTGAAG | GCCTCTGAGAGGGAGACCATC    c.2640
 N  R  V  T  E  N  E  F  V  R  S  L  K   | A  S  E  R  E  T  I      p.880

          .         .         .         .         .         .       g.56460
 AAGATGCAGGACAAGCTGAACCAGCTCAGCGAGGAGAAGGCGACCCTCCTGAATCAACTG       c.2700
 K  M  Q  D  K  L  N  Q  L  S  E  E  K  A  T  L  L  N  Q  L         p.900

          .  | 17      .         .         .         .         .    g.58181
 GTGGAAGCAGA | ACACCAGATTATGCTTTGGGAGAAAAAAATCCAACTGGCAAAAGAGATG    c.2760
 V  E  A  E  |  H  Q  I  M  L  W  E  K  K  I  Q  L  A  K  E  M      p.920

          .         .         .         .         .         .       g.58241
 CGTTCCTCAGTGGATTCCGAGATCGGCCAGACGGAGATCCGGGCCATGAAGGGCGAGATC       c.2820
 R  S  S  V  D  S  E  I  G  Q  T  E  I  R  A  M  K  G  E  I         p.940

          .   | 18     .         .         .         .         .    g.63679
 CACAGGATGAAG | GTCAGGCTCGGGCAGCTGCTGAAGCAGCAGGAGAAGATGATCCGTGCC    c.2880
 H  R  M  K   | V  R  L  G  Q  L  L  K  Q  Q  E  K  M  I  R  A      p.960

          .         .         .         .         .         .       g.63739
 ATGGAGTTGGCGGTTGCCCGCAGAGAGACCGTCACCACCCAGGCCGAGGGGCAGCGCAAG       c.2940
 M  E  L  A  V  A  R  R  E  T  V  T  T  Q  A  E  G  Q  R  K         p.980

          .         .         .         .         .         .       g.63799
 ATGGACAGGAAGGCGCTCACCCGCACCGACTTCCACCACAAGCAGCTTGAGCTGCGCCGG       c.3000
 M  D  R  K  A  L  T  R  T  D  F  H  H  K  Q  L  E  L  R  R         p.1000

          .         .  | 19      .         .         .         .    g.65652
 AAAATCAGGGACGTTCGCAAG | GCCACCGATGAGTGCACCAAAACCGTCCTGGAACTGGAA    c.3060
 K  I  R  D  V  R  K   | A  T  D  E  C  T  K  T  V  L  E  L  E      p.1020

          .         .         .         .         .         .       g.65712
 GAAACACAAAGAAATGTGAGCAGCTCCCTCCTAGAGAAGCAGGAAAAGCTGTCGGTGATT       c.3120
 E  T  Q  R  N  V  S  S  S  L  L  E  K  Q  E  K  L  S  V  I         p.1040

          .         .         .         .         .         .       g.65772
 CAGGCAGACTTCGACACACTCGAGGCCGACCTCACCCGGCTTGGGGCCCTCAAACGACAG       c.3180
 Q  A  D  F  D  T  L  E  A  D  L  T  R  L  G  A  L  K  R  Q         p.1060

  | 20       .         .         .         .         .         .    g.67955
  | AACCTTTCAGAGATCGTGGCCCTGCAGACACGCCTTAAGCACCTGCAGGCTGTGAAGGAG    c.3240
  | N  L  S  E  I  V  A  L  Q  T  R  L  K  H  L  Q  A  V  K  E      p.1080

          .         .         .         .         .         .       g.68015
 GGGCGCTACGTGTTCCTGTTCCGCTCCAAGCAGTCCCTAGTGCTGGAGCGCCAGCGCCTG       c.3300
 G  R  Y  V  F  L  F  R  S  K  Q  S  L  V  L  E  R  Q  R  L         p.1100

          .         .         .         .         .         .       g.68075
 GACAAGCGACTGGCTCTCATCGCCACCATCCTGGACCGCGTGCGGGACGAGTACCCCCAG       c.3360
 D  K  R  L  A  L  I  A  T  I  L  D  R  V  R  D  E  Y  P  Q         p.1120

          .         .         .         .         .         .       g.68135
 TTCCAGGAGGCCCTGCACAAGGTCAGCCAGATGATCGCCAACAAGCTCGAGTCACCAGGG       c.3420
 F  Q  E  A  L  H  K  V  S  Q  M  I  A  N  K  L  E  S  P  G         p.1140

                                                                    g.68144
 CCCTCCTAG                                                          c.3429
 P  S  X                                                            p.1142

          .         .         .         .         .         .       g.68204
 ggagcagcctggactccgccttgcaaggcctccaggaagagatccggaattgtgtttgtc       c.*60

          .         .         .         .         .         .       g.68264
 atgagggacttggaatcttttgtgttcctaaaaaccacatgtaccctcagaagggcatcg       c.*120

          .         .         .         .         .         .       g.68324
 tttaagagaaataagccagccccacccataggaatctttttagccactcagcaatttaat       c.*180

          .         .         .         .         .         .       g.68384
 aaaccaggtaaaatcctagcgtttcccatggcatcccatcgcaaagacagagcctgtgac       c.*240

          .         .         .         .         .         .       g.68444
 tgcagacccacacacccacactcccacactgggcttactcgtccaggtaacactttggtt       c.*300

          .         .         .         .         .         .       g.68504
 tgcagcactcccaaatctgcacgtgcctctcacaacacaacgctgccacaggtccacaag       c.*360

          .         .         .         .         .         .       g.68564
 ctggtgggctgagcagaggtgggaaagttaaggcagctccagccagcctggcccgggagg       c.*420

          .         .         .         .         .         .       g.68624
 ctggtccccccagcacttccctctactaggtgcatctgaaaacccacaaaccaccttctt       c.*480

          .         .         .         .         .         .       g.68684
 taccagttttcccatccccaccccttagaactctcaggtcccttttcctgcccccatgtc       c.*540

          .         .         .         .         .         .       g.68744
 cccatttgagttaaattcagatccacagcttgcaggagaaagtcagtggccccagacaca       c.*600

          .         .         .         .         .         .       g.68804
 cgtaacagggtgagcactgaaataagagcacgctggggcgtccacaccaagggactacgc       c.*660

          .         .         .         .         .         .       g.68864
 cccagtctgcccacctatcttttctccatcattaacccagcgctctttctccctggactt       c.*720

          .         .         .         .         .         .       g.68924
 ccaagtaccaatgaccttggggcttctttgcagtttaaagggaaaatgctctacaaaata       c.*780

          .         .         .         .         .                 g.68982
 atttcactttcaaacatttcagcagaagaataaaatcttttttctgaatatctagtaa         c.*838

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Coiled-coil domain containing 40 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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