cyclin O (CCNO) - coding DNA reference sequence

(used for variant description)

(last modified June 20, 2014)

This file was created to facilitate the description of sequence variants on transcript NM_021147.3 in the CCNO gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000005.9, covering CCNO transcript NM_021147.3.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                               .         .         .                g.5037
                        agtgagaggccgggggtgtggtagagagaaggagccg       c.-121

 .         .         .         .         .         .                g.5097
 gccgggtacttaggaccgcgccagcctctgagcccggcctccttcgcactttcgagtgcg       c.-61

 .         .         .         .         .         .                g.5157
 cgtttgctgcccgccgcagcccgggcgttgaaggtagtaaagcggccacccggccgcatc       c.-1

          .         .         .         .         .         .       g.5217
 ATGGTGACCCCCTGTCCCACCAGCCCCTCGAGCCCCGCCGCCCGAGCGGGGAGGCGGGAC       c.60
 M  V  T  P  C  P  T  S  P  S  S  P  A  A  R  A  G  R  R  D         p.20

          .         .         .         .         .         .       g.5277
 AACGACCAGAACCTTCGCGCCCCGGTGAAGAAGAGCAGGCGTCCGCGCCTCCGGAGGAAG       c.120
 N  D  Q  N  L  R  A  P  V  K  K  S  R  R  P  R  L  R  R  K         p.40

          .         .         .         .         .         .       g.5337
 CAGCCGCTGCATCCCCTGAACCCGTGCCCGCTCCCGGGAGACTCCGGCATTTGCGACCTG       c.180
 Q  P  L  H  P  L  N  P  C  P  L  P  G  D  S  G  I  C  D  L         p.60

          .         .         .         .         .         .       g.5397
 TTCGAGTCCCCCAGCTCCGGCTCAGACGGCGCAGAGAGCCCCTCTGCGGCGCGGGGTGGT       c.240
 F  E  S  P  S  S  G  S  D  G  A  E  S  P  S  A  A  R  G  G         p.80

          .         .         .         .         .         .       g.5457
 AGCCCCCTGCCCGGCCCGGCCCAGCCCGTGGCGCAGCTAGATCTACAGACCTTCCGCGAC       c.300
 S  P  L  P  G  P  A  Q  P  V  A  Q  L  D  L  Q  T  F  R  D         p.100

          .         .         .         .         .         .       g.5517
 TACGGCCAGAGCTGCTACGCCTTCCGCAAGGCGCAGGAGAGCCACTTCCACCCGCGGGAG       c.360
 Y  G  Q  S  C  Y  A  F  R  K  A  Q  E  S  H  F  H  P  R  E         p.120

          .         .  | 02      .         .         .         .    g.6173
 GCGCTGGCACGGCAGCCACAA | GTGACGGCGGAATCCCGCTGTAAGCTGCTCAGCTGGCTG    c.420
 A  L  A  R  Q  P  Q   | V  T  A  E  S  R  C  K  L  L  S  W  L      p.140

          .         .         .         .         .         .       g.6233
 ATCCCGGTGCACCGCCAATTCGGCCTCTCCTTCGAGTCGCTGTGCCTGACGGTGAACACT       c.480
 I  P  V  H  R  Q  F  G  L  S  F  E  S  L  C  L  T  V  N  T         p.160

          .         .         .         .         .         .       g.6293
 CTGGACCGCTTCCTCACCACCACGCCGGTGGCTGCAGACTGCTTCCAGCTGCTTGGGGTC       c.540
 L  D  R  F  L  T  T  T  P  V  A  A  D  C  F  Q  L  L  G  V         p.180

          .         .        | 03.         .         .         .    g.6853
 ACCTCCTTGCTCATCGCTTGCAAACAG | GTGGAGGTGCACCCGCCGCGCGTGAAGCAGCTT    c.600
 T  S  L  L  I  A  C  K  Q   | V  E  V  H  P  P  R  V  K  Q  L      p.200

          .         .         .         .         .         .       g.6913
 CTGGCCCTCTGCTGCGGCGCCTTCTCCCGGCAGCAGCTCTGCAACCTCGAGTGCATCGTG       c.660
 L  A  L  C  C  G  A  F  S  R  Q  Q  L  C  N  L  E  C  I  V         p.220

          .         .         .         .         .         .       g.6973
 CTGCACAAGCTGCACTTCACCCTGGGTGCGCCCACCATTAGCTTCTTCCTGGAGCATTTC       c.720
 L  H  K  L  H  F  T  L  G  A  P  T  I  S  F  F  L  E  H  F         p.240

          .         .         .         .         .         .       g.7033
 ACGCACGCTCGCGTGGAGGCGGGGCAGGCTGAGGCCTCCGAAGCTCTGGAAGCGCAAGCC       c.780
 T  H  A  R  V  E  A  G  Q  A  E  A  S  E  A  L  E  A  Q  A         p.260

          .         .         .         .         .         .       g.7093
 CTGGCGCGGGGGGTGGCAGAGCTGAGTCTGGCCGACTATGCCTTCACCAGCTACTCCCCT       c.840
 L  A  R  G  V  A  E  L  S  L  A  D  Y  A  F  T  S  Y  S  P         p.280

          .         .         .         .         .         .       g.7153
 TCCCTCCTGGCGATCTGCTGCCTGGCGCTGGCGGACCGCATGCTGCGGGTCTCGCGGCCC       c.900
 S  L  L  A  I  C  C  L  A  L  A  D  R  M  L  R  V  S  R  P         p.300

          .         .         .         .         .         .       g.7213
 GTGGACTTGCGACTGGGAGACCACCCGGAGGCGGCGCTGGAGGACTGTATGGGCAAGTTG       c.960
 V  D  L  R  L  G  D  H  P  E  A  A  L  E  D  C  M  G  K  L         p.320

          .         .         .         .         .         .       g.7273
 CAGCTGCTGGTGGCCATAAACAGTACTTCCTTGACTCACATGCTGCCCGTTCAGATCTGC       c.1020
 Q  L  L  V  A  I  N  S  T  S  L  T  H  M  L  P  V  Q  I  C         p.340

          .         .         .                                     g.7306
 GAGAAGTGCAGCCTGCCCCCGAGCTCGAAATAA                                  c.1053
 E  K  C  S  L  P  P  S  S  K  X                                    p.350

          .         .         .         .         .         .       g.7366
 aacagatccttcgtttccttttagtccctggcccggctgctggacctctcccgtagcctc       c.*60

          .         .         .         .         .         .       g.7426
 agaagagtgcagtactggtccacagagaaggcttcaggacctgcttggtcagctgcaggt       c.*120

          .         .         .         .         .         .       g.7486
 tgtaaatagtgtacgatactagcatctggtattttatttattttgcagcgagcacatgag       c.*180

          .         .         .         .                           g.7529
 gaagctgagtctttcaccaataaacagttgtggtttgtctaaa                        c.*223

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Cyclin O protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.