CD2-associated protein (CD2AP) - coding DNA reference sequence

(used for variant description)

(last modified August 8, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_012120.2 in the CD2AP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering CD2AP transcript NM_012120.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5036
                         ctctgtctgggtccccaccttagtctacggtgtcgc       c.-421

 .         .         .         .         .         .                g.5096
 cttttctaactgcgagtgctaaggaagaggcgaggggcgggctccgaggctaggcgggcg       c.-361

 .         .         .         .         .         .                g.5156
 ctcggggttggagccgagggtctgggcaaaccggtgggtccctccccactgcgggagcgg       c.-301

 .         .         .         .         .         .                g.5216
 ccagggtgggaaaaccgcggtcgggcgggcggggtagggccctcccgccgccgtggctcc       c.-241

 .         .         .         .         .         .                g.5276
 tggggaggccaggggtgaggagctgtcgccgcctttgcctctgcctcgagggccgcgctg       c.-181

 .         .         .         .         .         .                g.5336
 aagagactggtaggagagcgccgcgggcggatggaggcgactcttcgccccgcctgagct       c.-121

 .         .         .         .         .         .                g.5396
 caggaggggctagcgcggagcgcgggtcccgcctccagccgcgggagcggccgcgcgagc       c.-61

 .         .         .         .         .         .                g.5456
 caccactggaggaggaggaggaggagcggacgtcggcttctccccgcgggagcccccagc       c.-1

      | 02   .         .         .         .         .         .    g.30547
 ATGG | TTGACTATATTGTGGAGTATGACTATGATGCTGTACATGATGATGAATTAACTATT    c.60
 M  V |   D  Y  I  V  E  Y  D  Y  D  A  V  H  D  D  E  L  T  I      p.20

          .         .         .         .         .         .       g.30607
 CGAGTTGGAGAAATCATCAGGAATGTGAAAAAGCTACAGGAGGAAGGGTGGCTGGAAGGA       c.120
 R  V  G  E  I  I  R  N  V  K  K  L  Q  E  E  G  W  L  E  G         p.40

          .         .         .         .      | 03  .         .    g.60828
 GAACTAAATGGGAGAAGAGGAATGTTCCCTGACAATTTCGTTAAG | GAAATTAAAAGAGAG    c.180
 E  L  N  G  R  R  G  M  F  P  D  N  F  V  K   | E  I  K  R  E      p.60

          .         .         .         .         .         .       g.60888
 ACGGAATTCAAGGATGACAGTTTGCCCATCAAACGGGAAAGGCATGGGAATGTAGCAAGT       c.240
 T  E  F  K  D  D  S  L  P  I  K  R  E  R  H  G  N  V  A  S         p.80

          .         .         .         .         .         .       g.60948
 CTTGTACAACGAATAAGCACCTATGGACTTCCAGCTGGAGGAATTCAGCCACATCCACAA       c.300
 L  V  Q  R  I  S  T  Y  G  L  P  A  G  G  I  Q  P  H  P  Q         p.100

          .          | 04        .         .         .         .    g.71858
 ACCAAAAACATTAAGAAGA | AGACCAAGAAGCGTCAGTGTAAAGTTCTTTTTGAGTACATT    c.360
 T  K  N  I  K  K  K |   T  K  K  R  Q  C  K  V  L  F  E  Y  I      p.120

          .         .         .         .         .         .       g.71918
 CCACAAAATGAGGATGAACTGGAGCTGAAAGTGGGAGATATTATTGATATTAATGAAGAG       c.420
 P  Q  N  E  D  E  L  E  L  K  V  G  D  I  I  D  I  N  E  E         p.140

  | 05       .         .         .         .         .         .    g.81917
  | GTAGAAGAAGGCTGGTGGAGTGGAACCCTGAATAACAAGTTGGGACTGTTTCCCTCAAAT    c.480
  | V  E  E  G  W  W  S  G  T  L  N  N  K  L  G  L  F  P  S  N      p.160

          .         .         .         .         .         .       g.81977
 TTTGTGAAAGAATTAGAGGTAACAGATGATGGTGAAACTCATGAAGCCCAGGACGATTCA       c.540
 F  V  K  E  L  E  V  T  D  D  G  E  T  H  E  A  Q  D  D  S         p.180

   | 06      .         .         .         .         .         .    g.101334
 G | AAACTGTTTTGGCTGGGCCTACTTCACCTATACCTTCTCTGGGAAATGTGAGTGAAACT    c.600
 E |   T  V  L  A  G  P  T  S  P  I  P  S  L  G  N  V  S  E  T      p.200

          .         .         .         .         .         .       g.101394
 GCATCTGGATCAGTTACACAGCCAAAGAAAATTCGAGGAATTGGATTTGGAGACATTTTT       c.660
 A  S  G  S  V  T  Q  P  K  K  I  R  G  I  G  F  G  D  I  F         p.220

          .         .         .         .         .         .       g.101454
 AAAGAAGGCTCTGTGAAACTTCGGACAAGAACATCCAGTAGTGAAACAGAAGAGAAAAAA       c.720
 K  E  G  S  V  K  L  R  T  R  T  S  S  S  E  T  E  E  K  K         p.240

           | 07        .         .         .         .         .    g.103786
 CCAGAAAAG | CCCTTAATCCTACAGTCACTGGGACCCAAAACTCAGAGTGTGGAGATAACA    c.780
 P  E  K   | P  L  I  L  Q  S  L  G  P  K  T  Q  S  V  E  I  T      p.260

          .         .         | 08         .         .         .    g.104252
 AAAACAGATACCGAAGGTAAAATTAAAG | CTAAAGAATATTGTAGAACATTATTTGCCTAT    c.840
 K  T  D  T  E  G  K  I  K  A |   K  E  Y  C  R  T  L  F  A  Y      p.280

          .         .         .         .         .         .       g.104312
 GAAGGTACTAATGAAGATGAACTTACTTTTAAAGAGGGGGAGATAATCCATTTGATAAGT       c.900
 E  G  T  N  E  D  E  L  T  F  K  E  G  E  I  I  H  L  I  S         p.300

     | 09    .         .         .         .         .         .    g.106653
 AAG | GAGACTGGAGAAGCTGGCTGGTGGAGGGGCGAACTTAATGGTAAAGAAGGAGTATTT    c.960
 K   | E  T  G  E  A  G  W  W  R  G  E  L  N  G  K  E  G  V  F      p.320

          .         .         .         .         | 10         .    g.108087
 CCAGACAATTTTGCTGTCCAGATAAATGAACTTGATAAAGACTTTCCA | AAACCAAAGAAA    c.1020
 P  D  N  F  A  V  Q  I  N  E  L  D  K  D  F  P   | K  P  K  K      p.340

          .         .      | 11  .         .         .         .    g.109249
 CCACCACCTCCTGCTAAGGCTCCAG | CTCCAAAGCCTGAACTGATAGCTGCAGAGAAGAAA    c.1080
 P  P  P  P  A  K  A  P  A |   P  K  P  E  L  I  A  A  E  K  K      p.360

          .         .         | 12         .         .         .    g.123104
 TATTTTTCTTTAAAGCCTGAAGAAAAGG | ATGAAAAATCAACACTGGAACAGAAACCTTCT    c.1140
 Y  F  S  L  K  P  E  E  K  D |   E  K  S  T  L  E  Q  K  P  S      p.380

          .         .         .         .         .         .       g.123164
 AAACCAGCAGCTCCACAAGTCCCACCCAAGAAACCTACTCCACCTACCAAAGCCAGTAAT       c.1200
 K  P  A  A  P  Q  V  P  P  K  K  P  T  P  P  T  K  A  S  N         p.400

          .         .         .         .         .         .       g.123224
 TTACTGAGATCTTCTGGAACAGTGTACCCAAAGCGACCTGAAAAACCAGTTCCTCCACCA       c.1260
 L  L  R  S  S  G  T  V  Y  P  K  R  P  E  K  P  V  P  P  P         p.420

          .     | 13   .         .         .         .         .    g.126558
 CCTCCTATAGCCAA | GATTAATGGGGAAGTTTCTAGCATTTCATCAAAATTTGAAACTGAG    c.1320
 P  P  I  A  K  |  I  N  G  E  V  S  S  I  S  S  K  F  E  T  E      p.440

          .         .         .         .         .         .       g.126618
 CCAGTATCAAAACTAAAGCTAGATTCTGAACAGCTGCCCCTTAGACCAAAATCAGTAGAC       c.1380
 P  V  S  K  L  K  L  D  S  E  Q  L  P  L  R  P  K  S  V  D         p.460

          .         .         .        | 14.         .         .    g.133399
 TTTGATTCACTTACAGTAAGGACCTCCAAAGAAACAG | ATGTTGTAAATTTTGATGACATA    c.1440
 F  D  S  L  T  V  R  T  S  K  E  T  D |   V  V  N  F  D  D  I      p.480

          .         .         .         .         .         .       g.133459
 GCTTCCTCAGAAAACTTGCTTCATCTCACTGCAAATAGACCAAAGATGCCTGGAAGAAGG       c.1500
 A  S  S  E  N  L  L  H  L  T  A  N  R  P  K  M  P  G  R  R         p.500

          .         .         . | 15       .         .         .    g.135168
 TTGCCGGGCCGTTTCAATGGTGGACATTCT | CCAACTCACAGCCCCGAAAAAATCTTGAAG    c.1560
 L  P  G  R  F  N  G  G  H  S   | P  T  H  S  P  E  K  I  L  K      p.520

          .         .         .         .         .         .       g.135228
 TTACCAAAAGAAGAAGACAGTGCCAACCTGAAGCCATCTGAATTAAAAAAAGATACATGC       c.1620
 L  P  K  E  E  D  S  A  N  L  K  P  S  E  L  K  K  D  T  C         p.540

          .   | 16     .         .         .         .         .    g.136382
 TACTCTCCAAAG | CCATCTGTGTACCTTTCAACACCTTCCAGTGCTTCTAAAGCAAATACA    c.1680
 Y  S  P  K   | P  S  V  Y  L  S  T  P  S  S  A  S  K  A  N  T      p.560

          .         .         .         .         .         .       g.136442
 ACTGCTTTCCTGACTCCATTAGAAATCAAAGCTAAAGTGGAAACAGATGATGTGAAAAAA       c.1740
 T  A  F  L  T  P  L  E  I  K  A  K  V  E  T  D  D  V  K  K         p.580

          .         .         .         .         .         .       g.136502
 AATTCCCTGGATGAACTTAGAGCCCAGATTATTGAATTGTTGTGCATTGTAGAAGCACTG       c.1800
 N  S  L  D  E  L  R  A  Q  I  I  E  L  L  C  I  V  E  A  L         p.600

          .     | 17   .         .         .         .         .    g.139730
 AAAAAGGATCACGG | GAAAGAACTGGAAAAACTGCGAAAAGATTTGGAAGAAGAGAAGACA    c.1860
 K  K  D  H  G  |  K  E  L  E  K  L  R  K  D  L  E  E  E  K  T      p.620

          .         | 18         .         .         .         .    g.151439
 ATGAGAAGTAATCTAGAG | ATGGAAATAGAGAAGCTGAAAAAAGCTGTCCTGTCTTCTTGA    c.1920
 M  R  S  N  L  E   | M  E  I  E  K  L  K  K  A  V  L  S  S  X      p.639

          .         .         .         .         .         .       g.151499
 gtggtgtggacctggtgttcataatgttccagggattcagaagcaacgctatgaacttca       c.*60

          .         .         .         .         .         .       g.151559
 gctgacttgttacttaaaaattgtgaattctgttgttgtgataaatatgagcaaatgaag       c.*120

          .         .         .         .         .         .       g.151619
 tgtaatatctatagaaaagtagagtgagggtgaatttatatatatattttgttttgccaa       c.*180

          .         .         .         .         .         .       g.151679
 tatgaagaaaaagaggccttatttcttaactgtgctgggattgcaaacactttttaaaaa       c.*240

          .         .         .         .         .         .       g.151739
 attgtttgcttgaaaatactactgaatataaataagaatgtgcacagtagtttttttatt       c.*300

          .         .         .         .         .         .       g.151799
 gaaacttgtattatttttaaagagatctatactataaatatggtgatatatttacaagta       c.*360

          .         .         .         .         .         .       g.151859
 atctgttaagatatactatttgagagggacagattagccttttagtaactatagtcacta       c.*420

          .         .         .         .         .         .       g.151919
 ctttttccataatgcataagggatataaactctgtgtgtgtgtgtgtgtgtgtgtgtgtg       c.*480

          .         .         .         .         .         .       g.151979
 tgtgtgtgtgtgtgtatatatatatatatatttttacttttatcctcttaccgaaggtta       c.*540

          .         .         .         .         .         .       g.152039
 cactgttgtgcctgtttgtctgcaatgctgtttatattttgggtgatgaaataggagttt       c.*600

          .         .         .         .         .         .       g.152099
 cctagctatataaaccagattactcacccatgcatatagtaagaactaatgaataatcaa       c.*660

          .         .         .         .         .         .       g.152159
 aataatttcatcaacttttagaatattttatgttgcttgcactataggagtcataaaagg       c.*720

          .         .         .         .         .         .       g.152219
 aacttagttaaaatatgttggattgttaaacatttggggaaatatgaactgtattttaaa       c.*780

          .         .         .         .         .         .       g.152279
 tttgttaggtctgaagaatctaaaactgttaatttaacccttaacttgtgcctagaaact       c.*840

          .         .         .         .         .         .       g.152339
 acagcacatataaaatatgtaaacaccagcctgttgctgtacttttctgcttattttaca       c.*900

          .         .         .         .         .         .       g.152399
 gcctcaaatatttctcattatcttgtcacttagttcttcatgtttctccttctgactttt       c.*960

          .         .         .         .         .         .       g.152459
 aataatggtaataggaaaacaaaacccaaagcttttcagaacttcagtgtgaggtttcct       c.*1020

          .         .         .         .         .         .       g.152519
 attttgacaagttaacttgtaaatactcaggttttacgatgtataatttacctaatagac       c.*1080

          .         .         .         .         .         .       g.152579
 caaactaactcatggagatattttgaactattatttaggtacaaactttataaagaatgt       c.*1140

          .         .         .         .         .         .       g.152639
 tagtatgtcataaaatataacattacagcttatttaaaaccaaatatagttgaacatatt       c.*1200

          .         .         .         .         .         .       g.152699
 taaaatacattttcacagaatggatgaattagttgtttcttcagagttacttatgaacag       c.*1260

          .         .         .         .         .         .       g.152759
 ttgaatgctttaaaatgttctgtctgtaggtaacatctaaaacacaagtgggtttattta       c.*1320

          .         .         .         .         .         .       g.152819
 aatttttaaaatttgaaattttttatttgcaaaaaattgttttatgctttattatatcgc       c.*1380

          .         .         .         .         .         .       g.152879
 aaatgagtgtcagatttttgagtaccaatgatcatgcttccattttttttagttttaaac       c.*1440

          .         .         .         .         .         .       g.152939
 caccaaaccaatatttttcctttaaattttaatcttataatatagaaatcttatgtaaat       c.*1500

          .         .         .         .         .         .       g.152999
 gaaattttgtcatgtttcaaataaagagaactgaagtagaaaatagaaatgccagtaaac       c.*1560

          .         .         .         .         .         .       g.153059
 aacataatgtttaatttacaacttacattaggggtttgggggaatgctaattatatattg       c.*1620

          .         .         .         .         .         .       g.153119
 agaatatacattagaactcttcaaaatgggctcttctaatgaggtcactactgaacaaaa       c.*1680

          .         .         .         .         .         .       g.153179
 ttgttccctcttctgttaaatagaataggtttaaatgactagtcaaatgaattattttct       c.*1740

          .         .         .         .         .         .       g.153239
 tcttgttaaataaattaaatcttactttcttttaatgaccaaccttaggtaaaacaaaaa       c.*1800

          .         .         .         .         .         .       g.153299
 tattgtaatcctagaaattatcctccagctttctcacctgaaaatctattgaagtgatcc       c.*1860

          .         .         .         .         .         .       g.153359
 ctggtcatcctaataatgggatgagggaagtttccagcagatttcaggctgttcttaaag       c.*1920

          .         .         .         .         .         .       g.153419
 tttttgttggtcattttctcaatagtacatgaaatcaagatgcttatgagcatggaaatg       c.*1980

          .         .         .         .         .         .       g.153479
 tatttaaagtttttgcttgtgtcctcctcagtcagaatagaaaagtaactgaaatacttt       c.*2040

          .         .         .         .         .         .       g.153539
 tacctttctgtccttgataaaatagtaaagaaaaccaaacaaacccaggcctgatgggaa       c.*2100

          .         .         .         .         .         .       g.153599
 aaatgattcctttattctagcaacttactttctgttggtatgggaaatgttattaatttc       c.*2160

          .         .         .         .         .         .       g.153659
 tattactaaagttcatatcacaaaatgatatttaataataaccttggggtaaatcatgaa       c.*2220

          .         .         .         .         .         .       g.153719
 ttttttttctacgtgtgagtataaaagacaaaagttgaacagcatggaatctcattgcca       c.*2280

          .         .         .         .         .         .       g.153779
 aattattagtgaatgtatagttcaggtattctttgagacacacagtatcattaatttctg       c.*2340

          .         .         .         .         .         .       g.153839
 aattgtatttcagtgttattttttgtttgtgaccactaagcttctgtcttaatacaaagc       c.*2400

          .         .         .         .         .         .       g.153899
 tgttaccttctacagaatttaagtctgaagatgtaaagagagaacaggccttgtgtaaca       c.*2460

          .         .         .         .         .         .       g.153959
 gaagatactcttttttatgctccttactgtgatcacagaaaaattaaaaatccaagtgct       c.*2520

          .         .         .         .         .         .       g.154019
 ctctagatttgttgataaacattttatgcttgcatttaaacttgaaatgtatgagcagaa       c.*2580

          .         .         .         .         .         .       g.154079
 tgagacaatcagttaaatcagaaatgagaagtattataatgtaaaggccttgttttgctg       c.*2640

          .         .         .         .         .         .       g.154139
 tagcaataaaatgaccaagtgcaatgacttgatttaataaaatcatattttaaaagttgc       c.*2700

          .         .         .         .         .         .       g.154199
 tgctatgaatatttttggctataaaattttaccctgacttgctttcaataactgttacgt       c.*2760

          .         .         .         .         .         .       g.154259
 aatgcagttgatgttgtaacctaacattccaaaaaaaaaattgagagggggaatctcaaa       c.*2820

          .         .         .         .         .         .       g.154319
 atagtatatacttcactaacttgtttacaggtgctgtatttaaaagcatgcttctctctc       c.*2880

          .         .         .         .         .         .       g.154379
 aaaaagaaaaattaaaggattttattgccagtcgtgtcagtctttattggttattttttg       c.*2940

          .         .         .         .         .         .       g.154439
 ttaactttagcatttgtgtatttcagagtatgatgaaaattatattacttcaatttccaa       c.*3000

          .         .         .                                     g.154475
 atacaagaataaatagtaaaccaaaaacattaaaaa                               c.*3036

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The CD2-associated protein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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