CD40 ligand (CD40LG) - coding DNA reference sequence

(used for variant description)

(last modified July 27, 2015)

This file was created to facilitate the description of sequence variants on transcript NM_000074.2 in the CD40LG gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_007280.1, covering CD40LG transcript NM_000074.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                   .                g.5012
                                                 actttgacagtc       c.-61

 .         .         .         .         .         .                g.5072
 ttctcatgctgcctctgccaccttctctgccagaagataccatttcaactttaacacagc       c.-1

          .         .         .         .         .         .       g.5132
 ATGATCGAAACATACAACCAAACTTCTCCCCGATCTGCGGCCACTGGACTGCCCATCAGC       c.60
 M  I  E  T  Y  N  Q  T  S  P  R  S  A  A  T  G  L  P  I  S         p.20

          .         .         .         .         .         .       g.5192
 ATGAAAATTTTTATGTATTTACTTACTGTTTTTCTTATCACCCAGATGATTGGGTCAGCA       c.120
 M  K  I  F  M  Y  L  L  T  V  F  L  I  T  Q  M  I  G  S  A         p.40

          .         .         .       | 02 .         .         .    g.7113
 CTTTTTGCTGTGTATCTTCATAGAAGGTTGGACAAG | ATAGAAGATGAAAGGAATCTTCAT    c.180
 L  F  A  V  Y  L  H  R  R  L  D  K   | I  E  D  E  R  N  L  H      p.60

          .         .         .         .         .         .       g.7173
 GAAGATTTTGTATTCATGAAAACGATACAGAGATGCAACACAGGAGAAAGATCCTTATCC       c.240
 E  D  F  V  F  M  K  T  I  Q  R  C  N  T  G  E  R  S  L  S         p.80

          .         .         .         .         | 03         .    g.11208
 TTACTGAACTGTGAGGAGATTAAAAGCCAGTTTGAAGGCTTTGTGAAG | GATATAATGTTA    c.300
 L  L  N  C  E  E  I  K  S  Q  F  E  G  F  V  K   | D  I  M  L      p.100

          .         .         .         .       | 04 .         .    g.13193
 AACAAAGAGGAGACGAAGAAAGAAAACAGCTTTGAAATGCAAAAAG | GTGATCAGAATCCT    c.360
 N  K  E  E  T  K  K  E  N  S  F  E  M  Q  K  G |   D  Q  N  P      p.120

          .         .         .         .          | 05        .    g.15873
 CAAATTGCGGCACATGTCATAAGTGAGGCCAGCAGTAAAACAACATCTG | TGTTACAGTGG    c.420
 Q  I  A  A  H  V  I  S  E  A  S  S  K  T  T  S  V |   L  Q  W      p.140

          .         .         .         .         .         .       g.15933
 GCTGAAAAAGGATACTACACCATGAGCAACAACTTGGTAACCCTGGAAAATGGGAAACAG       c.480
 A  E  K  G  Y  Y  T  M  S  N  N  L  V  T  L  E  N  G  K  Q         p.160

          .         .         .         .         .         .       g.15993
 CTGACCGTTAAAAGACAAGGACTCTATTATATCTATGCCCAAGTCACCTTCTGTTCCAAT       c.540
 L  T  V  K  R  Q  G  L  Y  Y  I  Y  A  Q  V  T  F  C  S  N         p.180

          .         .         .         .         .         .       g.16053
 CGGGAAGCTTCGAGTCAAGCTCCATTTATAGCCAGCCTCTGCCTAAAGTCCCCCGGTAGA       c.600
 R  E  A  S  S  Q  A  P  F  I  A  S  L  C  L  K  S  P  G  R         p.200

          .         .         .         .         .         .       g.16113
 TTCGAGAGAATCTTACTCAGAGCTGCAAATACCCACAGTTCCGCCAAACCTTGCGGGCAA       c.660
 F  E  R  I  L  L  R  A  A  N  T  H  S  S  A  K  P  C  G  Q         p.220

          .         .         .         .         .         .       g.16173
 CAATCCATTCACTTGGGAGGAGTATTTGAATTGCAACCAGGTGCTTCGGTGTTTGTCAAT       c.720
 Q  S  I  H  L  G  G  V  F  E  L  Q  P  G  A  S  V  F  V  N         p.240

          .         .         .         .         .         .       g.16233
 GTGACTGATCCAAGCCAAGTGAGCCATGGCACTGGCTTCACGTCCTTTGGCTTACTCAAA       c.780
 V  T  D  P  S  Q  V  S  H  G  T  G  F  T  S  F  G  L  L  K         p.260

                                                                    g.16239
 CTCTGA                                                             c.786
 L  X                                                               p.261

          .         .         .         .         .         .       g.16299
 acagtgtcaccttgcaggctgtggtggagctgacgctgggagtcttcataatacagcaca       c.*60

          .         .         .         .         .         .       g.16359
 gcggttaagcccaccccctgttaactgcctatttataaccctaggatcctccttatggag       c.*120

          .         .         .         .         .         .       g.16419
 aactatttattatacactccaaggcatgtagaactgtaataagtgaattacaggtcacat       c.*180

          .         .         .         .         .         .       g.16479
 gaaaccaaaacgggccctgctccataagagcttatatatctgaagcagcaaccccactga       c.*240

          .         .         .         .         .         .       g.16539
 tgcagacatccagagagtcctatgaaaagacaaggccattatgcacaggttgaattctga       c.*300

          .         .         .         .         .         .       g.16599
 gtaaacagcagataacttgccaagttcagttttgtttctttgcgtgcagtgtctttccat       c.*360

          .         .         .         .         .         .       g.16659
 ggataatgcatttgatttatcagtgaagatgcagaagggaaatggggagcctcagctcac       c.*420

          .         .         .         .         .         .       g.16719
 attcagttatggttgactctgggttcctatggccttgttggagggggccaggctctagaa       c.*480

          .         .         .         .         .         .       g.16779
 cgtctaacacagtggagaaccgaaaccccccccccccccccgccaccctctcggacagtt       c.*540

          .         .         .         .         .         .       g.16839
 attcattctctttcaatctctctctctccatctctctctttcagtctctctctctcaacc       c.*600

          .         .         .         .         .         .       g.16899
 tctttcttccaatctctctttctcaatctctctgtttccctttgtcagtctcttccctcc       c.*660

          .         .         .         .         .         .       g.16959
 cccagtctctcttctcaatccccctttctaacacacacacacacacacacacacacacac       c.*720

          .         .         .         .         .         .       g.17019
 acacacacacacacacacacacagagtcaggccgttgctagtcagttctcttctttccac       c.*780

          .         .         .         .         .         .       g.17079
 cctgtccctatctctaccactatagatgagggtgaggagtagggagtgcagccctgagcc       c.*840

          .         .         .         .         .         .       g.17139
 tgcccactcctcattacgaaatgactgtatttaaaggaaatctattgtatctacctgcag       c.*900

          .         .         .         .         .         .       g.17199
 tctccattgtttccagagtgaacttgtaattatcttgttatttattttttgaataataaa       c.*960

          .                                                         g.17214
 gacctcttaacatta                                                    c.*975

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The CD40 ligand protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.