cell division cycle 20 (CDC20) - coding DNA reference sequence

(used for variant description)

(last modified October 29, 2020)

This file was created to facilitate the description of sequence variants on transcript NM_001255.2 in the CDC20 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000001.10, covering CDC20 transcript NM_001255.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                     .         .         .         .                g.5041
                    gaggcgtaagccaggcgtgttaaagccggtcggaactgctc       c.-61

 .         . | 02       .         .         .         .             g.5261
 cggagggcacg | ggctccgtaggcaccaactgcaaggacccctccccctgcgggcgctccc    c.-1

          .         .         .         .         .         .       g.5321
 ATGGCACAGTTCGCGTTCGAGAGTGACCTGCACTCGCTGCTTCAGCTGGATGCACCCATC       c.60
 M  A  Q  F  A  F  E  S  D  L  H  S  L  L  Q  L  D  A  P  I         p.20

          .         .         .         .         .         .       g.5381
 CCCAATGCACCCCCTGCGCGCTGGCAGCGCAAAGCCAAGGAAGCCGCAGGCCCGGCCCCC       c.120
 P  N  A  P  P  A  R  W  Q  R  K  A  K  E  A  A  G  P  A  P         p.40

          .         .         .         .         .         .       g.5441
 TCACCCATGCGGGCCGCCAACCGATCCCACAGCGCCGGCAGGACTCCGGGCCGAACTCCT       c.180
 S  P  M  R  A  A  N  R  S  H  S  A  G  R  T  P  G  R  T  P         p.60

   | 03      .         .         .         .         .         .    g.5594
 G | GCAAATCCAGTTCCAAGGTTCAGACCACTCCTAGCAAACCTGGCGGTGACCGCTATATC    c.240
 G |   K  S  S  S  K  V  Q  T  T  P  S  K  P  G  G  D  R  Y  I      p.80

          .         .         .         .         .         .       g.5654
 CCCCATCGCAGTGCTGCCCAGATGGAGGTGGCCAGCTTCCTCCTGAGCAAGGAGAACCAG       c.300
 P  H  R  S  A  A  Q  M  E  V  A  S  F  L  L  S  K  E  N  Q         p.100

          .         .         . | 04       .         .         .    g.5800
 CCTGAAAACAGCCAGACGCCCACCAAGAAG | GAACATCAGAAAGCCTGGGCTTTGAACCTG    c.360
 P  E  N  S  Q  T  P  T  K  K   | E  H  Q  K  A  W  A  L  N  L      p.120

          .         .         .         .         .         .       g.5860
 AACGGTTTTGATGTAGAGGAAGCCAAGATCCTTCGGCTCAGTGGAAAACCACAAAATGCG       c.420
 N  G  F  D  V  E  E  A  K  I  L  R  L  S  G  K  P  Q  N  A         p.140

         | 05.         .         .         .         .         .    g.6067
 CCAGAGG | GTTATCAGAACAGACTGAAAGTACTCTACAGCCAAAAGGCCACTCCTGGCTCC    c.480
 P  E  G |   Y  Q  N  R  L  K  V  L  Y  S  Q  K  A  T  P  G  S      p.160

          .         .         .         .         .         .       g.6127
 AGCCGGAAGACCTGCCGTTACATTCCTTCCCTGCCAGACCGTATCCTGGATGCGCCTGAA       c.540
 S  R  K  T  C  R  Y  I  P  S  L  P  D  R  I  L  D  A  P  E         p.180

          .       | 06 .         .         .         .         .    g.6282
 ATCCGAAATGACTATT | ACCTGAACCTTGTGGATTGGAGTTCTGGGAATGTACTGGCCGTG    c.600
 I  R  N  D  Y  Y |   L  N  L  V  D  W  S  S  G  N  V  L  A  V      p.200

          .         .         .         .         .         .       g.6342
 GCACTGGACAACAGTGTGTACCTGTGGAGTGCAAGCTCTGGTGACATCCTGCAGCTTTTG       c.660
 A  L  D  N  S  V  Y  L  W  S  A  S  S  G  D  I  L  Q  L  L         p.220

          .         .         .         .         .         .       g.6402
 CAAATGGAGCAGCCTGGGGAATATATATCCTCTGTGGCCTGGATCAAAGAGGGCAACTAC       c.720
 Q  M  E  Q  P  G  E  Y  I  S  S  V  A  W  I  K  E  G  N  Y         p.240

          .         .         .    | 07    .         .         .    g.6571
 TTGGCTGTGGGCACCAGCAGTGCTGAGGTGCAG | CTATGGGATGTGCAGCAGCAGAAACGG    c.780
 L  A  V  G  T  S  S  A  E  V  Q   | L  W  D  V  Q  Q  Q  K  R      p.260

          .         .         .         .         .         .       g.6631
 CTTCGAAATATGACCAGTCACTCTGCCCGAGTGGGCTCCCTAAGCTGGAACAGCTATATC       c.840
 L  R  N  M  T  S  H  S  A  R  V  G  S  L  S  W  N  S  Y  I         p.280

          | 08         .         .         .         .         .    g.6830
 CTGTCCAG | TGGTTCACGTTCTGGCCACATCCACCACCATGATGTTCGGGTAGCAGAACAC    c.900
 L  S  S  |  G  S  R  S  G  H  I  H  H  H  D  V  R  V  A  E  H      p.300

          .         .         .         .         .         .       g.6890
 CATGTGGCCACACTGAGTGGCCACAGCCAGGAAGTGTGTGGGCTGCGCTGGGCCCCAGAT       c.960
 H  V  A  T  L  S  G  H  S  Q  E  V  C  G  L  R  W  A  P  D         p.320

          .         .         .         .         .         .       g.6950
 GGACGACATTTGGCCAGTGGTGGTAATGATAACTTGGTCAATGTGTGGCCTAGTGCTCCT       c.1020
 G  R  H  L  A  S  G  G  N  D  N  L  V  N  V  W  P  S  A  P         p.340

          .         .         .         .         .        | 09.    g.7168
 GGAGAGGGTGGCTGGGTTCCTCTGCAGACATTCACCCAGCATCAAGGGGCTGTCAAG | GCC    c.1080
 G  E  G  G  W  V  P  L  Q  T  F  T  Q  H  Q  G  A  V  K   | A      p.360

          .         .         .         .         .         .       g.7228
 GTAGCATGGTGTCCCTGGCAGTCCAATGTCCTGGCAACAGGAGGGGGCACCAGTGATCGA       c.1140
 V  A  W  C  P  W  Q  S  N  V  L  A  T  G  G  G  T  S  D  R         p.380

          .         .         .         .         .         .       g.7288
 CACATTCGCATCTGGAATGTGTGCTCTGGGGCCTGTCTGAGTGCCGTGGATGCCCATTCC       c.1200
 H  I  R  I  W  N  V  C  S  G  A  C  L  S  A  V  D  A  H  S         p.400

     | 10    .         .         .         .         .         .    g.8297
 CAG | GTGTGCTCCATCCTCTGGTCTCCCCATTACAAGGAGCTCATCTCAGGCCATGGCTTT    c.1260
 Q   | V  C  S  I  L  W  S  P  H  Y  K  E  L  I  S  G  H  G  F      p.420

          .         .         .         .         .         .       g.8357
 GCACAGAACCAGCTAGTTATTTGGAAGTACCCAACCATGGCCAAGGTGGCTGAACTCAAA       c.1320
 A  Q  N  Q  L  V  I  W  K  Y  P  T  M  A  K  V  A  E  L  K         p.440

   | 11      .         .         .         .         .         .    g.9055
 G | GTCACACATCCCGGGTCCTGAGTCTGACCATGAGCCCAGATGGGGCCACAGTGGCATCC    c.1380
 G |   H  T  S  R  V  L  S  L  T  M  S  P  D  G  A  T  V  A  S      p.460

          .         .         .         .         .         .       g.9115
 GCAGCAGCAGATGAGACCCTGAGGCTATGGCGCTGTTTTGAGTTGGACCCTGCGCGGCGG       c.1440
 A  A  A  D  E  T  L  R  L  W  R  C  F  E  L  D  P  A  R  R         p.480

          .         .         .         .         .         .       g.9175
 CGGGAGCGGGAGAAGGCCAGTGCAGCCAAAAGCAGCCTCATCCACCAAGGCATCCGCTGA       c.1500
 R  E  R  E  K  A  S  A  A  K  S  S  L  I  H  Q  G  I  R  X         p.499

          .         .         .         .         .         .       g.9235
 agaccaacccatcacctcagttgttttttatttttctaataaagtcatgtctcccttcat       c.*60

          .                                                         g.9249
 gttttttttttaaa                                                     c.*74

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The Cell division cycle 20 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.