cadherin 13, H-cadherin (heart) (CDH13) - coding DNA reference sequence

(used for variant description)

(last modified March 2, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_001257.4 in the CDH13 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_052819.1, covering CDH13 transcript NM_001257.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5059
  aacagtccaaagaagcaaatgggatgccacctccgcggggctcgctcctcgcgaggtgc       c.-241

 .         .         .         .         .         .                g.5119
 tcaccccgtatctgccatgcaaaacgagggagcgttaggaaggaatccgtcttgtaaagc       c.-181

 .         .         .         .         .         .                g.5179
 cattggtcctggtcatcagcctctacccaatgctttcgtgatgctgctgctgatctattt       c.-121

 .         .         .         .         .         .                g.5239
 gggaagttggctggctggcgaggcagagcctctcctcaaagcctggctcccacggaaaat       c.-61

 .         .         .         .         .         .                g.5299
 atgctcagtgcagccgcgtgcatgaatgaaaacgccgccgggcgcttctagtcggacaaa       c.-1

          .         .         .         .      | 02  .         .    g.236583
 ATGCAGCCGAGAACTCCGCTCGTTCTGTGCGTTCTCCTGTCCCAG | GTGCTGCTGCTAACA    c.60
 M  Q  P  R  T  P  L  V  L  C  V  L  L  S  Q   | V  L  L  L  T      p.20

          .         .         .         .         .         .       g.236643
 TCTGCAGAAGATTTGGACTGCACTCCTGGATTTCAGCAGAAAGTGTTCCATATCAATCAG       c.120
 S  A  E  D  L  D  C  T  P  G  F  Q  Q  K  V  F  H  I  N  Q         p.40

          .         .         .        | 03.         .         .    g.410239
 CCAGCTGAATTCATTGAGGACCAGTCAATTCTAAACT | TGACCTTCAGTGACTGTAAGGGA    c.180
 P  A  E  F  I  E  D  Q  S  I  L  N  L |   T  F  S  D  C  K  G      p.60

          .         .         .         .         .         .       g.410299
 AACGACAAGCTACGCTATGAGGTCTCGAGCCCATACTTCAAGGTGAACAGCGATGGCGGC       c.240
 N  D  K  L  R  Y  E  V  S  S  P  Y  F  K  V  N  S  D  G  G         p.80

          .         .         .         .         .         .       g.410359
 TTAGTTGCTCTGAGAAACATAACTGCAGTGGGCAAAACTCTGTTCGTCCATGCACGGACC       c.300
 L  V  A  L  R  N  I  T  A  V  G  K  T  L  F  V  H  A  R  T         p.100

          .         .         .         .         .         .       g.410419
 CCCCATGCGGAAGATATGGCAGAACTCGTGATTGTCGGGGGGAAAGACATCCAGGGCTCC       c.360
 P  H  A  E  D  M  A  E  L  V  I  V  G  G  K  D  I  Q  G  S         p.120

        | 04 .         .         .         .         .         .    g.503645
 TTGCAG | GATATATTTAAATTTGCAAGAACTTCTCCTGTCCCAAGACAAAAGAGGTCCATT    c.420
 L  Q   | D  I  F  K  F  A  R  T  S  P  V  P  R  Q  K  R  S  I      p.140

          .         .         .         .         .         .       g.503705
 GTGGTATCTCCCATTTTAATTCCAGAGAATCAGAGACAGCCTTTCCCAAGAGATGTTGGC       c.480
 V  V  S  P  I  L  I  P  E  N  Q  R  Q  P  F  P  R  D  V  G         p.160

     | 05    .         .         .         .         .         .    g.595608
 AAG | GTAGTCGATAGTGACAGGCCAGAAAGGTCCAAGTTCCGGCTCACTGGAAAGGGAGTG    c.540
 K   | V  V  D  S  D  R  P  E  R  S  K  F  R  L  T  G  K  G  V      p.180

          .         .         .         .         .         .       g.595668
 GATCAAGAGCCTAAAGGAATTTTCAGAATCAATGAGAACACAGGGAGCGTCTCCGTGACA       c.600
 D  Q  E  P  K  G  I  F  R  I  N  E  N  T  G  S  V  S  V  T         p.200

          .         .         .       | 06 .         .         .    g.723092
 CGGACCTTGGACAGAGAAGTAATCGCTGTTTATCAA | CTATTTGTGGAGACCACTGATGTC    c.660
 R  T  L  D  R  E  V  I  A  V  Y  Q   | L  F  V  E  T  T  D  V      p.220

          .         .         .         .         .         .       g.723152
 AATGGCAAAACTCTCGAGGGGCCGGTGCCTCTGGAAGTCATTGTGATTGATCAGAATGAC       c.720
 N  G  K  T  L  E  G  P  V  P  L  E  V  I  V  I  D  Q  N  D         p.240

          .         .         .         .         .         .       g.723212
 AACCGACCGATCTTTCGGGAAGGCCCCTACATCGGCCACGTCATGGAAGGGTCACCCACA       c.780
 N  R  P  I  F  R  E  G  P  Y  I  G  H  V  M  E  G  S  P  T         p.260

   | 07      .         .         .         .         .         .    g.864742
 G | GCACCACAGTGATGCGGATGACAGCCTTTGATGCAGATGACCCAGCCACCGATAATGCC    c.840
 G |   T  T  V  M  R  M  T  A  F  D  A  D  D  P  A  T  D  N  A      p.280

          .         .         .         .         .         .       g.864802
 CTCCTGCGGTATAATATCCGTCAGCAGACGCCTGACAAGCCATCTCCCAACATGTTCTAC       c.900
 L  L  R  Y  N  I  R  Q  Q  T  P  D  K  P  S  P  N  M  F  Y         p.300

          .         .         .         .         .         .       g.864862
 ATCGATCCTGAGAAAGGAGACATTGTCACTGTTGTGTCACCTGCGCTGCTGGACCGAGAG       c.960
 I  D  P  E  K  G  D  I  V  T  V  V  S  P  A  L  L  D  R  E         p.320

  | 08       .         .         .         .         .         .    g.980720
  | ACTCTGGAAAATCCCAAGTATGAACTGATCATCGAGGCTCAAGATATGGCTGGACTGGAT    c.1020
  | T  L  E  N  P  K  Y  E  L  I  I  E  A  Q  D  M  A  G  L  D      p.340

          .         .         .         .         .         .       g.980780
 GTTGGATTAACAGGCACGGCCACAGCCACGATCATGATCGATGACAAAAATGATCACTCA       c.1080
 V  G  L  T  G  T  A  T  A  T  I  M  I  D  D  K  N  D  H  S         p.360

          .         .  | 09      .         .         .         .    g.1049035
 CCAAAATTCACCAAGAAAGAG | TTTCAAGCCACAGTCGAGGAAGGAGCTGTGGGAGTTATT    c.1140
 P  K  F  T  K  K  E   | F  Q  A  T  V  E  E  G  A  V  G  V  I      p.380

          .         .         .         .         .         .       g.1049095
 GTCAATTTGACAGTTGAAGATAAGGATGACCCCACCACAGGTGCATGGAGGGCTGCCTAC       c.1200
 V  N  L  T  V  E  D  K  D  D  P  T  T  G  A  W  R  A  A  Y         p.400

          .         .         .         .         .         .       g.1049155
 ACCATCATCAACGGAAACCCCGGGCAGAGCTTTGAAATCCACACCAACCCTCAAACCAAC       c.1260
 T  I  I  N  G  N  P  G  Q  S  F  E  I  H  T  N  P  Q  T  N         p.420

          .         .     | 10   .         .         .         .    g.1056450
 GAAGGGATGCTTTCTGTTGTCAAA | CCATTGGACTATGAAATTTCTGCCTTCCACACCCTG    c.1320
 E  G  M  L  S  V  V  K   | P  L  D  Y  E  I  S  A  F  H  T  L      p.440

          .         .         .         .         .         .       g.1056510
 CTGATCAAAGTGGAAAATGAAGACCCACTCGTACCCGACGTCTCCTACGGCCCCAGCTCC       c.1380
 L  I  K  V  E  N  E  D  P  L  V  P  D  V  S  Y  G  P  S  S         p.460

          .         .         .         .         .         .       g.1056570
 ACAGCCACCGTCCACATCACTGTCCTGGATGTCAACGAGGGCCCAGTCTTCTACCCAGAC       c.1440
 T  A  T  V  H  I  T  V  L  D  V  N  E  G  P  V  F  Y  P  D         p.480

          .         .         .         .         .         .       g.1056630
 CCCATGATGGTGACCAGGCAGGAGGACCTCTCTGTGGGCAGCGTGCTGCTGACAGTGAAT       c.1500
 P  M  M  V  T  R  Q  E  D  L  S  V  G  S  V  L  L  T  V  N         p.500

          .         .         .         | 11         .         .    g.1126336
 GCCACGGACCCCGACTCCCTGCAGCATCAAACCATCAG | GTATTCTGTTTACAAGGACCCA    c.1560
 A  T  D  P  D  S  L  Q  H  Q  T  I  R  |  Y  S  V  Y  K  D  P      p.520

          .         .         .         .         .         .       g.1126396
 GCAGGTTGGCTGAATATTAACCCCATCAATGGGACTGTTGACACCACAGCTGTGCTGGAC       c.1620
 A  G  W  L  N  I  N  P  I  N  G  T  V  D  T  T  A  V  L  D         p.540

          .         .         .         .         .         .       g.1126456
 CGTGAGTCCCCATTTGTCGACAACAGCGTGTACACTGCTCTCTTCCTGGCAATTGACAGT       c.1680
 R  E  S  P  F  V  D  N  S  V  Y  T  A  L  F  L  A  I  D  S         p.560

   | 12      .         .         .         .         .         .    g.1158233
 G | GCAACCCTCCCGCTACGGGCACTGGGACTTTGCTGATAACCCTGGAGGACGTGAATGAC    c.1740
 G |   N  P  P  A  T  G  T  G  T  L  L  I  T  L  E  D  V  N  D      p.580

          .         .         .         .         .         .       g.1158293
 AATGCCCCGTTCATTTACCCCACAGTAGCTGAAGTCTGTGATGATGCCAAAAACCTCAGT       c.1800
 N  A  P  F  I  Y  P  T  V  A  E  V  C  D  D  A  K  N  L  S         p.600

          .         .         .         .         .         .       g.1158353
 GTAGTCATTTTGGGAGCATCAGATAAGGATCTTCACCCGAATACAGATCCTTTCAAATTT       c.1860
 V  V  I  L  G  A  S  D  K  D  L  H  P  N  T  D  P  F  K  F         p.620

          .         .         .         .         .      | 13  .    g.1161465
 GAAATCCACAAACAAGCTGTTCCTGATAAAGTCTGGAAGATCTCCAAGATCAACA | ATACA    c.1920
 E  I  H  K  Q  A  V  P  D  K  V  W  K  I  S  K  I  N  N |   T      p.640

          .         .         .         .         .         .       g.1161525
 CACGCCCTGGTAAGCCTTCTTCAAAATCTGAACAAAGCAAACTACAACCTGCCCATCATG       c.1980
 H  A  L  V  S  L  L  Q  N  L  N  K  A  N  Y  N  L  P  I  M         p.660

          .         .         .         .         .         .       g.1161585
 GTGACAGATTCAGGGAAACCACCCATGACGAATATCACAGATCTCAGGGTACAAGTGTGC       c.2040
 V  T  D  S  G  K  P  P  M  T  N  I  T  D  L  R  V  Q  V  C         p.680

          .         .         .         .         .         .       g.1161645
 TCCTGCAGGAATTCCAAAGTGGACTGCAACGCGGCAGGGGCCCTGCGCTTCAGCCTGCCC       c.2100
 S  C  R  N  S  K  V  D  C  N  A  A  G  A  L  R  F  S  L  P         p.700

          .         .         .     | 14   .                        g.1173255
 TCAGTCCTGCTCCTCAGCCTCTTCAGCTTAGCTT | GTCTGTGA                      c.2142
 S  V  L  L  L  S  L  F  S  L  A  C |   L  X                        p.713

          .         .         .         .         .         .       g.1173315
 gaactcctgacgtctgaagcttgactcccaagtttccatagcaacaggaaaaaaaaaaat       c.*60

          .         .         .         .         .         .       g.1173375
 ctatccaaatctgaagattgcggtttacagctatcgaacttcacaactaggcctcaattg       c.*120

          .         .         .         .         .         .       g.1173435
 ttccggttttttattttctttacaatttcacttagtctgtacttcatcattttgacagca       c.*180

          .         .         .         .         .         .       g.1173495
 tcttcctccctcctttaattaatggaatcttctgaattttccctgaatgtttaaagatca       c.*240

          .         .         .         .         .         .       g.1173555
 tgacatatgacttgatcttctgggagcaggaacaatgactactttttctggtgtgttaac       c.*300

          .         .         .         .         .         .       g.1173615
 atgtcgctagccagtgctccaggcacccagctttgtctgtgggttagtattggtgtatgt       c.*360

          .         .         .         .         .         .       g.1173675
 atgagtatctgtatgtatatatacacggtatttatagagagagactatcctggagaagcc       c.*420

          .         .         .         .         .         .       g.1173735
 tcgttttgatgccattcttccttgcaaggttaagcaaggtgggtggaaactaagacacct       c.*480

          .         .         .         .         .         .       g.1173795
 gaaccctccagggcctcccgcatcaaggtcagcatgaggacagaccacagagctgtcact       c.*540

          .         .         .         .         .         .       g.1173855
 tttgctccgaagctacttctccactgtcccgttcagtctgaatgctgccacaaccagcca       c.*600

          .         .         .         .         .         .       g.1173915
 ggcaggtccacagagagggagagcagagaaagaagtcctttctctttattgagttcgagg       c.*660

          .         .         .         .         .         .       g.1173975
 actacaaccaatttacactgccatctgatgccgtgatcctgagccaaggaggtgaggagc       c.*720

          .         .         .         .         .         .       g.1174035
 agagcaggcaatttcaccaccaaatgccaagaaaagggctgacattttctttcatgggca       c.*780

          .         .         .         .         .         .       g.1174095
 ccaacctgcatttgtatgtgtcccgaatccacagtcgtactgattctaatggggacacag       c.*840

          .         .         .         .         .         .       g.1174155
 atcatggtagagaatctctccctcctcagtaaatgtacaactgcacctgtcatcatggag       c.*900

          .         .         .         .         .         .       g.1174215
 gtcatacatgcatacaaagaggtgtacaggtaccatcttgtatacacatatatacccaca       c.*960

          .         .         .         .         .         .       g.1174275
 tgtacagacatacatttatgcacattcacgctgtttgtttcatatatacaggcataaaat       c.*1020

          .         .         .         .         .         .       g.1174335
 agagtaaatacaggtagttttaaaagtacccttttgtgtgaattgactaccgttgtttgc       c.*1080

          .         .         .         .         .         .       g.1174395
 aaacccgaaaataaaagacgttcattatgtatgaaaagtaactgatttgtattctgtgag       c.*1140

          .         .         .         .         .         .       g.1174455
 catgtaaaagcggaaagttagtgcttgttctaagattaccttcttgttgataaaccataa       c.*1200

          .         .         .         .         .         .       g.1174515
 atgaatcatcaaagctcacaccaaatttttctatcaaataaaactagtgacagcttgtgg       c.*1260

          .         .         .         .         .         .       g.1174575
 ctttttattagagctcgccacgaactagggtaaggtgagtgtcttagcatattttaatgc       c.*1320

          .         .         .         .         .         .       g.1174635
 agttgcttactaaaggttttaaccgcacatgcacacacacacgctttcttatgcaatcta       c.*1380

          .         .         .         .         .         .       g.1174695
 tgtttgcacttgtgctttcagttagccttctgtaggaagtagaagtcatatgttgtcttt       c.*1440

          .         .         .         .         .         .       g.1174755
 gttgtagtgaaattatacagatagagttccatatattgtatttgtttcaatggtaaatcc       c.*1500

          .         .         .         .         .         .       g.1174815
 ttttggaacatatagaatgcagagatttttttttccattaaaataaatgggtattggtgg       c.*1560

          .         .                                               g.1174835
 ttaaaactgctggacagtaa                                               c.*1580

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cadherin 13, H-cadherin (heart) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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