cadherin 1, type 1, E-cadherin (epithelial) (CDH1) - coding DNA reference sequence

(used for variant description)

(last modified June 18, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_004360.3 in the CDH1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008021.1, covering CDH1 transcript NM_004360.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         agtg       c.-121

 .         .         .         .         .         .                g.5064
 gcgtcggaactgcaaagcacctgtgagcttgcggaagtcagttcagactccagcccgctc       c.-61

 .         .         .         .         .         .                g.5124
 cagcccggcccgacccgaccgcacccggcgcctgccctcgctcggcgtccccggccagcc       c.-1

          .         .         .         .         | 02         .    g.6017
 ATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTGCAG | GTCTCCTCTTGG    c.60
 M  G  P  W  S  R  S  L  S  A  L  L  L  L  L  Q   | V  S  S  W      p.20

          .         .         .         .         .         .       g.6077
 CTCTGCCAGGAGCCGGAGCCCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTTCACG       c.120
 L  C  Q  E  P  E  P  C  H  P  G  F  D  A  E  S  Y  T  F  T         p.40

          .         .         .         .    | 03    .         .    g.69395
 GTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAG | TGAATTTTGAAGATTGC    c.180
 V  P  R  R  H  L  E  R  G  R  V  L  G  R  V |   N  F  E  D  C      p.60

          .         .         .         .         .         .       g.69455
 ACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGAT       c.240
 T  G  R  Q  R  T  A  Y  F  S  L  D  T  R  F  K  V  G  T  D         p.80

          .         .         .         .         .         .       g.69515
 GGTGTGATTACAGTCAAAAGGCCTCTACGGTTTCATAACCCACAGATCCATTTCTTGGTC       c.300
 G  V  I  T  V  K  R  P  L  R  F  H  N  P  Q  I  H  F  L  V         p.100

          .         .         .         .         .         .       g.69575
 TACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGG       c.360
 Y  A  W  D  S  T  Y  R  K  F  S  T  K  V  T  L  N  T  V  G         p.120

          .         .        | 04.         .         .         .    g.76165
 CACCACCACCGCCCCCCGCCCCATCAG | GCCTCCGTTTCTGGAATCCAAGCAGAATTGCTC    c.420
 H  H  H  R  P  P  P  H  Q   | A  S  V  S  G  I  Q  A  E  L  L      p.140

          .         .         .         .         .         .       g.76225
 ACATTTCCCAACTCCTCTCCTGGCCTCAGAAGACAGAAGAGAGACTGGGTTATTCCTCCC       c.480
 T  F  P  N  S  S  P  G  L  R  R  Q  K  R  D  W  V  I  P  P         p.160

          .         .         .         .         .  | 05      .    g.76410
 ATCAGCTGCCCAGAAAATGAAAAAGGCCCATTTCCTAAAAACCTGGTTCAG | ATCAAATCC    c.540
 I  S  C  P  E  N  E  K  G  P  F  P  K  N  L  V  Q   | I  K  S      p.180

          .         .         .         .         .         .       g.76470
 AACAAAGACAAAGAAGGCAAGGTTTTCTACAGCATCACTGGCCAAGGAGCTGACACACCC       c.600
 N  K  D  K  E  G  K  V  F  Y  S  I  T  G  Q  G  A  D  T  P         p.200

          .         .         .         .         .         .       g.76530
 CCTGTTGGTGTCTTTATTATTGAAAGAGAAACAGGATGGCTGAAGGTGACAGAGCCTCTG       c.660
 P  V  G  V  F  I  I  E  R  E  T  G  W  L  K  V  T  E  P  L         p.220

          .         .        | 06.         .         .         .    g.77938
 GATAGAGAACGCATTGCCACATACACT | CTCTTCTCTCACGCTGTGTCATCCAACGGGAAT    c.720
 D  R  E  R  I  A  T  Y  T   | L  F  S  H  A  V  S  S  N  G  N      p.240

          .         .         .         .         .         .       g.77998
 GCAGTTGAGGATCCAATGGAGATTTTGATCACGGTAACCGATCAGAATGACAACAAGCCC       c.780
 A  V  E  D  P  M  E  I  L  I  T  V  T  D  Q  N  D  N  K  P         p.260

          .         .         .         .         .   | 07     .    g.79400
 GAATTCACCCAGGAGGTCTTTAAGGGGTCTGTCATGGAAGGTGCTCTTCCAG | GAACCTCT    c.840
 E  F  T  Q  E  V  F  K  G  S  V  M  E  G  A  L  P  G |   T  S      p.280

          .         .         .         .         .         .       g.79460
 GTGATGGAGGTCACAGCCACAGACGCGGACGATGATGTGAACACCTACAATGCCGCCATC       c.900
 V  M  E  V  T  A  T  D  A  D  D  D  V  N  T  Y  N  A  A  I         p.300

          .         .         .         .         .         .       g.79520
 GCTTACACCATCCTCAGCCAAGATCCTGAGCTCCCTGACAAAAATATGTTCACCATTAAC       c.960
 A  Y  T  I  L  S  Q  D  P  E  L  P  D  K  N  M  F  T  I  N         p.320

          .         .         .         .         | 08         .    g.79855
 AGGAACACAGGAGTCATCAGTGTGGTCACCACTGGGCTGGACCGAGAG | AGTTTCCCTACG    c.1020
 R  N  T  G  V  I  S  V  V  T  T  G  L  D  R  E   | S  F  P  T      p.340

          .         .         .         .         .         .       g.79915
 TATACCCTGGTGGTTCAAGCTGCTGACCTTCAAGGTGAGGGGTTAAGCACAACAGCAACA       c.1080
 Y  T  L  V  V  Q  A  A  D  L  Q  G  E  G  L  S  T  T  A  T         p.360

          .         .         .         .         .        | 09.    g.81024
 GCTGTGATCACAGTCACTGACACCAACGATAATCCTCCGATCTTCAATCCCACCACG | TAC    c.1140
 A  V  I  T  V  T  D  T  N  D  N  P  P  I  F  N  P  T  T   | Y      p.380

          .         .         .         .         .         .       g.81084
 AAGGGTCAGGTGCCTGAGAACGAGGCTAACGTCGTAATCACCACACTGAAAGTGACTGAT       c.1200
 K  G  Q  V  P  E  N  E  A  N  V  V  I  T  T  L  K  V  T  D         p.400

          .         .         .         .         .         .       g.81144
 GCTGATGCCCCCAATACCCCAGCGTGGGAGGCTGTATACACCATATTGAATGATGATGGT       c.1260
 A  D  A  P  N  T  P  A  W  E  A  V  Y  T  I  L  N  D  D  G         p.420

          .         .         .         .         .         .       g.81204
 GGACAATTTGTCGTCACCACAAATCCAGTGAACAACGATGGCATTTTGAAAACAGCAAAG       c.1320
 G  Q  F  V  V  T  T  N  P  V  N  N  D  G  I  L  K  T  A  K         p.440

  | 10       .         .         .         .         .         .    g.83283
  | GGCTTGGATTTTGAGGCCAAGCAGCAGTACATTCTACACGTAGCAGTGACGAATGTGGTA    c.1380
  | G  L  D  F  E  A  K  Q  Q  Y  I  L  H  V  A  V  T  N  V  V      p.460

          .         .         .         .         .         .       g.83343
 CCTTTTGAGGTCTCTCTCACCACCTCCACAGCCACCGTCACCGTGGATGTGCTGGATGTG       c.1440
 P  F  E  V  S  L  T  T  S  T  A  T  V  T  V  D  V  L  D  V         p.480

          .         .         .         .         .         .       g.83403
 AATGAAGCCCCCATCTTTGTGCCTCCTGAAAAGAGAGTGGAAGTGTCCGAGGACTTTGGC       c.1500
 N  E  A  P  I  F  V  P  P  E  K  R  V  E  V  S  E  D  F  G         p.500

          .         .         .         .         .         .       g.83463
 GTGGGCCAGGAAATCACATCCTACACTGCCCAGGAGCCAGACACATTTATGGAACAGAAA       c.1560
 V  G  Q  E  I  T  S  Y  T  A  Q  E  P  D  T  F  M  E  Q  K         p.520

       | 11  .         .         .         .         .         .    g.87043
 ATAAC | ATATCGGATTTGGAGAGACACTGCCAACTGGCTGGAGATTAATCCGGACACTGGT    c.1620
 I  T  |  Y  R  I  W  R  D  T  A  N  W  L  E  I  N  P  D  T  G      p.540

          .         .         .         .         .         .       g.87103
 GCCATTTCCACTCGGGCTGAGCTGGACAGGGAGGATTTTGAGCACGTGAAGAACAGCACG       c.1680
 A  I  S  T  R  A  E  L  D  R  E  D  F  E  H  V  K  N  S  T         p.560

          .         .         .  | 12      .         .         .    g.89738
 TACACAGCCCTAATCATAGCTACAGACAATG | GTTCTCCAGTTGCTACTGGAACAGGGACA    c.1740
 Y  T  A  L  I  I  A  T  D  N  G |   S  P  V  A  T  G  T  G  T      p.580

          .         .         .         .         .         .       g.89798
 CTTCTGCTGATCCTGTCTGATGTGAATGACAACGCCCCCATACCAGAACCTCGAACTATA       c.1800
 L  L  L  I  L  S  D  V  N  D  N  A  P  I  P  E  P  R  T  I         p.600

          .         .         .         .         .         .       g.89858
 TTCTTCTGTGAGAGGAATCCAAAGCCTCAGGTCATAAACATCATTGATGCAGACCTTCCT       c.1860
 F  F  C  E  R  N  P  K  P  Q  V  I  N  I  I  D  A  D  L  P         p.620

          .         .         .         .         .         .       g.89918
 CCCAATACATCTCCCTTCACAGCAGAACTAACACACGGGGCGAGTGCCAACTGGACCATT       c.1920
 P  N  T  S  P  F  T  A  E  L  T  H  G  A  S  A  N  W  T  I         p.640

          .       | 13 .         .         .         .         .    g.91151
 CAGTACAACGACCCAA | CCCAAGAATCTATCATTTTGAAGCCAAAGATGGCCTTAGAGGTG    c.1980
 Q  Y  N  D  P  T |   Q  E  S  I  I  L  K  P  K  M  A  L  E  V      p.660

          .         .         .         .         .         .       g.91211
 GGTGACTACAAAATCAATCTCAAGCTCATGGATAACCAGAATAAAGACCAAGTGACCACC       c.2040
 G  D  Y  K  I  N  L  K  L  M  D  N  Q  N  K  D  Q  V  T  T         p.680

          .         .         .         .         .         .       g.91271
 TTAGAGGTCAGCGTGTGTGACTGTGAAGGGGCCGCTGGCGTCTGTAGGAAGGCACAGCCT       c.2100
 L  E  V  S  V  C  D  C  E  G  A  A  G  V  C  R  K  A  Q  P         p.700

          .         .         .         .         .         .       g.91331
 GTCGAAGCAGGATTGCAAATTCCTGCCATTCTGGGGATTCTTGGAGGAATTCTTGCTTTG       c.2160
 V  E  A  G  L  Q  I  P  A  I  L  G  I  L  G  G  I  L  A  L         p.720

      | 14   .         .         .         .         .         .    g.95938
 CTAA | TTCTGATTCTGCTGCTCTTGCTGTTTCTTCGGAGGAGAGCGGTGGTCAAAGAGCCC    c.2220
 L  I |   L  I  L  L  L  L  L  F  L  R  R  R  A  V  V  K  E  P      p.740

          .         .         .         .         .         .       g.95998
 TTACTGCCCCCAGAGGATGACACCCGGGACAACGTTTATTACTATGATGAAGAAGGAGGC       c.2280
 L  L  P  P  E  D  D  T  R  D  N  V  Y  Y  Y  D  E  E  G  G         p.760

          .      | 15  .         .         .         .         .    g.97407
 GGAGAAGAGGACCAG | GACTTTGACTTGAGCCAGCTGCACAGGGGCCTGGACGCTCGGCCT    c.2340
 G  E  E  D  Q   | D  F  D  L  S  Q  L  H  R  G  L  D  A  R  P      p.780

          .         .         .         .         .         .       g.97467
 GAAGTGACTCGTAACGACGTTGCACCAACCCTCATGAGTGTCCCCCGGTATCTTCCCCGC       c.2400
 E  V  T  R  N  D  V  A  P  T  L  M  S  V  P  R  Y  L  P  R         p.800

          .         .         .          | 16        .         .    g.101019
 CCTGCCAATCCCGATGAAATTGGAAATTTTATTGATGAA | AATCTGAAAGCGGCTGATACT    c.2460
 P  A  N  P  D  E  I  G  N  F  I  D  E   | N  L  K  A  A  D  T      p.820

          .         .         .         .         .         .       g.101079
 GACCCCACAGCCCCGCCTTATGATTCTCTGCTCGTGTTTGACTATGAAGGAAGCGGTTCC       c.2520
 D  P  T  A  P  P  Y  D  S  L  L  V  F  D  Y  E  G  S  G  S         p.840

          .         .         .         .         .         .       g.101139
 GAAGCTGCTAGTCTGAGCTCCCTGAACTCCTCAGAGTCAGACAAAGACCAGGACTATGAC       c.2580
 E  A  A  S  L  S  S  L  N  S  S  E  S  D  K  D  Q  D  Y  D         p.860

          .         .         .         .         .         .       g.101199
 TACTTGAACGAATGGGGCAATCGCTTCAAGAAGCTGGCTGACATGTACGGAGGCGGCGAG       c.2640
 Y  L  N  E  W  G  N  R  F  K  K  L  A  D  M  Y  G  G  G  E         p.880

                                                                    g.101208
 GACGACTAG                                                          c.2649
 D  D  X                                                            p.882

          .         .         .         .         .         .       g.101268
 gggactcgagagaggcgggccccagacccatgtgctgggaaatgcagaaatcacgttgct       c.*60

          .         .         .         .         .         .       g.101328
 ggtggtttttcagctcccttcccttgagatgagtttctggggaaaaaaaagagactggtt       c.*120

          .         .         .         .         .         .       g.101388
 agtgatgcagttagtatagctttatactctctccactttatagctctaataagtttgtgt       c.*180

          .         .         .         .         .         .       g.101448
 tagaaaagtttcgacttatttcttaaagcttttttttttttcccatcactctttacatgg       c.*240

          .         .         .         .         .         .       g.101508
 tggtgatgtccaaaagatacccaaattttaatattccagaagaacaactttagcatcaga       c.*300

          .         .         .         .         .         .       g.101568
 aggttcacccagcaccttgcagattttcttaaggaattttgtctcacttttaaaaagaag       c.*360

          .         .         .         .         .         .       g.101628
 gggagaagtcagctactctagttctgttgttttgtgtatataattttttaaaaaaaattt       c.*420

          .         .         .         .         .         .       g.101688
 gtgtgcttctgctcattactacactggtgtgtccctctgccttttttttttttttaagac       c.*480

          .         .         .         .         .         .       g.101748
 agggtctcattctatcggccaggctggagtgcagtggtgcaatcacagctcactgcagcc       c.*540

          .         .         .         .         .         .       g.101808
 ttgtcctcccaggctcaagctatccttgcacctcagcctcccaagtagctgggaccacag       c.*600

          .         .         .         .         .         .       g.101868
 gcatgcaccactacgcatgactaattttttaaatatttgagacggggtctccctgtgtta       c.*660

          .         .         .         .         .         .       g.101928
 cccaggctggtctcaaactcctgggctcaagtgatcctcccatcttggcctcccagagta       c.*720

          .         .         .         .         .         .       g.101988
 ttgggattacagacatgagccactgcacctgcccagctccccaactccctgccatttttt       c.*780

          .         .         .         .         .         .       g.102048
 aagagacagtttcgctccatcgcccaggcctgggatgcagtgatgtgatcatagctcact       c.*840

          .         .         .         .         .         .       g.102108
 gtaacctcaaactctggggctcaagcagttctcccaccagcctcctttttatttttttgt       c.*900

          .         .         .         .         .         .       g.102168
 acagatggggtcttgctatgttgcccaagctggtcttaaactcctggcctcaagcaatcc       c.*960

          .         .         .         .         .         .       g.102228
 ttctgccttggccccccaaagtgctgggattgtgggcatgagctgctgtgcccagcctcc       c.*1020

          .         .         .         .         .         .       g.102288
 atgttttaatatcaactctcactcctgaattcagttgctttgcccaagataggagttctc       c.*1080

          .         .         .         .         .         .       g.102348
 tgatgcagaaattattgggctcttttagggtaagaagtttgtgtctttgtctggccacat       c.*1140

          .         .         .         .         .         .       g.102408
 cttgactaggtattgtctactctgaagacctttaatggcttccctctttcatctcctgag       c.*1200

          .         .         .         .         .         .       g.102468
 tatgtaacttgcaatgggcagctatccagtgacttgttctgagtaagtgtgttcattaat       c.*1260

          .         .         .         .         .         .       g.102528
 gtttatttagctctgaagcaagagtgatatactccaggacttagaatagtgcctaaagtg       c.*1320

          .         .         .         .         .         .       g.102588
 ctgcagccaaagacagagcggaactatgaaaagtgggcttggagatggcaggagagcttg       c.*1380

          .         .         .         .         .         .       g.102648
 tcattgagcctggcaatttagcaaactgatgctgaggatgattgaggtgggtctacctca       c.*1440

          .         .         .         .         .         .       g.102708
 tctctgaaaattctggaaggaatggaggagtctcaacatgtgtttctgacacaagatccg       c.*1500

          .         .         .         .         .         .       g.102768
 tggtttgtactcaaagcccagaatccccaagtgcctgcttttgatgatgtctacagaaaa       c.*1560

          .         .         .         .         .         .       g.102828
 tgctggctgagctgaacacatttgcccaattccaggtgtgcacagaaaaccgagaatatt       c.*1620

          .         .         .         .         .         .       g.102888
 caaaattccaaatttttttcttaggagcaagaagaaaatgtggccctaaagggggttagt       c.*1680

          .         .         .         .         .         .       g.102948
 tgaggggtagggggtagtgaggatcttgatttggatctctttttatttaaatgtgaattt       c.*1740

          .         .         .         .         .         .       g.103008
 caacttttgacaatcaaagaaaagacttttgttgaaatagctttactgtttctcaagtgt       c.*1800

          .         .         .         .         .         .       g.103068
 tttggagaaaaaaatcaaccctgcaatcactttttggaattgtcttgatttttcggcagt       c.*1860

          .         .         .         .         .         .       g.103128
 tcaagctatatcgaatatagttctgtgtagagaatgtcactgtagttttgagtgtataca       c.*1920

          .         .         .         .         .         .       g.103188
 tgtgtgggtgctgataattgtgtattttctttgggggtggaaaaggaaaacaattcaagc       c.*1980

          .         .         .         .         .         .       g.103248
 tgagaaaagtattctcaaagatgcatttttataaattttattaaacaattttgttaaacc       c.*2040

                                                                    g.103250
 at                                                                 c.*2042

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cadherin 1, type 1, E-cadherin (epithelial) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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