cyclin-dependent kinase 19 (CDK19) - coding DNA reference sequence

(used for variant description)

(last modified May 1, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_015076.3 in the CDK19 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering CDK19 transcript NM_015076.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5013
                                                cgcggggggagga       c.-61

 .         .         .         .         .         .                g.5073
 ggaggagggactgagcggcggcggcccccgcgtcccgtgcctctatgggggaagcagaca       c.-1

          .         .         .         .         .         .       g.5133
 ATGGATTATGATTTCAAGGCGAAGCTGGCGGCGGAGCGGGAGCGGGTGGAGGATTTGTTT       c.60
 M  D  Y  D  F  K  A  K  L  A  A  E  R  E  R  V  E  D  L  F         p.20

          .         .         .         .         .         .       g.5193
 GAGTACGAAGGGTGCAAAGTGGGACGCGGCACCTACGGTCACGTCTACAAGGCGAGGCGG       c.120
 E  Y  E  G  C  K  V  G  R  G  T  Y  G  H  V  Y  K  A  R  R         p.40

          | 02         .         .         .         .         .    g.74060
 AAAGATGG | AAAAGATGAAAAGGAATATGCATTGAAGCAAATTGAAGGCACAGGAATATCC    c.180
 K  D  G  |  K  D  E  K  E  Y  A  L  K  Q  I  E  G  T  G  I  S      p.60

          .         .     | 03   .         .         .         .    g.149704
 ATGTCGGCTTGTAGAGAGATTGCA | CTTTTGCGAGAATTGAAGCACCCTAATGTGATTGCA    c.240
 M  S  A  C  R  E  I  A   | L  L  R  E  L  K  H  P  N  V  I  A      p.80

          .         .         .         .         .         .       g.149764
 TTGCAGAAGGTGTTCCTTTCTCACAGTGACAGGAAGGTATGGCTGCTGTTTGATTATGCA       c.300
 L  Q  K  V  F  L  S  H  S  D  R  K  V  W  L  L  F  D  Y  A         p.100

          .      | 04  .         .         .         .         .    g.152680
 GAGCATGACTTGTGG | CATATTATTAAGTTTCACCGTGCATCAAAAGCAAATAAAAAGCCC    c.360
 E  H  D  L  W   | H  I  I  K  F  H  R  A  S  K  A  N  K  K  P      p.120

          .         .         .         .         .         .       g.152740
 ATGCAGTTGCCAAGATCTATGGTTAAATCCTTACTTTACCAGATTCTTGATGGTATCCAT       c.420
 M  Q  L  P  R  S  M  V  K  S  L  L  Y  Q  I  L  D  G  I  H         p.140

          .         .         .       | 05 .         .         .    g.181527
 TACCTCCATGCAAATTGGGTGCTTCACAGAGACTTG | AAACCAGCAAATATCCTAGTAATG    c.480
 Y  L  H  A  N  W  V  L  H  R  D  L   | K  P  A  N  I  L  V  M      p.160

          .         .         .     | 06   .         .         .    g.188074
 GGAGAAGGTCCTGAGAGGGGGAGAGTCAAAATAG | CTGACATGGGTTTTGCCAGATTATTC    c.540
 G  E  G  P  E  R  G  R  V  K  I  A |   D  M  G  F  A  R  L  F      p.180

          .         .         .         .         .         .       g.188134
 AATTCTCCTCTAAAGCCACTAGCAGATTTGGATCCAGTAGTTGTGACATTTTGGTATCGG       c.600
 N  S  P  L  K  P  L  A  D  L  D  P  V  V  V  T  F  W  Y  R         p.200

          .         .         .         .       | 07 .         .    g.193078
 GCTCCAGAACTTTTGCTTGGTGCAAGGCATTATACAAAGGCCATTG | ATATATGGGCAATA    c.660
 A  P  E  L  L  L  G  A  R  H  Y  T  K  A  I  D |   I  W  A  I      p.220

          .         .         .         .         .         .       g.193138
 GGTTGTATATTTGCTGAATTGTTGACTTCGGAACCTATTTTTCACTGTCGTCAGGAAGAT       c.720
 G  C  I  F  A  E  L  L  T  S  E  P  I  F  H  C  R  Q  E  D         p.240

          .         .         .         .         .         .       g.193198
 ATAAAAACAAGCAATCCCTTTCATCATGATCAACTGGATCGGATATTTAGTGTCATGGGG       c.780
 I  K  T  S  N  P  F  H  H  D  Q  L  D  R  I  F  S  V  M  G         p.260

          . | 08       .         .         .         .         .    g.193414
 TTTCCTGCAG | ATAAAGACTGGGAAGATATTAGAAAGATGCCAGAATATCCCACACTTCAA    c.840
 F  P  A  D |   K  D  W  E  D  I  R  K  M  P  E  Y  P  T  L  Q      p.280

          .         . | 09       .         .         .         .    g.196887
 AAAGACTTTAGAAGAACAAC | GTATGCCAACAGTAGCCTCATAAAGTACATGGAGAAACAC    c.900
 K  D  F  R  R  T  T  |  Y  A  N  S  S  L  I  K  Y  M  E  K  H      p.300

          .         .         .    | 10    .         .         .    g.197324
 AAGGTCAAGCCTGACAGCAAAGTGTTCCTCTTG | CTTCAGAAACTCCTGACCATGGATCCA    c.960
 K  V  K  P  D  S  K  V  F  L  L   | L  Q  K  L  L  T  M  D  P      p.320

          .         .         .         .         .         .       g.197384
 ACCAAGAGAATTACCTCGGAGCAAGCTCTGCAGGATCCCTATTTTCAGGAGGACCCTTTG       c.1020
 T  K  R  I  T  S  E  Q  A  L  Q  D  P  Y  F  Q  E  D  P  L         p.340

          .  | 11      .         .         .         .         .    g.198092
 CCAACATTAGA | TGTATTTGCCGGCTGCCAGATTCCATACCCCAAACGAGAATTCCTTAAT    c.1080
 P  T  L  D  |  V  F  A  G  C  Q  I  P  Y  P  K  R  E  F  L  N      p.360

          .         .         . | 12       .         .         .    g.198869
 GAAGATGATCCTGAAGAAAAAGGTGACAAG | AATCAGCAACAGCAGCAGAACCAGCATCAG    c.1140
 E  D  D  P  E  E  K  G  D  K   | N  Q  Q  Q  Q  Q  N  Q  H  Q      p.380

          .         .         .         .         .         .       g.198929
 CAGCCCACAGCCCCTCCACAGCAGGCAGCAGCCCCTCCACAGGCGCCCCCACCACAGCAG       c.1200
 Q  P  T  A  P  P  Q  Q  A  A  A  P  P  Q  A  P  P  P  Q  Q         p.400

          .         .         .         .         .         .       g.198989
 AACAGCACCCAGACCAACGGGACCGCAGGTGGGGCTGGGGCCGGGGTCGGGGGCACCGGA       c.1260
 N  S  T  Q  T  N  G  T  A  G  G  A  G  A  G  V  G  G  T  G         p.420

          .         .         .         .         .         .       g.199049
 GCAGGGTTGCAGCACAGCCAGGACTCCAGCCTGAACCAGGTGCCTCCAAACAAGAAGCCA       c.1320
 A  G  L  Q  H  S  Q  D  S  S  L  N  Q  V  P  P  N  K  K  P         p.440

          .         .         .         .         .        | 13.    g.205546
 CGGCTAGGGCCTTCAGGCGCAAACTCAGGTGGACCTGTGATGCCCTCGGATTATCAG | CAC    c.1380
 R  L  G  P  S  G  A  N  S  G  G  P  V  M  P  S  D  Y  Q   | H      p.460

          .         .         .         .         .         .       g.205606
 TCCAGTTCTCGCCTGAATTACCAAAGCAGCGTTCAGGGATCCTCTCAGTCCCAGAGCACA       c.1440
 S  S  S  R  L  N  Y  Q  S  S  V  Q  G  S  S  Q  S  Q  S  T         p.480

          .         .         .         .         .         .       g.205666
 CTTGGCTACTCTTCCTCGTCTCAGCAGAGCTCACAGTACCACCCATCTCACCAGGCCCAC       c.1500
 L  G  Y  S  S  S  S  Q  Q  S  S  Q  Y  H  P  S  H  Q  A  H         p.500

                                                                    g.205675
 CGGTACTGA                                                          c.1509
 R  Y  X                                                            p.502

          .         .         .         .         .         .       g.205735
 ccagctcccgttgggccaggccagcccagcccagagcacaggctccagcaatatgtctgc       c.*60

          .         .         .         .         .         .       g.205795
 attgaaaagaaccaaaaaaatgcaaactatgatgccatttaaaactcatacacatgggag       c.*120

          .         .         .         .         .         .       g.205855
 gaaaaccttatatactgagcattgtgcaggactgatagctcttctttattgacttaaaga       c.*180

          .         .         .         .         .         .       g.205915
 agattcttgtgaagtttccccagcaccccttccctgcatgtgttccattgtgacttctct       c.*240

          .         .         .         .         .         .       g.205975
 gataaagcgtctgatctaatcccagcacttctgtaaccttcagcatttctttgaaggatt       c.*300

          .         .         .         .         .         .       g.206035
 tcctggtgcacctttctcatgctgtagcaatcactatggtttatcttttcaaagctcttt       c.*360

          .         .         .         .         .         .       g.206095
 taataggattttaatgttttagaaacaggattccagtggtgtatagttttatacttcatg       c.*420

          .         .         .         .         .         .       g.206155
 aactgatttagcaacacaggtaaaaatgcaccttttaaagcactacgttttcacagacaa       c.*480

          .         .         .         .         .         .       g.206215
 taactgttctgctcatggaagtcttaaacagaaactgttactgtcccaaagtactttact       c.*540

          .         .         .         .         .         .       g.206275
 attacgttcgtatttatctagtttcagggaaggtctaataaaaagacaagcggtgggaca       c.*600

          .         .         .         .         .         .       g.206335
 gagggaacctacaaccaaaaactgcctagatctttgcagttatgtgctttatgccacgaa       c.*660

          .         .         .         .         .         .       g.206395
 gaactgaagtatgtggtaatttttatagaatcattcatatggaactgagttcccagcatc       c.*720

          .         .         .         .         .         .       g.206455
 atcttattctgaatagcattcagtaattaagaattacaattttaaccttcatgtagctaa       c.*780

          .         .         .         .         .         .       g.206515
 gtctaccttaaaaagggtttcaagagctttgtacagtctcgatggcccacaccaaaacgc       c.*840

          .         .         .         .         .         .       g.206575
 tgaagagagtaacaactgcactaggatttctgtaaggagtaattttgatcaaaagacgtg       c.*900

          .         .         .         .         .         .       g.206635
 ttacttccctttgaaggaaaagtttttagtgtgtattgtacataaagtcggcttctctaa       c.*960

          .         .         .         .         .         .       g.206695
 agaaccattggtttcttcacatctgggtctgcgtgagtaactttcttgcataatcaaggt       c.*1020

          .         .         .         .         .         .       g.206755
 tactcaagtagaagcctgaaaattaatctgcttttaaaataaagagcagtgttctccatt       c.*1080

          .         .         .         .         .         .       g.206815
 cgtatttgtattagatatagagtgactatttttaaagcatgttaaaaatttaggttttat       c.*1140

          .         .         .         .         .         .       g.206875
 tcatgtttaaagtatgtattatgtatgcataattttgctgttgttactgaaacttaattc       c.*1200

          .         .         .         .         .         .       g.206935
 tatcaagaatctttttcattgcactgaatgatttcttttgcccctaggagaaaacttaat       c.*1260

          .         .         .         .         .         .       g.206995
 aattgtgcctaaaaactatgggcggatagtataagactatactagacaaagtgaatattt       c.*1320

          .         .         .         .         .         .       g.207055
 gcatttccattatctatgaattagtggctgagttctttcttagctgctttaaggagcccc       c.*1380

          .         .         .         .         .         .       g.207115
 tcactccccagagtcaaaaggaaatgtaaaaacttagagctcccattgtaatgtaagggg       c.*1440

          .         .         .         .         .         .       g.207175
 caagaaatttgtgttcttctgaatgctactagcagcaccagccttgttttaaatgttttc       c.*1500

          .         .         .         .         .         .       g.207235
 ttgagctagaagaaatagctgattattgtatatgcaaattacatgcatttttaaaaacta       c.*1560

          .         .         .         .         .         .       g.207295
 ttctttctgaacttatctacctggttatgatactgtgggtccatacacaagtaaaataag       c.*1620

          .         .         .         .         .         .       g.207355
 attagacagaagccagtatacattttgcactattgatgtgatactgtagccagccaggac       c.*1680

          .         .         .         .         .         .       g.207415
 cttactgatctcagcataataatgctcactaataatgaagtctgcatagtgacactcatc       c.*1740

          .         .         .         .         .         .       g.207475
 aagactgaagatgaagcaggttacgtgctccattggaaggagtttctgatagtctcctgc       c.*1800

          .         .         .         .         .         .       g.207535
 tgttttaccccttccattttttaaaataagaaattagcagccctctgcataatgtagctg       c.*1860

          .         .         .         .         .         .       g.207595
 cctatatgcagttttatcctgtgccctaaagcctcactgtccagagctgttggtcatcag       c.*1920

          .         .         .         .         .         .       g.207655
 atgcttattgcaccctcaccatgtgcctggtgccctgctgggtagagaacacagaggaca       c.*1980

          .         .         .         .         .         .       g.207715
 gggcatacttcttgtccttaaggagcttgtgatctgtgacagtaagccctcctgggatgt       c.*2040

          .         .         .         .         .         .       g.207775
 ctgtgccatgtgattgacttacaagtgaaactgtcttataatatgaaggtctttttgttt       c.*2100

          .         .         .         .         .         .       g.207835
 acttctaaacccacttgggtagttactatccccaaatctgttctgtaaataatattatgg       c.*2160

          .         .         .         .         .         .       g.207895
 aagggtttctatgtcagtctaccttagagaaagccagtgattcaatatcacaaaaggcat       c.*2220

          .         .         .         .         .         .       g.207955
 tgacgtatctttgaaatgttcacagcagccttttaacaacaactgggtggtccttgtagg       c.*2280

          .         .         .         .         .         .       g.208015
 cagaacatactctcctaagtggttgtaggaaattgcaaggaaaatagaaggtctgttctt       c.*2340

          .         .         .         .         .         .       g.208075
 gctctcaaggaggttacctttaataaaagaagacaaacccagatagatatgtaaaccaaa       c.*2400

          .         .         .         .         .         .       g.208135
 atactatgccccttaatactttataagcagcattgttaaatagttcttacgcttatacat       c.*2460

          .         .         .         .         .         .       g.208195
 tcacagaactaccctgttttccttgtatataatgacttttgctggcagaactgaaatata       c.*2520

          .         .         .         .         .         .       g.208255
 aactgtaaggggatttcgtcagttgctcccagtatacaatatcctccaggacatagccag       c.*2580

          .         .         .         .         .         .       g.208315
 aaatctccattccacacatgactgagttcctatccctgcactggtactggctcttttctc       c.*2640

          .         .         .         .         .         .       g.208375
 ctctttccttgcctcagggttcgtgctacccactgattccctttacccttagtaataatt       c.*2700

          .         .         .         .         .         .       g.208435
 ttggatcattttctttcctttaaaggggaacaaagccttttttttttttgagacggagtg       c.*2760

          .         .         .         .         .         .       g.208495
 ttgctctgtcacccaagctggagtgcagtggcacgatcttggctcactccaacctccacc       c.*2820

          .         .         .         .         .         .       g.208555
 ttccaggttcaagtgattctcctgcctcagcctcccgagtagctgggactacgggcacgc       c.*2880

          .         .         .         .         .         .       g.208615
 accaccacgtctggctaatttttgtatttttagtagagatggggtttcaccctattggtc       c.*2940

          .         .         .         .         .         .       g.208675
 aggctggtcttgaattcctcacctcaggtcatccgcctgtctcggcctcccgaagtgctg       c.*3000

          .         .         .         .         .         .       g.208735
 ggattataggtgtgagccaccgcacccagttgggaacaaagcctttttaacacacgtaag       c.*3060

          .         .         .         .         .         .       g.208795
 ggccctcaaaccgtgggacctctaaggagacctttgaagctttttgagggcaaactttac       c.*3120

          .         .         .         .         .         .       g.208855
 ctttgtggtccccaaatgatggcatttctctttgaaatttattagatactgttatgtccc       c.*3180

          .         .         .         .         .         .       g.208915
 ccaagggtacaggaggggcatccctcagcctatgggaacacccaaactaggaggggttat       c.*3240

          .         .         .         .         .         .       g.208975
 tgacaggaaggaatgaatccaagtgaaggctttctgctcttcgtgttacaaaccagtttc       c.*3300

          .         .         .         .         .         .       g.209035
 agagttagctttctggggaggtgtgtgtttgtgaaaggaattcaagtgttgcaggacaga       c.*3360

          .         .         .         .         .         .       g.209095
 tgagctcaaggtaaggtagctttggcagcagggctgatactatgaggctgaaacaatcct       c.*3420

          .         .         .         .         .         .       g.209155
 tgtgatgaagtagatcatgcagtgacatacaaagaccaaggattatgtatatttttatat       c.*3480

          .         .         .         .         .         .       g.209215
 ctctgtggttttgaaactttagtacttagaattttggccttctgcactactcttttgctc       c.*3540

          .         .         .         .         .         .       g.209275
 ttacgaacataatggactcttaagaatggaaagggatgacatttacctatgtgtgctgcc       c.*3600

          .         .         .         .         .         .       g.209335
 tcattcctggtgaagcaactgctacttgttctctatgcctctaaaatgatgctgttttct       c.*3660

          .         .         .         .         .         .       g.209395
 ctgctaaaggtaaaagaaaagaaaaaaatagttggaaaataagacatgcaacttgatgtg       c.*3720

          .         .         .         .         .         .       g.209455
 cttttgagtaaatttatgcagcagaaactatacaatgaaggaagaattctatggaaatta       c.*3780

          .         .         .         .         .         .       g.209515
 caaatccaaaactctatgatgatgtcttcctagggagtagagaaaggcagtgaaatggca       c.*3840

          .         .         .         .         .         .       g.209575
 gttagaccaacagaggcttgaaggattcaagtacaagtaatattttgtataaaacatagc       c.*3900

          .         .         .         .         .         .       g.209635
 agtttaggtccccataatcctcaaaaatagtcacaaatataacaaagttcattgttttag       c.*3960

          .         .         .         .         .         .       g.209695
 ggtttttaaaaaacgtgttgtacctaaggccatacttactcttctatgctatcactgcaa       c.*4020

          .         .         .         .         .         .       g.209755
 aggggtgatatgtatgtattatataaaaaaaaaaacccttaatgcactgttatctcctaa       c.*4080

          .         .         .         .         .         .       g.209815
 atatttagtaaattaatactatttaatttttttaaagatttgtctgtgtagacactaaaa       c.*4140

          .         .         .         .         .         .       g.209875
 gtattacacaaaatctggactgaaggtgtcctttttaacaacaatttaaagtacttttta       c.*4200

          .         .         .         .         .         .       g.209935
 tatatgttatgtagtatatcctttctaaactgcctagtttgtatattcctataattccta       c.*4260

          .         .         .         .         .         .       g.209995
 tttgtgaagtgtacctgttcttgtctcttttttcagtcattttctgcacgcatccccctt       c.*4320

          .         .         .         .         .         .       g.210055
 tatatggttatagagatgactgtagcttttcgtgctccactgcgaggtttgtgctcagag       c.*4380

          .         .         .         .         .         .       g.210115
 ccgctgcaccccagcgaggcctgctccatggagtgcaggacgagctactgctttggagcg       c.*4440

          .         .         .         .         .         .       g.210175
 agggtttcctgcttttgagttgacctgacttccttcttgaaatgactgttaaaactaaaa       c.*4500

          .         .         .         .         .                 g.210232
 taaattacattgcatttattttatattcttggttgaaataaaatttaattgactttg          c.*4557

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cyclin-dependent kinase 19 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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