cyclin-dependent kinase inhibitor 1C (p57, Kip2) (CDKN1C) - coding DNA reference sequence

(used for variant description)

(last modified October 11, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_000076.2 in the CDKN1C gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008022.1, covering CDKN1C transcript NM_000076.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5036
                         agtgcgctgtgctcgaggggtgccggccaggcctga       c.-241

 .         .         .         .         .         .                g.5096
 gcgagcgagctagccagcaggcatcgagggggcgcggctgccgtccggacgagacaggcg       c.-181

 .         .         .         .         .         .                g.5156
 aacccgacgcagaagagtccaccaccggacagccaggtagccgccgcgtccctcgcacac       c.-121

 .         .         .         .         .         .                g.5216
 gcagagtcgggcggcgcggggtctcccttgcgcccggcctccgccctctcctcctctcct       c.-61

 .         .         .         .         .         .                g.5276
 ttccccttcttctcgctgtcctctcctctctcgctgcccgcgtttgcgcagccccgggcc       c.-1

          .         .         .         .         .         .       g.5336
 ATGTCCGACGCGTCCCTCCGCAGCACATCCACGATGGAGCGTCTTGTCGCCCGTGGGACC       c.60
 M  S  D  A  S  L  R  S  T  S  T  M  E  R  L  V  A  R  G  T         p.20

          .         .         .         .         .         .       g.5396
 TTCCCAGTACTAGTGCGCACCAGCGCCTGCCGCAGCCTCTTCGGGCCGGTGGACCACGAG       c.120
 F  P  V  L  V  R  T  S  A  C  R  S  L  F  G  P  V  D  H  E         p.40

          .         .         .         .         .         .       g.5456
 GAGCTGAGCCGCGAGCTGCAGGCCCGCCTGGCCGAGCTGAACGCCGAGGACCAGAACCGC       c.180
 E  L  S  R  E  L  Q  A  R  L  A  E  L  N  A  E  D  Q  N  R         p.60

          .         .         .         .         .         .       g.5516
 TGGGATTACGACTTCCAGCAGGACATGCCGCTGCGGGGCCCTGGACGCCTGCAGTGGACC       c.240
 W  D  Y  D  F  Q  Q  D  M  P  L  R  G  P  G  R  L  Q  W  T         p.80

          .         .         .         .         .         .       g.5576
 GAAGTGGACAGCGACTCGGTGCCCGCGTTCTACCGCGAGACGGTGCAGGTGGGGCGCTGC       c.300
 E  V  D  S  D  S  V  P  A  F  Y  R  E  T  V  Q  V  G  R  C         p.100

          .         .         .         .         .         .       g.5636
 CGCCTGCTGCTGGCGCCGCGGCCCGTCGCGGTCGCGGTGGCTGTCAGCCCGCCCCTCGAG       c.360
 R  L  L  L  A  P  R  P  V  A  V  A  V  A  V  S  P  P  L  E         p.120

          .         .         .         .         .         .       g.5696
 CCGGCCGCTGAGTCCCTCGACGGCCTCGAGGAGGCGCCGGAGCAGCTGCCTAGTGTCCCG       c.420
 P  A  A  E  S  L  D  G  L  E  E  A  P  E  Q  L  P  S  V  P         p.140

          .         .         .         .         .         .       g.5756
 GTCCCGGCCCCGGCGTCCACCCCGCCCCCAGTCCCGGTCCTGGCTCCAGCCCCGGCCCCG       c.480
 V  P  A  P  A  S  T  P  P  P  V  P  V  L  A  P  A  P  A  P         p.160

          .         .         .         .         .         .       g.5816
 GCTCCGGCTCCGGTCGCGGCTCCGGTCGCGGCTCCGGTCGCGGTCGCGGTCCTGGCCCCG       c.540
 A  P  A  P  V  A  A  P  V  A  A  P  V  A  V  A  V  L  A  P         p.180

          .         .         .         .         .         .       g.5876
 GCCCCGGCCCCGGCTCCGGCTCCGGCTCCGGCCCCGGCTCCAGTCGCGGCCCCGGCCCCA       c.600
 A  P  A  P  A  P  A  P  A  P  A  P  A  P  V  A  A  P  A  P         p.200

          .         .         .         .         .         .       g.5936
 GCCCCGGCCCCGGCCCCGGCCCCGGCCCCCGCCCCGGCCCCGGCCCCGGACGCGGCGCCT       c.660
 A  P  A  P  A  P  A  P  A  P  A  P  A  P  A  P  D  A  A  P         p.220

          .         .         .         .         .         .       g.5996
 CAAGAGAGCGCCGAGCAGGGCGCGAACCAGGGGCAGCGCGGCCAGGAGCCTCTCGCTGAC       c.720
 Q  E  S  A  E  Q  G  A  N  Q  G  Q  R  G  Q  E  P  L  A  D         p.240

          .         .         .         .         .         .       g.6056
 CAGCTGCACTCGGGGATTTCGGGACGTCCCGCGGCCGGCACCGCGGCCGCCAGCGCCAAC       c.780
 Q  L  H  S  G  I  S  G  R  P  A  A  G  T  A  A  A  S  A  N         p.260

          .         .         .         . | 02       .         .    g.6651
 GGCGCGGCGATCAAGAAGCTGTCCGGGCCTCTGATCTCCG | ATTTCTTCGCCAAGCGCAAG    c.840
 G  A  A  I  K  K  L  S  G  P  L  I  S  D |   F  F  A  K  R  K      p.280

          .         .         .         .         .         .       g.6711
 AGATCAGCGCCTGAGAAGTCGTCGGGCGATGTCCCCGCGCCGTGTCCCTCTCCAAGCGCC       c.900
 R  S  A  P  E  K  S  S  G  D  V  P  A  P  C  P  S  P  S  A         p.300

          .         .         .         .         .             g.6762
 GCCCCTGGCGTGGGCTCGGTGGAGCAGACCCCGCGCAAGAGGCTGCGGTGA |             c.952
 A  P  G  V  G  S  V  E  Q  T  P  R  K  R  L  R  X               p.316

       | 03  .         .         .         .         .         .    g.6905
 gccaa | tttagagcccaaagagccccgagggaacctgccggggcagcggacgttggaaggg    c.*60

          .         .         .         .         .         .       g.6965
 cgctgggcctcggctgggaccgttcatgtagcagcaaccggcggcggctgccgcagagca       c.*120

          .         .         .         .         .         .       g.7025
 gcgttcggttttgtttttaaattttgaaaactgtgcaatgtattaataacgtctttttat       c.*180

          .         .         .         .         .         .       g.7085
 atctaaatgtattctgcacgagaaggtacactggtcccaaggtgtaaagctttaagagtc       c.*240

          .         .         .         .         .         .       g.7145
 atttatataaaatgtttaatctctgctgaaactcagtgcaaaaaaaagaaaaaagaaaaa       c.*300

          .         .         .         .         .         .       g.7205
 aaaaaggaaaaaataaaaaaaccatgtatatttgtacaaaaagtttttaaagttatacta       c.*360

          .         .         .         .         .         .       g.7265
 acttatattttctatttatgtccaggcgtggaccgctctgccacgcactagctcggttat       c.*420

          .         .         .         .         .         .       g.7325
 tggttatgccaaaggcactctccatctcccacatctggttattgacaagtgtaactttat       c.*480

          .         .         .         .         .         .       g.7385
 tttcatcgcggactctggggaagggggtcactcacaagctgtagctgccatacatgccca       c.*540

          .         .         .         .         .         .       g.7445
 tctagcttgcagtctcttcgcgctttcgctgtctctcttattatgactgtgtttatctga       c.*600

          .         .         .         .         .         .       g.7505
 aacttgaagacaagtctgttaaaatggttcctgagccgtctgtaccactgccccggcccc       c.*660

          .         .         .         .                           g.7548
 tcgtccgccgggttctaaataaagaggccgaaaaatgctgcaa                        c.*703

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cyclin-dependent kinase inhibitor 1C (p57, Kip2) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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