carboxyl ester lipase (bile salt-stimulated lipase) (CEL) - coding DNA reference sequence

(used for variant description)

(last modified March 8, 2023)


This file was created to facilitate the description of sequence variants on transcript NM_001807.4 in the CEL gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000009.11, covering CEL transcript NM_001807.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5016
                                             ggccacccagaggctg       c.-1

          .         .         .         .         .         .       g.5076
 ATGCTCACCATGGGGCGCCTGCAACTGGTTGTGTTGGGCCTCACCTGCTGCTGGGCAGTG       c.60
 M  L  T  M  G  R  L  Q  L  V  V  L  G  L  T  C  C  W  A  V         p.20

          .      | 02  .         .         .         .         .    g.7471
 GCGAGTGCCGCGAAG | CTGGGCGCCGTGTACACAGAAGGTGGGTTCGTGGAAGGCGTCAAT    c.120
 A  S  A  A  K   | L  G  A  V  Y  T  E  G  G  F  V  E  G  V  N      p.40

          .         .         .         .         .         .       g.7531
 AAGAAGCTCGGCCTCCTGGGTGACTCTGTGGACATCTTCAAGGGCATCCCCTTCGCAGCT       c.180
 K  K  L  G  L  L  G  D  S  V  D  I  F  K  G  I  P  F  A  A         p.60

          .         .         .         .       | 03 .         .    g.7676
 CCCACCAAGGCCCTGGAAAATCCTCAGCCACATCCTGGCTGGCAAG | GGACCCTGAAGGCC    c.240
 P  T  K  A  L  E  N  P  Q  P  H  P  G  W  Q  G |   T  L  K  A      p.80

          .         .         .         .         .         .       g.7736
 AAGAACTTCAAGAAGAGATGCCTGCAGGCCACCATCACCCAGGACAGCACCTACGGGGAT       c.300
 K  N  F  K  K  R  C  L  Q  A  T  I  T  Q  D  S  T  Y  G  D         p.100

          .         .         .         .          | 04        .    g.8073
 GAAGACTGCCTGTACCTCAACATTTGGGTGCCCCAGGGCAGGAAGCAAG | TCTCCCGGGAC    c.360
 E  D  C  L  Y  L  N  I  W  V  P  Q  G  R  K  Q  V |   S  R  D      p.120

          .         .         .         .         .         .       g.8133
 CTGCCCGTTATGATCTGGATCTATGGAGGCGCCTTCCTCATGGGGTCCGGCCATGGGGCC       c.420
 L  P  V  M  I  W  I  Y  G  G  A  F  L  M  G  S  G  H  G  A         p.140

          .         .         .         .         .         .       g.8193
 AACTTCCTCAACAACTACCTGTATGACGGCGAGGAGATCGCCACACGCGGAAACGTCATC       c.480
 N  F  L  N  N  Y  L  Y  D  G  E  E  I  A  T  R  G  N  V  I         p.160

          .         .         .         .         .         .       g.8253
 GTGGTCACCTTCAACTACCGTGTCGGCCCCCTTGGGTTCCTCAGCACTGGGGACGCCAAT       c.540
 V  V  T  F  N  Y  R  V  G  P  L  G  F  L  S  T  G  D  A  N         p.180

         | 05.         .         .         .         .         .    g.9605
 CTGCCAG | GTAACTATGGCCTTCGGGATCAGCACATGGCCATTGCTTGGGTGAAGAGGAAT    c.600
 L  P  G |   N  Y  G  L  R  D  Q  H  M  A  I  A  W  V  K  R  N      p.200

          .         .         .         .         .         .       g.9665
 ATCGCGGCCTTCGGGGGGGACCCCAACAACATCACGCTCTTCGGGGAGTCTGCTGGAGGT       c.660
 I  A  A  F  G  G  D  P  N  N  I  T  L  F  G  E  S  A  G  G         p.220

          .         | 06         .         .         .         .    g.9902
 GCCAGCGTCTCTCTGCAG | ACCCTCTCCCCCTACAACAAGGGCCTCATCCGGCGAGCCATC    c.720
 A  S  V  S  L  Q   | T  L  S  P  Y  N  K  G  L  I  R  R  A  I      p.240

          .         .         .         .         .         .       g.9962
 AGCCAGAGCGGCGTGGCCCTGAGTCCCTGGGTCATCCAGAAAAACCCACTCTTCTGGGCC       c.780
 S  Q  S  G  V  A  L  S  P  W  V  I  Q  K  N  P  L  F  W  A         p.260

        | 07 .         .         .         .         .         .    g.10164
 AAAAAG | GTGGCTGAGAAGGTGGGTTGCCCTGTGGGTGATGCCGCCAGGATGGCCCAGTGT    c.840
 K  K   | V  A  E  K  V  G  C  P  V  G  D  A  A  R  M  A  Q  C      p.280

          .         .         .         .         .         .       g.10224
 CTGAAGGTTACTGATCCCCGAGCCCTGACGCTGGCCTATAAGGTGCCGCTGGCAGGCCTG       c.900
 L  K  V  T  D  P  R  A  L  T  L  A  Y  K  V  P  L  A  G  L         p.300

      | 08   .         .         .         .         .         .    g.11750
 GAGT | ACCCCATGCTGCACTATGTGGGCTTCGTCCCTGTCATTGATGGAGACTTCATCCCC    c.960
 E  Y |   P  M  L  H  Y  V  G  F  V  P  V  I  D  G  D  F  I  P      p.320

          .         .         .         .         .         .       g.11810
 GCTGACCCGATCAACCTGTACGCCAACGCCGCCGACATCGACTATATAGCAGGCACCAAC       c.1020
 A  D  P  I  N  L  Y  A  N  A  A  D  I  D  Y  I  A  G  T  N         p.340

          .         .         .         .         .         .       g.11870
 AACATGGACGGCCACATCTTCGCCAGCATCGACATGCCTGCCATCAACAAGGGCAACAAG       c.1080
 N  M  D  G  H  I  F  A  S  I  D  M  P  A  I  N  K  G  N  K         p.360

          .  | 09      .         .         .         .         .    g.12127
 AAAGTCACGGA | GGAGGACTTCTACAAGCTGGTCAGTGAGTTCACAATCACCAAGGGGCTC    c.1140
 K  V  T  E  |  E  D  F  Y  K  L  V  S  E  F  T  I  T  K  G  L      p.380

          .         .         .         .         .         .       g.12187
 AGAGGCGCCAAGACGACCTTTGATGTCTACACCGAGTCCTGGGCCCAGGACCCATCCCAG       c.1200
 R  G  A  K  T  T  F  D  V  Y  T  E  S  W  A  Q  D  P  S  Q         p.400

          .         .         .         .         .         .       g.12247
 GAGAATAAGAAGAAGACTGTGGTGGACTTTGAGACCGATGTCCTCTTCCTGGTGCCCACC       c.1260
 E  N  K  K  K  T  V  V  D  F  E  T  D  V  L  F  L  V  P  T         p.420

          .         .         .      | 10  .         .         .    g.13508
 GAGATTGCCCTAGCCCAGCACAGAGCCAATGCCAA | GAGTGCCAAGACCTACGCCTACCTG    c.1320
 E  I  A  L  A  Q  H  R  A  N  A  K  |  S  A  K  T  Y  A  Y  L      p.440

          .         .         .         .         .         .       g.13568
 TTTTCCCATCCCTCTCGGATGCCCGTCTACCCCAAATGGGTGGGGGCCGACCATGCAGAT       c.1380
 F  S  H  P  S  R  M  P  V  Y  P  K  W  V  G  A  D  H  A  D         p.460

          .         .         .         .         .         .       g.13628
 GACATTCAGTACGTTTTCGGGAAGCCCTTCGCCACCCCCACGGGCTACCGGCCCCAAGAC       c.1440
 D  I  Q  Y  V  F  G  K  P  F  A  T  P  T  G  Y  R  P  Q  D         p.480

          .         .         .         .         .    | 11    .    g.14016
 AGGACAGTCTCTAAGGCCATGATCGCCTACTGGACCAACTTTGCCAAAACAGG | GGACCCC    c.1500
 R  T  V  S  K  A  M  I  A  Y  W  T  N  F  A  K  T  G  |  D  P      p.500

          .         .         .         .         .         .       g.14076
 AACATGGGCGACTCGGCTGTGCCCACACACTGGGAACCCTACACTACGGAAAACAGCGGC       c.1560
 N  M  G  D  S  A  V  P  T  H  W  E  P  Y  T  T  E  N  S  G         p.520

          .         .         .         .         .         .       g.14136
 TACCTGGAGATCACCAAGAAGATGGGCAGCAGCTCCATGAAGCGGAGCCTGAGAACCAAC       c.1620
 Y  L  E  I  T  K  K  M  G  S  S  S  M  K  R  S  L  R  T  N         p.540

          .         .         .         .         .         .       g.14196
 TTCCTGCGCTACTGGACCCTCACCTATCTGGCGCTGCCCACAGTGACCGACCAGGAGGCC       c.1680
 F  L  R  Y  W  T  L  T  Y  L  A  L  P  T  V  T  D  Q  E  A         p.560

          .         .         .         .         .         .       g.14256
 ACCCCTGTGCCCCCCACAGGGGACTCCGAGGCCACTCCCGTGCCCCCCACGGGTGACTCC       c.1740
 T  P  V  P  P  T  G  D  S  E  A  T  P  V  P  P  T  G  D  S         p.580

          .         .         .         .         .         .       g.14316
 GAGACCGCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCCACGGGT       c.1800
 E  T  A  P  V  P  P  T  G  D  S  G  A  P  P  V  P  P  T  G         p.600

          .         .         .         .         .         .       g.14376
 GACTCCGGGGCCCCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCC       c.1860
 D  S  G  A  P  P  V  P  P  T  G  D  S  G  A  P  P  V  P  P         p.620

          .         .         .         .         .         .       g.14436
 ACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCCCCCGTG       c.1920
 T  G  D  S  G  A  P  P  V  P  P  T  G  D  S  G  A  P  P  V         p.640

          .         .         .         .         .         .       g.14496
 CCGCCCACGGGTGACTCCGGGGCCCCCCCCGTGCCGCCCACGGGTGACTCCGGGGCCCCC       c.1980
 P  P  T  G  D  S  G  A  P  P  V  P  P  T  G  D  S  G  A  P         p.660

          .         .         .         .         .         .       g.14556
 CCCGTGCCGCCCACGGGTGACTCCGGCGCCCCCCCCGTGCCGCCCACGGGTGACGCCGGG       c.2040
 P  V  P  P  T  G  D  S  G  A  P  P  V  P  P  T  G  D  A  G         p.680

          .         .         .         .         .         .       g.14616
 CCCCCCCCCGTGCCGCCCACGGGTGACTCCGGCGCCCCCCCCGTGCCGCCCACGGGTGAC       c.2100
 P  P  P  V  P  P  T  G  D  S  G  A  P  P  V  P  P  T  G  D         p.700

          .         .         .         .         .         .       g.14676
 TCCGGGGCCCCCCCCGTGACCCCCACGGGTGACTCCGAGACCGCCCCCGTGCCGCCCACG       c.2160
 S  G  A  P  P  V  T  P  T  G  D  S  E  T  A  P  V  P  P  T         p.720

          .         .         .         .         .         .       g.14736
 GGTGACTCCGGGGCCCCCCCTGTGCCCCCCACGGGTGACTCTGAGGCTGCCCCTGTGCCC       c.2220
 G  D  S  G  A  P  P  V  P  P  T  G  D  S  E  A  A  P  V  P         p.740

          .         .         .         .         .                 g.14787
 CCCACAGATGACTCCAAGGAAGCTCAGATGCCTGCAGTCATTAGGTTTTAG                c.2271
 P  T  D  D  S  K  E  A  Q  M  P  A  V  I  R  F  X                  p.756

          .         .         .         .         .         .       g.14847
 cgtcccatgagccttggtatcaagaggccacaagagtgggaccccaggggctcccctccc       c.*60

          .         .         .                                     g.14886
 atcttgagctcttcctgaataaagcctcatacccctgtc                            c.*99

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Carboxyl ester lipase (bile salt-stimulated lipase) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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