centrosomal protein 57kDa (CEP57) - coding DNA reference sequence

(used for variant description)

(last modified June 26, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_014679.4 in the CEP57 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_029829.1, covering CEP57 transcript NM_014679.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5058
   gattggctaggaaagacgtccgttaggacgtgttgccctttctgtgtaagctgtgagc       c.-181

 .         .         .         .         .         .                g.5118
 gtaggcggccctgagggggtgtgttgcaggggtttccaagcccagcaccagcacccttgc       c.-121

 .         .         .         .         .         .                g.5178
 ccttttccatcaggggttcagcctagggtccccgctggtgggcggctcccgagtcttgga       c.-61

 .         .         .         .         .         .                g.5238
 gaagagcacgagaacctagaccgcccccgaagtgcggagaccccctgggcaggctgaaag       c.-1

          .         .         .         .      | 02  .         .    g.13786
 ATGGCGGCGGCGTCTGTCTCTGCGGCTTCTGGTTCTCACTTGTCG | AACAGCTTTGCTGAG    c.60
 M  A  A  A  S  V  S  A  A  S  G  S  H  L  S   | N  S  F  A  E      p.20

          .         .         .         .         .         .       g.13846
 CCATCAAGGTCTAATGGAAGCATGGTTCGGCATTCTTCATCTCCATATGTAGTATATCCT       c.120
 P  S  R  S  N  G  S  M  V  R  H  S  S  S  P  Y  V  V  Y  P         p.40

          .         .         .         .         .         .       g.13906
 TCGGATAAGCCTTTCCTTAATAGTGATCTACGACGCTCCCCAAGTAAGCCTACACTTGCC       c.180
 S  D  K  P  F  L  N  S  D  L  R  R  S  P  S  K  P  T  L  A         p.60

          .         .   | 03     .         .         .         .    g.27509
 TATCCAGAAAGCAACAGCAGAG | CCATATTTTCTGCTCTTAAGAATCTTCAAGATAAGATT    c.240
 Y  P  E  S  N  S  R  A |   I  F  S  A  L  K  N  L  Q  D  K  I      p.80

          .         .         .         .         .         .       g.27569
 CGACGCTTGGAACTTGAGAGGATTCAGGCAGAAGAAAGTGTGAAAACCTTGTCTAGAGAA       c.300
 R  R  L  E  L  E  R  I  Q  A  E  E  S  V  K  T  L  S  R  E         p.100

          .         .         .         .         .         .       g.27629
 ACAATTGAATATAAGAAAGTACTGGATGAACAGATACAAGAAAGGGAGAATTCAAAGAAT       c.360
 T  I  E  Y  K  K  V  L  D  E  Q  I  Q  E  R  E  N  S  K  N         p.120

          .         .   | 04     .         .         .         .    g.28045
 GAGGAATCAAAGCACAATCAAG | AACTGACATCTCAGTTGTTAGCTGCAGAAAATAAATGC    c.420
 E  E  S  K  H  N  Q  E |   L  T  S  Q  L  L  A  A  E  N  K  C      p.140

          .         .         .         .         .         .       g.28105
 AATCTATTAGAAAAACAATTGGAATACATGCGAAATATGATAAAGCATGCCGAAATGGAG       c.480
 N  L  L  E  K  Q  L  E  Y  M  R  N  M  I  K  H  A  E  M  E         p.160

          .         .     | 05   .         .         .         .    g.32362
 AGGACATCTGTCTTAGAGAAACAA | GTTTCCCTAGAAAGAGAACGACAACATGATCAAACA    c.540
 R  T  S  V  L  E  K  Q   | V  S  L  E  R  E  R  Q  H  D  Q  T      p.180

          .         .         .         .         .         .       g.32422
 CATGTTCAGAGCCAACTTGAAAAATTGGATCTTCTTGAACAGGAGTATAACAAACTTACC       c.600
 H  V  Q  S  Q  L  E  K  L  D  L  L  E  Q  E  Y  N  K  L  T         p.200

          .         .  | 06      .         .         .         .    g.33405
 ACAATGCAGGCCCTTGCAGAA | AAAAAAATGCAAGAGTTGGAAGCAAAACTCCATGAAGAA    c.660
 T  M  Q  A  L  A  E   | K  K  M  Q  E  L  E  A  K  L  H  E  E      p.220

          .         .         .          | 07        .         .    g.36431
 GAACAGGAAAGGAAACGCATGCAAGCTAAGGCAGCTGAG | TTGCAGACTGGTCTAGAAACA    c.720
 E  Q  E  R  K  R  M  Q  A  K  A  A  E   | L  Q  T  G  L  E  T      p.240

          .         .         .         .         .         .       g.36491
 AATAGACTTATCTTTGAAGATAAGGCAACTCCGTGTGTTCCCAATGCAAGAAGAATTAAA       c.780
 N  R  L  I  F  E  D  K  A  T  P  C  V  P  N  A  R  R  I  K         p.260

          .         .        | 08.         .         .         .    g.37071
 AAAAAGAAGTCAAAACCACCAGAAAAG | AAAAGTTCTAGGAACTATTTTGGTGCACAACCA    c.840
 K  K  K  S  K  P  P  E  K   | K  S  S  R  N  Y  F  G  A  Q  P      p.280

          .         .         .         .      | 09  .         .    g.42340
 CATTATAGATTATGCTTGGGTGATATGCCATTTGTAGCTGGGAAG | TCCACAAGCCCTAGC    c.900
 H  Y  R  L  C  L  G  D  M  P  F  V  A  G  K   | S  T  S  P  S      p.300

          .         .         .         .         .         .       g.42400
 CATGCCGTGGTAGCCAATGTTCAGCTTGTCTTGCATCTAATGAAGCAACACAGTAAAGCT       c.960
 H  A  V  V  A  N  V  Q  L  V  L  H  L  M  K  Q  H  S  K  A         p.320

          .         .         .         .         .         .       g.42460
 TTGTGCAATGATCGAGTCATCAACAGTATTCCTTTGGCAAAGCAAGTATCTTCACGAGGT       c.1020
 L  C  N  D  R  V  I  N  S  I  P  L  A  K  Q  V  S  S  R  G         p.340

          .         .         .         .         .         .       g.42520
 GGTAAAAGTAAGAAGTTGTCAGTAACACCTCCCTCCTCCAACGGTATTAATGAGGAGTTG       c.1080
 G  K  S  K  K  L  S  V  T  P  P  S  S  N  G  I  N  E  E  L         p.360

          .         .         .         .        | 10.         .    g.43739
 TCAGAAGTCTTACAGACTTTACAGGATGAATTTGGGCAAATGAGCTT | TGATCACCAGCAG    c.1140
 S  E  V  L  Q  T  L  Q  D  E  F  G  Q  M  S  F  |  D  H  Q  Q      p.380

          .         .         .         .         .         .       g.43799
 CTTGCAAAACTTATCCAGGAGTCGCCAACCGTTGAACTGAAAGACAAGTTGGAGTGTGAA       c.1200
 L  A  K  L  I  Q  E  S  P  T  V  E  L  K  D  K  L  E  C  E         p.400

          .         .         .         .         .         .       g.43859
 TTGGAGGCATTAGTGGGAAGGATGGAAGCAAAAGCCAACCAAATAACTAAAGTTCGAAAA       c.1260
 L  E  A  L  V  G  R  M  E  A  K  A  N  Q  I  T  K  V  R  K         p.420

          .   | 11     .         .         .         .         .    g.45613
 TACCAAGCCCAG | CTGGAGAAACAGAAGTTAGAGAAGCAGAAGAAGGAATTAAAAGCTACC    c.1320
 Y  Q  A  Q   | L  E  K  Q  K  L  E  K  Q  K  K  E  L  K  A  T      p.440

          .         .         .         .         .         .       g.45673
 AAAAAGACTCTTGATGAAGAAAGAAACAGCAGCAGCCGTTCTGGAATCACAGGGACCACA       c.1380
 K  K  T  L  D  E  E  R  N  S  S  S  R  S  G  I  T  G  T  T         p.460

          .         .         .         .         .         .       g.45733
 AATAAGAAAGATTTTATGAAACTGAGACCTGGAGAAAAAAGGAGAAAAAATCTTCAGTTA       c.1440
 N  K  K  D  F  M  K  L  R  P  G  E  K  R  R  K  N  L  Q  L         p.480

          .         .         .         .         .         .       g.45793
 TTGAAGGACATGCAAAGCATACAGAATTCATTACAAAGCAGTAGTTTGTGTTGGGATTAC       c.1500
 L  K  D  M  Q  S  I  Q  N  S  L  Q  S  S  S  L  C  W  D  Y         p.500

                                                                    g.45796
 TGA                                                                c.1503
 X                                                                  p.500

          .         .         .         .         .         .       g.45856
 ctcataaccaggtcagaaattttattcagataatctgtacctcatcaatcagatgatgac       c.*60

          .         .         .         .         .         .       g.45916
 aatttacttcccaggtctcatactcacttatgttggaattaattaatagcaggtgttaaa       c.*120

          .         .         .         .         .         .       g.45976
 ggacccaggcttcattacacaggcttttcatgtatgcaggatgactcaatgttaaagcat       c.*180

          .         .         .         .         .         .       g.46036
 ttaaatggaaaccaggggagttttaaagcccgagaaaccacacataatcttttgttgaga       c.*240

          .         .         .         .         .         .       g.46096
 tgagtttgctgtactgacgctgcactttgtaaacagattaccagttttttacttgtgggt       c.*300

          .         .         .         .         .         .       g.46156
 gtgattttttaaaatagttctttatatataattaaaattaggtttaaattttcaaaatat       c.*360

          .         .         .         .         .         .       g.46216
 gagactatgctataggcagtgcttgcttgaaaagtctcatttttaaatctccctggcatg       c.*420

          .         .         .         .         .         .       g.46276
 aggtgcccacttcccctttccaaagcaaccattaaacatactttgtttctactattggtg       c.*480

          .         .         .         .         .         .       g.46336
 gagtttttctatatttaaaaatacatatatatttcagaggatttttattttgctttttgg       c.*540

          .         .         .         .         .         .       g.46396
 catttcagactttgatcagtgttaagtgcacttgtattgctttttaatctgttaattttt       c.*600

          .         .         .         .         .         .       g.46456
 taaagacccaagcagtcattttgagttatatctataaaaattataaaaggatttttgaaa       c.*660

          .         .         .         .         .         .       g.46516
 gtataaacaaattgtcagtgaaataaatgagattttggaataaagtgagaatgggagaag       c.*720

          .         .         .         .         .         .       g.46576
 ggatatgttgtgagcatataccttcacagttcttaatacctgttttgtaatcatgatatt       c.*780

          .         .         .         .         .         .       g.46636
 cagtcaaggcattatggtttttaatcttgaaacttagagaaccctttgaatatttgcttt       c.*840

          .         .         .         .         .         .       g.46696
 tactggtgtacagtatgagtggaatataaactgtacacataattatcatgttgatataaa       c.*900

          .         .         .         .         .         .       g.46756
 tcataatttcaactagatcaagacatgttaaccttttataaatttaaagtcaataaagca       c.*960

          .         .         .         .         .         .       g.46816
 cctttttaaaggaaacactgcaactttccttaacagcctgttaataaaggctttgtgaca       c.*1020

          .         .         .         .         .         .       g.46876
 agctctcaaaaaatgcatttctaaataggaggacatcaatgtattgatgaagagaaaaaa       c.*1080

          .         .         .         .         .         .       g.46936
 ctagtacttagttgccacactcatgcttacatagaaagagagcccaagaatattagattt       c.*1140

          .         .         .         .         .         .       g.46996
 cctcatgatacaagatactacagtaacaggctttaatttaggatccttaagattttgggg       c.*1200

          .         .         .         .         .         .       g.47056
 tattatttgtgactctcctgaaattgtaaacttgtgcttctgtgtccagttttctaatga       c.*1260

          .         .         .         .         .         .       g.47116
 gtaggttcgtagcttgattgaattaataattgtgagcccatagacacaagggaagtgaga       c.*1320

          .         .         .         .         .         .       g.47176
 aacagtgctctggtgacatgataaatatatgtgtcaaccaccatttcagctattaaaaac       c.*1380

          .         .         .         .         .                 g.47233
 tcctgttatctccttgtttgaatttcaggtcattaaattgtataaccatcatttgaa          c.*1437

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Centrosomal protein 57kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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