centrosomal protein 78kDa (CEP78) - coding DNA reference sequence

(used for variant description)

(last modified July 2, 2016)


This file was created to facilitate the description of sequence variants on transcript NM_001098802.1 in the CEP78 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000009.11, covering CEP78 transcript NM_001098802.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5036
                         ggcttgaatcccggcgcctcagaggactatgaggcg       c.-241

 .         .         .         .         .         .                g.5096
 ggcgccaactgcttgggccgcagggcgggaggcagcgcgggagtggggcgttgaggggcc       c.-181

 .         .         .         .         .         .                g.5156
 ggcctagcttggggctctggccttgcgtcttccgaccgaatcaccgctcctgagcccggt       c.-121

 .         .         .         .         .         .                g.5216
 gcggggctgccgctatcgcctggccgtgggtgccggagcggccgggttgcgactcagcgt       c.-61

 .         .         .         .         .         .                g.5276
 tcttgggtgggcgcgggcggcgtctccgcggcgggcatcccccgaggccgccctcgggcc       c.-1

          .         .         .         .         .         .       g.5336
 ATGATCGACTCCGTGAAGCTGCGCCGCGACAGCGCGGCGGACTTCTTCTCCCACTACGAG       c.60
 M  I  D  S  V  K  L  R  R  D  S  A  A  D  F  F  S  H  Y  E         p.20

          .         .         .         .         .         .       g.5396
 TACCTGTGCGCGCTGCAGAACTCGGTGCCGCTGCCCGCCGTGCGCGCCTGTCTCCGGGAG       c.120
 Y  L  C  A  L  Q  N  S  V  P  L  P  A  V  R  A  C  L  R  E         p.40

          .         .         .         .         .         .       g.5456
 GGCGTGCTGGATTTCAACGCCGACCGCCTCCGCGGGGTGGACTGGGCGCCTCTGCTGAGC       c.180
 G  V  L  D  F  N  A  D  R  L  R  G  V  D  W  A  P  L  L  S         p.60

          .         .         .         .         .         .       g.5516
 ACCCTCAAGATCAATAAAGACCTGCCCTTGGTCTCCATCAAGAGCTTCTTCCAGCCCTGG       c.240
 T  L  K  I  N  K  D  L  P  L  V  S  I  K  S  F  F  Q  P  W         p.80

          .    | 02    .         .         .         .         .    g.8995
 CTGGGGGACACAG | GTTCTGACATGAATAAATTTTGCAGAAGTCGTGTTCCTGCGATAAGA    c.300
 L  G  D  T  G |   S  D  M  N  K  F  C  R  S  R  V  P  A  I  R      p.100

          .         .         .         .         .         .       g.9055
 TACAAAGATGTGACCTTCCAGTTGTGTAAAGCTCTTAAAGGCTGTTTAAGTATATCAAGT       c.360
 Y  K  D  V  T  F  Q  L  C  K  A  L  K  G  C  L  S  I  S  S         p.120

          .         .         .         .         .         .       g.9115
 GTGCTAAAGAACCTGGAGCTAAATGGACTAATTCTGAGAGAGAGGGATTTAACTATTCTA       c.420
 V  L  K  N  L  E  L  N  G  L  I  L  R  E  R  D  L  T  I  L         p.140

        | 03 .         .         .         .         .         .    g.9271
 GCAAAG | GGATTGAATAAATCGGCTTCTTTGGTGCACCTGTCTCTTGCAAATTGTCCAATT    c.480
 A  K   | G  L  N  K  S  A  S  L  V  H  L  S  L  A  N  C  P  I      p.160

          .          | 04        .         .         .         .    g.10662
 GGAGATGGAGGTTTAGAAA | TTATTTGTCAAGGTATAAAGAGCTCTATCACTCTTAAGACA    c.540
 G  D  G  G  L  E  I |   I  C  Q  G  I  K  S  S  I  T  L  K  T      p.180

          .         .         .         .         .         .       g.10722
 GTCAACTTCACAGGATGTAATCTGACATGGCAGGGAGCAGATCACATGGCCAAGATCTTA       c.600
 V  N  F  T  G  C  N  L  T  W  Q  G  A  D  H  M  A  K  I  L         p.200

     | 05    .         .         .         .         .         .    g.12444
 AAG | TATCAGACCATGAGAAGGCATGAAGAAACCTGGGCTGAGAGTCTTCGCTATAGGAGA    c.660
 K   | Y  Q  T  M  R  R  H  E  E  T  W  A  E  S  L  R  Y  R  R      p.220

          .         .         .         .         .         .       g.12504
 CCTGATCTTGACTGTATGGCTGGCTTAAGACGTATCACACTGAATTGCAACACACTTATT       c.720
 P  D  L  D  C  M  A  G  L  R  R  I  T  L  N  C  N  T  L  I         p.240

          .         .         .         .         .         | 06    g.15596
 GGTGACCTAGGTGCATGTGCTTTTGCAGACTCTCTCAGTGAGGATTTATGGCTGAGAG | CT    c.780
 G  D  L  G  A  C  A  F  A  D  S  L  S  E  D  L  W  L  R  A |       p.260

          .         .         .         .         .         .       g.15656
 CTTGACCTGCAACAGTGCGGCCTCACCAATGAAGGAGCAAAGGCTTTGCTAGAGGCCCTT       c.840
 L  D  L  Q  Q  C  G  L  T  N  E  G  A  K  A  L  L  E  A  L         p.280

          .         .         .         .         .   | 07     .    g.17224
 GAAACCAATACAACTCTGGTCGTTCTGGATATAAGAAAAAATCCACTCATTG | ATCATTCT    c.900
 E  T  N  T  T  L  V  V  L  D  I  R  K  N  P  L  I  D |   H  S      p.300

          .         .         .         .         .        | 08.    g.17690
 ATGATGAAAGCAGTTATCAAAAAAGTCCTCCAGAATGGAAGGAGTGCCAAATCAGAG | TAC    c.960
 M  M  K  A  V  I  K  K  V  L  Q  N  G  R  S  A  K  S  E   | Y      p.320

          .         .         .         .         .         .       g.17750
 CAGTGGATAACTTCTCCATCAGTGAAGGAACCATCCAAAACTGCTAAACAGAAAAGGAGA       c.1020
 Q  W  I  T  S  P  S  V  K  E  P  S  K  T  A  K  Q  K  R  R         p.340

          .         .         .         .          | 09        .    g.20841
 ACTATAATTCTAGGAAGTGGTCACAAAGGAAAAGCTACTATTAGAATTG | TAGGATTGGCT    c.1080
 T  I  I  L  G  S  G  H  K  G  K  A  T  I  R  I  V |   G  L  A      p.360

          .         .         .         .         .         .       g.20901
 ACAAAGAAACCTGTAAGTAGTGGCAGAAAACACTCCCTTGGTAAAGAATATTATGCGCCC       c.1140
 T  K  K  P  V  S  S  G  R  K  H  S  L  G  K  E  Y  Y  A  P         p.380

          .         .         .         .         .         .       g.20961
 GCACCTCTTCCACCTGGTGTGTCTGGTTTCTTGCCGTGGCGTACTGCAGAACGTGCAAAA       c.1200
 A  P  L  P  P  G  V  S  G  F  L  P  W  R  T  A  E  R  A  K         p.400

          | 10         .         .         .         .     | 11   . g.23767
 AGACACAG | GGGTTTCCCATTAATCAAAACACGTGATATATGTAATCAGTTGCAG | CAACCA c.1260
 R  H  R  |  G  F  P  L  I  K  T  R  D  I  C  N  Q  L  Q   | Q  P   p.420

          .         .         .         .         .         .       g.23827
 GGTTTTCCTGTGACTGTGACAGTAGAGAGTCCTTCATCCTCTGAAGTTGAAGAGGTTGAT       c.1320
 G  F  P  V  T  V  T  V  E  S  P  S  S  S  E  V  E  E  V  D         p.440

          .         .         .         .         .         .       g.23887
 GATTCTTCAGAGAGTGTTCATGAAGTGCCTGAGAAAACTAGTATAGAACAAGAAGCATTA       c.1380
 D  S  S  E  S  V  H  E  V  P  E  K  T  S  I  E  Q  E  A  L         p.460

     | 12    .         .         .         .         .         .    g.31889
 CAG | GAAAAACTGGAGGAGTGCCTAAAGCAGTTAAAGGAAGAAAGAGTGATAAGGCTTAAG    c.1440
 Q   | E  K  L  E  E  C  L  K  Q  L  K  E  E  R  V  I  R  L  K      p.480

          .         .  | 13      .         .         .         .    g.33114
 GTTGATAAACGAGTCAGTGAG | CTGGAACATGAAAATGCCCAGTTAAGAAATATAAATTTC    c.1500
 V  D  K  R  V  S  E   | L  E  H  E  N  A  Q  L  R  N  I  N  F      p.500

          .         .         .         .         .         .       g.33174
 TCTTTGTCTGAAGCCCTTCATGCACAGTCATTGACAAATATGATCCTGGATGATGAAGGT       c.1560
 S  L  S  E  A  L  H  A  Q  S  L  T  N  M  I  L  D  D  E  G         p.520

          .         .         .         .         .         .       g.33234
 GTTTTGGGCAGCATTGAGAATTCTTTTCAGAAGTTTCATGCTTTCTTGGATCTCCTTAAA       c.1620
 V  L  G  S  I  E  N  S  F  Q  K  F  H  A  F  L  D  L  L  K         p.540

          | 14         .         .         .         .         .    g.34349
 GATGCTGG | GCTTGGGCAGCTTGCCACAATGGCTGGGATAGATCAGTCAGATTTTCAATTA    c.1680
 D  A  G  |  L  G  Q  L  A  T  M  A  G  I  D  Q  S  D  F  Q  L      p.560

          .         .         .         .         .         .       g.34409
 CTAGGTCATCCCCAGATGACTTCTACTGTTAGTAATCCACCTAAAGAAGAAAAGAAGGCG       c.1740
 L  G  H  P  Q  M  T  S  T  V  S  N  P  P  K  E  E  K  K  A         p.580

          .         .         .         .         .         .       g.34469
 CTTGAAGATGAAAAACCAGAACCGAAGCAGAATGCCCTAGGGCAAATGCAAAATATCCAG       c.1800
 L  E  D  E  K  P  E  P  K  Q  N  A  L  G  Q  M  Q  N  I  Q         p.600

  | 15       .         .         .         .         | 16         . g.35379
  | GTTTCTATTTGTATGCAGTCAGCTTACAATGAAGGAACACTAATGAAG | TTTCAGAAAATT c.1860
  | V  S  I  C  M  Q  S  A  Y  N  E  G  T  L  M  K   | F  Q  K  I   p.620

          .         .         .         .         .         .       g.35439
 ACAGGTGATGCTAGAATTCCTTTGCCTCTCGACTCCTTTCCTGTCCCAGTTTCTACTCCA       c.1920
 T  G  D  A  R  I  P  L  P  L  D  S  F  P  V  P  V  S  T  P         p.640

          .         .         .         .         .         .       g.35499
 GAGGGCTTAGGAACTTCCAGCAACAACCTAGGAGTCCCAGCTACTGAGCAGCGGCAGGAG       c.1980
 E  G  L  G  T  S  S  N  N  L  G  V  P  A  T  E  Q  R  Q  E         p.660

          .         .         .         .         .         .       g.35559
 TCTTTTGAAGGATTCATTGCTAGAATGTGTTCTCCTTCACCAGATGCGACTTCTGGAACT       c.2040
 S  F  E  G  F  I  A  R  M  C  S  P  S  P  D  A  T  S  G  T         p.680

          .         .         .         .         .         .       g.35619
 GGAAGTCAAAGAAAAGAAGAGGAGTTGTCCAGAAATAGCAGATCTTCTTCAGAGAAAAAG       c.2100
 G  S  Q  R  K  E  E  E  L  S  R  N  S  R  S  S  S  E  K  K         p.700

          .         .         .         .         .         .       g.35679
 ACCAAAACAGGTGAATATACCAAAAAACACTCTGATAAGCAACACCCTGGAAAGGACCTG       c.2160
 T  K  T  G  E  Y  T  K  K  H  S  D  K  Q  H  P  G  K  D  L         p.720

                                                                    g.35688
 CATTCCTGA                                                          c.2169
 H  S  X                                                            p.722

          .         .         .         .         .         .       g.35748
 tctgactgtcctgaaaaccagaaaagcaaagaaactagggaaactagttctttggttaat       c.*60

          .         .         .         .         .         .       g.35808
 gaaccaattaaaagtaggtctttgaaaaaatacgtttctgtcaagaaagaaaatagaata       c.*120

          .         .         .         .         .         .       g.35868
 gtgactgtttcatccaagacaaataaaagtaaatccagtccactagaacattctgaaagt       c.*180

          .         .         .         .         .         .       g.35928
 gatactcttggatgtgattttgaatttcaagaaagcatccattctctatcacacctttca       c.*240

          .         .         .         .         .         .       g.35988
 tatgactaaatcttttgaaactatgtttttacctttaaattttaataaattttcttatgt       c.*300

                                                                    g.35993
 tttta                                                              c.*305

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Centrosomal protein 78kDa protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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