ceramide synthase 3 (CERS3) - coding DNA reference sequence

(used for variant description)

(last modified June 14, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_178842.3 in the CERS3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_042826.1, covering CERS3 transcript NM_178842.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5004
                                                         cggg       c.-421

 .         .         .         .         .         .                g.5064
 atgcaccgctgcggggaccccccgcccggcctcgcggacccgcctcggcccaggacggag       c.-361

 .      | 02  .         .         .         .         .             g.20699
 gaggag | gtggtgaaacaggaagcaacatcccatcaggaagaacctgagggtgccatccag    c.-301

 .         .         .         .         .         .                g.20759
 tagcttcgcctcacgtcactgactgccctcagtcagaaatcttgactcgcaactttggag       c.-241

 .         .         .         .         .         .                g.20819
 ggtgggtctctgaaggaatttcaggtcttacacagagatgagttgtgctgctctctgagg       c.-181

 .         .         .         .         .         .                g.20879
 agaacgaagctggttggaacgttggaagctgctctctgactacacttcacaagcaagggg       c.-121

 .         .         .         | 03         .         .             g.27995
 caccttttgtggactgacatttcagaaag | ggatgttgtgaaacaaaagctgacatttata    c.-61

 .         .         .         .         .         .         | 04    g.47871
 tatatatacatatatacagtatttgagttcctcagtagaaagctatcatatatactcag | a    c.-1

          .         .         .         .         .         .       g.47931
 ATGTTTTGGACGTTTAAAGAATGGTTCTGGTTGGAAAGATTCTGGCTTCCTCCAACAATA       c.60
 M  F  W  T  F  K  E  W  F  W  L  E  R  F  W  L  P  P  T  I         p.20

          .         .         .         .         .         .       g.47991
 AAGTGGTCAGATCTTGAGGATCACGATGGACTCGTCTTTGTAAAACCTTCTCATTTATAC       c.120
 K  W  S  D  L  E  D  H  D  G  L  V  F  V  K  P  S  H  L  Y         p.40

          .         .         .         .         .    | 05    .    g.58796
 GTGACAATTCCATATGCTTTTCTCTTGCTGATTATCAGACGTGTATTTGAAAA | ATTTGTT    c.180
 V  T  I  P  Y  A  F  L  L  L  I  I  R  R  V  F  E  K  |  F  V      p.60

          .         .         .         .         .         .       g.58856
 GCTTCACCTCTAGCAAAATCATTTGGCATTAAAGAGACAGTTCGAAAGGTTACACCAAAT       c.240
 A  S  P  L  A  K  S  F  G  I  K  E  T  V  R  K  V  T  P  N         p.80

          .         .         .         .         | 06         .    g.65064
 ACTGTCTTAGAGAATTTTTTCAAACATTCCACAAGGCAACCATTGCAA | ACTGATATTTAT    c.300
 T  V  L  E  N  F  F  K  H  S  T  R  Q  P  L  Q   | T  D  I  Y      p.100

          .         .         .         .         .         .       g.65124
 GGACTGGCAAAGAAGTGTAACTTGACGGAGCGCCAGGTGGAAAGATGGTTTAGGAGTCGG       c.360
 G  L  A  K  K  C  N  L  T  E  R  Q  V  E  R  W  F  R  S  R         p.120

          .         .         .         .        | 07.         .    g.69687
 CGGAATCAAGAGAGGCCTTCCAGGCTGAAGAAATTCCAGGAAGCTTG | CTGGAGATTTGCA    c.420
 R  N  Q  E  R  P  S  R  L  K  K  F  Q  E  A  C  |  W  R  F  A      p.140

          .         .         .         .      | 08  .         .    g.70257
 TTTTACTTAATGATCACTGTTGCTGGAATTGCGTTTCTTTATGAT | AAACCTTGGCTATAT    c.480
 F  Y  L  M  I  T  V  A  G  I  A  F  L  Y  D   | K  P  W  L  Y      p.160

          .         .         .       | 09 .         .         .    g.73566
 GACTTATGGGAGGTTTGGAATGGCTATCCCAAACAG | CCCCTGCTGCCATCCCAGTACTGG    c.540
 D  L  W  E  V  W  N  G  Y  P  K  Q   | P  L  L  P  S  Q  Y  W      p.180

          .         .         .         .         .         .       g.73626
 TACTACATTTTAGAAATGAGTTTTTATTGGTCTCTGTTATTTAGACTTGGCTTTGATGTC       c.600
 Y  Y  I  L  E  M  S  F  Y  W  S  L  L  F  R  L  G  F  D  V         p.200

           | 10        .         .         .         .         .    g.76719
 AAGAGAAAG | GATTTTCTAGCTCATATCATCCACCACCTGGCTGCTATTAGTCTGATGAGC    c.660
 K  R  K   | D  F  L  A  H  I  I  H  H  L  A  A  I  S  L  M  S      p.220

          .         .         .         .         .         .       g.76779
 TTCTCTTGGTGTGCTAATTATATTCGCAGTGGGACCCTCGTGATGATTGTACACGATGTG       c.720
 F  S  W  C  A  N  Y  I  R  S  G  T  L  V  M  I  V  H  D  V         p.240

          .         | 11         .         .         .         .    g.80278
 GCTGACATTTGGCTGGAG | TCTGCTAAGATGTTTTCTTATGCTGGATGGACGCAGACCTGT    c.780
 A  D  I  W  L  E   | S  A  K  M  F  S  Y  A  G  W  T  Q  T  C      p.260

          .         .         .         .         .         .       g.80338
 AACACCCTGTTTTTCATCTTCTCCACCATATTTTTCATCAGCCGCCTCATTGTTTTTCCT       c.840
 N  T  L  F  F  I  F  S  T  I  F  F  I  S  R  L  I  V  F  P         p.280

       | 12  .         .         .         .         .         .    g.93729
 TTCTG | GATTTTATATTGCACGCTGATCTTGCCTATGTATCACCTCGAGCCTTTCTTTTCA    c.900
 F  W  |  I  L  Y  C  T  L  I  L  P  M  Y  H  L  E  P  F  F  S      p.300

          .         .         .         .         .         .       g.93789
 TACATCTTCCTCAACCTACAGCTCATGATCTTGCAGGTCCTTCACCTTTACTGGGGTTAT       c.960
 Y  I  F  L  N  L  Q  L  M  I  L  Q  V  L  H  L  Y  W  G  Y         p.320

          .         .         .          | 13        .         .    g.146876
 TACATCTTGAAGATGCTCAACAGATGTATATTCATGAAG | AGCATCCAGGATGTGAGGAGT    c.1020
 Y  I  L  K  M  L  N  R  C  I  F  M  K   | S  I  Q  D  V  R  S      p.340

          .         .         .         .         .         .       g.146936
 GATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAA       c.1080
 D  D  E  D  Y  E  E  E  E  E  E  E  E  E  E  A  T  K  G  K         p.360

          .         .         .         .         .         .       g.146996
 GAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAG       c.1140
 E  M  D  C  L  K  N  G  L  R  A  E  R  H  L  I  P  N  G  Q         p.380

          .                                                         g.147008
 CATGGCCATTAG                                                       c.1152
 H  G  H  X                                                         p.383

          .         .         .         .         .         .       g.147068
 ctggaagcctacaggactcccatggcacagcatgctgcaagtactgttggcagcctggct       c.*60

          .         .         .         .         .         .       g.147128
 tccaggccccacaccgaccccacattctgcccttccctctttctcaccaccgccttccct       c.*120

          .         .         .         .         .         .       g.147188
 cccacctaagatgtgtttaccaaaatgttgttaacttgtgttaaaatgttaaatataagc       c.*180

          .         .         .         .         .         .       g.147248
 atgcccatggatttttactgcagttaggactcagactggtcaaagatttcaaagatttct       c.*240

          .         .         .         .         .         .       g.147308
 ccacagaaccgtctcagttctaattgcactccctcatgcatgtcactttctcaggggctc       c.*300

          .         .         .         .         .         .       g.147368
 gctttgttatagaccctttcgcctcgccaccttgcctgtcctcaggacgctttcacaggt       c.*360

          .         .         .         .         .         .       g.147428
 gctaagtgatctcatttttcccaggtgtgtttggccacaaagagcagcttctttctcaaa       c.*420

          .         .         .         .         .         .       g.147488
 atgagttagaagtggcagtgggacaggagcggaaggaccacaccaggagacacttccatc       c.*480

          .         .         .         .         .         .       g.147548
 ctgaagcttaggtgcctcatctccacagggcggtggcagtccctgcctgccaccccacag       c.*540

          .         .         .         .         .         .       g.147608
 ggttacagcaaggattaagtgagatcacagaagtttaagtacacactgtcaaccgtgggg       c.*600

          .         .         .         .         .         .       g.147668
 tcatcgtgaaccaacccactttgcactgtttgggagacagaaacctggctaaacatggca       c.*660

          .         .         .         .         .         .       g.147728
 ctgcaatgggcctgaacaaaaggcagaatctttaaaaattcctcttaaatgactctggag       c.*720

          .         .         .         .         .         .       g.147788
 atacctggaaatgaaagtgccaagaaaggtgttccattttatttgctaactatttatgca       c.*780

          .         .         .         .         .         .       g.147848
 ttagctccccaagggtcattctcagattctcctggaattcttctccctcaggacccatgg       c.*840

          .         .         .         .         .         .       g.147908
 ttcaaggaaggaagcttaggccctgttccttcctgtcctttgctggtctttccctttttt       c.*900

          .         .         .         .         .         .       g.147968
 cctttctaggagggaagcttctgtgctgctgccctgagcccttccttcaggccagcacag       c.*960

          .         .         .         .         .         .       g.148028
 tacctggggacctccacgggggaatgggatccaggccaggttgcttgctgagcctcatca       c.*1020

          .         .         .         .         .         .       g.148088
 cccaggaggcctgagcctctggggagggcacgcatgtacactgccagacccaggggagat       c.*1080

          .         .         .         .         .         .       g.148148
 cttgggaacagaggatgctacgtgatttcctctggcttccaacccaatcagcctgcatca       c.*1140

          .         .         .         .         .         .       g.148208
 cagtgaaacacaacacaaaaggccataaaaggcatacccctgagaaatgtttaagggcag       c.*1200

          .         .         .         .         .         .       g.148268
 gtgctagagtcagtgccagctccctgggaggagggatagggacgggcagatcagtagcca       c.*1260

          .         .         .         .         .         .       g.148328
 gcttgtcctcaccctccggaagggagcaccggagaagacttgcacacgtccctgcctccc       c.*1320

          .         .         .         .         .         .       g.148388
 ttgcggccttgtcaccagagggacacatctcctgggcacaatgtgcagggctgacctggg       c.*1380

          .         .         .         .         .         .       g.148448
 agacttctcaggtggctgctggctgaggagaggccaggccttcccaaggaagaccctgag       c.*1440

          .         .         .         .         .         .       g.148508
 taaaatctgcatctgtcctcaccacctggcacagtctctcataacggtcagattttgtat       c.*1500

          .         .         .         .         .         .       g.148568
 gttcatcctatttattcaggggctcgtactagaaagccacaggagaggtcggcttgtagg       c.*1560

          .         .         .         .         .         .       g.148628
 gactggaaaatcagccccaagcagagcagctgcagggcccctggagccggaaggacactg       c.*1620

          .         .         .         .         .         .       g.148688
 cacagaacagactgcgttattgttatttttaaataaaaatatacatttgaaaccttaagg       c.*1680

          .         .         .         .         .         .       g.148748
 ctaaacaaaaataaacaaaaaatcctttagaattctttccacaacaatatctctttctga       c.*1740

          .         .         .         .         .         .       g.148808
 gaaattgttacaaacaaggtcagattttctctgtataacatttgcttttatgaggacaat       c.*1800

          .         .         .         .         .         .       g.148868
 atcatatgcattatatgcataatatgatattataaatcaaaatgcctgcacccactttag       c.*1860

          .         .         .         .         .         .       g.148928
 ggtatagctattgacttattattaatattatattattattattttgctggaagaaggtca       c.*1920

          .         .         .         .         .         .       g.148988
 cactaagatataattttttatgttttcagttaacggtatgctttcttctttgcttatttg       c.*1980

          .         .         .         .         .         .       g.149048
 gtttttgtctctgtaccaaatatcttcttgcttaaggtagaaaagtatttgtttacctct       c.*2040

          .         .         .         .         .         .       g.149108
 atctccagttttttttcttatttgaatgttgaaggtaaaattgatataccaattttaact       c.*2100

          .         .         .         .         .         .       g.149168
 atttctgatacagctgaaagcactaaactacttcataagaagtagatactcatttttgta       c.*2160

          .         .         .         .         .         .       g.149228
 acactatttagggcttttgtggttaattttaaaggaaaccactctttctacaggaaacaa       c.*2220

          .         .         .         .         .         .       g.149288
 gggctcaggattcttcagatgaccttataaaaatgcagtccacagtgctatcaatattgt       c.*2280

          .         .         .                                     g.149326
 aacagtaatgactacaataaagccaaaagtccagtgta                             c.*2318

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ceramide synthase 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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