complement factor H-related 3 (CFHR3) - coding DNA reference sequence

(used for variant description)

(last modified January 11, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_021023.5 in the CFHR3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_015993.1, covering CFHR3 transcript NM_021023.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5027
                                  acacttggtaactaataatgaaagatt       c.-61

 .         .         .         .         .         .                g.5087
 tcaaaccccaaacagtgcaactgaaacttttgtattagcatactactgagaatatctaac       c.-1

          .         .         .         .         .         | 02    g.9364
 ATGTTGTTACTAATCAATGTCATTCTGACCTTGTGGGTTTCCTGTGCTAATGGACAAG | TG    c.60
 M  L  L  L  I  N  V  I  L  T  L  W  V  S  C  A  N  G  Q  V |       p.20

          .         .         .         .         .         .       g.9424
 AAACCTTGTGATTTTCCAGACATTAAACATGGAGGTCTATTTCATGAGAATATGCGTAGA       c.120
 K  P  C  D  F  P  D  I  K  H  G  G  L  F  H  E  N  M  R  R         p.40

          .         .         .         .         .         .       g.9484
 CCATACTTTCCAGTAGCTGTAGGAAAATATTACTCCTATTACTGTGATGAACATTTTGAG       c.180
 P  Y  F  P  V  A  V  G  K  Y  Y  S  Y  Y  C  D  E  H  F  E         p.60

          .         .         .         .         .         .       g.9544
 ACTCCTTCAGGAAGTTACTGGGATTACATTCATTGCACACAAAATGGGTGGTCACCAGCA       c.240
 T  P  S  G  S  Y  W  D  Y  I  H  C  T  Q  N  G  W  S  P  A         p.80

          .    | 03    .         .         .         .         .    g.10044
 GTACCATGTCTCA | GAAAATGTTATTTTCCTTATTTGGAAAATGGATATAATCAAAATTAT    c.300
 V  P  C  L  R |   K  C  Y  F  P  Y  L  E  N  G  Y  N  Q  N  Y      p.100

          .         .         .         .         .         .       g.10104
 GGAAGAAAGTTTGTACAGGGTAACTCTACAGAAGTTGCCTGCCATCCTGGCTACGGTCTT       c.360
 G  R  K  F  V  Q  G  N  S  T  E  V  A  C  H  P  G  Y  G  L         p.120

          .         .         .         .         .         .       g.10164
 CCAAAAGCGCAGACCACAGTTACATGTACGGAGAAAGGCTGGTCTCCTACTCCCAGATGC       c.420
 P  K  A  Q  T  T  V  T  C  T  E  K  G  W  S  P  T  P  R  C         p.140

          . | 04       .         .         .         .         .    g.18466
 ATCCGTGTCA | GAACATGCTCAAAATCAGATATAGAAATTGAAAATGGATTCATTTCCGAA    c.480
 I  R  V  R |   T  C  S  K  S  D  I  E  I  E  N  G  F  I  S  E      p.160

          .         .         .         .         .         .       g.18526
 TCTTCCTCTATTTATATTTTAAATAAAGAAATACAATATAAATGTAAACCAGGATATGCA       c.540
 S  S  S  I  Y  I  L  N  K  E  I  Q  Y  K  C  K  P  G  Y  A         p.180

          .         .         .         .         .         .       g.18586
 ACAGCAGATGGAAATTCTTCAGGATCAATTACATGTTTGCAAAATGGATGGTCAGCACAA       c.600
 T  A  D  G  N  S  S  G  S  I  T  C  L  Q  N  G  W  S  A  Q         p.200

          .    | 05    .         .         .         .         .    g.20292
 CCAATTTGCATTA | ATTCTTCAGAAAAGTGTGGGCCTCCTCCACCTATTAGCAATGGTGAT    c.660
 P  I  C  I  N |   S  S  E  K  C  G  P  P  P  P  I  S  N  G  D      p.220

          .         .         .         .         .         .       g.20352
 ACCACCTCCTTTCTACTAAAAGTGTATGTGCCACAGTCAAGAGTCGAGTACCAATGCCAG       c.720
 T  T  S  F  L  L  K  V  Y  V  P  Q  S  R  V  E  Y  Q  C  Q         p.240

          .         .         .         .         .         .       g.20412
 CCCTACTATGAACTTCAGGGTTCTAATTATGTAACATGTAGTAATGGAGAGTGGTCGGAA       c.780
 P  Y  Y  E  L  Q  G  S  N  Y  V  T  C  S  N  G  E  W  S  E         p.260

          .       | 06 .         .         .         .         .    g.23561
 CCACCAAGATGCATAC | ATCCATGTATAATAACTGAAGAAAACATGAATAAAAATAACATA    c.840
 P  P  R  C  I  H |   P  C  I  I  T  E  E  N  M  N  K  N  N  I      p.280

          .         .         .         .         .         .       g.23621
 AAGTTAAAAGGAAGAAGTGACAGAAAATATTATGCAAAAACAGGGGATACCATTGAATTT       c.900
 K  L  K  G  R  S  D  R  K  Y  Y  A  K  T  G  D  T  I  E  F         p.300

          .         .         .         .         .         .       g.23681
 ATGTGTAAATTGGGATATAATGCAAATACATCAATTCTATCATTTCAAGCAGTGTGTCGG       c.960
 M  C  K  L  G  Y  N  A  N  T  S  I  L  S  F  Q  A  V  C  R         p.320

          .         .         .                                     g.23714
 GAAGGGATAGTGGAATACCCCAGATGCGAATAA                                  c.993
 E  G  I  V  E  Y  P  R  C  E  X                                    p.330

          .         .         .         .         .         .       g.23774
 ggcagcattgttaccctaaatgtatgtccaacttccacttttccacttctcactcttatg       c.*60

          .         .         .         .         .         .       g.23834
 gtctcaaagcttgcaaagatagcttctgatattgttgtaatttctactttatttcaaaga       c.*120

          .         .         .         .         .         .       g.23894
 aaattaatataatagtttcaatttgcaacttaatatattctcaaaaatatattaaaacaa       c.*180

          .         .         .         .         .         .       g.23954
 actaaattattgcttatgcttgtactaaaataataaaaactactcttatattggacttct       c.*240

          .         .         .         .         .         .       g.24014
 tatcaatgaattagtaagtatagagacagacagctgaatggctttctgcatattgtatag       c.*300

          .         .         .         .         .         .       g.24074
 tatacctagacatagaaacaaaatgactttagattttatttggggaagtaataataccat       c.*360

          .         .         .         .         .         .       g.24134
 aaaattagatattaaaattgtaagtgaagataaacacactatagtattcccttattgtag       c.*420

          .         .         .         .         .         .       g.24194
 ccatggtcctctagatgcagttaaccaaatagggtcatttttattaaaagtagtgtttcc       c.*480

          .         .         .         .         .         .       g.24254
 tggcaaacactgacattacatcattatcatgatttaaaggaaatagtactagagaaggtg       c.*540

          .         .                                               g.24274
 aattattatcattttcctgt                                               c.*560

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Complement factor H-related 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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