complement factor I (CFI) - coding DNA reference sequence

(used for variant description)

(last modified March 13, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_000204.3 in the CFI gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering CFI transcript NM_000204.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                         .         .                g.5028
                                 tctttaatgggaaggccattttttggtt       c.-181

 .         .         .         .         .         .                g.5088
 tcagttacggtaaatctctctggatttcagccaaattctttcagagttcaaaagtacaaa       c.-121

 .         .         .         .         .         .                g.5148
 gctctttaggaggtttgttcttttgaaacattttttcagaggttaaaaattaaatttcaa       c.-61

 .         .         .         .         .         .                g.5208
 aagaatacctggagtggaaaagagttctcagcagagacaaagaccccgaacacctccaac       c.-1

          .         .         .         .         .        | 02.    g.40358
 ATGAAGCTTCTTCATGTTTTCCTGTTATTTCTGTGCTTCCACTTAAGGTTTTGCAAG | GTC    c.60
 M  K  L  L  H  V  F  L  L  F  L  C  F  H  L  R  F  C  K   | V      p.20

          .         .         .         .         .         .       g.40418
 ACTTATACATCTCAAGAGGATCTGGTGGAGAAAAAGTGCTTAGCAAAAAAATATACTCAC       c.120
 T  Y  T  S  Q  E  D  L  V  E  K  K  C  L  A  K  K  Y  T  H         p.40

          .         .         .         .         .         .       g.40478
 CTCTCCTGCGATAAAGTCTTCTGCCAGCCATGGCAGAGATGCATTGAGGGCACCTGTGTT       c.180
 L  S  C  D  K  V  F  C  Q  P  W  Q  R  C  I  E  G  T  C  V         p.60

          .         .         .         .         .         .       g.40538
 TGTAAACTACCGTATCAGTGCCCAAAGAATGGCACTGCAGTGTGTGCAACTAACAGGAGA       c.240
 C  K  L  P  Y  Q  C  P  K  N  G  T  A  V  C  A  T  N  R  R         p.80

          .         .         .         .         .         .       g.40598
 AGCTTCCCAACATACTGTCAACAAAAGAGTTTGGAATGTCTTCATCCAGGGACAAAGTTT       c.300
 S  F  P  T  Y  C  Q  Q  K  S  L  E  C  L  H  P  G  T  K  F         p.100

          .         .         | 03         .         .         .    g.42521
 TTAAATAACGGAACATGCACAGCCGAAG | GAAAGTTTAGTGTTTCCTTGAAGCATGGAAAT    c.360
 L  N  N  G  T  C  T  A  E  G |   K  F  S  V  S  L  K  H  G  N      p.120

          .         .         .         .         .         .       g.42581
 ACAGATTCAGAGGGAATAGTTGAAGTAAAACTTGTGGACCAAGATAAGACAATGTTCATA       c.420
 T  D  S  E  G  I  V  E  V  K  L  V  D  Q  D  K  T  M  F  I         p.140

          .         .         .         .         .         .       g.42641
 TGCAAAAGCAGCTGGAGCATGAGGGAAGCCAACGTGGCCTGCCTTGACCTTGGGTTTCAA       c.480
 C  K  S  S  W  S  M  R  E  A  N  V  A  C  L  D  L  G  F  Q         p.160

    | 04     .         .         .         .         .         .    g.45545
 CA | AGGTGCTGATACTCAAAGAAGGTTTAAGTTGTCTGATCTCTCTATAAATTCCACTGAA    c.540
 Q  |  G  A  D  T  Q  R  R  F  K  L  S  D  L  S  I  N  S  T  E      p.180

          .         .         .         .         .         .       g.45605
 TGTCTACATGTGCATTGCCGAGGATTAGAGACCAGTTTGGCTGAATGTACTTTTACTAAG       c.600
 C  L  H  V  H  C  R  G  L  E  T  S  L  A  E  C  T  F  T  K         p.200

          .         .         .         .         .         | 05    g.46545
 AGAAGAACTATGGGTTACCAGGATTTCGCTGATGTGGTTTGTTATACACAGAAAGCAG | AT    c.660
 R  R  T  M  G  Y  Q  D  F  A  D  V  V  C  Y  T  Q  K  A  D |       p.220

          .         .         .         .         .         .       g.46605
 TCTCCAATGGATGACTTCTTTCAGTGTGTGAATGGGAAATACATTTCTCAGATGAAAGCC       c.720
 S  P  M  D  D  F  F  Q  C  V  N  G  K  Y  I  S  Q  M  K  A         p.240

          .         .         .         .         .   | 06     .    g.46807
 TGTGATGGTATCAATGATTGTGGAGACCAAAGTGATGAACTGTGTTGTAAAG | CATGCCAA    c.780
 C  D  G  I  N  D  C  G  D  Q  S  D  E  L  C  C  K  A |   C  Q      p.260

          .         .         .         .         .         .       g.46867
 GGCAAAGGCTTCCATTGCAAATCGGGTGTTTGCATTCCAAGCCAGTATCAATGCAATGGT       c.840
 G  K  G  F  H  C  K  S  G  V  C  I  P  S  Q  Y  Q  C  N  G         p.280

          .         .         .         .    | 07    .         .    g.49413
 GAGGTGGACTGCATTACAGGGGAAGATGAAGTTGGCTGTGCAG | GCTTTGCATCTGTGACT    c.900
 E  V  D  C  I  T  G  E  D  E  V  G  C  A  G |   F  A  S  V  T      p.300

      | 08   .         .         .         . | 09       .         . g.57597
 CAAG | AAGAAACAGAAATTTTGACTGCTGACATGGATGCAG | AAAGAAGACGGATAAAATCA c.960
 Q  E |   E  T  E  I  L  T  A  D  M  D  A  E |   R  R  R  I  K  S   p.320

          .         .         .         .         .         .       g.57657
 TTATTACCTAAACTATCTTGTGGAGTTAAAAACAGAATGCACATTCGAAGGAAACGAATT       c.1020
 L  L  P  K  L  S  C  G  V  K  N  R  M  H  I  R  R  K  R  I         p.340

          .         .     | 10   .         .         .         .    g.57894
 GTGGGAGGAAAGCGAGCACAACTG | GGAGACCTCCCATGGCAGGTGGCAATTAAGGATGCC    c.1080
 V  G  G  K  R  A  Q  L   | G  D  L  P  W  Q  V  A  I  K  D  A      p.360

          .         .         .         .         .         .       g.57954
 AGTGGAATCACCTGTGGGGGAATTTATATTGGTGGCTGTTGGATTCTGACTGCTGCACAT       c.1140
 S  G  I  T  C  G  G  I  Y  I  G  G  C  W  I  L  T  A  A  H         p.380

          | 11         .         .         .         .         .    g.60729
 TGTCTCAG | AGCCAGTAAAACTCATCGTTACCAAATATGGACAACAGTAGTAGACTGGATA    c.1200
 C  L  R  |  A  S  K  T  H  R  Y  Q  I  W  T  T  V  V  D  W  I      p.400

          .         .         .         .         .         .       g.60789
 CACCCCGACCTTAAACGTATAGTAATTGAATACGTGGATAGAATTATTTTCCATGAAAAC       c.1260
 H  P  D  L  K  R  I  V  I  E  Y  V  D  R  I  I  F  H  E  N         p.420

          .         .         .         .         .         .       g.60849
 TACAATGCAGGCACTTACCAAAATGACATCGCTTTGATTGAAATGAAAAAAGACGGAAAC       c.1320
 Y  N  A  G  T  Y  Q  N  D  I  A  L  I  E  M  K  K  D  G  N         p.440

          .         .         .         .         .         .       g.60909
 AAAAAAGATTGTGAGCTGCCTCGTTCCATCCCTGCCTGTGTCCCCTGGTCTCCTTACCTA       c.1380
 K  K  D  C  E  L  P  R  S  I  P  A  C  V  P  W  S  P  Y  L         p.460

          .         .         .         .          | 12        .    g.64595
 TTCCAACCTAATGATACATGCATCGTTTCTGGCTGGGGACGAGAAAAAG | ATAACGAAAGA    c.1440
 F  Q  P  N  D  T  C  I  V  S  G  W  G  R  E  K  D |   N  E  R      p.480

          .         .         .         .         .         .       g.64655
 GTCTTTTCACTTCAGTGGGGTGAAGTTAAACTAATAAGCAACTGCTCTAAGTTTTACGGA       c.1500
 V  F  S  L  Q  W  G  E  V  K  L  I  S  N  C  S  K  F  Y  G         p.500

          .         .         .     | 13   .         .         .    g.66095
 AATCGTTTCTATGAAAAAGAAATGGAATGTGCAG | GTACATATGATGGTTCCATCGATGCC    c.1560
 N  R  F  Y  E  K  E  M  E  C  A  G |   T  Y  D  G  S  I  D  A      p.520

          .         .         .         .         .         .       g.66155
 TGTAAAGGGGACTCTGGAGGCCCCTTAGTCTGTATGGATGCCAACAATGTGACTTATGTC       c.1620
 C  K  G  D  S  G  G  P  L  V  C  M  D  A  N  N  V  T  Y  V         p.540

          .         .         .         .         .         .       g.66215
 TGGGGTGTTGTGAGTTGGGGGGAAAACTGTGGAAAACCAGAGTTCCCAGGTGTTTACACC       c.1680
 W  G  V  V  S  W  G  E  N  C  G  K  P  E  F  P  G  V  Y  T         p.560

          .         .         .         .         .         .       g.66275
 AAAGTGGCCAATTATTTTGACTGGATTAGCTACCATGTAGGAAGGCCTTTTATTTCTCAG       c.1740
 K  V  A  N  Y  F  D  W  I  S  Y  H  V  G  R  P  F  I  S  Q         p.580

          .                                                         g.66287
 TACAATGTATAA                                                       c.1752
 Y  N  V  X                                                         p.583

          .         .         .         .         .         .       g.66347
 aattgtgatctctctcttcattctattctttttctctcaagagttccatttaatggaaat       c.*60

          .         .         .         .         .         .       g.66407
 aaaacggtataattaataattctctaggggggaaaaatgaagcaaatctcactggatatt       c.*120

          .         .         .         .         .         .       g.66467
 tttaaaggtctccacagagtttatgccatattggaattttgttgtataattctcaaataa       c.*180

          .         .                                               g.66488
 atattttggtgaagcatacaa                                              c.*201

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Complement factor I protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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