cholinergic receptor, muscarinic 1 (CHRM1) - coding DNA reference sequence

(used for variant description)

(last modified May 24, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_000738.2 in the CHRM1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering CHRM1 transcript NM_000738.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5041
                    tggggctcaaattgggtgccctggtgaaggaggggggcaca       c.-361

 .         .         .         .         .         .                g.5101
 ctccagaacctagtccaaccccagacgctgcctgaggcttccctccagctcccctccctt       c.-301

 .         .         .         .         .         .                g.5161
 ccttttctccctttcctccctccctctctttccctttctccctccccgctaaggctggcg       c.-241

 .         .         .         .         .         .                g.5221
 tgccagggggtgggacatgccaatcactggctgtgcctctcccgctgccagcacagggcg       c.-181

 .         .         .         .         .         .                g.5281
 cagctccccctgggagccaggtgtttgggtccctggagacgccgcaggcccccagggagg       c.-121

 .         .         .         .         .  | 02      .             g.15380
 cagtggggctgaggaccctacagacccctcttcagccccgtg | gtgatgactttcccctga    c.-61

 .         .         .         .         .         .                g.15440
 ggaagccctgtagcgtgcctggaggaaggggctctccaaccccagccccacctagccacc       c.-1

          .         .         .         .         .         .       g.15500
 ATGAACACTTCAGCCCCACCTGCTGTCAGCCCCAACATCACCGTCCTGGCACCAGGAAAG       c.60
 M  N  T  S  A  P  P  A  V  S  P  N  I  T  V  L  A  P  G  K         p.20

          .         .         .         .         .         .       g.15560
 GGTCCCTGGCAAGTGGCCTTCATTGGGATCACCACGGGCCTCCTGTCGCTAGCCACAGTG       c.120
 G  P  W  Q  V  A  F  I  G  I  T  T  G  L  L  S  L  A  T  V         p.40

          .         .         .         .         .         .       g.15620
 ACAGGCAACCTGCTGGTACTCATCTCTTTCAAGGTCAACACGGAGCTCAAGACAGTCAAT       c.180
 T  G  N  L  L  V  L  I  S  F  K  V  N  T  E  L  K  T  V  N         p.60

          .         .         .         .         .         .       g.15680
 AACTACTTCCTGCTGAGCCTGGCCTGTGCTGACCTCATCATCGGTACCTTCTCCATGAAC       c.240
 N  Y  F  L  L  S  L  A  C  A  D  L  I  I  G  T  F  S  M  N         p.80

          .         .         .         .         .         .       g.15740
 CTCTATACCACGTACCTGCTCATGGGCCACTGGGCTCTGGGCACGCTGGCTTGTGACCTC       c.300
 L  Y  T  T  Y  L  L  M  G  H  W  A  L  G  T  L  A  C  D  L         p.100

          .         .         .         .         .         .       g.15800
 TGGCTGGCCCTGGACTATGTGGCCAGCAATGCCTCCGTCATGAATCTGCTGCTCATCAGC       c.360
 W  L  A  L  D  Y  V  A  S  N  A  S  V  M  N  L  L  L  I  S         p.120

          .         .         .         .         .         .       g.15860
 TTTGACCGCTACTTCTCCGTGACTCGGCCCCTGAGCTACCGTGCCAAGCGCACACCCCGC       c.420
 F  D  R  Y  F  S  V  T  R  P  L  S  Y  R  A  K  R  T  P  R         p.140

          .         .         .         .         .         .       g.15920
 CGGGCAGCTCTGATGATCGGCCTGGCCTGGCTGGTTTCCTTTGTGCTCTGGGCCCCAGCC       c.480
 R  A  A  L  M  I  G  L  A  W  L  V  S  F  V  L  W  A  P  A         p.160

          .         .         .         .         .         .       g.15980
 ATCCTCTTCTGGCAGTACCTGGTAGGGGAGCGGACAGTGCTAGCTGGGCAGTGCTACATC       c.540
 I  L  F  W  Q  Y  L  V  G  E  R  T  V  L  A  G  Q  C  Y  I         p.180

          .         .         .         .         .         .       g.16040
 CAGTTCCTCTCCCAGCCCATCATCACCTTTGGCACAGCCATGGCTGCCTTCTACCTCCCT       c.600
 Q  F  L  S  Q  P  I  I  T  F  G  T  A  M  A  A  F  Y  L  P         p.200

          .         .         .         .         .         .       g.16100
 GTCACAGTCATGTGCACGCTCTACTGGCGCATCTACCGGGAGACAGAGAACCGAGCACGG       c.660
 V  T  V  M  C  T  L  Y  W  R  I  Y  R  E  T  E  N  R  A  R         p.220

          .         .         .         .         .         .       g.16160
 GAGCTGGCAGCCCTTCAGGGCTCCGAGACGCCAGGCAAAGGGGGTGGCAGCAGCAGCAGC       c.720
 E  L  A  A  L  Q  G  S  E  T  P  G  K  G  G  G  S  S  S  S         p.240

          .         .         .         .         .         .       g.16220
 TCAGAGAGGTCTCAGCCAGGGGCTGAGGGCTCACCAGAGACTCCTCCAGGCCGCTGCTGT       c.780
 S  E  R  S  Q  P  G  A  E  G  S  P  E  T  P  P  G  R  C  C         p.260

          .         .         .         .         .         .       g.16280
 CGCTGCTGCCGGGCCCCCAGGCTGCTGCAGGCCTACAGCTGGAAGGAAGAAGAGGAAGAG       c.840
 R  C  C  R  A  P  R  L  L  Q  A  Y  S  W  K  E  E  E  E  E         p.280

          .         .         .         .         .         .       g.16340
 GACGAAGGCTCCATGGAGTCCCTCACATCCTCAGAGGGAGAGGAGCCTGGCTCCGAAGTG       c.900
 D  E  G  S  M  E  S  L  T  S  S  E  G  E  E  P  G  S  E  V         p.300

          .         .         .         .         .         .       g.16400
 GTGATCAAGATGCCAATGGTGGACCCCGAGGCACAGGCCCCCACCAAGCAGCCCCCACGG       c.960
 V  I  K  M  P  M  V  D  P  E  A  Q  A  P  T  K  Q  P  P  R         p.320

          .         .         .         .         .         .       g.16460
 AGCTCCCCAAATACAGTCAAGAGGCCGACTAAGAAAGGGCGTGATCGAGCTGGCAAGGGC       c.1020
 S  S  P  N  T  V  K  R  P  T  K  K  G  R  D  R  A  G  K  G         p.340

          .         .         .         .         .         .       g.16520
 CAGAAGCCCCGTGGAAAGGAGCAGCTGGCCAAGCGGAAGACCTTCTCGCTGGTCAAGGAG       c.1080
 Q  K  P  R  G  K  E  Q  L  A  K  R  K  T  F  S  L  V  K  E         p.360

          .         .         .         .         .         .       g.16580
 AAGAAGGCGGCTCGGACCCTGAGTGCCATCCTCCTGGCCTTCATCCTCACCTGGACACCG       c.1140
 K  K  A  A  R  T  L  S  A  I  L  L  A  F  I  L  T  W  T  P         p.380

          .         .         .         .         .         .       g.16640
 TACAACATCATGGTGCTGGTGTCCACCTTCTGCAAGGACTGTGTTCCCGAGACCCTGTGG       c.1200
 Y  N  I  M  V  L  V  S  T  F  C  K  D  C  V  P  E  T  L  W         p.400

          .         .         .         .         .         .       g.16700
 GAGCTGGGCTACTGGCTGTGCTACGTCAACAGCACCATCAACCCCATGTGCTACGCACTC       c.1260
 E  L  G  Y  W  L  C  Y  V  N  S  T  I  N  P  M  C  Y  A  L         p.420

          .         .         .         .         .         .       g.16760
 TGCAACAAAGCCTTCCGGGACACCTTTCGCCTGCTGCTGCTTTGCCGCTGGGACAAGAGA       c.1320
 C  N  K  A  F  R  D  T  F  R  L  L  L  L  C  R  W  D  K  R         p.440

          .         .         .         .         .         .       g.16820
 CGCTGGCGCAAGATCCCCAAGCGCCCTGGCTCCGTGCACCGCACTCCCTCCCGCCAATGC       c.1380
 R  W  R  K  I  P  K  R  P  G  S  V  H  R  T  P  S  R  Q  C         p.460

                                                                    g.16823
 TGA                                                                c.1383
 X                                                                  p.460

          .         .         .         .         .         .       g.16883
 tagtcccctctcctgcatccctccaccccagtccccgggaaaggccggtgggaagagggc       c.*60

          .         .         .         .         .         .       g.16943
 aggggctgcatcctcagccccagggccctgctcaggcctcacctggcttcccaggaccct       c.*120

          .         .         .         .         .         .       g.17003
 gggtcaccttcctgggcagcccagagagaccctgccaactttccagacttcgctattccc       c.*180

          .         .         .         .         .         .       g.17063
 aggcagggagggaaacccggggaactggtttttctgttccctgctgggtgggaatgcgct       c.*240

          .         .         .         .         .         .       g.17123
 cttcaccaggaagaaggcccgggaggaggatccgggctttggactccttgtttgccttta       c.*300

          .         .         .         .         .         .       g.17183
 ggcaggaagtcaggagccagcagggcgggccaggagaaagaaggcttaacattaagtatt       c.*360

          .         .         .         .         .         .       g.17243
 ccttggcccagcagcggcccagattgcggtgtgagatggtgccccctggggggcacagcc       c.*420

          .         .         .         .         .         .       g.17303
 agaaactgaactggccgctgggagaaaagccagatgacagggagctggggaatcccctcg       c.*480

          .         .         .         .         .         .       g.17363
 cttcataggcagagcccgcccacctgggccctaggcatactctccaggattgtccacaaa       c.*540

          .         .         .         .         .         .       g.17423
 tgtcctcagagggtccctaggtgggtcaactccaaggcaaatgtccaagcatcagcaaga       c.*600

          .         .         .         .         .         .       g.17483
 caatgacactggaagggtccggcttggctagtcacatatcaagtcccgaggcagcaacag       c.*660

          .         .         .         .         .         .       g.17543
 gaccaggagccaggtgtcctgactgtcctacaatatcattttcctgggagtgggagtcaa       c.*720

          .         .         .         .         .         .       g.17603
 gtgtgcctgctatccagccgcaaatccataccccctgccccagagaagcctcagtccctc       c.*780

          .         .         .         .         .         .       g.17663
 cctcctggctcacagccaccacctggatggatctgctccatgcagatctagccaggcctc       c.*840

          .         .         .         .         .         .       g.17723
 ccgcatgctgcctgcctccggccctgccccacacaggcctggcccagccagcaggttctc       c.*900

          .         .         .         .         .         .       g.17783
 tcctgtgagctccccaatccaacccatgcatggcctcccagccacccggatctccaggcc       c.*960

          .         .         .         .         .         .       g.17843
 cagcctggccccaaatgttctttcctttcatcctcagcaagtgctgagtctgtgaataaa       c.*1020

          .                                                         g.17862
 gccacataaccagcgggca                                                c.*1039

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cholinergic receptor, muscarinic 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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