cholinergic receptor, nicotinic, alpha 4 (neuronal) (CHRNA4) - coding DNA reference sequence

(used for variant description)

(last modified December 17, 2022)


This file was created to facilitate the description of sequence variants on transcript NM_000744.6 in the CHRNA4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000020.10, covering CHRNA4 transcript NM_000744.6.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5051
          tcccagccggctgaggcgggcagggccgggcggggccgcgccacggagccc       c.-181

 .         .         .         .         .         .                g.5111
 acagcccggcgctccctgccgcgccgccgccgcaccgcgccccacaggagaagacgaacc       c.-121

 .         .         .         .         .         .                g.5171
 gggcccggcggccgaagcggcccgcgaggcgcgggaggcatgaagttgggcgcgcacggg       c.-61

 .         .         .         .         .         .                g.5231
 cctcgaagcggcggggagccgggagccgcccgcatctagagcccgcgaggtgcgtgcgcc       c.-1

          .         .         .         .         .         .       g.5291
 ATGGAGCTAGGGGGCCCCGGAGCGCCGCGGCTGCTGCCGCCGCTGCTGCTGCTTCTGGGG       c.60
 M  E  L  G  G  P  G  A  P  R  L  L  P  P  L  L  L  L  L  G         p.20

          .       | 02 .         .         .         .         .    g.6741
 ACCGGCCTCCTGCGCG | CCAGCAGCCATGTGGAGACCCGGGCCCACGCCGAGGAGCGGCTC    c.120
 T  G  L  L  R  A |   S  S  H  V  E  T  R  A  H  A  E  E  R  L      p.40

          .         .         .         .         .         .       g.6801
 CTGAAGAAACTCTTCTCCGGTTACAACAAGTGGTCCCGACCCGTGGCCAACATCTCGGAC       c.180
 L  K  K  L  F  S  G  Y  N  K  W  S  R  P  V  A  N  I  S  D         p.60

          .         .         .         .         | 03         .    g.9993
 GTGGTCCTCGTCCGCTTCGGCCTGTCCATCGCTCAGCTCATTGACGTG | GATGAGAAGAAC    c.240
 V  V  L  V  R  F  G  L  S  I  A  Q  L  I  D  V   | D  E  K  N      p.80

          .         .         .    | 04    .         .         .    g.10339
 CAGATGATGACCACGAACGTATGGGTGAAGCAG | GAGTGGCACGACTACAAGCTGCGCTGG    c.300
 Q  M  M  T  T  N  V  W  V  K  Q   | E  W  H  D  Y  K  L  R  W      p.100

          .         .         .         .         .         .       g.10399
 GACCCAGCTGACTATGAGAATGTCACCTCCATCCGCATCCCCTCCGAGCTCATCTGGCGG       c.360
 D  P  A  D  Y  E  N  V  T  S  I  R  I  P  S  E  L  I  W  R         p.120

          .         .    | 05    .         .         .         .    g.15406
 CCGGACATCGTCCTCTACAACAA | TGCTGACGGGGACTTCGCGGTCACCCACCTGACCAAG    c.420
 P  D  I  V  L  Y  N  N  |  A  D  G  D  F  A  V  T  H  L  T  K      p.140

          .         .         .         .         .         .       g.15466
 GCCCACCTGTTCCATGACGGGCGGGTGCAGTGGACTCCCCCGGCCATTTACAAGAGCTCC       c.480
 A  H  L  F  H  D  G  R  V  Q  W  T  P  P  A  I  Y  K  S  S         p.160

          .         .         .         .         .         .       g.15526
 TGCAGCATCGACGTCACCTTCTTCCCCTTCGACCAGCAGAACTGCACCATGAAATTCGGC       c.540
 C  S  I  D  V  T  F  F  P  F  D  Q  Q  N  C  T  M  K  F  G         p.180

          .         .         .         .         .         .       g.15586
 TCCTGGACCTACGACAAGGCCAAGATCGACCTGGTGAACATGCACAGCCGCGTGGACCAG       c.600
 S  W  T  Y  D  K  A  K  I  D  L  V  N  M  H  S  R  V  D  Q         p.200

          .         .         .         .         .         .       g.15646
 CTGGACTTCTGGGAGAGTGGCGAGTGGGTCATCGTGGATGCCGTGGGCACCTACAACACC       c.660
 L  D  F  W  E  S  G  E  W  V  I  V  D  A  V  G  T  Y  N  T         p.220

          .         .         .         .         .         .       g.15706
 AGGAAGTACGAGTGCTGTGCCGAGATCTACCCGGACATCACCTATGCCTTCGTCATCCGG       c.720
 R  K  Y  E  C  C  A  E  I  Y  P  D  I  T  Y  A  F  V  I  R         p.240

          .         .         .         .         .         .       g.15766
 CGGCTGCCGCTCTTCTACACCATCAACCTCATCATCCCCTGCCTGCTCATCTCCTGCCTC       c.780
 R  L  P  L  F  Y  T  I  N  L  I  I  P  C  L  L  I  S  C  L         p.260

          .         .         .         .         .         .       g.15826
 ACCGTGCTGGTCTTCTACCTGCCCTCCGAGTGTGGCGAGAAGATCACGCTGTGCATCTCC       c.840
 T  V  L  V  F  Y  L  P  S  E  C  G  E  K  I  T  L  C  I  S         p.280

          .         .         .         .         .         .       g.15886
 GTGCTGCTGTCGCTCACCGTCTTCCTGCTGCTCATCACCGAGATCATCCCGTCCACCTCA       c.900
 V  L  L  S  L  T  V  F  L  L  L  I  T  E  I  I  P  S  T  S         p.300

          .         .         .         .         .         .       g.15946
 CTGGTCATCCCACTCATCGGCGAGTACCTGCTGTTCACCATGATCTTCGTCACCCTGTCC       c.960
 L  V  I  P  L  I  G  E  Y  L  L  F  T  M  I  F  V  T  L  S         p.320

          .         .         .         .         .         .       g.16006
 ATCGTCATCACGGTCTTCGTGCTCAACGTGCACCACCGCTCGCCACGCACGCACACCATG       c.1020
 I  V  I  T  V  F  V  L  N  V  H  H  R  S  P  R  T  H  T  M         p.340

          .         .         .         .         .         .       g.16066
 CCCACCTGGGTACGCAGGGTCTTCCTGGACATCGTGCCACGCCTGCTCCTCATGAAGCGG       c.1080
 P  T  W  V  R  R  V  F  L  D  I  V  P  R  L  L  L  M  K  R         p.360

          .         .         .         .         .         .       g.16126
 CCGTCCGTGGTCAAGGACAATTGCCGGCGGCTCATCGAGTCCATGCATAAGATGGCCAGT       c.1140
 P  S  V  V  K  D  N  C  R  R  L  I  E  S  M  H  K  M  A  S         p.380

          .         .         .         .         .         .       g.16186
 GCCCCGCGCTTCTGGCCCGAGCCAGAAGGGGAGCCCCCTGCCACGAGCGGCACCCAGAGC       c.1200
 A  P  R  F  W  P  E  P  E  G  E  P  P  A  T  S  G  T  Q  S         p.400

          .         .         .         .         .         .       g.16246
 CTGCACCCGCCCTCACCGTCCTTCTGTGTCCCCCTGGATGTGCCGGCTGAGCCTGGGCCT       c.1260
 L  H  P  P  S  P  S  F  C  V  P  L  D  V  P  A  E  P  G  P         p.420

          .         .         .         .         .         .       g.16306
 TCCTGCAAGTCACCCTCCGACCAGCTCCCTCCTCAGCAGCCCCTGGAAGCTGAGAAAGCC       c.1320
 S  C  K  S  P  S  D  Q  L  P  P  Q  Q  P  L  E  A  E  K  A         p.440

          .         .         .         .         .         .       g.16366
 AGCCCCCACCCCTCGCCTGGACCCTGCCGCCCGCCCCACGGCACCCAGGCACCAGGGCTG       c.1380
 S  P  H  P  S  P  G  P  C  R  P  P  H  G  T  Q  A  P  G  L         p.460

          .         .         .         .         .         .       g.16426
 GCCAAAGCCAGGTCCCTCAGCGTCCAGCACATGTCCAGCCCTGGCGAAGCGGTGGAAGGC       c.1440
 A  K  A  R  S  L  S  V  Q  H  M  S  S  P  G  E  A  V  E  G         p.480

          .         .         .         .         .         .       g.16486
 GGCGTCCGGTGCCGGTCTCGGAGCATCCAGTACTGTGTTCCCCGAGACGATGCCGCCCCC       c.1500
 G  V  R  C  R  S  R  S  I  Q  Y  C  V  P  R  D  D  A  A  P         p.500

          .         .         .         .         .         .       g.16546
 GAGGCAGATGGCCAGGCTGCCGGCGCCCTGGCCTCTCGCAACACCCACTCGGCTGAGCTC       c.1560
 E  A  D  G  Q  A  A  G  A  L  A  S  R  N  T  H  S  A  E  L         p.520

          .         .         .         .         .         .       g.16606
 CCACCCCCAGACCAGCCCTCTCCGTGCAAATGCACATGCAAGAAGGAGCCCTCTTCGGTG       c.1620
 P  P  P  D  Q  P  S  P  C  K  C  T  C  K  K  E  P  S  S  V         p.540

          .         .         .         .         .         .       g.16666
 TCCCCGAGCGCCACGGTCAAGACCCGCAGCACCAAAGCGCCGCCCCCGCACCTGCCCCTG       c.1680
 S  P  S  A  T  V  K  T  R  S  T  K  A  P  P  P  H  L  P  L         p.560

          .         .         .         .         .         .       g.16726
 TCGCCGGCCCTGACCCGGGCGGTGGAGGGCGTCCAGTACATTGCAGACCACCTGAAGGCC       c.1740
 S  P  A  L  T  R  A  V  E  G  V  Q  Y  I  A  D  H  L  K  A         p.580

          .         | 06         .         .         .         .    g.19575
 GAAGACACAGACTTCTCG | GTGAAGGAGGACTGGAAGTACGTGGCCATGGTCATCGACCGC    c.1800
 E  D  T  D  F  S   | V  K  E  D  W  K  Y  V  A  M  V  I  D  R      p.600

          .         .         .         .         .         .       g.19635
 ATCTTCCTCTGGATGTTCATCATCGTCTGCCTGCTGGGGACGGTGGGCCTCTTCCTGCCG       c.1860
 I  F  L  W  M  F  I  I  V  C  L  L  G  T  V  G  L  F  L  P         p.620

          .         .                                               g.19659
 CCCTGGCTGGCTGGCATGATCTAG                                           c.1884
 P  W  L  A  G  M  I  X                                             p.627

          .         .         .         .         .         .       g.19719
 gaagggaccgggagcctgcgtggcctggggctgccgtgcacggggccagcatccatgcgg       c.*60

          .         .         .         .         .         .       g.19779
 ccggcctggggccgggctggcttctccctggactctgtggggccacacgtttgccaaatt       c.*120

          .         .         .         .         .         .       g.19839
 ttccttcctgttctgtgtctgctgtaagacggccttggacggggacacggcctctgggga       c.*180

          .         .         .         .         .         .       g.19899
 gaccgagtgtggagctgcttccagttggactgtggcctcaggaggcagtggcttggagca       c.*240

          .         .         .         .         .         .       g.19959
 gaggtgggggtcggcgccttctacctgcaggactcgggctaagtccagttcaagagtctc       c.*300

          .         .         .         .         .         .       g.20019
 ctgagctcccctgcagatggaactcactcctcccagtctctcagcagatctggtgatggt       c.*360

          .         .         .         .         .         .       g.20079
 cccgaccgccccaaggggcccttgaagggagttcacgccccttcagccccaagcgccccg       c.*420

          .         .         .         .         .         .       g.20139
 tcttctggaggcccggccgcctctcccacccaccgtgtcctgcgcctgtgtgggcttcaa       c.*480

          .         .         .         .         .         .       g.20199
 cttctcccccagggtccttgagcctctcgggccccatgagggtgagccagcagcgctcca       c.*540

          .         .         .         .         .         .       g.20259
 atctgcttcgctaggagagggtccaggcagggattgtgtttggttgtgttttgggtaagt       c.*600

          .         .         .         .         .         .       g.20319
 tagtgagaactcaagtcttgtgcctaaggagccttggagaacagagttttgtggagctgg       c.*660

          .         .         .         .         .         .       g.20379
 ttccgcgtggggagaatcgggaggcccacgcgggaccagctctcccctgcgcaggccctc       c.*720

          .         .         .         .         .         .       g.20439
 cgcgggggacaggaacacccagccccagcgagtctggagaccaggactctgccttccagg       c.*780

          .         .         .         .         .         .       g.20499
 cgtagggccagggctctggcaggtggccagggctccacgggggcctagtggcttcagccc       c.*840

          .         .         .         .         .         .       g.20559
 ctggggtacttctgtgttgtgattccccggagctgggaaggtcccgaatggagtccagac       c.*900

          .         .         .         .         .         .       g.20619
 ctgggccctggttcccccaggaccctgagggtttccaccttggcgcgcagcccgggagat       c.*960

          .         .         .         .         .         .       g.20679
 ccgccctgggctctgggttcgggaagaaggacttcctgctacagtagctgtggggagctg       c.*1020

          .         .         .         .         .         .       g.20739
 gtgggggcatccttgaggacctccacctgggagatgctgggaccctcggggcaggaagtc       c.*1080

          .         .         .         .         .         .       g.20799
 cctgagaagcctcatgggagtcagggagccctggggtttccacacaggcccatgccctcc       c.*1140

          .         .         .         .         .         .       g.20859
 gtcctggcagggcaggcagagctcagcacagcctcacccctgcaggcggtatccagaggt       c.*1200

          .         .         .         .         .         .       g.20919
 gagggaggcctgaaatgtttccaggcatgaccctggagcccggcagtgcaccccctaaag       c.*1260

          .         .         .         .         .         .       g.20979
 atggcgcacccggcagccccccagtgtccccaggggcacacttccccttgggatgggcac       c.*1320

          .         .         .         .         .         .       g.21039
 aggctgccccacccctccatgattccaagggcccagaggggcggggccaggatggcgtgt       c.*1380

          .         .         .         .         .         .       g.21099
 cccctgcctgtgagtgacatcggttcaggaggagacagtcaggaagcctcctgctgagtg       c.*1440

          .         .         .         .         .         .       g.21159
 gtccacattctgctgcccccagaccccatccagccaggggtggggatggggttgggctct       c.*1500

          .         .         .         .         .         .       g.21219
 gcgtcccactgagtctcattcctctgtccccgagccgagctctcctgggccagggtctcg       c.*1560

          .         .         .         .         .         .       g.21279
 tcaggaggtgcctgagagcagaatgaataattgaggttaggaacccggcatgccgagtgc       c.*1620

          .         .         .         .         .         .       g.21339
 cccagaaatgccgctgtgtccccgcgggcagtgacgtgagtggggaggagactcaggccc       c.*1680

          .         .         .         .         .         .       g.21399
 acattgcccacacctgcctctgaactgctgctggtcacccccacccccgggtgcctgtga       c.*1740

          .         .         .         .         .         .       g.21459
 ccggggtcctgaggctggggcttttgtgccaggagtgggtgggacacagagacccccgtg       c.*1800

          .         .         .         .         .         .       g.21519
 ccaaatcctgggcatccccagccccctggcccctcccacatcccccgtgtattcaggacc       c.*1860

          .         .         .         .         .         .       g.21579
 ccatctgctgagctctgacctgcccccgctctgccatcagcccctgctgctcctcggcca       c.*1920

          .         .         .         .         .         .       g.21639
 gagctcccaggacgcagggagaccctgggagagtgaggtcatcccggggccatggaagct       c.*1980

          .         .         .         .         .         .       g.21699
 ggcaggagacactggtctcagaggagggatagagacgcagatttcagatgtaagaagccc       c.*2040

          .         .         .         .         .         .       g.21759
 gatccacattgcataagtggacccagctgccagatgtgtgggcagctgcagggagtggcc       c.*2100

          .         .         .         .         .         .       g.21819
 cggggtgctgggcccagctgtggttgttcttttctgggtcaggagtgactgcggagtggc       c.*2160

          .         .         .         .         .         .       g.21879
 tgggacgctcctgccgggggaccctcctgccgggggtggccgcttgcctgggggaagacc       c.*2220

          .         .         .         .         .         .       g.21939
 cctttccctttctttttttttttgaggctcaaaaaaaaaatccaaataaagcaccatatt       c.*2280

          .         .         .         .         .         .       g.21999
 cccaccacgccaaattaaccttgacaacaatgttggcgtatttgcgtccagtgctgtttt       c.*2340

          .         .         .         .         .         .       g.22059
 tattaattaaggtaaaatttacatatggtgagatgcatgctcttcagtggagacccagcc       c.*2400

          .         .         .         .         .         .       g.22119
 cctagaaggtccctccagcccttcctgtcggcgtccctccccatctgtggctctgactta       c.*2460

          .         .         .         .         .         .       g.22179
 agcaccgtggattgacctctccggctcacgaccttcgaggagtcagaatcctgcagttgg       c.*2520

          .         .         .         .         .         .       g.22239
 agcctttgatgtctggcttcttcatcctatgacttagagcttcatccgtgctgttgtgtg       c.*2580

          .         .         .         .         .         .       g.22299
 tgtccgtagctccttgctgtctgttccttcgtttttaattgtgagcagtgttcttctgtc       c.*2640

          .         .         .         .         .         .       g.22359
 tgaataaactaagacgcagtttgtccatcacctgttagtggactttgcttgcagctgtcg       c.*2700

          .         .         .         .         .         .       g.22419
 gtgattaggaatggaggtgccggtgtgtgcatggcactctatccgttatgcatgtttatt       c.*2760

          .         .         .         .         .         .       g.22479
 ttctgcatctgttaatgttttaacatctttcagacccaggactgctcctcctagggccag       c.*2820

          .         .         .         .         .         .       g.22539
 ttagttcccgggggtggacagcttgcctagaacccaccttgccagggctgtgacccccga       c.*2880

          .         .         .         .         .         .       g.22599
 ccccctatcaaagtctcacactaagccaacgtttccccgccctgtgccaggcaccaggca       c.*2940

          .         .         .         .         .         .       g.22659
 gcgggagacactgctgcagctcgaagcctgccggggcgccggcccctctgcggctgcttg       c.*3000

          .         .         .         .         .         .       g.22719
 cgccatcctgccccctccttcccaggggaggccccagtgaaggccctggccagggcttcc       c.*3060

          .         .         .         .         .         .       g.22779
 cagccccttctgcctccggaccggcctgggtgcttcccgtgtggcccggcctggggcgac       c.*3120

          .         .         .         .         .         .       g.22839
 gtggccctcctctcaggaagcgtggtaatctctcaatggctggcctccggagttgtcact       c.*3180

          .         .         .         .         .         .       g.22899
 caggctcccttgtaagttaaggccgggcccaggacactctagggcacgcagctgctgtgg       c.*3240

          .         .         .         .         .         .       g.22959
 gactgctgggttaggtgtcccctggagcagaggcggcttcggatttctaaagtggctgag       c.*3300

          .         .         .         .         .         .       g.23019
 tcctttcaccttgcaccagaaatgctggatcaggcgcagcacacacagcacctggggatg       c.*3360

          .         .         .         .         .         .       g.23079
 caagcccggccagccccatggaccaagccccgccgaccgtgtggcccgccgagcccaggt       c.*3420

                                                                    g.23087
 gcggccgc                                                           c.*3428

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cholinergic receptor, nicotinic, alpha 4 (neuronal) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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