cholinergic receptor, nicotinic, alpha 7 (neuronal) (CHRNA7) - coding DNA reference sequence

(used for variant description)

(last modified March 1, 2014)


This file was created to facilitate the description of sequence variants on transcript NM_001190455.2 in the CHRNA7 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000015.9, covering CHRNA7 transcript NM_001190455.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5052
         tccttaaaggcgcgcgagccgagcggcgaggtgcctctgtggccgcaggcgc       c.-61

 .         .         .         .         .         .                g.5112
 aggcccgggcgacagccgagacgtggagcgcgccggctcgctgcagctccgggactcaac       c.-1

          .         .         .         .         .         .       g.5172
 ATGCGCTGCTCGCCGGGAGGCGTCTGGCTGGCGCTGGCCGCGTCGCTCCTGCACGGTAAA       c.60
 M  R  C  S  P  G  G  V  W  L  A  L  A  A  S  L  L  H  G  K         p.20

          .         .         .         .         .         .       g.5232
 GCCACTGCCTCCCCGCCCTCCACTCCTCCGTGGGATCCCGGGCACATCCCGGGCGCCTCT       c.120
 A  T  A  S  P  P  S  T  P  P  W  D  P  G  H  I  P  G  A  S         p.40

          .         .   | 02     .         .         .         .    g.5453
 GTGCGCCCCGCGCCTGGGCCAG | TGTCCCTGCAAGGCGAGTTCCAGAGGAAGCTTTACAAG    c.180
 V  R  P  A  P  G  P  V |   S  L  Q  G  E  F  Q  R  K  L  Y  K      p.60

          .         .         .         .         .         .       g.5513
 GAGCTGGTCAAGAACTACAATCCCTTGGAGAGGCCCGTGGCCAATGACTCGCAACCACTC       c.240
 E  L  V  K  N  Y  N  P  L  E  R  P  V  A  N  D  S  Q  P  L         p.80

          .         .         .         .   | 03     .         .    g.75838
 ACCGTCTACTTCTCCCTGAGCCTCCTGCAGATCATGGACGTG | GATGAGAAGAACCAAGTT    c.300
 T  V  Y  F  S  L  S  L  L  Q  I  M  D  V   | D  E  K  N  Q  V      p.100

          .         .        | 04.         .         .         .    g.86338
 TTAACCACCAACATTTGGCTGCAAATG | TCTTGGACAGATCACTATTTACAGTGGAATGTG    c.360
 L  T  T  N  I  W  L  Q  M   | S  W  T  D  H  Y  L  Q  W  N  V      p.120

          .         .         .         .         .         .       g.86398
 TCAGAATATCCAGGGGTGAAGACTGTTCGTTTCCCAGATGGCCAGATTTGGAAACCAGAC       c.420
 S  E  Y  P  G  V  K  T  V  R  F  P  D  G  Q  I  W  K  P  D         p.140

          .        | 05.         .         .         .         .    g.128465
 ATTCTTCTCTATAACAG | TGCTGATGAGCGCTTTGACGCCACATTCCACACTAACGTGTTG    c.480
 I  L  L  Y  N  S  |  A  D  E  R  F  D  A  T  F  H  T  N  V  L      p.160

          .         .         .        | 06.         .         .    g.132146
 GTGAATTCTTCTGGGCATTGCCAGTACCTGCCTCCAG | GCATATTCAAGAGTTCCTGCTAC    c.540
 V  N  S  S  G  H  C  Q  Y  L  P  P  G |   I  F  K  S  S  C  Y      p.180

          .         .         .         .         .         .       g.132206
 ATCGATGTACGCTGGTTTCCCTTTGATGTGCAGCACTGCAAACTGAAGTTTGGGTCCTGG       c.600
 I  D  V  R  W  F  P  F  D  V  Q  H  C  K  L  K  F  G  S  W         p.200

          .         .         .         .         .         .       g.132266
 TCTTACGGAGGCTGGTCCTTGGATCTGCAGATGCAGGAGGCAGATATCAGTGGCTATATC       c.660
 S  Y  G  G  W  S  L  D  L  Q  M  Q  E  A  D  I  S  G  Y  I         p.220

          .         .      | 07  .         .         .         .    g.132962
 CCCAATGGAGAATGGGACCTAGTGG | GAATCCCCGGCAAGAGGAGTGAAAGGTTCTATGAG    c.720
 P  N  G  E  W  D  L  V  G |   I  P  G  K  R  S  E  R  F  Y  E      p.240

          .         .         .         .         .         .       g.133022
 TGCTGCAAAGAGCCCTACCCCGATGTCACCTTCACAGTGACCATGCGCCGCAGGACGCTC       c.780
 C  C  K  E  P  Y  P  D  V  T  F  T  V  T  M  R  R  R  T  L         p.260

          .         .         .         .         .         .       g.133082
 TACTATGGCCTCAACCTGCTGATCCCCTGTGTGCTCATCTCCGCCCTCGCCCTGCTGGTG       c.840
 Y  Y  G  L  N  L  L  I  P  C  V  L  I  S  A  L  A  L  L  V         p.280

          .         .         .         . | 08       .         .    g.134104
 TTCCTGCTTCCTGCAGATTCCGGGGAGAAGATTTCCCTGG | GGATAACAGTCTTACTCTCT    c.900
 F  L  L  P  A  D  S  G  E  K  I  S  L  G |   I  T  V  L  L  S      p.300

          .         .         .         .         .         .       g.134164
 CTTACCGTCTTCATGCTGCTCGTGGCTGAGATCATGCCCGCAACATCCGATTCGGTACCA       c.960
 L  T  V  F  M  L  L  V  A  E  I  M  P  A  T  S  D  S  V  P         p.320

         | 09.         .         .         .         .         .    g.137794
 TTGATAG | CCCAGTACTTCGCCAGCACCATGATCATCGTGGGCCTCTCGGTGGTGGTGACA    c.1020
 L  I  A |   Q  Y  F  A  S  T  M  I  I  V  G  L  S  V  V  V  T      p.340

          .         .         .         .         .        | 10.    g.142458
 GTGATCGTGCTGCAGTACCACCACCACGACCCCGACGGGGGCAAGATGCCCAAGTGG | ACC    c.1080
 V  I  V  L  Q  Y  H  H  H  D  P  D  G  G  K  M  P  K  W   | T      p.360

          .         .         .         .         .         .       g.142518
 AGAGTCATCCTTCTGAACTGGTGCGCGTGGTTCCTGCGAATGAAGAGGCCCGGGGAGGAC       c.1140
 R  V  I  L  L  N  W  C  A  W  F  L  R  M  K  R  P  G  E  D         p.380

          .         .         .         .         .         .       g.142578
 AAGGTGCGCCCGGCCTGCCAGCACAAGCAGCGGCGCTGCAGCCTGGCCAGTGTGGAGATG       c.1200
 K  V  R  P  A  C  Q  H  K  Q  R  R  C  S  L  A  S  V  E  M         p.400

          .         .         .         .         .         .       g.142638
 AGCGCCGTGGCGCCGCCGCCCGCCAGCAACGGGAACCTGCTGTACATCGGCTTCCGCGGC       c.1260
 S  A  V  A  P  P  P  A  S  N  G  N  L  L  Y  I  G  F  R  G         p.420

          .         .         .         .         .         .       g.142698
 CTGGACGGCGTGCACTGTGTCCCGACCCCCGACTCTGGGGTAGTGTGTGGCCGCATGGCC       c.1320
 L  D  G  V  H  C  V  P  T  P  D  S  G  V  V  C  G  R  M  A         p.440

          .         .         .         .         .         .       g.142758
 TGCTCCCCCACGCACGATGAGCACCTCCTGCACGGCGGGCAACCCCCCGAGGGGGACCCG       c.1380
 C  S  P  T  H  D  E  H  L  L  H  G  G  Q  P  P  E  G  D  P         p.460

          .         .         .         .         .         .       g.142818
 GACTTGGCCAAGATCCTGGAGGAGGTCCGCTACATTGCCAACCGCTTCCGCTGCCAGGAC       c.1440
 D  L  A  K  I  L  E  E  V  R  Y  I  A  N  R  F  R  C  Q  D         p.480

          .         .         .         .         .         .       g.142878
 GAAAGCGAGGCGGTCTGCAGCGAGTGGAAGTTCGCCGCCTGTGTGGTGGACCGCCTGTGC       c.1500
 E  S  E  A  V  C  S  E  W  K  F  A  A  C  V  V  D  R  L  C         p.500

          .         .         .         .         .         .       g.142938
 CTCATGGCCTTCTCGGTCTTCACCATCATCTGCACCATCGGCATCCTGATGTCGGCTCCC       c.1560
 L  M  A  F  S  V  F  T  I  I  C  T  I  G  I  L  M  S  A  P         p.520

          .         .         .                                     g.142974
 AACTTCGTGGAGGCCGTGTCCAAAGACTTTGCGTAA                               c.1596
 N  F  V  E  A  V  S  K  D  F  A  X                                 p.531

          .         .         .         .         .         .       g.143034
 ccacgcctggttctgtacatgtggaaaactcacagatgggcaaggcctttggcttggcga       c.*60

          .         .         .         .         .         .       g.143094
 gatttgggggtgctaatccaggacagcattacacgccacaactccagtgttcccttctgg       c.*120

          .         .         .         .         .         .       g.143154
 ctgtcagtcgtgttgcttacggtttctttgttactttaggtagtagaatctcagcacttt       c.*180

          .         .         .         .         .         .       g.143214
 gtttcatattctcagatgggctgatagatatccttggcacatccgtaccatcggtcagca       c.*240

          .         .         .         .         .         .       g.143274
 gggccactgagtagtcattttgcccattagcccactgcctggaaagcccttcggagagct       c.*300

          .         .         .         .         .         .       g.143334
 ccccatggctcctcaccaccgagacagttggttttgcatgtctgcatgaaggtctacctg       c.*360

          .         .         .         .         .         .       g.143394
 aaaattcaacatttgctttttgcttgtgtacaaacccagattgaagctaaaataaaccag       c.*420

          .         .         .         .         .         .       g.143454
 actcactaaatcctttccaataattgactggtggaaggaaaacaaaaaacaaaaactaaa       c.*480

          .         .         .         .         .         .       g.143514
 aacctcttagcttttctgcaattcaactttttatttttatttttatttctatcaaagacg       c.*540

          .         .         .         .         .         .       g.143574
 gtagagagaaacagcttgatgctgtttctacattaaaaaaaaaaaaaaaagacagactgt       c.*600

          .         .         .         .         .         .       g.143634
 tggtcttactaaggatgtttttaccagcctgcctgacttctgcaaacctaccctgtcaag       c.*660

          .         .         .         .         .         .       g.143694
 gagatcaaagggacgcaggtttctgtttattctgaacaagggccaggccccgcggagtgt       c.*720

          .         .         .         .         .         .       g.143754
 ctttggtggatcccagataactcctaggtgctgctctcagacactgaggagttgagcaaa       c.*780

          .         .         .         .         .         .       g.143814
 tctgttctattctgcagaacccacaggacaaataagagttctactagaattaacagccca       c.*840

          .         .         .         .         .         .       g.143874
 aaagaatagctacagctaagtgaagccacttacgtgggctttaaaaaaataatgtgttag       c.*900

          .         .         .         .         .         .       g.143934
 ctgattcacatgcactggagttaattagtcttagaaatgtgtgcatccatacaaatgcac       c.*960

          .         .         .         .         .         .       g.143994
 aacataaagtgaacatattcctaggccctttctgcctgtgtcagggccaggaagtagagg       c.*1020

          .         .         .         .         .         .       g.144054
 ctgggaactcttctggtccccagtatggcaggcgccagggaggggatggtgtggcccatc       c.*1080

          .         .         .         .         .         .       g.144114
 ccttctctggatacctggccagtggcaggcagcagggaggagctggccgaccctcagtga       c.*1140

          .         .         .         .         .         .       g.144174
 ctgacaagccagcaattctgagttctggcctttgggagtctgcctgctccaagccagtcc       c.*1200

          .         .         .         .         .         .       g.144234
 accccagctgcagccccaaaagctggctcaaagtccttgggtggattcactggagatggg       c.*1260

          .         .         .         .         .         .       g.144294
 caacttaaaacaagagaaactttaatttttaaacctaagtgatgatacagctcttccctt       c.*1320

          .         .         .         .         .         .       g.144354
 agattatcgcccaggctggagtgcagtggcatgatctcagctcactgcaagctccacctc       c.*1380

          .         .         .         .         .         .       g.144414
 ctgggttcatgccattctcctgcctcagcctccccccgagtaactgggaatacaggcgcc       c.*1440

          .         .         .         .         .         .       g.144474
 cgccaccatgcctggctaattttttgtatttttagtagagatagggtttcatcatgttag       c.*1500

          .         .         .         .         .         .       g.144534
 ccaggatggtctcattcttattctttaatgagatcagagggtaattcaccaagaaagacc       c.*1560

          .         .         .         .         .         .       g.144594
 tctcctgttccattgtgtcatccaacaactgctcagagctcaaaattatagaaggcttct       c.*1620

          .         .         .         .         .         .       g.144654
 gagcccctagagatttttaatttgcttctaatccctgaggtgggaacatcatgagggaag       c.*1680

          .         .         .         .                           g.144699
 atttgattttcagagttaaataaattgtatgtgcttttccagcca                      c.*1725

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cholinergic receptor, nicotinic, alpha 7 (neuronal) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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