chloride channel, voltage-sensitive 3 (CLCN3) - coding DNA reference sequence

(used for variant description)

(last modified October 31, 2025)


This file was created to facilitate the description of sequence variants on transcript NM_001829.3 in the CLCN3 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000004.11, covering CLCN3 transcript NM_001829.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5019
                                          gtgacgtcacgcgtcgacg       c.-541

 .         .         .         .         .         .                g.5079
 ctggggcgtacctttcgggctcctgactcctgccgcttctcttccccttccgtgggtcag       c.-481

 .         .         .         .         .         .                g.5139
 ggccggtccggtccggaacctgcagcccctttcccagtgttctagttcgcccgtgacccg       c.-421

 .         .         .         .         .         .                g.5199
 gaataatgagcaaggagggtgtggtgggttgaaagccatcctactttactcccgagttag       c.-361

 .         .         .         .         .         .                g.5259
 agcatggattcagttttagtcttaagggggaagtgagattggagatttttatttttaatt       c.-301

 .         .         .         .         .         .                g.5319
 ttgggcagaagcaggttgactctagggatctccagagcgagaggatttaacttcatgttg       c.-241

 .         .         .         .         .         .                g.5379
 ctcccgtgtttgaaggaggacaataaaagtcccaccgggcaaaattttcgtaacctctgc       c.-181

 .         .         .         .         .         .                g.5439
 ggtagaaaacgtcaggtatcttttaaatcgcgatagttttcgctgtgtcaggctttcttc       c.-121

 .         .         .         .         .         .                g.5499
 ggtggagctccgagggtagctaggttctaggtttgaaacagatgcagaatccaaaggcag       c.-61

 .         .         .         .         .    | 02    .             g.20408
 cgcaaaaaacagccaccgattttgctatgtctctgagctgcgag | ataatcagacagctaa    c.-1

          .         .         .         .         .         .       g.20468
 ATGGAGTCTGAGCAGCTGTTCCATAGAGGCTACTATAGAAACAGCTACAACAGTATAACA       c.60
 M  E  S  E  Q  L  F  H  R  G  Y  Y  R  N  S  Y  N  S  I  T         p.20

          .         .         .         .         .         .       g.20528
 AGTGCAAGTAGTGATGAGGAACTTTTAGATGGAGCAGGTGTTATTATGGACTTTCAAACA       c.120
 S  A  S  S  D  E  E  L  L  D  G  A  G  V  I  M  D  F  Q  T         p.40

          .         .         .         . | 03       .         .    g.64549
 TCTGAAGATGACAATTTATTAGATGGTGACACTGCAGTTG | GAACTCATTATACAATGACA    c.180
 S  E  D  D  N  L  L  D  G  D  T  A  V  G |   T  H  Y  T  M  T      p.60

          .         .         .         .         .         .       g.64609
 AATGGAGGCAGCATTAACAGTTCTACACATTTACTGGATCTTTTGGATGAACCAATTCCA       c.240
 N  G  G  S  I  N  S  S  T  H  L  L  D  L  L  D  E  P  I  P         p.80

          .         .         .         .         .         .       g.64669
 GGTGTTGGTACATATGATGATTTCCATACTATTGATTGGGTGCGAGAAAAATGTAAAGAC       c.300
 G  V  G  T  Y  D  D  F  H  T  I  D  W  V  R  E  K  C  K  D         p.100

          .         | 04         .         .         .         .    g.72179
 AGAGAAAGGCATAGACGG | ATCAACAGCAAAAAGAAAGAATCAGCATGGGAAATGACAAAA    c.360
 R  E  R  H  R  R   | I  N  S  K  K  K  E  S  A  W  E  M  T  K      p.120

          .         .         .         .         .         | 05    g.73524
 AGTTTGTATGATGCGTGGTCAGGATGGCTAGTAGTAACACTAACAGGATTGGCATCAG | GG    c.420
 S  L  Y  D  A  W  S  G  W  L  V  V  T  L  T  G  L  A  S  G |       p.140

          .         .         .         .         .         .       g.73584
 GCACTGGCCGGATTAATAGACATTGCTGCCGATTGGATGACTGACCTAAAGGAGGGCATT       c.480
 A  L  A  G  L  I  D  I  A  A  D  W  M  T  D  L  K  E  G  I         p.160

          .         .         .         .         .         .       g.73644
 TGCCTTAGTGCGTTGTGGTACAACCACGAACAGTGCTGTTGGGGATCTAATGAAACAACA       c.540
 C  L  S  A  L  W  Y  N  H  E  Q  C  C  W  G  S  N  E  T  T         p.180

          .         .         .         .         .         .       g.73704
 TTTGAAGAGAGGGATAAATGTCCACAGTGGAAAACATGGGCAGAATTAATCATAGGTCAA       c.600
 F  E  E  R  D  K  C  P  Q  W  K  T  W  A  E  L  I  I  G  Q         p.200

        | 06 .         .         .         .         .         .    g.75063
 GCAGAG | GGTCCTGGTTCTTATATCATGAACTACATAATGTACATCTTCTGGGCCTTGAGT    c.660
 A  E   | G  P  G  S  Y  I  M  N  Y  I  M  Y  I  F  W  A  L  S      p.220

          .         .         .         .         .         .       g.75123
 TTTGCCTTTCTTGCAGTTTCCCTGGTAAAGGTATTTGCTCCATATGCCTGTGGCTCTGGA       c.720
 F  A  F  L  A  V  S  L  V  K  V  F  A  P  Y  A  C  G  S  G         p.240

           | 07        .         .         .         .         .    g.76644
 ATTCCAGAG | ATTAAAACTATTTTAAGTGGATTCATCATCAGAGGTTACTTGGGAAAATGG    c.780
 I  P  E   | I  K  T  I  L  S  G  F  I  I  R  G  Y  L  G  K  W      p.260

          .         .         .         .         .         .       g.76704
 ACTTTAATGATTAAAACCATCACATTAGTCCTGGCTGTGGCATCAGGTTTGAGTTTAGGA       c.840
 T  L  M  I  K  T  I  T  L  V  L  A  V  A  S  G  L  S  L  G         p.280

          .         .         .         .         .         .       g.76764
 AAAGAAGGTCCCCTGGTACATGTTGCCTGTTGCTGCGGAAATATCTTTTCCTACCTCTTT       c.900
 K  E  G  P  L  V  H  V  A  C  C  C  G  N  I  F  S  Y  L  F         p.300

          .         .         .       | 08 .         .         .    g.80115
 CCAAAGTATAGCACAAACGAAGCTAAAAAAAGGGAG | GTGCTATCAGCTGCCTCAGCTGCA    c.960
 P  K  Y  S  T  N  E  A  K  K  R  E   | V  L  S  A  A  S  A  A      p.320

          .         .         .         .         .        | 09.    g.81671
 GGGGTTTCTGTAGCTTTTGGTGCACCAATTGGAGGAGTTCTTTTTAGCCTGGAAGAG | GTT    c.1020
 G  V  S  V  A  F  G  A  P  I  G  G  V  L  F  S  L  E  E   | V      p.340

          .         .         .         .         .         .       g.81731
 AGCTATTATTTTCCTCTCAAAACTTTATGGAGATCATTTTTTGCTGCTTTAGTGGCTGCA       c.1080
 S  Y  Y  F  P  L  K  T  L  W  R  S  F  F  A  A  L  V  A  A         p.360

          .         .         .         .         .         .       g.81791
 TTTGTTTTGAGGTCCATCAATCCATTTGGTAACAGCCGTCTGGTCCTTTTTTATGTGGAG       c.1140
 F  V  L  R  S  I  N  P  F  G  N  S  R  L  V  L  F  Y  V  E         p.380

          .         .         .         .         .         .       g.81851
 TATCATACACCATGGTACCTTTTTGAACTGTTTCCTTTTATTCTTCTAGGGGTATTTGGA       c.1200
 Y  H  T  P  W  Y  L  F  E  L  F  P  F  I  L  L  G  V  F  G         p.400

          .         .         .         .         .         .       g.81911
 GGGCTTTGGGGAGCCTTTTTCATTAGGGCAAATATTGCCTGGTGTCGTCGACGCAAGTCC       c.1260
 G  L  W  G  A  F  F  I  R  A  N  I  A  W  C  R  R  R  K  S         p.420

          .         .         .         .         .         .       g.81971
 ACGAAATTTGGAAAGTATCCCGTTCTGGAAGTCATTATTGTTGCAGCCATTACTGCTGTG       c.1320
 T  K  F  G  K  Y  P  V  L  E  V  I  I  V  A  A  I  T  A  V         p.440

          .         .         .         .         .         .       g.82031
 ATAGCCTTCCCTAATCCATACACTAGGCTAAACACCAGTGAACTGATCAAAGAGCTTTTT       c.1380
 I  A  F  P  N  P  Y  T  R  L  N  T  S  E  L  I  K  E  L  F         p.460

          .         .         .         .         .         .       g.82091
 ACAGACTGTGGTCCCCTGGAATCCTCTTCTCTTTGTGACTACAGAAATGACATGAATGCC       c.1440
 T  D  C  G  P  L  E  S  S  S  L  C  D  Y  R  N  D  M  N  A         p.480

          .         .         .         .         .         .       g.82151
 AGTAAAATTGTCGATGACATTCCTGATCGTCCAGCAGGCATTGGAGTATATTCAGCTATA       c.1500
 S  K  I  V  D  D  I  P  D  R  P  A  G  I  G  V  Y  S  A  I         p.500

          .         .         .         .         .         .       g.82211
 TGGCAGTTATGCCTGGCACTCATATTTAAAATCATAATGACAGTATTCACTTTTGGCATC       c.1560
 W  Q  L  C  L  A  L  I  F  K  I  I  M  T  V  F  T  F  G  I         p.520

     | 10    .         .         .         .         .         .    g.88534
 AAG | GTTCCATCAGGCTTGTTCATCCCCAGCATGGCCATTGGAGCGATCGCAGGAAGGATT    c.1620
 K   | V  P  S  G  L  F  I  P  S  M  A  I  G  A  I  A  G  R  I      p.540

          .         .         .         .         .         .       g.88594
 GTGGGGATTGCGGTGGAGCAGCTTGCCTACTATCACCACGACTGGTTTATCTTTAAGGAG       c.1680
 V  G  I  A  V  E  Q  L  A  Y  Y  H  H  D  W  F  I  F  K  E         p.560

          .         .         .         .         .         .       g.88654
 TGGTGTGAGGTCGGGGCTGATTGCATTACACCTGGCCTTTATGCCATGGTTGGTGCTGCT       c.1740
 W  C  E  V  G  A  D  C  I  T  P  G  L  Y  A  M  V  G  A  A         p.580

          . | 11       .         .         .         .         .    g.91397
 GCATGCTTAG | GTGGTGTGACAAGAATGACTGTCTCCCTGGTGGTTATTGTTTTTGAGCTT    c.1800
 A  C  L  G |   G  V  T  R  M  T  V  S  L  V  V  I  V  F  E  L      p.600

          .         .         .         .         .         .       g.91457
 ACTGGAGGCTTGGAATATATTGTTCCCCTTATGGCTGCAGTCATGACCAGTAAATGGGTT       c.1860
 T  G  G  L  E  Y  I  V  P  L  M  A  A  V  M  T  S  K  W  V         p.620

          .         .         .         .         .         .       g.91517
 GGAGATGCCTTTGGCAGGGAAGGCATTTATGAAGCACACATCCGATTAAATGGATACCCT       c.1920
 G  D  A  F  G  R  E  G  I  Y  E  A  H  I  R  L  N  G  Y  P         p.640

          .         .         .         .         .         .       g.91577
 TTCTTGGATGCAAAAGAAGAATTCACTCATACCACCCTGGCTGCTGACGTTATGAGACCT       c.1980
 F  L  D  A  K  E  E  F  T  H  T  T  L  A  A  D  V  M  R  P         p.660

          .         .         .         .         .         .       g.91637
 CGAAGGAATGATCCTCCCTTAGCTGTCCTGACACAGGACAATATGACAGTGGATGATATA       c.2040
 R  R  N  D  P  P  L  A  V  L  T  Q  D  N  M  T  V  D  D  I         p.680

          .         .         .         .         .         .       g.91697
 GAAAACATGATTAATGAAACCAGCTACAATGGATTTCCTGTCATAATGTCAAAAGAATCT       c.2100
 E  N  M  I  N  E  T  S  Y  N  G  F  P  V  I  M  S  K  E  S         p.700

          .         .         .         .          | 12        .    g.97569
 CAGAGATTAGTGGGATTTGCCCTCAGAAGAGACCTGACAATTGCAATAG | AAAGTGCCAGG    c.2160
 Q  R  L  V  G  F  A  L  R  R  D  L  T  I  A  I  E |   S  A  R      p.720

          .         .         .         .         .         .       g.97629
 AAAAAACAAGAAGGTATCGTTGGCAGTTCTCGGGTGTGTTTTGCACAGCACACCCCATCT       c.2220
 K  K  Q  E  G  I  V  G  S  S  R  V  C  F  A  Q  H  T  P  S         p.740

          .         .         .         .         .         .       g.97689
 CTTCCAGCAGAAAGTCCTCGGCCATTGAAGCTTCGAAGCATTCTTGACATGAGCCCTTTT       c.2280
 L  P  A  E  S  P  R  P  L  K  L  R  S  I  L  D  M  S  P  F         p.760

          .         .         .         .         .         .       g.97749
 ACAGTGACAGACCACACCCCAATGGAGATCGTGGTGGATATTTTCCGAAAGCTGGGACTG       c.2340
 T  V  T  D  H  T  P  M  E  I  V  V  D  I  F  R  K  L  G  L         p.780

          .         .       | 13 .         .         .         .    g.104420
 AGGCAGTGCCTTGTAACTCACAATGG | GCGCCTCCTTGGCATTATAACAAAAAAAGATATC    c.2400
 R  Q  C  L  V  T  H  N  G  |  R  L  L  G  I  I  T  K  K  D  I      p.800

          .         .         .         .         .                 g.104477
 CTCCGGCATATGGCCCAGACGGCAAACCAAGACCCCGCTTCAATAATGTTCAACTGA          c.2457
 L  R  H  M  A  Q  T  A  N  Q  D  P  A  S  I  M  F  N  X            p.818

          .         .         .         .         .         .       g.104537
 atctcacagatgaggagagagaagaaacggaagaggaagtttatttgttgaatagcacaa       c.*60

          .         .         .         .         .         .       g.104597
 ctctttaacctgagggagtcatctacttttttttcctcctttacaaaaaaagaaaggaaa       c.*120

          .         .         .         .         .         .       g.104657
 tataaaagccgggtttttgcaacatggtttgcaaataatgctggtggaatggaggagttg       c.*180

          .         .         .         .         .         .       g.104717
 tttggggagggaaaggagagagaaggaaaggagtgaggtatttcccgtctaacagaaagc       c.*240

          .         .         .         .         .         .       g.104777
 agcgtatcaactcctattgttctgcactggatgcattcagctgaggatgtgcctgatagt       c.*300

          .         .         .         .         .         .       g.104837
 gcaggcttgcgcctcaacagagatgacagcagagtcctcgagcacctggcctgttgctcc       c.*360

          .         .         .         .         .         .       g.104897
 aacattgcaaagacacattatcagtccctatttctagagggattactttgaattgagcca       c.*420

          .         .         .         .         .         .       g.104957
 tctataaaactgcaaggtcttgcccttttttttaatcaaaactgttctgtttaattcatg       c.*480

          .         .         .         .         .         .       g.105017
 aattgtatagttaagcattacctttctacattccagaagagcctttatttctctctctct       c.*540

          .         .         .         .         .         .       g.105077
 ctctctctctctctctctctctactgagctgtaacaaagcctctttaaatcggtgtatcc       c.*600

          .         .         .         .         .         .       g.105137
 ttttgaagcagtcctttctcatattgagatgtactgtgattttactgaggtttcatcaca       c.*660

          .         .         .         .         .         .       g.105197
 agaagggagtgtttcttgtgccattaaccatgtagtttgtaccatcactaaatgcttgga       c.*720

          .         .         .         .         .         .       g.105257
 acagtacacatgcaccacaacaaaggctcatcaaacaggtaaagtctcgaaggaagcgag       c.*780

          .         .         .         .         .         .       g.105317
 aacgaaatctctcattgtgtgccgtgtggctcaaaaccgaaaacaatgaagcttggtttt       c.*840

          .         .         .         .         .         .       g.105377
 aaaggataaagttttcttttttgttttcctctcagactttatggataatgtgaccgggtc       c.*900

          .         .         .         .         .         .       g.105437
 ttatgcaaattttctatttctaaaactactactatgatatacaagtgctgttgagcataa       c.*960

          .         .         .         .         .         .       g.105497
 ttaaataaaatgctgctgctttgacagtaaagagaaggaagtattctgattagctgtatc       c.*1020

          .         .         .         .         .         .       g.105557
 tggtattaattgcatgttaaaacactggaatttttaaaattgaaattagatcagtcattc       c.*1080

          .         .         .         .         .         .       g.105617
 ttttcttttctcaagatatctcatggctgacactgaagaagaaatgtaattcataacttg       c.*1140

          .         .         .         .         .         .       g.105677
 cactaaatgtatattttttttcttaaaaatttaccattcttatttatatttttatggatt       c.*1200

          .         .         .         .         .         .       g.105737
 aaaatttataaaatacagatcagttaatattgcacttaagtaattttacctttttaatgt       c.*1260

          .         .         .         .         .         .       g.105797
 gatttttatagaataattcagacttacaaatacagagatatgaacaaagtttacagtggg       c.*1320

          .         .         .         .         .         .       g.105857
 aacaaaggtttaaaaaaaggttgtggttctctctctgtgatccagtgtgcacataaacct       c.*1380

          .         .         .         .         .         .       g.105917
 ttctctgatctttcactgccatcctctggattatgtcttctgacctgtccattttgaccc       c.*1440

          .         .         .         .         .         .       g.105977
 attaactggaaagttgaaaaactacattaactggaaagttgaaaaactacattactttgg       c.*1500

          .         .         .         .         .         .       g.106037
 agaataaaaccgaaagttcgtgtataccttcttaaaaaaaaaatcaaaccaaaaatgtga       c.*1560

          .         .         .         .         .         .       g.106097
 aaacaatagaattgcaaagatagcagttaaaattttaatctgaaaataacctttgaatct       c.*1620

          .         .         .         .         .         .       g.106157
 cgggctaggttacgtccatatttgaagtggtcagtgatggtttgaacattttttgcagga       c.*1680

          .         .         .         .         .         .       g.106217
 tgagtgaaaatgcactggattatatttgggatttttgtttttggaattgtctgttttaat       c.*1740

          .         .         .         .         .         .       g.106277
 cacagccttaattcacaattggcaaaggcagtttactcaaaggactgggctaaatattct       c.*1800

          .         .         .         .         .         .       g.106337
 gtaattatgcatttttgataggaaaatgaaatttttgcaaacagacattttctttttttt       c.*1860

          .         .         .         .         .         .       g.106397
 tggctggagtgcagtggggcatggtcttggctcactgcagcgttgaccacctgggctcaa       c.*1920

          .         .         .         .         .         .       g.106457
 gtgatactcccgcctcagccacccaagtagctggcactacgggcacacgccaccatgccc       c.*1980

          .         .         .         .         .         .       g.106517
 agctaatttttttgtatttttagtagagatggggttttgccatgctgcccaggctggtct       c.*2040

          .         .         .         .         .         .       g.106577
 caactcctcagctcaagcaatctgcctgcgtgagcctcccaaagtggtggaattacaggc       c.*2100

          .         .         .         .         .         .       g.106637
 gtgggccactgcgcctggcccagacagacattttctgaaacacaactggcaatgagctgt       c.*2160

          .         .         .         .         .         .       g.106697
 ttttacattttgaaagtgattcttcacttcctagttcttaattatagtatacctattaag       c.*2220

          .         .         .         .         .         .       g.106757
 atctgtaagatcctgaagacataagatcatgaagccatataagaatgaggattgaaagtt       c.*2280

          .         .         .         .         .         .       g.106817
 gagcaaaattttcgggattttgggaaacattcttagctgtgctatctgcctaaaattatt       c.*2340

          .         .         .         .         .         .       g.106877
 ccttattacttctctcctttgacagacttcaagttttcttcatagccctttcaaagtttt       c.*2400

          .         .         .         .         .         .       g.106937
 ttgagccatccagagtaaaatcatttctaaatgatagttctgtatatctccaactcgtct       c.*2460

          .         .         .         .         .         .       g.106997
 taagtgtatttgcctgtgtgcaacgtattgctagactatgaactcctcagcatggctgct       c.*2520

          .         .         .         .         .         .       g.107057
 ggataacttaattgtcctgagttaatagccttcaaaggacaaatcggtttctttgcagat       c.*2580

          .         .         .         .         .         .       g.107117
 agcttcgtaaaacttcacatggagtttattttatcatatttcccttttttatttctgctc       c.*2640

          .         .         .         .         .         .       g.107177
 ctcctttaattgcccatcttgcttcagagactgacatttcagggtggatattaattaaag       c.*2700

          .         .         .         .         .         .       g.107237
 cattaattttgttttttggtatatttctatccctagtatttctatcttactgctaaaata       c.*2760

          .         .         .         .         .         .       g.107297
 caggaaaagtgccgtatttttaatgcatttagtggttttctttggtgttatctgttccat       c.*2820

          .         .         .         .         .         .       g.107357
 ttttctttttcatacattgaagtgtgtctccttttcaaccaaaataatgaaatagtggag       c.*2880

          .         .         .         .         .         .       g.107417
 accatgaaattgttgtgcctggctaattggcaaattaatttaccaatataataagtgtag       c.*2940

          .         .         .         .         .         .       g.107477
 cgccttgtttgaataccctttttgagaaggtatgatgagaatgggcaagggtgtcagcat       c.*3000

          .         .         .         .         .         .       g.107537
 ctcttcttcttaataattaattgttttcagttttggttcacgaagaatgcttagttaatc       c.*3060

          .         .         .         .         .         .       g.107597
 tgtaatgttgcctagagctgtatttatctgtttttatttatactagtgtagtaaagctgc       c.*3120

          .         .         .         .         .         .       g.107657
 atatcattacagtaaaaacgactactgtgatgagttaatcagaaaatctattaaaatcta       c.*3180

          .                                                         g.107667
 tatgacaatg                                                         c.*3190

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Chloride channel, voltage-sensitive 3 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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