chloride channel, voltage-sensitive 4 (CLCN4) - coding DNA reference sequence

(used for variant description)

(last modified October 14, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_001830.3 in the CLCN4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_012496.1, covering CLCN4 transcript NM_001830.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   tcccagccgg       c.-421

 .         .         .         .         .         .                g.5070
 cctccggggccctccgggctgaaatcgacatttgcctctggcaggaaaatgagcttgtca       c.-361

 .         .         .         .         .         .                g.5130
 gtttctgcctccattagaccctcaacccaaaggagcaggagatttcggtagcgttttaac       c.-301

 .         .         .      | 02  .         .         .             g.6378
 tttatctcagaatctgaaagcggaag | gccaggcaagctgcacacatcaagcgaaacgcct    c.-241

 .         .         .         .         .         .                g.6438
 gaggggcggccagcgcgagggtttctggccatcgaccctcacctcccgggacttccaggg       c.-181

 .         .         .         .         .         .                g.6498
 tcttccccccaccccgcgcacacctccctgcctcgccccgagggcgtcacgtggcagcgt       c.-121

 .         .         .         .         .         .                g.6558
 ggggcccgcctcctggtgatgtcacggcgctcgcagccgtcgcgctgaagaaaggatgct       c.-61

 .         .         .         .         .         | 03             g.33088
 cgaggatgctgtccaggtgggcggccgcgggcgcgatgcggcactgcag | gtgtaattagc    c.-1

          .         .         .         .         .         .       g.33148
 ATGGTCAATGCGGGAGCGATGAGTGGCTCTGGAAACCTGATGGATTTCCTCGATGAGCCG       c.60
 M  V  N  A  G  A  M  S  G  S  G  N  L  M  D  F  L  D  E  P         p.20

          .         .         .         .         .         .       g.33208
 TTCCCTGATGTGGGGACGTATGAGGACTTCCACACCATCGACTGGCTAAGGGAAAAGTCA       c.120
 F  P  D  V  G  T  Y  E  D  F  H  T  I  D  W  L  R  E  K  S         p.40

          .         .     | 04   .         .         .         .    g.35606
 CGGGACACCGACAGACACAGGAAG | ATCACCAGCAAGAGCAAGGAGTCCATATGGGAGTTC    c.180
 R  D  T  D  R  H  R  K   | I  T  S  K  S  K  E  S  I  W  E  F      p.60

          .         .         .         .         .         .       g.35666
 ATCAAGAGCCTGCTGGATGCCTGGTCGGGATGGGTGGTGATGCTGCTCATCGGCCTGCTG       c.240
 I  K  S  L  L  D  A  W  S  G  W  V  V  M  L  L  I  G  L  L         p.80

      | 05   .         .         .         .         .         .    g.43022
 GCGG | GCACCTTGGCTGGGGTCATCGATCTCGCCGTGGACTGGATGACGGACCTGAAGGAG    c.300
 A  G |   T  L  A  G  V  I  D  L  A  V  D  W  M  T  D  L  K  E      p.100

          .         .         .         .         .         .       g.43082
 GGGGTCTGCCTGTCTGCCTTCTGGTATAGCCATGAGCAGTGTTGCTGGACTTCTAACGAG       c.360
 G  V  C  L  S  A  F  W  Y  S  H  E  Q  C  C  W  T  S  N  E         p.120

          .         .         .         .         .         .       g.43142
 ACCACTTTTGAGGACAGAGACAAGTGTCCCCTGTGGCAGAAATGGTCGGAGCTGCTGGTG       c.420
 T  T  F  E  D  R  D  K  C  P  L  W  Q  K  W  S  E  L  L  V         p.140

          .   | 06     .         .         .         .         .    g.46042
 AATCAGTCAGAG | GGTGCCAGTGCTTACATTCTGAATTACTTAATGTACATCCTATGGGCG    c.480
 N  Q  S  E   | G  A  S  A  Y  I  L  N  Y  L  M  Y  I  L  W  A      p.160

          .         .         .         .         .         .       g.46102
 CTGCTGTTTGCATTTTTGGCTGTCTCCCTGGTGCGTGTATTTGCACCATATGCCTGTGGC       c.540
 L  L  F  A  F  L  A  V  S  L  V  R  V  F  A  P  Y  A  C  G         p.180

          .      | 07  .         .         .         .         .    g.54458
 TCTGGCATACCAGAG | ATAAAGACCATTTTGAGCGGCTTTATCATCAGGGGCTACTTGGGG    c.600
 S  G  I  P  E   | I  K  T  I  L  S  G  F  I  I  R  G  Y  L  G      p.200

          .         .         .         .         .         .       g.54518
 AAGTGGACCCTGCTAATCAAGACAGTCACGCTGGTGCTGGTAGTGTCCTCCGGTCTGAGC       c.660
 K  W  T  L  L  I  K  T  V  T  L  V  L  V  V  S  S  G  L  S         p.220

          .         .         .         .         .         .       g.54578
 CTTGGGAAGGAAGGGCCGCTAGTGCACGTGGCTTGTTGCTGTGGCAACTTCTTCAGCAGC       c.720
 L  G  K  E  G  P  L  V  H  V  A  C  C  C  G  N  F  F  S  S         p.240

          .         .         .         .   | 08     .         .    g.54769
 CTTTTCTCCAAGTACAGCAAGAATGAGGGCAAGAGGCGGGAG | GTGCTTTCAGCTGCAGCG    c.780
 L  F  S  K  Y  S  K  N  E  G  K  R  R  E   | V  L  S  A  A  A      p.260

          .         .         .         .         .         .       g.54829
 GCTGCTGGAGTCTCTGTTGCCTTTGGTGCACCAATTGGAGGCGTGCTTTTCAGTCTAGAA       c.840
 A  A  G  V  S  V  A  F  G  A  P  I  G  G  V  L  F  S  L  E         p.280

     | 09    .         .         .         .         .         .    g.56157
 GAG | GTCAGTTACTACTTTCCCCTGAAGACCTTGTGGAGGTCATTTTTCGCAGCCCTGGTG    c.900
 E   | V  S  Y  Y  F  P  L  K  T  L  W  R  S  F  F  A  A  L  V      p.300

          .         .         .         .         .         .       g.56217
 GCGGCCTTTACGCTGAGATCCATCAATCCCTTTGGGAATAGCCGTCTCGTTCTCTTTTAT       c.960
 A  A  F  T  L  R  S  I  N  P  F  G  N  S  R  L  V  L  F  Y         p.320

          .         .         .         .         .         .       g.56277
 GTGGAATACCACACGCCCTGGTACATGGCTGAACTCTTCCCCTTCATCCTGCTTGGGGTC       c.1020
 V  E  Y  H  T  P  W  Y  M  A  E  L  F  P  F  I  L  L  G  V         p.340

          .         .         .         .         .         .       g.56337
 TTCGGGGGCTTGTGGGGAACCCTCTTCATCCGCTGCAACATCGCCTGGTGCAGGAGGCGC       c.1080
 F  G  G  L  W  G  T  L  F  I  R  C  N  I  A  W  C  R  R  R         p.360

          .         .         .         .         .         .       g.56397
 AAGACCACCAGGCTGGGGAAGTACCCGGTGCTGGAGGTCATTGTGGTGACTGCCATCACT       c.1140
 K  T  T  R  L  G  K  Y  P  V  L  E  V  I  V  V  T  A  I  T         p.380

          .         .         .         .         .         .       g.56457
 GCCATCATTGCCTACCCCAATCCCTACACACGCCAGAGCACCAGCGAGCTCATTTCTGAG       c.1200
 A  I  I  A  Y  P  N  P  Y  T  R  Q  S  T  S  E  L  I  S  E         p.400

          .         .         .         .         .         .       g.56517
 CTGTTCAATGACTGTGGAGCCCTTGAGTCTTCCCAGCTCTGTGACTACATCAATGACCCC       c.1260
 L  F  N  D  C  G  A  L  E  S  S  Q  L  C  D  Y  I  N  D  P         p.420

          .         .         .         .         .         .       g.56577
 AACATGACTCGGCCTGTGGATGACATTCCAGACCGGCCGGCTGGTGTCGGTGTTTACACG       c.1320
 N  M  T  R  P  V  D  D  I  P  D  R  P  A  G  V  G  V  Y  T         p.440

          .         .         .         .         .         .       g.56637
 GCCATGTGGCAGCTGGCCCTGGCACTGATCTTCAAAATCGTCGTTACCATATTTACCTTT       c.1380
 A  M  W  Q  L  A  L  A  L  I  F  K  I  V  V  T  I  F  T  F         p.460

           | 10        .         .         .         .         .    g.60573
 GGCATGAAG | ATCCCGTCGGGCCTCTTCATCCCCAGCATGGCTGTGGGCGCGATAGCGGGC    c.1440
 G  M  K   | I  P  S  G  L  F  I  P  S  M  A  V  G  A  I  A  G      p.480

          .         .         .         .         .         .       g.60633
 AGGATGGTGGGAATTGGCGTGGAGCAGCTGGCCTACCATCACCATGACTGGATCATCTTC       c.1500
 R  M  V  G  I  G  V  E  Q  L  A  Y  H  H  H  D  W  I  I  F         p.500

          .         .         .         .         .         .       g.60693
 AGGAACTGGTGCAGACCCGGTGCAGACTGTGTCACGCCAGGGCTGTACGCAATGGTGGGA       c.1560
 R  N  W  C  R  P  G  A  D  C  V  T  P  G  L  Y  A  M  V  G         p.520

          .       | 11 .         .         .         .         .    g.61780
 GCTGCGGCCTGCCTCG | GTGGAGTTACCAGGATGACGGTGTCATTGGTGGTCATCATGTTT    c.1620
 A  A  A  C  L  G |   G  V  T  R  M  T  V  S  L  V  V  I  M  F      p.540

          .         .         .         .         .         .       g.61840
 GAATTAACCGGGGGTCTGGAGTACATCGTGCCCCTGATGGCGGCGGCTGTGACCAGCAAG       c.1680
 E  L  T  G  G  L  E  Y  I  V  P  L  M  A  A  A  V  T  S  K         p.560

          .         .         .         .         .         .       g.61900
 TGGGTAGCTGATGCATTTGGGAAAGAAGGCATCTACGAGGCCCACATCCACTTAAATGGG       c.1740
 W  V  A  D  A  F  G  K  E  G  I  Y  E  A  H  I  H  L  N  G         p.580

          .         .         .         .         .         .       g.61960
 TACCCTTTCCTTGACGTGAAGGACGAGTTTACTCACCGCACACTGGCCACCGACGTCATG       c.1800
 Y  P  F  L  D  V  K  D  E  F  T  H  R  T  L  A  T  D  V  M         p.600

          .         .         .         .         .         .       g.62020
 CGGCCCCGGCGGGGAGAGCCGCCACTGTCGGTGCTCACCCAGGACAGCATGACTGTCGAG       c.1860
 R  P  R  R  G  E  P  P  L  S  V  L  T  Q  D  S  M  T  V  E         p.620

          .         .         .         .         .         .       g.62080
 GACGTGGAGACGCTCATCAAGGAGACCGACTACAACGGCTTCCCCGTGGTGGTCTCCAGA       c.1920
 D  V  E  T  L  I  K  E  T  D  Y  N  G  F  P  V  V  V  S  R         p.640

          .         .         .         .         .      | 12  .    g.68721
 GACTCCGAGCGCCTCATTGGATTTGCCCAGAGGAGGGAACTGATTCTCGCAATAA | AGAAC    c.1980
 D  S  E  R  L  I  G  F  A  Q  R  R  E  L  I  L  A  I  K |   N      p.660

          .         .         .         .         .         .       g.68781
 GCCAGACAGAGGCAGGAGGGCATTGTGAGCAATTCCATCATGTACTTCACGGAGGAACCC       c.2040
 A  R  Q  R  Q  E  G  I  V  S  N  S  I  M  Y  F  T  E  E  P         p.680

          .         .         .         .         .         .       g.68841
 CCCGAGCTGCCGGCCAACAGCCCACATCCCCTGAAGCTGCGGCGCATCCTGAACCTCAGC       c.2100
 P  E  L  P  A  N  S  P  H  P  L  K  L  R  R  I  L  N  L  S         p.700

          .         .         .         .         .         .       g.68901
 CCGTTTACAGTGACAGACCACACTCCGATGGAAACGGTGGTGGATATCTTCCGGAAACTG       c.2160
 P  F  T  V  T  D  H  T  P  M  E  T  V  V  D  I  F  R  K  L         p.720

          .         .         .   | 13     .         .         .    g.81577
 GGGCTTCGGCAGTGCCTGGTGACGCGGAGCGG | GAGACTTCTTGGCATCATCACAAAAAAG    c.2220
 G  L  R  Q  C  L  V  T  R  S  G  |  R  L  L  G  I  I  T  K  K      p.740

          .         .         .         .         .         .       g.81637
 GATGTTCTGAGACATATGGCCCAGATGGCAAACCAGGACCCCGAATCCATCATGTTTAAT       c.2280
 D  V  L  R  H  M  A  Q  M  A  N  Q  D  P  E  S  I  M  F  N         p.760

                                                                    g.81640
 TAG                                                                c.2283
 X                                                                  p.760

          .         .         .         .         .         .       g.81700
 caacaaggtggcaattattttcagaaaaacactgactgtgtcatttaaaaagaaataaat       c.*60

          .         .         .         .         .         .       g.81760
 gatatgttattatcccaatgaaagatcatgcattggggacagcagaaacaaaagcttttt       c.*120

          .         .         .         .         .         .       g.81820
 tggaaaggcggggaagaaggatgaaacctttaaaaacaaaaacaaaaacatcaatgagta       c.*180

          .         .         .         .         .         .       g.81880
 ggcattttatagctttaaccccgtatgagtttcaagctgtgtttcctaatgagtttgcta       c.*240

          .         .         .         .         .         .       g.81940
 ctgctgtgggggcatgtgggtgggtaaatgatgtaaatgatgtgatctgtacaagtatgt       c.*300

          .         .         .         .         .         .       g.82000
 ggagcatgaatgctgactcaagaaacttttactccttctgctcaaggctgatgtttgtaa       c.*360

          .         .         .         .         .         .       g.82060
 cttatgaacacacgtgaagtgttgagtccaaaagacaaaggggcatcggcatgtcagcgt       c.*420

          .         .         .         .         .         .       g.82120
 ccttatttattggttcttgaagttttgctgctatgttactgaatcatactaaagacattt       c.*480

          .         .         .         .         .         .       g.82180
 gcgcttactttgttgaaaaagaaaaagaaattaaatttgaacacagtgaaagctgcaagt       c.*540

          .         .         .         .         .         .       g.82240
 atgccagtgggtccgctcacgaccgtcctgtttcttgctcctgttctcagcctgttatct       c.*600

          .         .         .         .         .         .       g.82300
 ggcttatccatcagtttctgaaccaacatcaggggcacctgccatgatgagtgtgaagaa       c.*660

          .         .         .         .         .         .       g.82360
 atcatttctctatgcaagactggcatcctgggactgcacgatgaactattggagcataca       c.*720

          .         .         .         .         .         .       g.82420
 gtactgcggtgtgtctcctcccatacaaagggacacatccttattttgagggtatactca       c.*780

          .         .         .         .         .         .       g.82480
 cccgatcattgatttgcatccccatggcatttgcttcatttatttattgcttttgcccat       c.*840

          .         .         .         .         .         .       g.82540
 gcattcaatattgatcagctcagcacttccatgggccatagccggtatgcccccagcctg       c.*900

          .         .         .         .         .         .       g.82600
 ccataagcgtgctttcattttcaagtagcatatgcaagagtccaaacaggctacccaatg       c.*960

          .         .         .         .         .         .       g.82660
 ttactacttatttttcctctcaggtcttatcagatacggctgtggagaggatgaggcata       c.*1020

          .         .         .         .         .         .       g.82720
 tgcgttgtcagttggaatccctccaaatggattgcaagagaaatactaaattgattctaa       c.*1080

          .         .         .         .         .         .       g.82780
 atctgttccattatcttctctgtaggatgcaaaacatccagttgtaatgtataagcatgc       c.*1140

          .         .         .         .         .         .       g.82840
 acttcatactagcaatcacagcacaggaggacagcattaaattttatatagccaatttgg       c.*1200

          .         .         .         .         .         .       g.82900
 gcactgggcatctttgtatttgaacttaacgacacatttactcttttagtcaggatttcg       c.*1260

          .         .         .         .         .         .       g.82960
 gtcttttctgcgggaaggaattaagctatgtattaggtccaccatacgatctgtgtaagt       c.*1320

          .         .         .         .         .         .       g.83020
 aagattatcccacttgccctttctctttagtctttgtcccttccttttcactaagtgccc       c.*1380

          .         .         .         .         .         .       g.83080
 ctcatccttttcaatctcattgtcactggatagtgctgtatcacttaggtgtgcattcgg       c.*1440

          .         .         .         .         .         .       g.83140
 ctgcaaataacagaaaacccagcaaacactgaagggctggataagaaccctgagaggggg       c.*1500

          .         .         .         .         .         .       g.83200
 tactccaggactgtctccataacatcattgggatccccatcccgttgctatttctttttc       c.*1560

          .         .         .         .         .         .       g.83260
 accgtttttaccttttgtcctctggcttattgcctcagagttgcaagatggttcctgaac       c.*1620

          .         .         .         .         .         .       g.83320
 tgtcaggtatcatgtctgctttctaagtgggaagaggaagggagaggcaagcaactaggt       c.*1680

          .         .         .         .         .         .       g.83380
 acaatgtctatcaggaaagcaaagcttccccagagacgctcagcttgtatccattgactg       c.*1740

          .         .         .         .         .         .       g.83440
 gaagtctgtcacgtggctccccctagccgcacactagtgtgggaaggaaaatattgagct       c.*1800

          .         .         .         .         .         .       g.83500
 aggcacattactctctgaacgaaattcatattatcttattaaggaagagtgttggtcttc       c.*1860

          .         .         .         .         .         .       g.83560
 aggaggggaagtttgctgtattggatgccatcatcgtgtccttgtcattgcccttccggt       c.*1920

          .         .         .         .         .         .       g.83620
 tttcattcttgctaaacccctgtgaatgttcttctaaccttcctgttccccacccctttt       c.*1980

          .         .         .         .         .         .       g.83680
 ctcagatttgacctagaattcccagcccaaatccataatttcttagctctaatacgaatt       c.*2040

          .         .         .         .         .         .       g.83740
 ttcatgttggacaaaaacctagctacaaatgggtttctatggaacttctaattaatgtgc       c.*2100

          .         .         .         .         .         .       g.83800
 aaaatacatattttctccaggttaagaaattttaagtcagatcatgctgacacaataaga       c.*2160

          .         .         .         .         .         .       g.83860
 aaatttgtttgtgtaattcattgacctcttccttccaaaataacatcaagtagccacctc       c.*2220

          .         .         .         .         .         .       g.83920
 agtgtgacaatatccagtcaatagtagagaatttaatccttggtcctataaaagaataaa       c.*2280

          .         .         .         .         .         .       g.83980
 attcattgtcgtatttatagcacgtaagccttgagtaacaggtcttaatgttagtgttgg       c.*2340

          .         .         .         .         .         .       g.84040
 tgttgtggtttctgcggaacgtttacaagtgaagttggattctcctgggctttaaatcca       c.*2400

          .         .         .         .         .         .       g.84100
 aaaagtcttaatgaccgcttcatgtagttcccctcttattcccctgtggtctcctcagag       c.*2460

          .         .         .         .         .         .       g.84160
 ccagcgtgtgctgggaaagagtattagtcatagcctggctttatagaatccaggaggtcc       c.*2520

          .         .         .         .         .         .       g.84220
 ttttagctgaaacaagtggcttcaaaagggaacatgaaacagtgaaaagatagccaaagg       c.*2580

          .         .         .         .         .         .       g.84280
 tcagtgaaaccacagcatttctttctaatctggctgaggccatgggggggaatgagggga       c.*2640

          .         .         .         .         .         .       g.84340
 aattatgcttccgggccaaggtcaccgagggggaccttgggatttgtgtcctccccagtg       c.*2700

          .         .         .         .         .         .       g.84400
 cttagagtagagatacctgcaaattcatggcaaacagttggaagagttacttgactgaaa       c.*2760

          .         .         .         .         .         .       g.84460
 caacccaatcttactttctttcgtaagttgaacctctgatttattgtggggttcaggctc       c.*2820

          .         .         .         .         .         .       g.84520
 tcctcaatagaaggccagagttggacaggtggactaaggtcaaggatgaggagtctgcag       c.*2880

          .         .         .         .         .         .       g.84580
 tggggactaccacagcaaactgccttccttccgtggagtcctaactcagccatgtggtcc       c.*2940

          .         .         .         .         .         .       g.84640
 actcacccaggggcccgggggctcagacaaaccccatggggaacatgctgccatgctctg       c.*3000

          .         .         .         .         .         .       g.84700
 tctttcttgtaaacgtagttgggtagggatcccaagggtatttgctctctccaaatgcag       c.*3060

          .         .         .         .         .         .       g.84760
 aacttccatccactttatctggtgatctgatgaacagcatggggacgtggaggtgaaata       c.*3120

          .         .         .         .         .         .       g.84820
 agcatctttcagaataaggtttttttttttttcctcttccagaaccaaaggctttagaca       c.*3180

          .         .         .         .         .         .       g.84880
 tttgtagaactttctggattccttctgaatcgggttttaacataaaaaaccatcaacaca       c.*3240

          .         .         .         .         .         .       g.84940
 tcatgggaaaggagctctttcatgatatacatcacatgtttcttgctctcactgaggaaa       c.*3300

          .         .         .         .         .         .       g.85000
 tgtgttgtacaaaagcaccaaataagggcaccctggaagtgacatgtgtgtttcttctaa       c.*3360

          .         .         .         .         .         .       g.85060
 gtcgtttttagtgcatcccctgcgattgcatgatgctcatgtggcttttagggaaaggca       c.*3420

          .         .         .         .         .         .       g.85120
 gaatgtgctagaagtcgaagtcattcaatattcagtgcttactgttactttgaaccaggt       c.*3480

          .         .         .         .         .         .       g.85180
 aatctcagttctttattcagtccttcccaaagaccttacaaaggagatgtgtaaactgat       c.*3540

          .         .         .         .         .         .       g.85240
 agattttgagcctaataagtcacagaaatggaaaattttagagcagtttgtttcacttag       c.*3600

          .         .         .         .         .         .       g.85300
 gtgagaactgattactttaaattaccaacatgtgcaaattctacttagtattcattatta       c.*3660

          .         .         .         .         .         .       g.85360
 gatgctaagctggaaaagatgagaaacccaaggagaactattgaattaccacataattgt       c.*3720

          .         .         .         .         .         .       g.85420
 aatattatgctttaattttgtatgggcagtgttctatcagactaagcttctagcctttga       c.*3780

          .         .         .         .         .         .       g.85480
 aatgatttacatgaggagagagcctgtatatctgacttgggaaacattaagcagacccta       c.*3840

          .         .         .         .         .         .       g.85540
 ttttcactggcgcggtaataactatttatttgctatcctagaggtgctgggaatgagcct       c.*3900

          .         .         .         .         .         .       g.85600
 acgtgcgactttgatgagatatattcacatttggtgttggaacgaccacatagcaacgtg       c.*3960

          .         .         .         .         .         .       g.85660
 ttggtttttttttattgtaacactctgtgtaaacgttgacaccttattaaatattaaatg       c.*4020

          .         .         .         .         .                 g.85716
 tctgaactctatttttaaaaataaaacaagcacagagtctgcaacaaacatgtaaa           c.*4076

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Chloride channel, voltage-sensitive 4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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