chloride channel, voltage-sensitive 6 (CLCN6) - coding DNA reference sequence

(used for variant description)

(last modified April 3, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_001286.3 in the CLCN6 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_008766.1, covering CLCN6 transcript NM_001286.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.4993
              atcgtcatgtgacgcgagtcctcgccccacccgtctgcagccactcc       c.-121

 .         .         .         .         .         .                g.5053
 tggtctcagtcccagagctcgagagggccacgtgaccgtcccggggccagtcacgtgagg       c.-61

 .         .         .         .         .         .                g.5113
 cgcagatcctggctgggagggggttggtagaggggtccagagtggcagtaaaggaggaag       c.-1

          .         .         .         .         .         .       g.5173
 ATGGCGGGGTGCAGGGGGTCTCTGTGCTGCTGCTGCAGGTGGTGCTGCTGCTGCGGTGAG       c.60
 M  A  G  C  R  G  S  L  C  C  C  C  R  W  C  C  C  C  G  E         p.20

          .         .        | 02.         .         .         .    g.6014
 CGTGAGACCCGCACCCCCGAGGAGCTG | ACCATCCTTGGAGAAACACAGGAGGAGGAGGAT    c.120
 R  E  T  R  T  P  E  E  L   | T  I  L  G  E  T  Q  E  E  E  D      p.40

          .         .        | 03.         .         .         .    g.14729
 GAGATTCTTCCAAGGAAAGACTATGAG | AGTTTGGATTATGATCGCTGTATCAATGACCCT    c.180
 E  I  L  P  R  K  D  Y  E   | S  L  D  Y  D  R  C  I  N  D  P      p.60

          .         .         .    | 04    .         .         .    g.15492
 TACCTGGAAGTTTTGGAGACCATGGATAATAAG | AAAGGTCGAAGATATGAGGCGGTGAAG    c.240
 Y  L  E  V  L  E  T  M  D  N  K   | K  G  R  R  Y  E  A  V  K      p.80

          .         .         .          | 05        .         .    g.18359
 TGGATGGTGGTGTTTGCCATTGGAGTCTGCACTGGCCTG | GTGGGTCTCTTTGTGGACTTT    c.300
 W  M  V  V  F  A  I  G  V  C  T  G  L   | V  G  L  F  V  D  F      p.100

          .         .         .         .       | 06 .         .    g.21559
 TTTGTGCGACTCTTCACCCAACTCAAGTTCGGAGTGGTACAGACAT | CGGTGGAGGAGTGC    c.360
 F  V  R  L  F  T  Q  L  K  F  G  V  V  Q  T  S |   V  E  E  C      p.120

          .         .         .         .         .         .       g.21619
 AGCCAGAAAGGCTGCCTCGCTCTGTCTCTCCTTGAACTCCTGGGTTTTAACCTCACCTTT       c.420
 S  Q  K  G  C  L  A  L  S  L  L  E  L  L  G  F  N  L  T  F         p.140

          .         .         .    | 07    .         .         .    g.22584
 GTCTTCCTGGCAAGCCTCCTTGTTCTCATTGAG | CCGGTGGCAGCAGGTTCCGGGATACCC    c.480
 V  F  L  A  S  L  L  V  L  I  E   | P  V  A  A  G  S  G  I  P      p.160

          .         .         .         .         .         .       g.22644
 GAGGTCAAATGCTATCTGAATGGCGTAAAGGTGCCAGGAATCGTCCGTCTCCGGACCCTG       c.540
 E  V  K  C  Y  L  N  G  V  K  V  P  G  I  V  R  L  R  T  L         p.180

          .         .         .         . | 08       .         .    g.23356
 CTCTGCAAGGTCCTTGGAGTGCTGTTCAGTGTGGCTGGAG | GGCTCTTCGTGGGGAAGGAA    c.600
 L  C  K  V  L  G  V  L  F  S  V  A  G  G |   L  F  V  G  K  E      p.200

          .         .         .         .         | 09         .    g.25018
 GGCCCCATGATCCACAGTGGTTCGGTGGTGGGAGCTGGCCTCCCTCAG | TTTCAGAGCATC    c.660
 G  P  M  I  H  S  G  S  V  V  G  A  G  L  P  Q   | F  Q  S  I      p.220

          .         .         .         .        | 10.         .    g.25952
 TCCTTACGGAAGATCCAGTTTAACTTCCCCTATTTCCGAAGCGACAG | AGACAAGAGAGAC    c.720
 S  L  R  K  I  Q  F  N  F  P  Y  F  R  S  D  R  |  D  K  R  D      p.240

          .         .         .         .         .         .       g.26012
 TTTGTATCAGCAGGAGCGGCTGCTGGAGTTGCTGCAGCTTTCGGGGCGCCAATCGGGGGT       c.780
 F  V  S  A  G  A  A  A  G  V  A  A  A  F  G  A  P  I  G  G         p.260

          .         .         .         .         .         .       g.26072
 ACCTTGTTCAGTCTAGAGGAGGGTTCGTCCTTCTGGAACCAAGGGCTCACGTGGAAAGTG       c.840
 T  L  F  S  L  E  E  G  S  S  F  W  N  Q  G  L  T  W  K  V         p.280

  | 11       .         .         .         .         .         .    g.27016
  | CTCTTTTGTTCCATGTCTGCCACCTTCACCCTCAACTTCTTCCGTTCTGGGATTCAGTTT    c.900
  | L  F  C  S  M  S  A  T  F  T  L  N  F  F  R  S  G  I  Q  F      p.300

          .         .         .         .         .     | 12   .    g.27314
 GGAAGCTGGGGTTCCTTCCAGCTCCCTGGATTGCTGAACTTTGGCGAGTTTAAG | TGCTCT    c.960
 G  S  W  G  S  F  Q  L  P  G  L  L  N  F  G  E  F  K   | C  S      p.320

          .         .         .         .         .         .       g.27374
 GACTCTGATAAAAAATGTCATCTCTGGACAGCTATGGATTTGGGTTTCTTCGTCGTGATG       c.1020
 D  S  D  K  K  C  H  L  W  T  A  M  D  L  G  F  F  V  V  M         p.340

          .         .         .         .         .         .       g.27434
 GGGGTCATTGGGGGCCTCCTGGGAGCCACATTCAACTGTCTGAACAAGAGGCTTGCAAAG       c.1080
 G  V  I  G  G  L  L  G  A  T  F  N  C  L  N  K  R  L  A  K         p.360

          .         .         .         .  | 13      .         .    g.28065
 TACCGTATGCGAAACGTGCACCCGAAACCTAAGCTCGTCAG | AGTCTTAGAGAGCCTCCTT    c.1140
 Y  R  M  R  N  V  H  P  K  P  K  L  V  R  |  V  L  E  S  L  L      p.380

          .         .         .         .         .         .       g.28125
 GTGTCTCTGGTAACCACCGTGGTGGTGTTTGTGGCCTCGATGGTGTTAGGAGAATGCCGA       c.1200
 V  S  L  V  T  T  V  V  V  F  V  A  S  M  V  L  G  E  C  R         p.400

          .         .         .         .         | 14         .    g.32377
 CAGATGTCCTCTTCGAGTCAAATCGGTAATGACTCATTCCAGCTCCAG | GTCACAGAAGAT    c.1260
 Q  M  S  S  S  S  Q  I  G  N  D  S  F  Q  L  Q   | V  T  E  D      p.420

          .         .         .         .         .         .       g.32437
 GTGAATTCAAGTATCAAGACATTTTTTTGTCCCAATGATACCTACAATGACATGGCCACA       c.1320
 V  N  S  S  I  K  T  F  F  C  P  N  D  T  Y  N  D  M  A  T         p.440

          .         .         .         .         .   | 15     .    g.32735
 CTCTTCTTCAACCCGCAGGAGTCTGCCATCCTCCAGCTCTTCCACCAGGATG | GTACTTTC    c.1380
 L  F  F  N  P  Q  E  S  A  I  L  Q  L  F  H  Q  D  G |   T  F      p.460

          .         .         .         .         .         .       g.32795
 AGCCCCGTCACTCTGGCCTTGTTCTTCGTTCTCTATTTCTTGCTTGCATGTTGGACTTAC       c.1440
 S  P  V  T  L  A  L  F  F  V  L  Y  F  L  L  A  C  W  T  Y         p.480

          .         .         .         .         .         .       g.32855
 GGCATTTCTGTTCCAAGTGGCCTTTTTGTGCCTTCTCTGCTGTGTGGAGCTGCTTTTGGA       c.1500
 G  I  S  V  P  S  G  L  F  V  P  S  L  L  C  G  A  A  F  G         p.500

          .         .       | 16 .         .         .         .    g.33120
 CGTTTAGTTGCCAATGTCCTAAAAAG | CTACATTGGATTGGGCCACATCTATTCGGGGACC    c.1560
 R  L  V  A  N  V  L  K  S  |  Y  I  G  L  G  H  I  Y  S  G  T      p.520

          .         .         .         .         .         .       g.33180
 TTTGCCCTGATTGGTGCAGCGGCTTTCTTGGGCGGGGTGGTCCGCATGACCATCAGCCTC       c.1620
 F  A  L  I  G  A  A  A  F  L  G  G  V  V  R  M  T  I  S  L         p.540

          .         .         .         .         .         .       g.33240
 ACGGTCATCCTGATCGAGTCCACCAATGAGATCACCTACGGGCTCCCCATCATGGTCACA       c.1680
 T  V  I  L  I  E  S  T  N  E  I  T  Y  G  L  P  I  M  V  T         p.560

        | 17 .         .         .         .         .         .    g.33388
 CTGATG | GTGGCCAAATGGACAGGGGACTTTTTCAATAAGGGCATTTATGATATCCACGTG    c.1740
 L  M   | V  A  K  W  T  G  D  F  F  N  K  G  I  Y  D  I  H  V      p.580

          .         .         .         .         .    | 18    .    g.34824
 GGCCTGCGAGGCGTGCCGCTTCTGGAATGGGAGACAGAGGTGGAAATGGACAA | GCTGAGA    c.1800
 G  L  R  G  V  P  L  L  E  W  E  T  E  V  E  M  D  K  |  L  R      p.600

          .         .         .         .         .         .       g.34884
 GCCAGCGACATCATGGAGCCCAACCTGACCTACGTCTACCCGCACACCCGCATCCAGTCT       c.1860
 A  S  D  I  M  E  P  N  L  T  Y  V  Y  P  H  T  R  I  Q  S         p.620

          .         .         .         .         .         .       g.34944
 CTGGTGAGCATCCTGCGCACCACGGTCCACCATGCCTTCCCGGTGGTCACAGAGAACCGC       c.1920
 L  V  S  I  L  R  T  T  V  H  H  A  F  P  V  V  T  E  N  R         p.640

          .         .         .         .         .         .       g.35004
 GGTAACGAGAAGGAGTTCATGAAGGGCAACCAGCTCATCAGCAACAACATCAAGTTCAAG       c.1980
 G  N  E  K  E  F  M  K  G  N  Q  L  I  S  N  N  I  K  F  K         p.660

  | 19       .         .         .         .         .         .    g.35909
  | AAATCCAGCATCCTCACCCGGGCTGGCGAGCAGCGCAAACGGAGCCAGTCCATGAAGTCC    c.2040
  | K  S  S  I  L  T  R  A  G  E  Q  R  K  R  S  Q  S  M  K  S      p.680

          .         .         .         .         .         .       g.35969
 TACCCATCCAGCGAGCTACGGAACATGTGTGATGAGCACATCGCCTCTGAGGAGCCAGCC       c.2100
 Y  P  S  S  E  L  R  N  M  C  D  E  H  I  A  S  E  E  P  A         p.700

          .         .         .         | 20         .         .    g.36215
 GAGAAGGAGGACCTCCTGCAGCAGATGCTGGAAAGGAG | ATACACTCCCTACCCCAACCTA    c.2160
 E  K  E  D  L  L  Q  Q  M  L  E  R  R  |  Y  T  P  Y  P  N  L      p.720

          .         .         .         .         .         .       g.36275
 TACCCTGACCAGTCCCCAAGTGAAGACTGGACCATGGAGGAGCGGTTCCGCCCTCTGACC       c.2220
 Y  P  D  Q  S  P  S  E  D  W  T  M  E  E  R  F  R  P  L  T         p.740

          .         .         .         .         .         .       g.36335
 TTCCACGGCCTGATCCTTCGGTCGCAGCTTGTCACCCTGCTTGTCCGAGGAGTTTGTTAC       c.2280
 F  H  G  L  I  L  R  S  Q  L  V  T  L  L  V  R  G  V  C  Y         p.760

          .      | 21  .         .         .         .         .    g.37230
 TCTGAAAGCCAGTCG | AGCGCCAGCCAGCCGCGCCTCTCCTATGCCGAGATGGCCGAGGAC    c.2340
 S  E  S  Q  S   | S  A  S  Q  P  R  L  S  Y  A  E  M  A  E  D      p.780

          .         .         .         .         .         .       g.37290
 TACCCGCGGTACCCCGACATCCACGACCTGGACCTGACGCTGCTCAACCCGCGCATGATC       c.2400
 Y  P  R  Y  P  D  I  H  D  L  D  L  T  L  L  N  P  R  M  I         p.800

     | 22    .         .         .         .         .         .    g.37442
 GTG | GATGTCACCCCATACATGAACCCTTCGCCTTTCACCGTCTCGCCCAACACCCACGTC    c.2460
 V   | D  V  T  P  Y  M  N  P  S  P  F  T  V  S  P  N  T  H  V      p.820

          .         .         .         .         .         .       g.37502
 TCCCAAGTCTTCAACCTGTTCAGAACGATGGGCCTGCGCCACCTGCCCGTGGTGAACGCT       c.2520
 S  Q  V  F  N  L  F  R  T  M  G  L  R  H  L  P  V  V  N  A         p.840

           | 23        .         .         .         .         .    g.39044
 GTGGGAGAG | ATCGTGGGGATCATCACACGGCACAACCTCACCTATGAATTTCTGCAGGCC    c.2580
 V  G  E   | I  V  G  I  I  T  R  H  N  L  T  Y  E  F  L  Q  A      p.860

          .         .         .                                     g.39074
 CGGCTGAGGCAGCACTACCAGACCATCTGA                                     c.2610
 R  L  R  Q  H  Y  Q  T  I  X                                       p.869

          .         .         .         .         .         .       g.39134
 cagcccagcccaccctctcctggtgctgcctggggaggcaaatcatgctcactccggcgg       c.*60

          .         .         .         .         .         .       g.39194
 gcacagctggctggggctgttccggggcatggaagattcccagtcacccactcactcaga       c.*120

          .         .         .         .         .         .       g.39254
 aagccgggagtcatcggacaccttgctggtcagaggtcctgggggtggttttgaaccatc       c.*180

          .         .         .         .         .         .       g.39314
 agagcttggacttttctgacttccccagcaaggatcttcccacttcctgctccctgtgtt       c.*240

          .         .         .         .         .         .       g.39374
 cccaccctccagtgttggcacaggcccacccctggctccaccagagccagaagcagaggt       c.*300

          .         .         .         .         .         .       g.39434
 agaatcaggcgggccccgggctgcactccgagcagtgttcctggccatctttgctacttt       c.*360

          .         .         .         .         .         .       g.39494
 cctagagaacccggctgttgccttaaatgtgtgagagggacttggccaaggcaaaagctg       c.*420

          .         .         .         .         .         .       g.39554
 gggagatgccagtgacaacatacagttcatgactaggtttaggaattgggcactgagaaa       c.*480

          .         .         .         .         .         .       g.39614
 attctcaatatttcagagagtccttcccttatttgggactcttaacacggtatcctcgct       c.*540

          .         .         .         .         .         .       g.39674
 agttggttttaagggaaacactctgctcctgggtgtgagcagaggctctggtcttgccct       c.*600

          .         .         .         .         .         .       g.39734
 gtggtttgactctccttagaaccaccgcccaccagaaacataaaggattaaaatcacact       c.*660

          .         .         .         .         .         .       g.39794
 aataacccctggatggtcaatctgataataggatcagatttacgtctaccctaattctta       c.*720

          .         .         .         .         .         .       g.39854
 acattgcagctttctctccatctgcagattattcccagtctcccagtaacacgtttctac       c.*780

          .         .         .         .         .         .       g.39914
 ccagatcctttttcatttccttaagttttgatctccgtcttcctgatgaagcaggcagag       c.*840

          .         .         .         .         .         .       g.39974
 ctcagaggatcttggcatcacccaccaaagttagctgaaagcagggcactcctggataaa       c.*900

          .         .         .         .         .         .       g.40034
 gcagcttcactcaactctggggaatgctaccattttttttccaaagtagaaaggaagcac       c.*960

          .         .         .         .         .         .       g.40094
 ttctgagccagtgaccactgaaaggtatgtgctatgataaagcagatggcctatttgagg       c.*1020

          .         .         .         .         .         .       g.40154
 aagagggtgtctgcccttcacaaacacctctctctcccctgcactagctgtcccaagctt       c.*1080

          .         .         .         .         .         .       g.40214
 acatacagaggcccttcaggagggcctcctgtgccgcagggagggtgcgtggggaagatg       c.*1140

          .         .         .         .         .         .       g.40274
 cttcctgccagcacgtgcctgaaggtttcacatgaagcatgggaagcgcaccctgtcgtt       c.*1200

          .         .         .         .         .         .       g.40334
 cagtgacgtcattcttctccaggctggcccgccccctctgactaggcacccaaagtgagc       c.*1260

          .         .         .         .         .         .       g.40394
 atctgggcattgggcattcatgcttatcttcccccaccttctacatggtattagtcccag       c.*1320

          .         .         .         .         .         .       g.40454
 caggcatccctggggcagacgtgctttggctcaagatggccttcatttacgtttagtttt       c.*1380

          .         .         .         .         .         .       g.40514
 ttttaaaaccgtggaggttgcccacgggcctcggcacctggccctggcagcacagctctc       c.*1440

          .         .         .         .         .         .       g.40574
 aggcccagccctgggcgacctccttggccaagtctgcctttcaccctggggtgagcatca       c.*1500

          .         .         .         .         .         .       g.40634
 gtcctggctctgctggtccagatcttgcgctcagcacactctagggaataattccactcc       c.*1560

          .         .         .         .         .         .       g.40694
 agagatggggctgcttcaaggtcttttctagctgattgtggcccctccattttccccatt       c.*1620

          .         .         .         .         .         .       g.40754
 ttcttatctccctgaccaaaattgctttgacttctaaatgtttctgcttcccagaatgca       c.*1680

          .         .         .         .         .         .       g.40814
 cctgacttatgaaatggggataatactcccaggaaatagcgcaggacatcacaaggacca       c.*1740

          .         .         .         .         .         .       g.40874
 aaaaggcaattcttatttaaatgttactatttggccagctgctgctgtgttttatggcag       c.*1800

          .         .         .         .         .         .       g.40934
 tgttcagagcttgatcacgttatttcttccttttattaagaaggaagccaattgtccaag       c.*1860

          .         .         .         .         .         .       g.40994
 tcaggagaatggtgtgatcacctgtcacagacactttgtcccctctccccgccccttcct       c.*1920

          .         .         .         .         .         .       g.41054
 ggagctggcagagctaacgccctgcaggaggaccccggcctctcgagggctggatcagca       c.*1980

          .         .         .         .         .         .       g.41114
 gccgcctgccctgaggctgccccggtgaatgttattggaattcatccctcgtgcacatcc       c.*2040

          .         .         .         .         .         .       g.41174
 tgttgtgtttaagtcaccagatattttgttcccatcagtttagcccagagatagacagta       c.*2100

          .         .         .         .         .         .       g.41234
 gaatgcaaatacctccctcccctaaactgactggacggctgccaaggaggccccaaaccc       c.*2160

          .         .         .         .         .         .       g.41294
 aggccccatgcaaaggcacgtggtttccttttctcctctctctgcatctgcgctttccag       c.*2220

          .         .         .         .         .         .       g.41354
 ataagcccaaagacagcaacttctccactcatgacaaatcaactgtgaccctcgctcctt       c.*2280

          .         .         .         .         .         .       g.41414
 ccatttctgtccattagaaaccagccttttcagcatctcacccattagcagccccatcac       c.*2340

          .         .         .         .         .         .       g.41474
 ccagtgatcagtcgcctcagtaaagcagatctgtggatggggagcctacgggtggtaaga       c.*2400

          .         .         .         .         .         .       g.41534
 agtggtgttttgtgtttcatctccagcttggtgttccatggcccctaggcgaggtgatca       c.*2460

          .         .         .         .         .         .       g.41594
 gggagtggggccaatgggcccccggccctggctttgggaccttgtgctgagggatgattt       c.*2520

          .         .         .         .         .         .       g.41654
 gctcctgaccttgattaacttaacagttcccagctggaagggacactttcaggacccagt       c.*2580

          .         .         .         .         .         .       g.41714
 ccactgtatggcatttgtgatgcagaattatgcactgacatgaccctgggtgacaggaaa       c.*2640

          .         .         .         .         .         .       g.41774
 gcctttcgagaggcccaaggtggcctcgccagccctgcagtattgatgtgcagtattgca       c.*2700

          .         .         .         .         .         .       g.41834
 ccacagctctgcggaccttggccattgccgcagtcgcagcttccttttttctgtttgcac       c.*2760

          .         .         .         .         .         .       g.41894
 tgtttgtttgtatgatgttagctaattccactgtgtatataaattgtattttttttaatt       c.*2820

          .         .         .         .         .         .       g.41954
 tgtaaaatgctatttttatttgaacctttggaacttgggagttctcattgtaaccctaac       c.*2880

          .         .         .         .                           g.41995
 atgtgagaataaaatgtcttctgtctcctctgtctccttta                          c.*2921

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Chloride channel, voltage-sensitive 6 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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