chloride channel, voltage-sensitive Kb (CLCNKB) - coding DNA reference sequence

(used for variant description)

(last modified October 12, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000085.4 in the CLCNKB gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_013079.1, covering CLCNKB transcript NM_000085.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5016
                             attctaagtgttcgccataaaccctgggccca       c.-121

 .         .         .         .         .         .                g.5076
 ggcgggaaaggggggaggatgttgattgttggaacacacacctgtccaggtgcaggggag       c.-61

 .         .         .         .         .         .   | 02         g.5741
 ctggaggctctgtgagaggagggccagctcagccacagcaggaggactgacag | gggcctg    c.-1

          .         .         .         .         .         .       g.5801
 ATGGAGGAGTTTGTGGGGCTGCGTGAAGGCTCCTCAGGGAACCCTGTGACTCTGCAGGAG       c.60
 M  E  E  F  V  G  L  R  E  G  S  S  G  N  P  V  T  L  Q  E         p.20

          .         .         .         . | 03       .         .    g.6826
 CTGTGGGGCCCCTGTCCCCGCATCCGCCGAGGCATCCGAG | GTGGCCTGGAGTGGCTGAAG    c.120
 L  W  G  P  C  P  R  I  R  R  G  I  R  G |   G  L  E  W  L  K      p.40

          .         .         .         .         .         .       g.6886
 CAGAAGCTCTTCCGCCTGGGCGAGGACTGGTACTTCCTGATGACCCTCGGGGTGCTCATG       c.180
 Q  K  L  F  R  L  G  E  D  W  Y  F  L  M  T  L  G  V  L  M         p.60

          .         .         .         .          | 04        .    g.7794
 GCCCTGGTCAGCTGTGCCATGGACTTGGCTGTTGAGAGTGTGGTCCGAG | CGCACCAGTGG    c.240
 A  L  V  S  C  A  M  D  L  A  V  E  S  V  V  R  A |   H  Q  W      p.80

          .         .         .         .         .         .       g.7854
 CTGTACAGGGAGATTGGGGACAGCCACCTGCTCCGGTATCTCTCCTGGACTGTGTACCCT       c.300
 L  Y  R  E  I  G  D  S  H  L  L  R  Y  L  S  W  T  V  Y  P         p.100

          .         .         .         .         .         | 05    g.9155
 GTGGCCCTCGTCTCTTTCTCTTCAGGCTTCTCTCAGAGCATCACACCCTCCTCTGGAG | GT    c.360
 V  A  L  V  S  F  S  S  G  F  S  Q  S  I  T  P  S  S  G  G |       p.120

          .         .         .         .         .         .       g.9215
 TCTGGAATCCCGGAGGTGAAGACCATGTTGGCGGGTGTGGTCTTGGAGGACTACCTGGAT       c.420
 S  G  I  P  E  V  K  T  M  L  A  G  V  V  L  E  D  Y  L  D         p.140

          .         .         .         .         .         .       g.9275
 ATCAAGAACTTTGGGGCCAAAGTGGTGGGCCTCTCCTGCACCCTGGCCTGTGGCAGCACC       c.480
 I  K  N  F  G  A  K  V  V  G  L  S  C  T  L  A  C  G  S  T         p.160

          .         | 06         .         .         .         .    g.9633
 CTCTTCCTCGGGAAAGTG | GGCCCTTTCGTGCACCTGTCTGTGATGATGGCTGCCTACCTG    c.540
 L  F  L  G  K  V   | G  P  F  V  H  L  S  V  M  M  A  A  Y  L      p.180

          .         .         .       | 07 .         .         .    g.9776
 GGCCGTGTGCGCACCACGACCATCGGGGAGCCTGAG | AACAAGAGCAAGCAAAACGAAATG    c.600
 G  R  V  R  T  T  T  I  G  E  P  E   | N  K  S  K  Q  N  E  M      p.200

          .         .         .         .         .      | 08  .    g.10373
 CTGGTGGCAGCGGCGGCAGTGGGCGTGGCCACAGTCTTTGCAGCTCCCTTCAGCG | GCGTC    c.660
 L  V  A  A  A  A  V  G  V  A  T  V  F  A  A  P  F  S  G |   V      p.220

          .         .         .         .         .         .       g.10433
 CTGTTCAGCATCGAGGTCATGTCTTCCCACTTCTCTGTCTGGGATTACTGGAGGGGCTTC       c.720
 L  F  S  I  E  V  M  S  S  H  F  S  V  W  D  Y  W  R  G  F         p.240

          .         .         .         .         .         .       g.10493
 TTTGCGGCCACCTGCGGGGCCTTCATGTTCCGGCTCCTGGCGGTCTTCAACAGCGAGCAG       c.780
 F  A  A  T  C  G  A  F  M  F  R  L  L  A  V  F  N  S  E  Q         p.260

   | 09      .         .         .         .         .         .    g.10925
 G | AGACCATCACCTCCCTCTACAAGACCAGTTTCCGGGTGGACGTTCCCTTCGACCTGCCT    c.840
 E |   T  I  T  S  L  Y  K  T  S  F  R  V  D  V  P  F  D  L  P      p.280

          .         .       | 10 .         .         .         .    g.11097
 GAGATCTTCTTTTTTGTGGCGCTGGG | GGGTCTCTGTGGCATCCTGGGCAGCGCTTACCTC    c.900
 E  I  F  F  F  V  A  L  G  |  G  L  C  G  I  L  G  S  A  Y  L      p.300

          .         .         .         .         .         .       g.11157
 TTCTGTCAGCGAATCTTCTTTGGCTTCATCAGGAACAATAGGTTCAGCTCCAAACTGCTG       c.960
 F  C  Q  R  I  F  F  G  F  I  R  N  N  R  F  S  S  K  L  L         p.320

          | 11         .         .         .         .         .    g.11816
 GCCACCAG | CAAGCCTGTGTACTCCGCTCTGGCCACCTTGGTTCTCGCCTCCATCACCTAC    c.1020
 A  T  S  |  K  P  V  Y  S  A  L  A  T  L  V  L  A  S  I  T  Y      p.340

          .         .         .    | 12    .         .         .    g.12150
 CCACCCAGCGCCGGCCGCTTCCTAGCTTCTCGG | CTGTCCATGAAGCAGCATCTGGACTCG    c.1080
 P  P  S  A  G  R  F  L  A  S  R   | L  S  M  K  Q  H  L  D  S      p.360

          .         .         .         .         .         .       g.12210
 CTGTTCGACAACCACTCCTGGGCGCTGATGACCCAGAACTCCAGCCCACCCTGGCCCGAG       c.1140
 L  F  D  N  H  S  W  A  L  M  T  Q  N  S  S  P  P  W  P  E         p.380

          .         .         .         .         .         .       g.12270
 GAGCTCGACCCCCAGCACCTGTGGTGGGAATGGTACCACCCGCGGTTCACCATCTTTGGG       c.1200
 E  L  D  P  Q  H  L  W  W  E  W  Y  H  P  R  F  T  I  F  G         p.400

          .         .        | 13.         .         .         .    g.12759
 ACCCTTGCCTTCTTCCTGGTTATGAAG | TTCTGGATGCTGATTCTGGCCACCACCATCCCC    c.1260
 T  L  A  F  F  L  V  M  K   | F  W  M  L  I  L  A  T  T  I  P      p.420

          .         .         .        | 14.         .         .    g.12981
 ATGCCTGCCGGGTACTTCATGCCCATCTTTGTCTATG | GAGCTGCTATCGGGCGCCTCTTT    c.1320
 M  P  A  G  Y  F  M  P  I  F  V  Y  G |   A  A  I  G  R  L  F      p.440

          .         .         .         .         .         .       g.13041
 GGGGAGACTCTCTCTTTTATCTTCCCTGAGGGCATCGTGGCTGGAGGGATCACCAATCCC       c.1380
 G  E  T  L  S  F  I  F  P  E  G  I  V  A  G  G  I  T  N  P         p.460

          .         .         | 15         .         .         .    g.13478
 ATCATGCCAGGGGGGTATGCTCTGGCAG | GGGCTGCAGCCTTCTCAGGGGCTGTGACCCAC    c.1440
 I  M  P  G  G  Y  A  L  A  G |   A  A  A  F  S  G  A  V  T  H      p.480

          .         .         .         .         .         .       g.13538
 ACCATCTCCACGGCGCTGCTGGCCTTCGAGGTGACCGGCCAGATAGTGCATGCACTGCCC       c.1500
 T  I  S  T  A  L  L  A  F  E  V  T  G  Q  I  V  H  A  L  P         p.500

          .         .         .         .         .         .       g.13598
 GTGCTGATGGCGGTGCTGGCAGCCAACGCCATTGCACAGAGCTGCCAGCCCTCCTTCTAT       c.1560
 V  L  M  A  V  L  A  A  N  A  I  A  Q  S  C  Q  P  S  F  Y         p.520

          .         .         .         .         .         .       g.13658
 GATGGCACCGTCATTGTCAAGAAGCTGCCATACCTGCCACGGATTCTGGGCCGCAACATC       c.1620
 D  G  T  V  I  V  K  K  L  P  Y  L  P  R  I  L  G  R  N  I         p.540

    | 16     .         .         .         .         .         .    g.14945
 GG | TTCCCACCGCGTGAGGGTGGAGCACTTCATGAACCACAGCATCACCACACTGGCCAAG    c.1680
 G  |  S  H  R  V  R  V  E  H  F  M  N  H  S  I  T  T  L  A  K      p.560

          .         .         .         .         .         .       g.15005
 GACATGCCACTGGAGGAGGTGGTCAAGGTTGTGACCTCCACAGACGTGGCCAAGTATCCC       c.1740
 D  M  P  L  E  E  V  V  K  V  V  T  S  T  D  V  A  K  Y  P         p.580

          .       | 17 .         .         .         .         .    g.16727
 CTGGTGGAGAGCACAG | AGTCCCAGATCCTGGTGGGCATAGTGCGAAGGGCCCAGCTGGTG    c.1800
 L  V  E  S  T  E |   S  Q  I  L  V  G  I  V  R  R  A  Q  L  V      p.600

          .         .         .         .      | 18  .         .    g.16938
 CAGGCCCTGAAGGCTGAGCCTCCTTCCTGGGCTCCTGGACACCAG | CAGTGTCTCCAGGAC    c.1860
 Q  A  L  K  A  E  P  P  S  W  A  P  G  H  Q   | Q  C  L  Q  D      p.620

          .         .         .         .         .         .       g.16998
 ATCTTGGCTGCAGGCTGCCCCACAGAACCAGTGACCCTGAAGCTGTCCCCAGAGACTTCC       c.1920
 I  L  A  A  G  C  P  T  E  P  V  T  L  K  L  S  P  E  T  S         p.640

           | 19        .         .         .         .         .    g.17721
 CTGCATGAG | GCACACAACCTCTTTGAGCTGTTGAACCTTCATTCCCTCTTTGTGACGTCG    c.1980
 L  H  E   | A  H  N  L  F  E  L  L  N  L  H  S  L  F  V  T  S      p.660

          .         .         .       | 20 .         .         .    g.18141
 CGGGGCAGAGCTGTGGGCTGCGTGTCCTGGGTGGAG | ATGAAGAAAGCAATTTCCAACCTG    c.2040
 R  G  R  A  V  G  C  V  S  W  V  E   | M  K  K  A  I  S  N  L      p.680

          .         .                                               g.18165
 ACAAATCCGCCAGCCCCAAAGTGA                                           c.2064
 T  N  P  P  A  P  K  X                                             p.687

          .         .         .         .         .         .       g.18225
 gccggcccagcaagatgaaacagggcaccccagctgacctggtactgaggttgggctgag       c.*60

          .         .         .         .         .         .       g.18285
 accctgcttctcttcccccatcaccacctgcccctccctccagcccagctccattctttg       c.*120

          .         .         .         .         .         .       g.18345
 gcataacaggcaactttaacctagcccagaagaggatggctcatcctgggtgggacgatg       c.*180

          .         .         .         .         .         .       g.18405
 gctcctgccttgaaagacaaaaatcccaccttgggcagagctgagtgtgagaagatggaa       c.*240

          .         .         .         .         .         .       g.18465
 aaccagtatctgccaggtgctcagtgactggccatcacattaatgaatgatgagattgga       c.*300

          .         .         .         .         .         .       g.18525
 gtacactgtcaccaagggcaggcacagatgccttctggggttgtctggttcccagtgaga       c.*360

          .         .         .         .         .                 g.18575
 ggctcctgagaaaaataaagctggttcccagagctggtgtccatccctca                 c.*410

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Chloride channel, voltage-sensitive Kb protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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