chloride intracellular channel 5 (CLIC5) - coding DNA reference sequence

(used for variant description)

(last modified October 27, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_016929.4 in the CLIC5 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000006.11, covering CLIC5 transcript NM_016929.4.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.69506
              attttgggcgcgttggcggcggcgggatcgctgacagtcgcggatcc       c.-301

 .         .         .         .         .         .                g.69566
 tgtgacacctccgggcagcccggcacttgttgctcccacgacctgttgtcattcccttaa       c.-241

 .         .         .         .         .         .                g.69626
 cccggctttccccgtggccccccgcctcctcccggcttcgctccttttcatgtgagcatc       c.-181

 .         .         .         .         .         .                g.69686
 tgggacactgatctctcagaccccgctgctcgggctggagaatagatggttttgtgaaaa       c.-121

 .         .         .         .         .         .                g.69746
 attaaacaccgccctgaagaggagccccgctgggcagcggcaggagcgcagagtgctggc       c.-61

 .         .         .         .         .         .                g.69806
 ccaggtgctgcagaggtggcgcctccccggcccgggacggtagccccgggcgccaacggc       c.-1

          .         .         .         .         .         .       g.69866
 ATGACAGACTCGGCGACAGCTAACGGGGACGACAGGGACCCCGAGATCGAGCTCTTTGTG       c.60
 M  T  D  S  A  T  A  N  G  D  D  R  D  P  E  I  E  L  F  V         p.20

     | 02    .         .         .         .         .         .    g.130161
 AAG | GCTGGAATCGATGGAGAAAGCATCGGCAACTGTCCTTTCTCTCAGCGCCTCTTCATG    c.120
 K   | A  G  I  D  G  E  S  I  G  N  C  P  F  S  Q  R  L  F  M      p.40

          .         .         .         .         .    | 03    .    g.135974
 ATCCTCTGGCTGAAAGGAGTCGTGTTCAATGTCACCACTGTGGATCTGAAAAG | AAAGCCA    c.180
 I  L  W  L  K  G  V  V  F  N  V  T  T  V  D  L  K  R  |  K  P      p.60

          .         .         .         .         .         .       g.136034
 GCTGACCTGCACAACCTAGCCCCCGGCACGCACCCGCCCTTCCTGACCTTCAACGGGGAC       c.240
 A  D  L  H  N  L  A  P  G  T  H  P  P  F  L  T  F  N  G  D         p.80

          .         .         .         .         .          | 04    g.143696
 GTGAAGACAGACGTCAATAAGATCGAGGAGTTCCTGGAGGAGACCTTGACCCCTGAAAA | G    c.300
 V  K  T  D  V  N  K  I  E  E  F  L  E  E  T  L  T  P  E  K  |      p.100

          .         .         .         .         .         .       g.143756
 TACCCCAAACTGGCTGCAAAACACCGGGAATCCAACACAGCGGGCATCGACATCTTTTCC       c.360
 Y  P  K  L  A  A  K  H  R  E  S  N  T  A  G  I  D  I  F  S         p.120

          .         .         .         .       | 05 .         .    g.170953
 AAGTTTTCTGCCTACATCAAAAATACCAAGCAGCAGAACAATGCTG | CTCTTGAAAGAGGC    c.420
 K  F  S  A  Y  I  K  N  T  K  Q  Q  N  N  A  A |   L  E  R  G      p.140

          .         .         .         .         .         .       g.171013
 CTAACCAAGGCTCTAAAGAAATTGGATGACTACCTGAACACCCCTCTACCAGAGGAGATT       c.480
 L  T  K  A  L  K  K  L  D  D  Y  L  N  T  P  L  P  E  E  I         p.160

          .         .         .         .         .         .       g.171073
 GACGCCAACACTTGTGGGGAAGACAAGGGGTCCCGGCGCAAGTTCCTGGATGGGGATGAG       c.540
 D  A  N  T  C  G  E  D  K  G  S  R  R  K  F  L  D  G  D  E         p.180

          .         .         .         .         | 06         .    g.182105
 CTGACCCTGGCTGACTGCAATCTGTTGCCCAAGCTCCATGTGGTCAAG | ATTGTGGCCAAG    c.600
 L  T  L  A  D  C  N  L  L  P  K  L  H  V  V  K   | I  V  A  K      p.200

          .         .         .         .         .         .       g.182165
 AAATACCGCAACTATGATATCCCGGCTGAGATGACAGGCCTGTGGCGGTACCTCAAGAAC       c.660
 K  Y  R  N  Y  D  I  P  A  E  M  T  G  L  W  R  Y  L  K  N         p.220

          .         .         .         .         .         .       g.182225
 GCCTATGCCCGTGATGAGTTCACCAACACCTGTGCAGCTGACAGTGAGATCGAGTTGGCC       c.720
 A  Y  A  R  D  E  F  T  N  T  C  A  A  D  S  E  I  E  L  A         p.240

          .         .         .                                     g.182261
 TACGCTGATGTCGCCAAACGCCTCAGCCGATCCTGA                               c.756
 Y  A  D  V  A  K  R  L  S  R  S  X                                 p.251

          .         .         .         .         .         .       g.182321
 gcacagccattttgccccatccccgctgcagaaggactcaaccactcccctaagactcca       c.*60

          .         .         .         .         .         .       g.182381
 gcttcatagactcctctgtatcactgccttgaggcgcactttttataatcaagcctcatc       c.*120

          .         .         .         .         .         .       g.182441
 ttgctggtatcatgggaactccagcctgctatctttcatgaaggtcagcaccatccctgg       c.*180

          .         .         .         .         .         .       g.182501
 cctcctcacataggaatctagcagaaatgatagacacagtccacctttcggccggccagc       c.*240

          .         .         .         .         .         .       g.182561
 ctgatctgggctcagcatgtttggggtcagtcagtgttggagagcccacatatgggattg       c.*300

          .         .         .         .         .         .       g.182621
 ccactagcttcttctgccaatatcaaaataccttctcagatgctttagaaacatgcaaca       c.*360

          .         .         .         .         .         .       g.182681
 ccaactccttttctaccctcctctccgtccatacctacaaggccaaggacaaacgccatc       c.*420

          .         .         .         .         .         .       g.182741
 ttcatccttcttagaaagagatctattaccccattaggggagacagagagagtgaatgga       c.*480

          .         .         .         .         .         .       g.182801
 ggagtaccgagctggctatggacttgggtgtctggcaaacacagcttcagtctcactact       c.*540

          .         .         .         .         .         .       g.182861
 tctgacactctggttattgggcactaagggccagactggaaagtcacttgagacacattc       c.*600

          .         .         .         .         .         .       g.182921
 tcagtttgttgcagtgccaggaatgctgcgctgctgctgctgcgcacctggcccatgctg       c.*660

          .         .         .         .         .         .       g.182981
 tccctggcttccatgccgtccaggccctgccagaaaaggaaattggcatgcaattctaaa       c.*720

          .         .         .         .         .         .       g.183041
 ctgcagtgactgggatgggaggggaggggagcagtgttgatgccaaaatacccacggggt       c.*780

          .         .         .         .         .         .       g.183101
 ctaccagccatggggtttgcttgcttaggagtagttgtttcagaggtgattacaggcctg       c.*840

          .         .         .         .         .         .       g.183161
 ggtttgactgtgcttaccaatgagtggtttttgagctatgagaaagtggatgggagtggg       c.*900

          .         .         .         .         .         .       g.183221
 aggaggagagatgggtgaagacaaaagagttctttatgagcctcgatgttccctggtaaa       c.*960

          .         .         .         .         .         .       g.183281
 cttttaaaaaggccttctctcatgatctaagtcttggactggtggcatcatgtaactgct       c.*1020

          .         .         .         .         .         .       g.183341
 aaccttacagtaaaaacccaagaatgggtcaaaaatgtcttcccagtttctccaagctgc       c.*1080

          .         .         .         .         .         .       g.183401
 ttctggaatgcaggtctgtcggctgggtgctctccagcagctgctcctgcctgattcaac       c.*1140

          .         .         .         .         .         .       g.183461
 tgtagcctgtaatgggtaaaagccacatttaggaggtggtctgatcatagaacaccttag       c.*1200

          .         .         .         .         .         .       g.183521
 gaagaaagtccatgagactttctgactaggaaaccatgtggtttgaacttgaagaaaaat       c.*1260

          .         .         .         .         .         .       g.183581
 gtagacccatctgggttaattttcctacaatctgactcaactgccaggtgaaaaaaaaaa       c.*1320

          .         .         .         .         .         .       g.183641
 ggaaaaatttttaagctaatatttcactcttttgtcattctccttaagtttcatctccta       c.*1380

          .         .         .         .         .         .       g.183701
 aaaagcttacccagcctgagcttggggacctgtgcagaggaaactaagaaaaatgcactc       c.*1440

          .         .         .         .         .         .       g.183761
 atcaactccttctcccagtgaacgcccggtgagaaaatccatttgccacaggcccttacc       c.*1500

          .         .         .         .         .         .       g.183821
 ttcaacaatcccccttctatagtgttcgctggtaaagggtgaggctcccaagtgctggaa       c.*1560

          .         .         .         .         .         .       g.183881
 agcccctggacttggctcatttctcagcaagggcaggatagcacgggtcctttccataga       c.*1620

          .         .         .         .         .         .       g.183941
 aatatcaacaaattctaacccaagcaatccctggacctacctgcctccagggatctctga       c.*1680

          .         .         .         .         .         .       g.184001
 agaaaaaaagtaacccattgatcaaatcagaggagaggaagcaggaggtctcctagagcc       c.*1740

          .         .         .         .         .         .       g.184061
 cattgaggaagaggaactttctcagtaggacactttataagcctgagaaagctttgaaaa       c.*1800

          .         .         .         .         .         .       g.184121
 ggcggaatgagttgattcatttccacctcaaaaggaacctttccaggtccccctggaaat       c.*1860

          .         .         .         .         .         .       g.184181
 tgtgccctggagatgtttaacaaggagaactggtgaggaaagagtccttttttactgtag       c.*1920

          .         .         .         .         .         .       g.184241
 ggaaaagccccaaactggcctcctgggggatgagggctgaaatgatcccgaaggcctttt       c.*1980

          .         .         .         .         .         .       g.184301
 aattagtgtgaaatcctgctgtactcagaaatccttccccgaatttacagcacaggcagg       c.*2040

          .         .         .         .         .         .       g.184361
 atgacctaagaggcagtttacttccctgagacccacagttgggctgttctggaaacacat       c.*2100

          .         .         .         .         .         .       g.184421
 ctgtgaatcatagccaattgccacagagaaaacagaaccaagcctccggtgaggccactc       c.*2160

          .         .         .         .         .         .       g.184481
 caccccagagaagtctgcagaattccaaggactcggattggatgttcagaattcagcaac       c.*2220

          .         .         .         .         .         .       g.184541
 tggaaagtccttaaaaacaaacaggccaaaccaaatcaatattgctgtttctagatgtcc       c.*2280

          .         .         .         .         .         .       g.184601
 cttctgtggttgagctagttttacagagataaatatattaagacaaggaggtgggggtgt       c.*2340

          .         .         .         .         .         .       g.184661
 tatatgatcaatgatagccatttgaaagagagggaggagtacagaaggaaggcacttctg       c.*2400

          .         .         .         .         .         .       g.184721
 ggtacttaattcagaaatttctttatatttcagcactggattatcatataatgcaagtga       c.*2460

          .         .         .         .         .         .       g.184781
 ctatggactaagagttagttatggtgtcttatgactagatttattatggtatattaaagt       c.*2520

          .         .         .         .         .         .       g.184841
 aacaataatattaatattaccttcctttttttttttgtttcaaaagagatctttctccag       c.*2580

          .         .         .         .         .         .       g.184901
 atgcttcagcctgtctggccttcttatcatatgtgcagcacatcatgtctcagcaacagt       c.*2640

          .         .         .         .         .         .       g.184961
 gtggtgaggtccttaggtgtcccaagaacaactcagggagcacgggagggtctgcagttg       c.*2700

          .         .         .         .         .         .       g.185021
 ggaccccacaactatacagctatagggtaggaggcttccttttcattggtcctgaatgaa       c.*2760

          .         .         .         .         .         .       g.185081
 tacaaatcgctcagaaagcattttggtggcacagaaaggggatgtatttgtgttgagatc       c.*2820

          .         .         .         .         .         .       g.185141
 ttattttattttgtatttatttatcttctttgacttgcacagcactattgggggtggggg       c.*2880

          .         .         .         .         .         .       g.185201
 aagcagggtagtgggagacgaaggcagaagcaagagtcaaactcagaatgactgagttga       c.*2940

          .         .         .         .         .         .       g.185261
 attcactgtctagtcagcaatgcctgcttctgagtttggcccagagagaaggtattgagt       c.*3000

          .         .         .         .         .         .       g.185321
 aagattttaataactgtaaaaagtaagctggataagtaaaatcatgatggatccaaagca       c.*3060

          .         .         .         .         .         .       g.185381
 cagtttcttcatctcctgataaagaaagtcaaatgcttgataaattcagagtcacagatg       c.*3120

          .         .         .         .         .         .       g.185441
 tgagcatagctatattcttttaaacgagaggtagagtgacctagcactaagcaaatgagc       c.*3180

          .         .         .         .         .         .       g.185501
 tgaaatgtcggaaacagagtccatcagcttatttggccacacgatcccaaactagtttta       c.*3240

          .         .         .         .         .         .       g.185561
 tcttgggaaatggccctgtcctcagcattcccttcttgtgctggtggggccagtgaagtc       c.*3300

          .         .         .         .         .         .       g.185621
 ttgatcttatcagaaaaaggccacaccaagtgcgagttttcccaggctgactttccaggc       c.*3360

          .         .         .         .         .         .       g.185681
 ccttatcaaatgaaacaacagaagctcttcacagttctgtgccccatggccactccacag       c.*3420

          .         .         .         .         .         .       g.185741
 acagacaataccaagcatcttagaactgtcataagataggtcatgcctgaaatagatctt       c.*3480

          .         .         .         .         .         .       g.185801
 gaccatatgagagtcccagaaatcagcaaggcctggacaaatagaactaagagagaggca       c.*3540

          .         .         .         .         .         .       g.185861
 gaggcaggaagctgcgggtctatcttgtaaagagtttagcatcactgtgagagtgtgtgt       c.*3600

          .         .         .         .         .         .       g.185921
 ctaaaattaaattaaactagaagcagcaggtgagtatttggtaagtacttctgtgactcg       c.*3660

          .         .         .         .         .         .       g.185981
 cctcaattcccactggccaggggccatctcaactgcacggtgaatcaagatgctggtgtc       c.*3720

          .         .         .         .         .         .       g.186041
 atcctccttggaaaaaggaaatgttaactcatggttaaaactaagtacaatgattcccaa       c.*3780

          .         .         .         .         .         .       g.186101
 gggatcactttcttatttttttaaatgacattaaggagaatcttaagaaagcatcagaga       c.*3840

          .         .         .         .         .         .       g.186161
 aagacatgtgcatgtgaagcaccctgattctgatgttaggaaaacttaagcgaacaggac       c.*3900

          .         .         .         .         .         .       g.186221
 ctgctgcacacagccccattgtcttctatccatttctctttatcattcaaatcaagcaac       c.*3960

          .         .         .         .         .         .       g.186281
 atgtgccctcctcatcaacacacattcttcccctttgtcagtatgcatctcccagcttag       c.*4020

          .         .         .         .         .         .       g.186341
 tgtcaggatactttcgattcataattatgtatgatccaaagtgtgcataatttcatttaa       c.*4080

          .         .         .         .         .         .       g.186401
 cgttaaagaaatagatccaattcctttcttgcaaccaaaaataaataaaatacgttgcct       c.*4140

          .         .         .         .         .         .       g.186461
 caatataaggtttgggctattctgtgtttctatagaagcaatctgtttttggtaaaatgt       c.*4200

          .         .         .         .         .         .       g.186521
 acttttaaggatccagtcatctgaagtattttatgtagagttagagatttcacaatattg       c.*4260

          .         .         .         .         .         .       g.186581
 actatacatatatttaaaatataaattatccagctgatgtttgaatttgtcttactttcc       c.*4320

          .         .         .         .         .         .       g.186641
 tggccacctcgttgtcctattttataagctggggagttaactagcttaacaaaagatgct       c.*4380

          .         .         .         .         .         .       g.186701
 tagcttttgtaaaagaacaagtgtttcattttacaaagacactccaaatgatagttactt       c.*4440

          .         .         .         .         .         .       g.186761
 gattttctcgagacctttaactatggtgatgaataacaggacttgctttcaagccttaat       c.*4500

          .         .         .         .         .         .       g.186821
 aaatgtaaaatgccttttaatgaagatacagctgagtgttttcctcatgaatctgaacca       c.*4560

          .         .         .         .         .         .       g.186881
 attaccaatttgtgttccagtcttgattggtattgactgattcaaataaagttggtttat       c.*4620

          .                                                         g.186898
 tttcaaatattacaaaa                                                  c.*4637

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Chloride intracellular channel 5 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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