ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) (CLPP) - coding DNA reference sequence

(used for variant description)

(last modified December 18, 2015)

This file was created to facilitate the description of sequence variants on transcript NM_006012.2 in the CLPP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000019.9, covering CLPP transcript NM_006012.2.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                                                    g.5003
                                                          cct       c.-121

 .         .         .         .         .         .                g.5063
 taatggcgcccgcccagactcctggaagtgagcggcctagcgagcgagctcccaggcgca       c.-61

 .         .         .         .         .         .                g.5123
 aagcacgccggaagctgtagttccgccatcggacggaagccgaccggggcgtgcggaggg       c.-1

          .         .         .         .         .         .       g.5183
 ATGTGGCCCGGAATATTGGTAGGGGGGGCCCGGGTGGCGTCATGCAGGTACCCCGCGCTG       c.60
 M  W  P  G  I  L  V  G  G  A  R  V  A  S  C  R  Y  P  A  L         p.20

          .         .         .         .         .         .       g.5243
 GGGCCTCGCCTCGCCGCTCACTTTCCAGCGCAGCGGCCGCCGCAGCGGACACTCCAGAAC       c.120
 G  P  R  L  A  A  H  F  P  A  Q  R  P  P  Q  R  T  L  Q  N         p.40

          .         .         .         .         .         .       g.5303
 GGCCTGGCCCTGCAGCGGTGCCTGCACGCGACGGCGACCCGGGCTCTCCCGCTCATTCCC       c.180
 G  L  A  L  Q  R  C  L  H  A  T  A  T  R  A  L  P  L  I  P         p.60

          .         | 02         .         .         .         .    g.5459
 ATCGTGGTGGAGCAGACG | GGTCGCGGCGAGCGCGCCTATGACATCTACTCGCGGCTGCTG    c.240
 I  V  V  E  Q  T   | G  R  G  E  R  A  Y  D  I  Y  S  R  L  L      p.80

          .         .         . | 03       .         .         .    g.6024
 CGGGAGCGCATCGTGTGCGTCATGGGCCCG | ATCGATGACAGCGTTGCCAGCCTTGTTATC    c.300
 R  E  R  I  V  C  V  M  G  P   | I  D  D  S  V  A  S  L  V  I      p.100

          .         .         .         .         .         .       g.6084
 GCACAGCTCCTCTTCCTGCAATCCGAGAGCAACAAGAAGCCCATCCACATGTACATCAAC       c.360
 A  Q  L  L  F  L  Q  S  E  S  N  K  K  P  I  H  M  Y  I  N         p.120

         | 04.         .         .         .         .         .    g.8053
 AGCCCTG | GTGGTGTGGTGACCGCGGGCCTGGCCATCTACGACACGATGCAGTACATCCTC    c.420
 S  P  G |   G  V  V  T  A  G  L  A  I  Y  D  T  M  Q  Y  I  L      p.140

          .         .         .         .         .         .       g.8113
 AACCCGATCTGCACCTGGTGCGTGGGCCAGGCCGCCAGCATGGGCTCCCTGCTTCTCGCC       c.480
 N  P  I  C  T  W  C  V  G  Q  A  A  S  M  G  S  L  L  L  A         p.160

          .         .         .         .         .         .       g.8173
 GCCGGCACCCCAGGCATGCGCCACTCGCTCCCCAACTCCCGTATCATGATCCACCAGCCC       c.540
 A  G  T  P  G  M  R  H  S  L  P  N  S  R  I  M  I  H  Q  P         p.180

          .      | 05  .         .         .         .         .    g.9851
 TCAGGAGGCGCCCGG | GGCCAAGCCACAGACATTGCCATCCAGGCAGAGGAGATCATGAAG    c.600
 S  G  G  A  R   | G  Q  A  T  D  I  A  I  Q  A  E  E  I  M  K      p.200

          .         .         .         .         .         .       g.9911
 CTCAAGAAGCAGCTCTATAACATCTACGCCAAGCACACCAAACAGAGCCTGCAGGTGATC       c.660
 L  K  K  Q  L  Y  N  I  Y  A  K  H  T  K  Q  S  L  Q  V  I         p.220

   | 06      .         .         .         .         .         .    g.12145
 G | AGTCCGCCATGGAGAGGGACCGCTACATGAGCCCCATGGAGGCCCAGGAGTTTGGCATC    c.720
 E |   S  A  M  E  R  D  R  Y  M  S  P  M  E  A  Q  E  F  G  I      p.240

          .         .         .         .         .         .       g.12205
 TTAGACAAGGTTCTGGTCCACCCTCCCCAGGACGGTGAGGATGAGCCCACGCTGGTGCAG       c.780
 L  D  K  V  L  V  H  P  P  Q  D  G  E  D  E  P  T  L  V  Q         p.260

          .         .         .         .         .                 g.12259
 AAGGAGCCTGTAGAAGCAGCGCCGGCAGCAGAACCTGTCCCAGCTAGCACCTGA             c.834
 K  E  P  V  E  A  A  P  A  A  E  P  V  P  A  S  T  X               p.277

          .         .         .         .         .         .       g.12319
 gagctgggcctcctctccagaatcatgtggaggggccagaggcctgccagacccccagct       c.*60

          .         .         .         .         .         .       g.12379
 gggccctgctcaccccttgttgctgggcttggaggggcctcttgaggaacttttaatttg       c.*120

          .         .         .         .         .         .       g.12439
 caggggtgcccgctatggacggggcattccagctgagacactgtgattttaaattaaatc       c.*180

          .                                                         g.12453
 tttgtggtctttgc                                                     c.*194

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog (E. coli) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.