CCHC-type zinc finger, nucleic acid binding protein (CNBP) - coding DNA reference sequence

(used for variant description)

(last modified January 21, 2023)

This file was created to facilitate the description of sequence variants on transcript NM_003418.4 in the CNBP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering CNBP transcript NM_003418.4.

Please note that introns are available by clicking on the exon numbers above the sequence.

 (upstream sequence)
                                         .         .                g.5026
                                   aaccccgcgcgctgattggccgcgtg       c.-181

 .         .         .         .         .         .                g.5086
 ggcgaggcggaggagagccgtgcgcagcggcgtatgtggggccgtgtgcagacccgcgtg       c.-121

 .         .         .         .         .         .                g.5146
 tggcgcaggcaaggaccctcaaaataaacagcctctaccttgcgagccgtcttccccagg       c.-61

 .         .         .         .         .      | 02  .             g.17210
 cctgcgtccgagtctccgccgctgcgggcccgctccgacgcggaag | atctgactgcagcc    c.-1

          .         .         .         .         .         .       g.17270
 ATGAGCAGCAATGAGTGCTTCAAGTGTGGACGATCTGGCCACTGGGCCCGGGAATGTCCT       c.60
 M  S  S  N  E  C  F  K  C  G  R  S  G  H  W  A  R  E  C  P         p.20

          .         .         .         .         .         .       g.17330
 ACTGGTGGAGGCCGTGGTCGTGGAATGAGAAGCCGTGGCAGAGGTGGTTTTACCTCGGAT       c.120
 T  G  G  G  R  G  R  G  M  R  S  R  G  R  G  G  F  T  S  D         p.40

      | 03   .         .         .         .         .         .    g.17485
 AGAG | GTTTCCAGTTTGTTTCCTCGTCTCTTCCAGACATTTGTTATCGCTGTGGTGAGTCT    c.180
 R  G |   F  Q  F  V  S  S  S  L  P  D  I  C  Y  R  C  G  E  S      p.60

          .         .         .        | 04.         .         .    g.17713
 GGTCATCTTGCCAAGGATTGTGATCTTCAGGAGGATG | CCTGCTATAACTGCGGTAGAGGT    c.240
 G  H  L  A  K  D  C  D  L  Q  E  D  A |   C  Y  N  C  G  R  G      p.80

          .         .         .         .         .         .       g.17773
 GGCCACATTGCCAAGGACTGCAAGGAGCCCAAGAGAGAGCGAGAGCAATGCTGCTACAAC       c.300
 G  H  I  A  K  D  C  K  E  P  K  R  E  R  E  Q  C  C  Y  N         p.100

          .         .         .         .         .         .       g.17833
 TGTGGCAAACCAGGCCATCTGGCTCGTGACTGCGACCATGCAGATGAGCAGAAATGCTAT       c.360
 C  G  K  P  G  H  L  A  R  D  C  D  H  A  D  E  Q  K  C  Y         p.120

          .         .         .         .         .       | 05 .    g.18401
 TCTTGTGGAGAATTCGGACACATTCAAAAAGACTGCACCAAAGTGAAGTGCTATAG | GTGT    c.420
 S  C  G  E  F  G  H  I  Q  K  D  C  T  K  V  K  C  Y  R  |  C      p.140

          .         .         .         .         .         .       g.18461
 GGTGAAACTGGTCATGTAGCCATCAACTGCAGCAAGACAAGTGAAGTCAACTGTTACCGC       c.480
 G  E  T  G  H  V  A  I  N  C  S  K  T  S  E  V  N  C  Y  R         p.160

          .         .         .         .         .                 g.18515
 TGTGGCGAGTCAGGGCACCTTGCACGGGAATGCACAATTGAGGCTACAGCCTAA             c.534
 C  G  E  S  G  H  L  A  R  E  C  T  I  E  A  T  A  X               p.177

          .         .         .         .         .         .       g.18575
 ttattttcctttgtcgcccctcctttttctgattgatggttgtattattttctctgaatc       c.*60

          .         .         .         .         .         .       g.18635
 ctcttcactggccaaaggttggcagatagaggcaactcccaggccagtgagctttacttg       c.*120

          .         .         .         .         .         .       g.18695
 ccgtgtaaaaggaggaaaggggtggaaaaaaaccgactttctgcatttaactacaaaaaa       c.*180

          .         .         .         .         .         .       g.18755
 agtttatgtttagtttggtagaggtgttatgtataatgctttgttaaagaaccccctttc       c.*240

          .         .         .         .         .         .       g.18815
 cgtgccactggtgaatagggattgatgaatgggaagagttgagtcagaccagtaagcccg       c.*300

          .         .         .         .         .         .       g.18875
 tcctgggttccttgaacatgttcccatgtaggaggtaaaaccaattctggaagtgtctat       c.*360

          .         .         .         .         .         .       g.18935
 gaacttccataaataactttaattttagtataatgatggtcttggattgtctgacctcag       c.*420

          .         .         .         .         .         .       g.18995
 tagctattaaataacatcaagtaacatctgtatcaggccctacatagaacatacagttga       c.*480

          .         .         .         .         .         .       g.19055
 gtgggagtaaacaaaaagataaacatgcgtgttaatggctgttcgagagaaatcggaata       c.*540

          .         .         .         .         .         .       g.19115
 aaagcctaaacaggaacaacttcatcacagtgttgatgttggacacatagatggtgatgg       c.*600

          .         .         .         .         .         .       g.19175
 caaaggtttagaacacattattttcaaagactaaatctaaaacccagagtaaacatcaat       c.*660

          .         .         .         .         .         .       g.19235
 gctcagagttagcataatttggagctattcaggaattgcagagaaatgcattttcacaga       c.*720

          .         .         .         .         .         .       g.19295
 aatcaagatgttatttttgtatactatatcacttagacaactgtgtttcatttgctgtaa       c.*780

          .         .         .         .         .         .       g.19355
 tcagtttttaaaagtcagatggaaagagcaactgaagtcctagaaaatagaaatgtaatt       c.*840

          .         .         .         .         .         .       g.19415
 ttaaactattccaataaagctggaggaggaaggggagtttgactaaagttctttttgttt       c.*900

          .         .         .         .         .         .       g.19475
 gtttcaaattttcattaatgtatatagtgcaaaataccatattaaagaggggaatgtgga       c.*960

          .         .         .         .         .         .       g.19535
 ggactgaaagctgacagtttggacttttctttttgtacttaagtcatgtcttcaataatg       c.*1020

          .         .         .         .         .         .       g.19595
 aaaattgctgttaaaaggatgtatgggatttagatacttttgcaaagctatagaaaattc       c.*1080

          .         .         .         .         .         .       g.19655
 actttgtaatctgttataataatgcccttgagttctgtgttcagtctgaacaggtttttt       c.*1140

          .         .         .         .         .         .       g.19715
 ggtggtggtggttttgttttgttttggagacggagtctcactcttgtcgcccaggctgga       c.*1200

          .         .         .         .         .         .       g.19775
 gtgcaggcttggctcactgcaacctccacctcccgggttcaagcaattctcctgcctcag       c.*1260

          .         .         .         .         .         .       g.19835
 cctcctgagtagctgggattacaggcacccgccaccaccccccgctaattttttgtattt       c.*1320

          .         .         .         .         .         .       g.19895
 ttatttttattttatttttttatttttttttgagacagagtgtcgctctgttgcccaggc       c.*1380

          .         .         .         .         .         .       g.19955
 tggagtgtagtggtgcgatctcggctcactgcaagctccgcctcctgggttcgtgccatt       c.*1440

          .         .         .         .         .         .       g.20015
 ctcctgcctcagcctcctgagtagctggggctacaggtacccgccaccgcgcccagctaa       c.*1500

          .         .         .         .         .         .       g.20075
 ttttttttttttgtatttttagtaaagacggggtttcacggtgttagccaggatggtctc       c.*1560

          .         .         .         .         .         .       g.20135
 aatctcctgacctcgtgatccgcccgccttggcctcccaaagtgctgggatcacaggcgt       c.*1620

          .         .         .         .         .         .       g.20195
 gagccaccgcgcccggcctattttttgtatttttagtagagactgggtttcatcatgttg       c.*1680

          .         .         .         .         .         .       g.20255
 gtcgggctggtctccaactcctgacctcaggtgatccacctgccccgccccccaaagtgc       c.*1740

          .         .         .         .         .         .       g.20315
 tagtgttacaggtgcgagccaccgtgtctggccgattctgaacagttttaataccattgc       c.*1800

          .         .         .         .         .         .       g.20375
 tatttttgtgtttttcctgggccttttttttttttttttttttttttgagacagtctcgc       c.*1860

          .         .         .         .         .         .       g.20435
 tctgttgcccaggctagagtgcaatggtgcaatctcagctcactgcaacctccacccccc       c.*1920

          .         .         .         .         .         .       g.20495
 acccccacaccccgttcaagtaattctcctgcctcagcctcccaaatagctgggattaca       c.*1980

          .         .         .         .         .         .       g.20555
 ggtgtccgccaccacacccagctaatttttgttatttttagtagagatggggtttcactg       c.*2040

          .         .         .         .         .         .       g.20615
 tgttggtcaggctggtctccaactgttgccctcaggtgagccactgtgccccaccttttc       c.*2100

          .         .         .         .         .         .       g.20675
 ctgggtttcataaggatctgaagtggtggattccttgtttttgctagtgtctcatttaga       c.*2160

          .         .         .         .         .         .       g.20735
 gttgagatggaccttaaaactcatctgttttaactcactttttaatagatgagttaaact       c.*2220

          .         .         .         .         .         .       g.20795
 taatttacttaaggatgtacagttagagcctggaacttcaaccattattcactccccatg       c.*2280

          .         .         .         .         .         .       g.20855
 ccctgtttccccccacttcgaaattaaatgcggttagcatcatatagttcattttccccc       c.*2340

          .         .         .         .         .         .       g.20915
 tccatgctgctgtgtgattcttgactttgggtatgagtttttcatccttcatgcagggtt       c.*2400

          .         .         .         .         .         .       g.20975
 ctgtcagttcatggtatagtgattcagtgttaaaatggtggtgtctcagctgtgctgtgc       c.*2460

          .         .         .         .         .         .       g.21035
 acattccaaccttgtcaaattaatagtcctgagcaagcaagaaaaagaggtaataacata       c.*2520

          .         .         .         .         .         .       g.21095
 cccatttctttatgaatataagcttataatattttttcatgtgctatttttactgagcaa       c.*2580

          .         .         .         .         .                 g.21153
 attgtatgtctcacatgttaacacaataaatatcttgacaattttattttctaccata         c.*2638

 (downstream sequence)

Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10^th nucleotide is indicated by a "." above the sequence. The CCHC-type zinc finger, nucleic acid binding protein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10^th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.