cyclin M4 (CNNM4) - coding DNA reference sequence

(used for variant description)

(last modified November 13, 2020)


This file was created to facilitate the description of sequence variants on transcript NM_020184.3 in the CNNM4 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_016608.1, covering CNNM4 transcript NM_020184.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.5038
                       agttggctcggcggcagcggagcggccggagctgcggt       c.-61

 .         .         .         .         .         .                g.5098
 gcggaccggggccgcgcggcgtggcgcggggagcggcggcggcggcagagccagagcaac       c.-1

          .         .         .         .         .         .       g.5158
 ATGGCGCCGGTGGGCGGGGGCGGGCGCCCGGTCGGCGGACCGGCCCGCGGGCGCCTCCTC       c.60
 M  A  P  V  G  G  G  G  R  P  V  G  G  P  A  R  G  R  L  L         p.20

          .         .         .         .         .         .       g.5218
 CTGGCGGCGCCGGTGCTGCTGGTGCTGCTGTGGGCGCTGGGGGCCCGGGGCCAGGGCAGC       c.120
 L  A  A  P  V  L  L  V  L  L  W  A  L  G  A  R  G  Q  G  S         p.40

          .         .         .         .         .         .       g.5278
 CCCCAGCAGGGCACGATCGTGGGCATGAGGCTGGCGAGCTGCAACAAGTCGTGTGGGACG       c.180
 P  Q  Q  G  T  I  V  G  M  R  L  A  S  C  N  K  S  C  G  T         p.60

          .         .         .         .         .         .       g.5338
 AACCCGGATGGCATCATCTTCGTGTCCGAGGGCAGCACCGTGAACCTGAGGCTGTACGGC       c.240
 N  P  D  G  I  I  F  V  S  E  G  S  T  V  N  L  R  L  Y  G         p.80

          .         .         .         .         .         .       g.5398
 TACAGCCTGGGCAACATCTCCAGCAACCTGATCTCCTTCACCGAGGTGGACGATGCCGAG       c.300
 Y  S  L  G  N  I  S  S  N  L  I  S  F  T  E  V  D  D  A  E         p.100

          .         .         .         .         .         .       g.5458
 ACCCTCCACAAGTCCACCAGCTGCCTCGAGCTCACCAAGGACCTGGTCGTCCAGCAGCTG       c.360
 T  L  H  K  S  T  S  C  L  E  L  T  K  D  L  V  V  Q  Q  L         p.120

          .         .         .         .         .         .       g.5518
 GTCAACGTGAGCCGCGGGAACACGTCCGGCGTGCTGGTGGTGCTCACCAAGTTCCTCCGG       c.420
 V  N  V  S  R  G  N  T  S  G  V  L  V  V  L  T  K  F  L  R         p.140

          .         .         .         .         .         .       g.5578
 AGGAGCGAGAGCATGAAGCTGTATGCACTGTGCACCCGGGCCCAGCCCGACGGGCCCTGG       c.480
 R  S  E  S  M  K  L  Y  A  L  C  T  R  A  Q  P  D  G  P  W         p.160

          .         .         .         .         .         .       g.5638
 CTGAAGTGGACGGACAAGGACTCACTGCTCTTCATGGTGGAGGAGCCTGGGAGGTTCCTG       c.540
 L  K  W  T  D  K  D  S  L  L  F  M  V  E  E  P  G  R  F  L         p.180

          .         .         .         .         .         .       g.5698
 CCTCTCTGGCTGCACATTCTCCTAATTACGGTGCTGCTGGTGCTGTCGGGCATATTTTCT       c.600
 P  L  W  L  H  I  L  L  I  T  V  L  L  V  L  S  G  I  F  S         p.200

          .         .         .         .         .         .       g.5758
 GGCCTCAACCTCGGGCTTATGGCCCTGGACCCCATGGAGCTGCGCATCGTGCAGAACTGT       c.660
 G  L  N  L  G  L  M  A  L  D  P  M  E  L  R  I  V  Q  N  C         p.220

          .         .         .         .         .         .       g.5818
 GGCACCGAGAAGGAGAGGCGCTATGCCCGCAAGATTGAGCCCATCCGGCGCAAGGGCAAC       c.720
 G  T  E  K  E  R  R  Y  A  R  K  I  E  P  I  R  R  K  G  N         p.240

          .         .         .         .         .         .       g.5878
 TACCTTCTCTGCTCGTTGCTCCTAGGGAACGTGCTGGTCAACACCTCCCTCACAATCCTT       c.780
 Y  L  L  C  S  L  L  L  G  N  V  L  V  N  T  S  L  T  I  L         p.260

          .         .         .         .         .         .       g.5938
 CTAGACAACCTCATCGGGTCCGGCCTCATGGCGGTGGCCTCCTCCACCATTGGCATTGTC       c.840
 L  D  N  L  I  G  S  G  L  M  A  V  A  S  S  T  I  G  I  V         p.280

          .         .         .         .         .         .       g.5998
 ATCTTTGGGGAGATCCTACCTCAGGCCCTGTGCTCCCGACATGGGCTGGCTGTGGGTGCC       c.900
 I  F  G  E  I  L  P  Q  A  L  C  S  R  H  G  L  A  V  G  A         p.300

          .         .         .         .         .         .       g.6058
 AACACCATCCTTCTCACCAAATTCTTTATGCTACTCACCTTCCCCCTCAGTTTTCCCATT       c.960
 N  T  I  L  L  T  K  F  F  M  L  L  T  F  P  L  S  F  P  I         p.320

          .         .         .         .         .         .       g.6118
 AGCAAGCTCCTGGACTTTTTTCTGGGCCAGGAGATTCGCACTGTTTACAACCGGGAGAAG       c.1020
 S  K  L  L  D  F  F  L  G  Q  E  I  R  T  V  Y  N  R  E  K         p.340

          .         .         .         .         .         .       g.6178
 CTGATGGAGATGTTGAAGGTGACGGAGCCCTATAATGACCTCGTGAAAGAGGAGCTCAAT       c.1080
 L  M  E  M  L  K  V  T  E  P  Y  N  D  L  V  K  E  E  L  N         p.360

          .         .         .         .         .         .       g.6238
 ATGATCCAGGGTGCCCTGGAACTACGGACCAAAACTGTAGAGGATATCATGACCCAGCTC       c.1140
 M  I  Q  G  A  L  E  L  R  T  K  T  V  E  D  I  M  T  Q  L         p.380

          .         .         .         .         .         .       g.6298
 CAGGACTGCTTCATGATCCGCAGCGATGCCATCCTGGACTTCAACACCATGTCGGAGATA       c.1200
 Q  D  C  F  M  I  R  S  D  A  I  L  D  F  N  T  M  S  E  I         p.400

          .         .         .         .         .         .       g.6358
 ATGGAAAGCGGCTATACTCGCATCCCGGTGTTCGAAGACGAGCAGTCCAATATTGTAGAT       c.1260
 M  E  S  G  Y  T  R  I  P  V  F  E  D  E  Q  S  N  I  V  D         p.420

          .         .         .         .         .         .       g.6418
 ATTCTCTACGTCAAAGACTTGGCCTTTGTGGACCCCGATGACTGCACCCCCCTCAAGACT       c.1320
 I  L  Y  V  K  D  L  A  F  V  D  P  D  D  C  T  P  L  K  T         p.440

          .         .         .         .         .         .       g.6478
 ATCACTCGCTTCTATAACCACCCGGTGCACTTTGTCTTCCATGACACCAAGTTGGATGCC       c.1380
 I  T  R  F  Y  N  H  P  V  H  F  V  F  H  D  T  K  L  D  A         p.460

          .         .   | 02     .         .         .         .    g.41148
 ATGCTGGAGGAGTTCAAGAAGG | GGAAGTCCCACCTGGCCATCGTGCAGAAGGTAAACAAC    c.1440
 M  L  E  E  F  K  K  G |   K  S  H  L  A  I  V  Q  K  V  N  N      p.480

          .         .         .         .         .         .       g.41208
 GAGGGTGAGGGTGACCCCTTCTACGAGGTCCTGGGCCTGGTCACCCTGGAGGACGTGATC       c.1500
 E  G  E  G  D  P  F  Y  E  V  L  G  L  V  T  L  E  D  V  I         p.500

          .         .         .         .       | 03 .         .    g.41625
 GAGGAGATCATCAAGTCGGAGATCCTGGACGAGTCCGACATGTACA | CTGACAACCGAAGC    c.1560
 E  E  I  I  K  S  E  I  L  D  E  S  D  M  Y  T |   D  N  R  S      p.520

          .         .         .         .         .         .       g.41685
 CGGAAGCGGGTGTCTGAGAAGAACAAGCGTGACTTCTCTGCCTTCAAGGATGCGGACAAT       c.1620
 R  K  R  V  S  E  K  N  K  R  D  F  S  A  F  K  D  A  D  N         p.540

          .         .         .         .         .         .       g.41745
 GAGCTCAAAGTGAAAATCTCCCCGCAGCTCCTCCTGGCCGCTCATCGCTTCCTAGCCACA       c.1680
 E  L  K  V  K  I  S  P  Q  L  L  L  A  A  H  R  F  L  A  T         p.560

   | 04      .         .         .         .         .         .    g.43214
 G | AGGTCTCTCAGTTTAGCCCCTCCCTGATATCAGAGAAGATCCTGCTGCGGCTACTCAAG    c.1740
 E |   V  S  Q  F  S  P  S  L  I  S  E  K  I  L  L  R  L  L  K      p.580

          .         .         .         .         .         .       g.43274
 TACCCAGATGTCATTCAGGAACTCAAGTTTGACGAGCACAATAAGTACTACGCCCGCCAT       c.1800
 Y  P  D  V  I  Q  E  L  K  F  D  E  H  N  K  Y  Y  A  R  H         p.600

          .         .         .         .         .  | 05      .    g.43659
 TACCTGTACACCCGAAATAAGCCGGCCGACTACTTCATCCTCATCCTGCAG | GGGAAGGTG    c.1860
 Y  L  Y  T  R  N  K  P  A  D  Y  F  I  L  I  L  Q   | G  K  V      p.620

          .         .         .         .         .         .       g.43719
 GAGGTGGAGGCAGGGAAGGAGAACATGAAGTTTGAGACGGGCGCCTTCTCCTACTATGGG       c.1920
 E  V  E  A  G  K  E  N  M  K  F  E  T  G  A  F  S  Y  Y  G         p.640

          .         .         | 06         .         .         .    g.52691
 ACTATGGCCCTGACCTCGGTCCCCTCCG | ACCGTTCCCCAGCACACCCCACCCCACTCAGC    c.1980
 T  M  A  L  T  S  V  P  S  D |   R  S  P  A  H  P  T  P  L  S      p.660

          .         .         .         .         .         .       g.52751
 CGCTCAGCCTCCCTCAGTTACCCAGACCGCACAGACGTCTCAACTGCAGCAACCTTGGCA       c.2040
 R  S  A  S  L  S  Y  P  D  R  T  D  V  S  T  A  A  T  L  A         p.680

          .         .         .         .         .         .       g.52811
 GGCAGCAGCAACCAGTTTGGCAGCTCTGTCCTGGGCCAGTACATCTCTGACTTCAGCGTC       c.2100
 G  S  S  N  Q  F  G  S  S  V  L  G  Q  Y  I  S  D  F  S  V         p.700

          .         .         . | 07       .         .         .    g.53448
 CGGGCACTCGTGGACTTGCAGTACATCAAG | ATCACTCGGCAGCAGTACCAGAACGGGCTG    c.2160
 R  A  L  V  D  L  Q  Y  I  K   | I  T  R  Q  Q  Y  Q  N  G  L      p.720

          .         .         .         .         .         .       g.53508
 CTGGCTTCTCGCATGGAGAACAGCCCTCAGTTTCCCATAGACGGGTGCACCACCCACATG       c.2220
 L  A  S  R  M  E  N  S  P  Q  F  P  I  D  G  C  T  T  H  M         p.740

          .         .         .         .         .         .       g.53568
 GAGAACTTGGCCGAGAAGTCTGAGCTGCCTGTGGTGGACGAGACCACAACTCTTCTCAAC       c.2280
 E  N  L  A  E  K  S  E  L  P  V  V  D  E  T  T  T  L  L  N         p.760

          .         .         .         .                           g.53616
 GAGCGTAACTCCTTGCTGCACAAAGCCTCCCACGAGAATGCCATCTGA                   c.2328
 E  R  N  S  L  L  H  K  A  S  H  E  N  A  I  X                     p.775

          .         .         .         .         .         .       g.53676
 caggagggcccggggccccctgcccaccctgcgggggcctccccagtgggcccacatgaa       c.*60

          .         .         .         .         .         .       g.53736
 gagagggaacctgttagtccagaaaggatacggatagatagcctgtctgactgaacagcc       c.*120

          .         .         .         .         .         .       g.53796
 agatggcccccagcctatgggggatctggcctctgccagggacctctgagtagctctgag       c.*180

          .         .         .         .         .         .       g.53856
 gtggcactgtccagccctggatagggggggcagtgggccagctaccgtaagcaaaggctg       c.*240

          .         .         .         .         .         .       g.53916
 ttttttactgagagaatttctaaagtaggctcatcacttttttttaaatatcattttggg       c.*300

          .         .         .         .         .         .       g.53976
 aagggaagacagggttaaggaactttatttaaaaaaaaaatatttttttcctaaaaacta       c.*360

          .         .         .         .         .         .       g.54036
 taaaagaggaagggtttcttgtcccgggaagcaacggacataatctgttcccagccatgg       c.*420

          .         .         .         .         .         .       g.54096
 ccttccagcttgtgtccctgattcagggagctctcccttcctcctcctcctcctcctccg       c.*480

          .         .         .         .         .         .       g.54156
 gaggtgggatcccagagcctgccagtggaggcttatctgttgggaggaagacagctcttc       c.*540

          .         .         .         .         .         .       g.54216
 acagaagcaaagaacaaaatggcatggagatcagctgcctgagcacctgcgctgtagctt       c.*600

          .         .         .         .         .         .       g.54276
 atctgacaacgctgaggccacgagctcctgggtagctgtgatcagggacatgataatctg       c.*660

          .         .         .         .         .         .       g.54336
 agctatgcagaggagcacatctgttgtcaactgctgtacccagaaatctagaactctgcc       c.*720

          .         .         .         .         .         .       g.54396
 gacagcctctcctggtgagtcgggactcagctgaggacacatccccaccctgcctcccat       c.*780

          .         .         .         .         .         .       g.54456
 ctggccctttggacaactggccctttgtgacagggctgactcaagtgttaggcagggtct       c.*840

          .         .         .         .         .         .       g.54516
 caggcctttgattgctcacccctgctccccaggccctgccctcacttttaccaaaggttc       c.*900

          .         .         .         .         .         .       g.54576
 tccctcggcgggagggcatctgtgttggaggtgatttgtctgggttcttccttttggttc       c.*960

          .         .         .         .         .         .       g.54636
 cagaaggaactgtcagtcatcagcatctgcgttgttagcagtcagtaccacccccgcccc       c.*1020

          .         .         .         .         .         .       g.54696
 acaatgacagtcaaggctgacttgttgactgaagcctttttcccagaccccttatttcga       c.*1080

          .         .         .         .         .         .       g.54756
 atccccaagcttcagtccctcttgggggtggagacaagaggacatgtgggaagccacgga       c.*1140

          .         .         .         .         .         .       g.54816
 agcaggttctttatgtcctctcctctgtggctggcaaggctcacctggccttatccaccc       c.*1200

          .         .         .         .         .         .       g.54876
 acttatggaacctcaggagaggagggctcctcctaaaggcatgcagcttgcagcccctct       c.*1260

          .         .         .         .         .         .       g.54936
 ttctcacacgtgtgatcctagcgtgagaggtcatcctgcccttgctgaagttagtagtac       c.*1320

          .         .         .         .         .         .       g.54996
 tgtactaagagctctgccctcatgtgaattcctgccctggcgcctcttccctggggctga       c.*1380

          .         .         .         .         .         .       g.55056
 atcaggccctgctgcaaaactccaggcttcccagggttggggaggctgtgggaccaaggt       c.*1440

          .         .         .         .         .         .       g.55116
 ccatgttggtccttccactgggtgcagcaggagctgggtcccgagagcctggcaggtgaa       c.*1500

          .         .         .         .         .         .       g.55176
 actctgcaggccttccgcctgattattatttattcactcctttcctcaccccaagtgccc       c.*1560

          .         .         .         .         .         .       g.55236
 tgctctccaggtgcctagagtatcctaactcttaggaccagggattgtcttgcaccaagt       c.*1620

          .         .         .         .         .         .       g.55296
 atgcctacccctggccagtctgaggtctcctagccatagaactgactcctggaagcctgg       c.*1680

          .         .         .         .         .         .       g.55356
 agagaaggtggtgacacccatgggttctcaactgtaaggaaaaaagacaccagacttttg       c.*1740

          .         .         .         .         .         .       g.55416
 ttccctagtgggggaaagcccttagtcttgtacaggagcagcttgctcccaagtcctttt       c.*1800

          .         .         .         .         .         .       g.55476
 ggaagctggcagagctatattcctgacagccctgactgccaggtagagcaaaagacattg       c.*1860

          .         .         .         .         .         .       g.55536
 gtgggggtatgtgaagcaaaaggggcaggtgcacacacctccacagtgacctctgtgcac       c.*1920

          .         .         .         .         .         .       g.55596
 acggttaccaccaactggctggccctcctcctcttccctggcccattgatcatcccttct       c.*1980

          .         .         .         .         .         .       g.55656
 cacagagggtcatcattatttccaaatattgtttgtctgatgacttcctcttcccagtgc       c.*2040

          .         .         .         .         .         .       g.55716
 aatttttcccttcctatttcaacctctggttcctgggatgagccataccctggaactggc       c.*2100

          .         .         .         .         .         .       g.55776
 ccacccactgtgtcttccacgtaagggagacctttgcaaagggcatccaaatgggtaggc       c.*2160

          .         .         .         .         .         .       g.55836
 aggtgacagccgccgtatttattttgcataatattttaatttgtatatttttgtgattta       c.*2220

          .         .         .         .         .         .       g.55896
 ttttggcgttatgagtttgactctcggggagttttgttgttatgactcttgtgtcttttg       c.*2280

          .         .         .         .         .         .       g.55956
 tcacaaaacaatgatatttgctaaacgatatatggaatttatttttgattggtaataaaa       c.*2340

          .         .         .                                     g.55990
 aatcaaatatgtataaatcctggtgaatctacaa                                 c.*2374

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Cyclin M4 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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