CoA synthase (COASY) - coding DNA reference sequence

(used for variant description)

(last modified December 1, 2015)


This file was created to facilitate the description of sequence variants on transcript NM_025233.6 in the COASY gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000017.10, covering COASY transcript NM_025233.6.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                                    g.5009
                                                    agaatcccg       c.-541

 .         .         .         .         .         .                g.5069
 cgctgaagcgaagtcgagacgtttgaccttcctccgtttccgtagttccgagttgcggtt       c.-481

 .         .         .         .         .         .                g.5129
 tctccgttagtgcttccgggttgcagccagggaagcctccgcggtggtgcaagtggaacc       c.-421

 .         .         .         .         .         .                g.5189
 caagccttgaggtttcagtgagtagggggccgacgtgagctttagcgtccccctttagcc       c.-361

 .         .         .         .         .         .                g.5249
 tccctcttcgattccttgaagaccctggtgcagcttagcaagagggcccaggatttttgg       c.-301

 .         .         .         .         .         .                g.5309
 atccccagccctgtgacaagggttcctgtccagtttccccctcccaggatttcgactcag       c.-241

 .         .         .         .         .         .                g.5369
 ttcagcgaagtcaccgccccgtctgagaaatgaggacaccaaggcttagagcacagcccc       c.-181

 .         .         .         .         .         .                g.5429
 gaggcgccgtctaccaggccccgtcccctcccccggctcctgtcggtcagcactgaaacc       c.-121

 .         .         .         .         .         .                g.5489
 ccgtccctgctccaggcctccttctctggggtccaaggtcccatacaggcctctgcctcg       c.-61

 .         .         .         .         .         .                g.5549
 gccgcaggcccttcagtcaccgtcgcctcgtctccctgactgtccgcaggcctgggcagc       c.-1

          .         .         .         .         .         .       g.5609
 ATGGCCGTATTCCGGTCGGGTCTCCTGGTGCTGACGACGCCGCTGGCCTCCCTAGCCCCT       c.60
 M  A  V  F  R  S  G  L  L  V  L  T  T  P  L  A  S  L  A  P         p.20

          .         .         .         .         .         .       g.5669
 CGCCTGGCCTCCATCCTGACCTCGGCGGCCCGGCTGGTGAATCACACACTCTATGTTCAC       c.120
 R  L  A  S  I  L  T  S  A  A  R  L  V  N  H  T  L  Y  V  H         p.40

          .         .         .         .         .         .       g.5729
 CTGCAGCCGGGCATGAGCCTGGAGGGCCCGGCTCAGCCCCAGTCCAGCCCCGTGCAGGCC       c.180
 L  Q  P  G  M  S  L  E  G  P  A  Q  P  Q  S  S  P  V  Q  A         p.60

          .         .         .         .         .         .       g.5789
 ACGTTTGAGGTTCTTGATTTCATCACGCACCTCTATGCTGGCGCCGACGTCCACAGGCAC       c.240
 T  F  E  V  L  D  F  I  T  H  L  Y  A  G  A  D  V  H  R  H         p.80

          .         .         .         .         .         .       g.5849
 TTGGACGTCAGAATCCTACTGACCAATATCCGAACCAAGAGCACCTTTCTCCCTCCCCTG       c.300
 L  D  V  R  I  L  L  T  N  I  R  T  K  S  T  F  L  P  P  L         p.100

          .         .         .         .         .         .       g.5909
 CCCACCTCAGTCCAGAATCTCGCCCACCCGCCAGAAGTCGTGTTGACAGATTTCCAGACC       c.360
 P  T  S  V  Q  N  L  A  H  P  P  E  V  V  L  T  D  F  Q  T         p.120

          .         .         .         .         .         .       g.5969
 CTGGATGGAAGCCAGTACAACCCGGTCAAACAGCAGCTAGTGCGTTACGCCACCAGCTGT       c.420
 L  D  G  S  Q  Y  N  P  V  K  Q  Q  L  V  R  Y  A  T  S  C         p.140

          .         .         .         .         .         .       g.6029
 TACAGCTGTTGTCCGCGACTGGCCTCGGTGCTGCTATACTCCGATTATGGGATAGGAGAA       c.480
 Y  S  C  C  P  R  L  A  S  V  L  L  Y  S  D  Y  G  I  G  E         p.160

          .         .         .         .         .         .       g.6089
 GTGCCCGTGGAGCCCCTGGATGTCCCCTTACCCTCCACGATCAGGCCAGCTTCCCCCGTG       c.540
 V  P  V  E  P  L  D  V  P  L  P  S  T  I  R  P  A  S  P  V         p.180

          .         .         .         .         .         .       g.6149
 GCCGGGTCTCCAAAGCAGCCGGTGCGTGGCTACTACCGTGGCGCTGTCGGTGGCACGTTT       c.600
 A  G  S  P  K  Q  P  V  R  G  Y  Y  R  G  A  V  G  G  T  F         p.200

          .         .         .         .         .         .       g.6209
 GACCGCCTGCACAACGCCCACAAGGTGTTGCTCAGTGTCGCGTGCATCCTGGCCCAGGAG       c.660
 D  R  L  H  N  A  H  K  V  L  L  S  V  A  C  I  L  A  Q  E         p.220

          .         .         .         . | 02       .         .    g.6907
 CAGCTTGTGGTGGGAGTAGCAGACAAAGATCTGTTGAAGA | GCAAGTTGCTCCCTGAGCTG    c.720
 Q  L  V  V  G  V  A  D  K  D  L  L  K  S |   K  L  L  P  E  L      p.240

          .         .         .         .         .         .       g.6967
 CTCCAACCTTATACAGAACGTGTGGAACATCTGAGTGAATTCCTGGTGGACATCAAGCCC       c.780
 L  Q  P  Y  T  E  R  V  E  H  L  S  E  F  L  V  D  I  K  P         p.260

          .         .         .         .         .         .       g.7027
 TCCTTGACTTTTGATGTCATCCCCCTGCTGGACCCCTATGGGCCCGCTGGCTCTGACCCC       c.840
 S  L  T  F  D  V  I  P  L  L  D  P  Y  G  P  A  G  S  D  P         p.280

          .         .         .         .         .         .       g.7087
 TCCCTGGAGTTCCTGGTGGTCAGCGAGGAGACCTATCGTGGGGGGATGGCCATCAACCGC       c.900
 S  L  E  F  L  V  V  S  E  E  T  Y  R  G  G  M  A  I  N  R         p.300

          .      | 03  .         .         .         .         .    g.7417
 TTCCGCCTTGAGAAT | GACCTGGAGGAACTTGCTTTGTACCAGATCCAGCTGCTGAAGGAC    c.960
 F  R  L  E  N   | D  L  E  E  L  A  L  Y  Q  I  Q  L  L  K  D      p.320

          .         .         .         .         .         .       g.7477
 CTCAGACATACAGAGAATGAAGAGGACAAAGTCAGCTCCTCCAGCTTCCGCCAGCGAATG       c.1020
 L  R  H  T  E  N  E  E  D  K  V  S  S  S  S  F  R  Q  R  M         p.340

          .         .        | 04.         .         .         .    g.7668
 TTGGGGAACCTGCTTCGGCCTCCATAT | GAAAGGCCAGAGCTCCCCACATGTCTCTATGTA    c.1080
 L  G  N  L  L  R  P  P  Y   | E  R  P  E  L  P  T  C  L  Y  V      p.360

          .         .         .         .         .         .       g.7728
 ATTGGGCTGACTGGCATCAGTGGCTCTGGGAAGAGCTCAATAGCTCAGCGACTGAAGGGC       c.1140
 I  G  L  T  G  I  S  G  S  G  K  S  S  I  A  Q  R  L  K  G         p.380

          .         .         .         .         .         .       g.7788
 CTGGGGGCGTTTGTCATTGACAGTGACCACCTGGGTCATCGGGCCTATGCCCCAGGTGGC       c.1200
 L  G  A  F  V  I  D  S  D  H  L  G  H  R  A  Y  A  P  G  G         p.400

          .         .         .        | 05.         .         .    g.7932
 CCTGCCTACCAGCCTGTGGTGGAGGCCTTTGGAACAG | ATATTCTCCATAAAGATGGCATC    c.1260
 P  A  Y  Q  P  V  V  E  A  F  G  T  D |   I  L  H  K  D  G  I      p.420

          .         .         .         .   | 06     .         .    g.8171
 ATCAACAGGAAGGTCCTAGGCAGCCGGGTGTTTGGGAATAAG | AAGCAGCTGAAGATACTC    c.1320
 I  N  R  K  V  L  G  S  R  V  F  G  N  K   | K  Q  L  K  I  L      p.440

          .         .         .         .         .         .       g.8231
 ACGGACATTATGTGGCCAATTATCGCAAAGCTGGCCCGAGAGGAGATGGATCGGGCTGTG       c.1380
 T  D  I  M  W  P  I  I  A  K  L  A  R  E  E  M  D  R  A  V         p.460

         | 07.         .         .         .         .         .    g.8450
 GCTGAGG | GAAAGCGTGTGTGTGTGATTGATGCCGCTGTGTTGCTTGAAGCCGGCTGGCAG    c.1440
 A  E  G |   K  R  V  C  V  I  D  A  A  V  L  L  E  A  G  W  Q      p.480

          .         .         .         .      | 08  .         .    g.8600
 AACCTGGTCCATGAGGTGTGGACTGCTGTCATCCCAGAGACTGAG | GCTGTAAGACGCATT    c.1500
 N  L  V  H  E  V  W  T  A  V  I  P  E  T  E   | A  V  R  R  I      p.500

          .         .         .         .         .         .       g.8660
 GTGGAGAGGGATGGCCTCAGTGAAGCCGCGGCTCAAAGCCGGCTGCAGAGCCAGATGAGC       c.1560
 V  E  R  D  G  L  S  E  A  A  A  Q  S  R  L  Q  S  Q  M  S         p.520

          .         .         .         .         .         .       g.8720
 GGGCAGCAGCTTGTGGAACAGAGCCACGTGGTGCTCAGCACCTTGTGGGAGCCGCATATC       c.1620
 G  Q  Q  L  V  E  Q  S  H  V  V  L  S  T  L  W  E  P  H  I         p.540

          .   | 09     .         .         .         .         .    g.8880
 ACCCAACGCCAG | GTGGAGAAAGCCTGGGCCCTCTTGCAGAAGCGCATTCCCAAGACTCAT    c.1680
 T  Q  R  Q   | V  E  K  A  W  A  L  L  Q  K  R  I  P  K  T  H      p.560

          .                                                         g.8895
 CAGGCCCTCGACTGA                                                    c.1695
 Q  A  L  D  X                                                      p.564

          .         .         .         .         .         .       g.8955
 aaagttctcagtggggccagactggctcctggagctgacaagcgaccccgtggtgaggag       c.*60

          .         .         .         .         .         .       g.9015
 aaatgggggccttgatgctcaccctggttcaggcccagaggtccaagctatactgtgcag       c.*120

          .         .         .         .         .         .       g.9075
 gacatggccaggcctggtggacacaggaagcctacccaacacgctggtatttggccaaca       c.*180

          .         .         .         .         .         .       g.9135
 ctgaggatgtggttcatgggggagcagtcccctccccactcttgcccatgggtgactctt       c.*240

          .         .         .         .         .         .       g.9195
 acccacagctgactagggccagcgcaaatactggaacctgtaacagaattaaaggtgaat       c.*300

          .                                                         g.9208
 gttctgagatgtt                                                      c.*313

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The CoA synthase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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