collagen, type IV, alpha 3 (Goodpasture antigen) binding protein (COL4A3BP) - coding DNA reference sequence

(used for variant description)

(last modified October 26, 2019)


This file was created to facilitate the description of sequence variants on transcript NM_001130105.1 in the COL4A3BP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000005.9, covering COL4A3BP transcript NM_001130105.1.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5017
                                            aaacgaagcccacccac       c.-121

 .         .         .         .         .         .                g.5077
 cgactgacaaggccccaaggggacaagcgatccccgcgcgggatactcacccgttacctc       c.-61

 .         .         .         .         .         .                g.5137
 aggatcgcgactacaactcccaggaggctgcgcgagcgacggaccaacgcccttcccaga       c.-1

          .         .         .         .         .         .       g.5197
 ATGCAGCACAGCTGCATCCCTACCCCGCCCTCTCCTTTCTCCGCTCCTCCTGCTTTTCTA       c.60
 M  Q  H  S  C  I  P  T  P  P  S  P  F  S  A  P  P  A  F  L         p.20

          .         .       | 02 .         .         .         .    g.5510
 CCCGTCGTCACCCGGGAGAGCCGGAG | GGGGCTAAGTTCGGGTGGCAGCGCCGGGCGCAAC    c.120
 P  V  V  T  R  E  S  R  R  |  G  L  S  S  G  G  S  A  G  R  N      p.40

          .         .         .         .         .         .       g.5570
 GCAGGGGTCACGGCGACGGCGGCGGCGGCTGACGGCTGGAAGGGTAGGCTTCCTTCACCG       c.180
 A  G  V  T  A  T  A  A  A  A  D  G  W  K  G  R  L  P  S  P         p.60

          .         .         .         .         .         .       g.5630
 CTCGTCCTCCTTCCTCGCTCCGCTCGGTGTCAGGCGCGGCGGCGGCGCGGCGGGCGGACT       c.240
 L  V  L  L  P  R  S  A  R  C  Q  A  R  R  R  R  G  G  R  T         p.80

          .         .         .         .         .         .       g.5690
 TCGTCCCTCCTCCTGCTCCCCCCCACACCGGAGCGGGCACTCTTCGCTTCGCCATCCCCC       c.300
 S  S  L  L  L  L  P  P  T  P  E  R  A  L  F  A  S  P  S  P         p.100

          .         .         .         .         .         .       g.5750
 GACCCTTCACCCCGAGGACTGGGCGCCTCCTCCGGCGCAGCTGAGGGAGCGGGGGCCGGT       c.360
 D  P  S  P  R  G  L  G  A  S  S  G  A  A  E  G  A  G  A  G         p.120

          .         .         .         .         .         .       g.5810
 CTCCTGCTCGGTTGTCGAGCCTCCATGTCGGATAATCAGAGCTGGAACTCGTCGGGCTCG       c.420
 L  L  L  G  C  R  A  S  M  S  D  N  Q  S  W  N  S  S  G  S         p.140

          .         .         .         .         .         .       g.5870
 GAGGAGGATCCAGAGACGGAGTCTGGGCCGCCTGTGGAGCGCTGCGGGGTCCTCAGTAAG       c.480
 E  E  D  P  E  T  E  S  G  P  P  V  E  R  C  G  V  L  S  K         p.160

  | 03       .         .         .         .         .         .    g.10925
  | TGGACAAACTACATTCATGGGTGGCAGGATCGTTGGGTAGTTTTGAAAAATAATGCTCTG    c.540
  | W  T  N  Y  I  H  G  W  Q  D  R  W  V  V  L  K  N  N  A  L      p.180

          .         .         .         .         .         .       g.10985
 AGTTACTACAAATCTGAAGATGAAACAGAGTATGGCTGCAGAGGATCCATCTGTCTTAGC       c.600
 S  Y  Y  K  S  E  D  E  T  E  Y  G  C  R  G  S  I  C  L  S         p.200

          .      | 04  .         .         .         .         .    g.57845
 AAGGCTGTCATCACA | CCTCACGATTTTGATGAATGTCGATTTGATATTAGTGTAAATGAT    c.660
 K  A  V  I  T   | P  H  D  F  D  E  C  R  F  D  I  S  V  N  D      p.220

          .         .         .         .         .         .       g.57905
 AGTGTTTGGTATCTTCGTGCTCAGGATCCAGATCATAGACAGCAATGGATAGATGCCATT       c.720
 S  V  W  Y  L  R  A  Q  D  P  D  H  R  Q  Q  W  I  D  A  I         p.240

          .   | 05     .         .         .         .         .    g.90551
 GAACAGCACAAG | ACTGAATCTGGATATGGATCTGAATCCAGCTTGCGTCGACATGGCTCA    c.780
 E  Q  H  K   | T  E  S  G  Y  G  S  E  S  S  L  R  R  H  G  S      p.260

          .         .         .         .         .         .       g.90611
 ATGGTGTCCCTGGTGTCTGGAGCAAGTGGCTACTCTGCAACATCCACCTCTTCATTCAAG       c.840
 M  V  S  L  V  S  G  A  S  G  Y  S  A  T  S  T  S  S  F  K         p.280

  | 06       .         .         .         .         .         .    g.91542
  | AAAGGCCACAGTTTACGTGAGAAGTTGGCTGAAATGGAAACATTTAGAGACATCTTATGT    c.900
  | K  G  H  S  L  R  E  K  L  A  E  M  E  T  F  R  D  I  L  C      p.300

          .         .         .         .         .         .       g.91602
 AGACAAGTTGACACGCTACAGAAGTACTTTGATGCCTGTGCTGATGCTGTCTCTAAGGAT       c.960
 R  Q  V  D  T  L  Q  K  Y  F  D  A  C  A  D  A  V  S  K  D         p.320

          .          | 07        .         .         .         .    g.97598
 GAACTTCAAAGGGATAAAG | TGGTAGAAGATGATGAAGATGACTTTCCTACAACGCGTTCT    c.1020
 E  L  Q  R  D  K  V |   V  E  D  D  E  D  D  F  P  T  T  R  S      p.340

          .         .         .         .    | 08    .         .    g.99965
 GATGGTGACTTCTTGCATAGTACCAACGGCAATAAAGAAAAGT | TATTTCCACATGTGACA    c.1080
 D  G  D  F  L  H  S  T  N  G  N  K  E  K  L |   F  P  H  V  T      p.360

          .         .         .         .         .         .       g.100025
 CCAAAAGGAATTAATGGTATAGACTTTAAAGGGGAAGCGATAACTTTTAAAGCAACTACT       c.1140
 P  K  G  I  N  G  I  D  F  K  G  E  A  I  T  F  K  A  T  T         p.380

          .         .         .         .         .         .       g.100085
 GCTGGAATCCTTGCAACACTTTCTCATTGTATTGAACTAATGGTTAAACGTGAGGACAGC       c.1200
 A  G  I  L  A  T  L  S  H  C  I  E  L  M  V  K  R  E  D  S         p.400

          .         .  | 09      .         .         .         .    g.105917
 TGGCAGAAGAGACTGGATAAG | GAAACTGAGAAGAAAAGAAGAACAGAGGAAGCATATAAA    c.1260
 W  Q  K  R  L  D  K   | E  T  E  K  K  R  R  T  E  E  A  Y  K      p.420

          .         .         .         .         .     | 10   .    g.113929
 AATGCAATGACAGAACTTAAGAAAAAATCCCACTTTGGAGGACCAGATTATGAA | GAAGGC    c.1320
 N  A  M  T  E  L  K  K  K  S  H  F  G  G  P  D  Y  E   | E  G      p.440

          .         .         .         .         .         .       g.113989
 CCTAACAGTCTGATTAATGAAGAAGAGTTCTTTGATGCTGTTGAAGCTGCTCTTGACAGA       c.1380
 P  N  S  L  I  N  E  E  E  F  F  D  A  V  E  A  A  L  D  R         p.460

          .         .  | 11      .         .         .         .    g.116723
 CAAGATAAAATAGAAGAACAG | TCACAGAGTGAAAAGGTGAGATTACATTGGCCTACATCC    c.1440
 Q  D  K  I  E  E  Q   | S  Q  S  E  K  V  R  L  H  W  P  T  S      p.480

          .         .         .         .         .     | 12   .    g.117600
 TTGCCCTCTGGAGATGCCTTTTCTTCTGTGGGGACACATAGATTTGTCCAAAAG | CCCTAT    c.1500
 L  P  S  G  D  A  F  S  S  V  G  T  H  R  F  V  Q  K   | P  Y      p.500

          .         .         .         .         .         .       g.117660
 AGTCGCTCTTCCTCCATGTCTTCCATTGATCTAGTCAGTGCCTCTGATGATGTTCACAGA       c.1560
 S  R  S  S  S  M  S  S  I  D  L  V  S  A  S  D  D  V  H  R         p.520

          .   | 13     .         .         .         .         .    g.127342
 TTCAGCTCCCAG | GTTGAAGAGATGGTGCAGAACCACATGACTTACTCATTACAGGATGTA    c.1620
 F  S  S  Q   | V  E  E  M  V  Q  N  H  M  T  Y  S  L  Q  D  V      p.540

          .         .         .         .         | 14         .    g.130959
 GGCGGAGATGCCAATTGGCAGTTGGTTGTAGAAGAAGGAGAAATGAAG | GTATACAGAAGA    c.1680
 G  G  D  A  N  W  Q  L  V  V  E  E  G  E  M  K   | V  Y  R  R      p.560

          .         .         .         .         .         .       g.131019
 GAAGTAGAAGAAAATGGGATTGTTCTGGATCCTTTAAAAGCTACCCATGCAGTTAAAGGC       c.1740
 E  V  E  E  N  G  I  V  L  D  P  L  K  A  T  H  A  V  K  G         p.580

          .         .         .         .         .         .       g.131079
 GTCACAGGACATGAAGTCTGCAATTATTTCTGGAATGTTGACGTTCGCAATGACTGGGAA       c.1800
 V  T  G  H  E  V  C  N  Y  F  W  N  V  D  V  R  N  D  W  E         p.600

   | 15      .         .         .         .         .         .    g.132328
 A | CAACTATAGAAAACTTTCATGTGGTGGAAACATTAGCTGATAATGCAATCATCATTTAT    c.1860
 T |   T  I  E  N  F  H  V  V  E  T  L  A  D  N  A  I  I  I  Y      p.620

          .   | 16     .         .         .         .         .    g.134952
 CAAACACACAAG | AGGGTGTGGCCTGCTTCTCAGCGAGACGTATTATATCTTTCTGTCATT    c.1920
 Q  T  H  K   | R  V  W  P  A  S  Q  R  D  V  L  Y  L  S  V  I      p.640

          .         .         .         .         .         .       g.135012
 CGAAAGATACCAGCCTTGACTGAAAATGACCCTGAAACTTGGATAGTTTGTAATTTTTCT       c.1980
 R  K  I  P  A  L  T  E  N  D  P  E  T  W  I  V  C  N  F  S         p.660

          .         .  | 17      .         .         .         .    g.135819
 GTGGATCATGACAGTGCTCCT | CTAAACAACCGATGTGTCCGTGCCAAAATAAATGTTGCT    c.2040
 V  D  H  D  S  A  P   | L  N  N  R  C  V  R  A  K  I  N  V  A      p.680

          .         .         .         .         .         .       g.135879
 ATGATTTGTCAAACCTTGGTAAGCCCACCAGAGGGAAACCAGGAAATTAGCAGGGACAAC       c.2100
 M  I  C  Q  T  L  V  S  P  P  E  G  N  Q  E  I  S  R  D  N         p.700

          .         .         .  | 18      .         .         .    g.137537
 ATTCTATGCAAGATTACATATGTAGCTAATG | TGAACCCTGGAGGATGGGCACCAGCCTCA    c.2160
 I  L  C  K  I  T  Y  V  A  N  V |   N  P  G  G  W  A  P  A  S      p.720

          .         .         .         .         .         .       g.137597
 GTGTTAAGGGCAGTGGCAAAGCGAGAGTATCCTAAATTTCTAAAACGTTTTACTTCTTAC       c.2220
 V  L  R  A  V  A  K  R  E  Y  P  K  F  L  K  R  F  T  S  Y         p.740

          .         .         .                                 g.137636
 GTCCAAGAAAAAACTGCAGGAAAGCCTATTTTGTTCTAG |                         c.2260
 V  Q  E  K  T  A  G  K  P  I  L  F  X                           p.752

           | 19        .         .         .         .         .    g.142841
 tattaacag | tgactgaagcaaggctgtgtgacattccatgttggagaaaaaaagaaaaaa    c.*60

          .         .         .         .         .         .       g.142901
 aaaagctgaatgctctaagctggaacgtaggatctatagccttgtctgtggcccaagacc       c.*120

          .         .         .         .         .         .       g.142961
 ttggccttgtgtacaaaaatgacaaaatattgcaatagcaaagctgaacatctaacacta       c.*180

          .         .         .         .         .         .       g.143021
 gctatctcttgctagatctccttgctcagcatataactataaatacatgtaaaattacat       c.*240

          .         .         .         .         .         .       g.143081
 gtatatggctatatttttatttgcttgctcctagaagagaaaaaaaaatcaactttgaat       c.*300

          .         .         .         .         .         .       g.143141
 cacaactaggaattgatgctttaatttttggatactttttcagaatttttaatttactat       c.*360

          .         .         .         .         .         .       g.143201
 ggtccggcctaagatcctctgttgtatcaggttttgtgcacaaaagaaaagcacaaaagt       c.*420

          .         .         .         .         .         .       g.143261
 tgaatgcacatggggcatgtgctttctgtgcaccaaatatctggatgaggttcttttttc       c.*480

          .         .         .         .         .         .       g.143321
 aggcctacagtcaaatctgtgtccagaattttttgacttttttgctttgtataatcatag       c.*540

          .         .         .         .         .         .       g.143381
 aattcattgctgctgatttctataatgattcatgttgtcatgtgtctcttaataactgag       c.*600

          .         .         .         .         .         .       g.143441
 ggctgtcagtaacctgtgattttgccttttctatagtcttactcccatgaagaaccttgg       c.*660

          .         .         .         .         .         .       g.143501
 ttctgatggagaaagtgaaaagctttatttcttcccctagatatctttatatttctatta       c.*720

          .         .         .         .         .         .       g.143561
 tattttttagttgtgtactgtgtactagagatttttttcagtttgttatgaacacaattt       c.*780

          .         .         .         .         .         .       g.143621
 ggtaagccctaaattggttctgcctgtctccaaacagaaacatctgtacaaatcttgttg       c.*840

          .         .         .         .         .         .       g.143681
 gtatagactactttctggaaaatggtcaagataagttcatgttttcttgaaatttctaag       c.*900

          .         .         .         .         .         .       g.143741
 atagtatatggtatcacttgtttaaagcaaatcagactgagtttgacatttaattcaata       c.*960

          .         .         .         .         .         .       g.143801
 tttctggtattcagtaacgggtatatatgtttgttcttccagtttgggtcagtttaaaag       c.*1020

          .         .         .         .         .         .       g.143861
 atatgttgcaaagtatacatagaaaatgtgagcaatgcctctctttgccttttgatcaga       c.*1080

          .         .         .         .         .         .       g.143921
 aacttcagcagagcggtaaggattccacatgatttaaactgaaatgcttttctttgttgc       c.*1140

          .         .         .         .         .         .       g.143981
 tgtaagaacttaaaatgtaaaatacctttttcagtttaagtcctgtaaacaacattgaag       c.*1200

          .         .         .         .         .         .       g.144041
 catggagatgaggcaaggaatagtactcactgaagttgaaatgactgcccacttcaaaat       c.*1260

          .         .         .         .         .         .       g.144101
 cttcattgtgtttacacaccagtgtatttatacaaatcagaggcattttgtagatgcttt       c.*1320

          .         .         .         .         .         .       g.144161
 gctgacttgttcagctctgtaaaaacacagaaatcagacccattttgtaaagcggaaaat       c.*1380

          .         .         .         .         .         .       g.144221
 catgttacatggaacatgtcctgtatatatcacatacatggtaatggagtcttaatgata       c.*1440

          .         .         .         .         .         .       g.144281
 agtgcaagataataatttaatgatgggattagtctgatcgcttaatatgcacaatcctgg       c.*1500

          .         .         .         .         .         .       g.144341
 aagtgaattacttgcatcagatatagtgatatttattattctgtacagagagaaaaatac       c.*1560

          .         .         .         .         .         .       g.144401
 atataaaacatatgcttacattacatgcacgcggatttcatgctccataatcttttctat       c.*1620

          .         .         .         .         .         .       g.144461
 tttttaatttacctttctgtaaatgatgtgcatggaatatgccttatagaaaaatgctgt       c.*1680

          .         .         .         .         .         .       g.144521
 tcataatttgactacgtggaaaagtgcctatatggtggtaatgctagtaaggcaaataag       c.*1740

          .         .         .         .         .         .       g.144581
 acaaattatcatgttggtttactacatcaccagttaacattttatattgtgatgtttaaa       c.*1800

          .         .         .         .         .         .       g.144641
 aaagaaaaatttatacctcaaatgtgtattttattttacaatcagctgtggggtatgggg       c.*1860

          .         .         .         .         .         .       g.144701
 ttgggatgggagaatgggggggttggggagggcaggtttattcaccatagccgctgataa       c.*1920

          .         .         .         .         .         .       g.144761
 gaatcttcaaaaaaattctatatgcgcactataaatgtttctctgtttgccatttctggt       c.*1980

          .         .         .         .         .         .       g.144821
 aactatcatgaacacagacagttaactctttcataactgaattggatagctttattttac       c.*2040

          .         .         .         .         .         .       g.144881
 agaagtatggcaagtttacaaagcaatatctaaatctaattatcattagttgcatttgga       c.*2100

          .         .         .         .         .         .       g.144941
 ctaaatgtgatgatatacttttgcaattgattctgtaaataaaaggattacactaaaata       c.*2160

          .         .         .         .         .         .       g.145001
 tttgtattaaaagaagaaaagataacattttacctttagataactgcacttgtacctcac       c.*2220

          .         .         .         .         .         .       g.145061
 tagagttaatcccacccaatcagattgagaaataaattggggaatgtggaaagagtccaa       c.*2280

          .         .         .         .         .         .       g.145121
 aagaggtcagaatttggagaggtactggccttctggacaacatttagaccctctacaatt       c.*2340

          .         .         .         .         .         .       g.145181
 attttcattaagctgattcctacatcctgaatattcatgttttctcatctacagatattt       c.*2400

          .         .         .         .         .         .       g.145241
 gtcttcccccaaactaaaagaaaaaaaactaccctttactctcttttctactcagttact       c.*2460

          .         .         .         .         .         .       g.145301
 cttttgtgctatgttagaaacttgaaatatattggtgatgtggggattttgtccctgact       c.*2520

          .         .         .         .         .         .       g.145361
 gcccactgtacaggacaagagagtacagtgtttcagttggaattcaggactcctggtttt       c.*2580

          .         .         .         .         .         .       g.145421
 gaggtagaggatgatcactgcagtacttggtttggaattgccacaggggtagctaaacca       c.*2640

          .         .         .         .         .         .       g.145481
 aaggagggttatatctgcaagggaggtgtaagaaggcaaaataaggaaaaggaggaatgg       c.*2700

          .         .         .         .         .         .       g.145541
 gttttctatttgttcagtttcatcaactaatttatacacttaatacaacttcagtgtcaa       c.*2760

          .         .         .         .         .         .       g.145601
 ttgctattaagaaatttttagttgggctgagctggttctcttgtgaaattgtgctggtta       c.*2820

          .         .         .         .         .         .       g.145661
 tctttaagcttatcagttatttgtccaattaaacacttttcaccagtatttagtccgagt       c.*2880

          .         .         .         .         .         .       g.145721
 tgtacagacgatgtatttggattttgtcatggttcatctacagactcaaaacataatcat       c.*2940

          .         .         .         .         .         .       g.145781
 tttaaagtaccttgggagtgtgtagagtaacttctataatagctttatgatcctgatgat       c.*3000

          .         .         .         .         .         .       g.145841
 gttttttaaacacaataaagttggatcttccatgttacaatcacagaattaaaaccagta       c.*3060

          .         .         .                                     g.145879
 tttaaagtggaaaagtattaaaatattatggacaaata                             c.*3098

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Collagen, type IV, alpha 3 (Goodpasture antigen) binding protein protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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