coatomer protein complex, subunit beta 2 (beta prime) (COPB2) - coding DNA reference sequence

(used for variant description)

(last modified September 28, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_004766.2 in the COPB2 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering COPB2 transcript NM_004766.2.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5010
                                                   gactatcgcg       c.-121

 .         .         .         .         .         .                g.5070
 agaatcggctcccggaagttccacgtcagtcagtctgacggtcagtggatcggtgggttt       c.-61

 .         .         .         .         .         .                g.5130
 atctcaaggcctgagtagccggtaacaaacgagggttcccgggattggaccgacgcagcc       c.-1

     | 02    .         .         .         .         .         .    g.11302
 ATG | CCTCTGCGACTTGATATCAAAAGAAAGCTAACTGCTAGATCTGATCGAGTTAAGAGT    c.60
 M   | P  L  R  L  D  I  K  R  K  L  T  A  R  S  D  R  V  K  S      p.20

          .         .         .         .         .         .       g.11362
 GTGGATCTGCATCCTACAGAGCCATGGATGTTGGCAAGTCTTTACAATGGCAGTGTGTGT       c.120
 V  D  L  H  P  T  E  P  W  M  L  A  S  L  Y  N  G  S  V  C         p.40

          .         .  | 03      .         .         .         .    g.15253
 GTTTGGAATCATGAAACACAG | ACACTGGTGAAGACATTTGAAGTATGTGATCTTCCTGTT    c.180
 V  W  N  H  E  T  Q   | T  L  V  K  T  F  E  V  C  D  L  P  V      p.60

          .         .         .         .         | 04         .    g.15519
 CGAGCTGCAAAGTTTGTTGCAAGGAAGAATTGGGTTGTGACAGGAGCG | GATGACATGCAG    c.240
 R  A  A  K  F  V  A  R  K  N  W  V  V  T  G  A   | D  D  M  Q      p.80

          .         .         .         .         .         .       g.15579
 ATTAGAGTGTTCAATTACAATACTCTGGAGAGAGTTCATATGTTTGAAGCACACTCAGAC       c.300
 I  R  V  F  N  Y  N  T  L  E  R  V  H  M  F  E  A  H  S  D         p.100

          .         .         .         .         .      | 05  .    g.16496
 TACATTCGCTGTATTGCTGTTCATCCAACCCAGCCTTTCATTCTAACTAGCAGTG | ATGAC    c.360
 Y  I  R  C  I  A  V  H  P  T  Q  P  F  I  L  T  S  S  D |   D      p.120

          .         .         .         .         .         .       g.16556
 ATGCTTATTAAGCTCTGGGACTGGGATAAAAAATGGTCTTGCTCACAAGTGTTTGAAGGA       c.420
 M  L  I  K  L  W  D  W  D  K  K  W  S  C  S  Q  V  F  E  G         p.140

          .         .         .         .         .         .       g.16616
 CACACCCATTATGTTATGCAGATTGTGATCAACCCCAAAGATAACAATCAGTTTGCCAGT       c.480
 H  T  H  Y  V  M  Q  I  V  I  N  P  K  D  N  N  Q  F  A  S         p.160

          .         .     | 06   .         .         .         .    g.19102
 GCCTCTTTGGACAGGACTATCAAG | GTGTGGCAGTTGGGCTCTTCGTCACCAAACTTCACT    c.540
 A  S  L  D  R  T  I  K   | V  W  Q  L  G  S  S  S  P  N  F  T      p.180

          .         .         .         .         .         .       g.19162
 TTGGAAGGACATGAGAAAGGCGTGAATTGCATTGATTACTACAGTGGTGGGGACAAGCCA       c.600
 L  E  G  H  E  K  G  V  N  C  I  D  Y  Y  S  G  G  D  K  P         p.200

          .         .         .         .         .  | 07      .    g.20101
 TACCTCATTTCAGGTGCAGATGACCGTCTTGTTAAAATATGGGATTATCAG | AATAAAACA    c.660
 Y  L  I  S  G  A  D  D  R  L  V  K  I  W  D  Y  Q   | N  K  T      p.220

          .         .         .         .         .         .       g.20161
 TGTGTGCAGACACTGGAAGGACATGCCCAAAATGTGTCTTGTGCCAGCTTTCATCCTGAG       c.720
 C  V  Q  T  L  E  G  H  A  Q  N  V  S  C  A  S  F  H  P  E         p.240

          .         .         .  | 08      .         .         .    g.20901
 TTGCCAATCATTATCACAGGTTCAGAAGATG | GAACAGTACGTATTTGGCATTCAAGCACC    c.780
 L  P  I  I  I  T  G  S  E  D  G |   T  V  R  I  W  H  S  S  T      p.260

          .         .         .         .         .         .       g.20961
 TACCGGCTTGAGAGCACACTGAATTATGGAATGGAGAGGGTATGGTGCGTGGCCAGTCTA       c.840
 Y  R  L  E  S  T  L  N  Y  G  M  E  R  V  W  C  V  A  S  L         p.280

          .         .         .         .         .     | 09   .    g.21274
 AGAGGGTCAAACAATGTCGCTTTGGGCTATGATGAAGGGAGCATCATTGTTAAG | CTTGGT    c.900
 R  G  S  N  N  V  A  L  G  Y  D  E  G  S  I  I  V  K   | L  G      p.300

          .         .         .         .         .         .       g.21334
 CGGGAGGAACCTGCCATGTCCATGGATGCCAATGGAAAGATAATTTGGGCCAAGCATTCA       c.960
 R  E  E  P  A  M  S  M  D  A  N  G  K  I  I  W  A  K  H  S         p.320

          .         .         .         .         .         .       g.21394
 GAAGTCCAGCAGGCCAACCTAAAAGCAATGGGAGATGCTGAAATTAAAGATGGTGAAAGA       c.1020
 E  V  Q  Q  A  N  L  K  A  M  G  D  A  E  I  K  D  G  E  R         p.340

          .         .         .         .         .         .       g.21454
 TTGCCACTGGCAGTAAAGGATATGGGCAGTTGTGAAATATACCCTCAGACTATTCAGCAC       c.1080
 L  P  L  A  V  K  D  M  G  S  C  E  I  Y  P  Q  T  I  Q  H         p.360

          .     | 10   .         .         .         .         .    g.22893
 AATCCTAATGGGCG | GTTTGTGGTGGTGTGTGGTGATGGGGAGTATATCATCTACACAGCA    c.1140
 N  P  N  G  R  |  F  V  V  V  C  G  D  G  E  Y  I  I  Y  T  A      p.380

          .         .         .         .         .         .       g.22953
 ATGGCATTGAGAAACAAGAGCTTTGGATCTGCTCAGGAGTTTGCATGGGCCCACGATTCT       c.1200
 M  A  L  R  N  K  S  F  G  S  A  Q  E  F  A  W  A  H  D  S         p.400

       | 11  .         .         .         .         .         .    g.25191
 TCAGA | GTATGCAATAAGAGAGAGCAACAGCATTGTAAAGATATTTAAGAACTTTAAGGAA    c.1260
 S  E  |  Y  A  I  R  E  S  N  S  I  V  K  I  F  K  N  F  K  E      p.420

          .         .         .     | 12   .         .         .    g.25339
 AAAAAATCATTTAAACCAGATTTTGGAGCAGAAA | GTATCTACGGCGGCTTCTTATTGGGA    c.1320
 K  K  S  F  K  P  D  F  G  A  E  S |   I  Y  G  G  F  L  L  G      p.440

          .         .         .         .         .         .       g.25399
 GTCAGATCTGTAAATGGCTTAGCCTTCTATGACTGGGACAATACAGAACTCATACGAAGA       c.1380
 V  R  S  V  N  G  L  A  F  Y  D  W  D  N  T  E  L  I  R  R         p.460

          .         .  | 13      .         .         .         .    g.26431
 ATTGAAATTCAGCCCAAACAT | ATTTTCTGGTCTGACTCTGGAGAGCTAGTCTGTATTGCT    c.1440
 I  E  I  Q  P  K  H   | I  F  W  S  D  S  G  E  L  V  C  I  A      p.480

          .         .         .         .         .         .       g.26491
 ACTGAGGAATCATTTTTTATCCTTAAGTATCTGTCAGAAAAAGTCTTGGCTGCACAGGAA       c.1500
 T  E  E  S  F  F  I  L  K  Y  L  S  E  K  V  L  A  A  Q  E         p.500

          .         .         .         .      | 14  .         .    g.27550
 ACACATGAGGGAGTTACTGAAGATGGCATTGAAGATGCCTTTGAG | GTTCTTGGTGAGATT    c.1560
 T  H  E  G  V  T  E  D  G  I  E  D  A  F  E   | V  L  G  E  I      p.520

          .         .         .         .         .         .       g.27610
 CAGGAAATTGTGAAAACAGGGCTTTGGGTAGGCGATTGCTTCATTTACACAAGTTCTGTG       c.1620
 Q  E  I  V  K  T  G  L  W  V  G  D  C  F  I  Y  T  S  S  V         p.540

          .         .         .         .         .       | 15 .    g.27909
 AACAGATTAAATTATTATGTTGGAGGAGAAATAGTCACCATTGCCCACTTGGACAG | GACG    c.1680
 N  R  L  N  Y  Y  V  G  G  E  I  V  T  I  A  H  L  D  R  |  T      p.560

          .         .         .         .         .         .       g.27969
 ATGTATCTCCTAGGCTACATTCCTAAAGACAACAGGCTTTATCTGGGGGATAAAGAATTG       c.1740
 M  Y  L  L  G  Y  I  P  K  D  N  R  L  Y  L  G  D  K  E  L         p.580

          .         .         .         .         .         .       g.28029
 AACATCATTAGCTATTCCCTGCTGGTTTCAGTCCTGGAATACCAGACAGCTGTCATGCGG       c.1800
 N  I  I  S  Y  S  L  L  V  S  V  L  E  Y  Q  T  A  V  M  R         p.600

          .         .         .         .         .         .       g.28089
 AGGGACTTTAGCATGGCTGATAAGGTCCTTCCTACCATTCCAAAAGAACAGAGGACCAGA       c.1860
 R  D  F  S  M  A  D  K  V  L  P  T  I  P  K  E  Q  R  T  R         p.620

          .         .     | 16   .         .         .         .    g.32199
 GTTGCACACTTTTTGGAAAAGCAG | GGCTTCAAGCAGCAAGCTCTTACAGTATCCACAGAT    c.1920
 V  A  H  F  L  E  K  Q   | G  F  K  Q  Q  A  L  T  V  S  T  D      p.640

          .         .         .         .         .         .       g.32259
 CCTGAGCATCGTTTTGAGCTTGCTCTTCAGCTTGGAGAGTTAAAAATTGCATACCAGTTA       c.1980
 P  E  H  R  F  E  L  A  L  Q  L  G  E  L  K  I  A  Y  Q  L         p.660

          .      | 17  .         .         .         .         .    g.33430
 GCAGTGGAAGCAGAG | TCAGAACAGAAGTGGAAACAACTTGCTGAACTTGCCATTAGTAAA    c.2040
 A  V  E  A  E   | S  E  Q  K  W  K  Q  L  A  E  L  A  I  S  K      p.680

          .         .         .         .         .         .       g.33490
 TGTCAGTTTGGCCTAGCCCAGGAGTGCCTGCATCATGCACAGGATTATGGGGGCCTGCTG       c.2100
 C  Q  F  G  L  A  Q  E  C  L  H  H  A  Q  D  Y  G  G  L  L         p.700

          .         .         .         .         .         .       g.33550
 CTTTTGGCCACTGCCTCTGGAAATGCTAATATGGTGAACAAGCTAGCAGAGGGTGCGGAG       c.2160
 L  L  A  T  A  S  G  N  A  N  M  V  N  K  L  A  E  G  A  E         p.720

          .         .         .         .         . | 18       .    g.35328
 AGAGATGGCAAAAATAATGTGGCATTCATGAGCTACTTTTTACAGGGCAA | GGTTGATGCC    c.2220
 R  D  G  K  N  N  V  A  F  M  S  Y  F  L  Q  G  K  |  V  D  A      p.740

          .         .         .         .         .         .       g.35388
 TGCCTAGAGCTCTTAATTAGAACTGGACGGCTGCCAGAAGCTGCCTTCTTGGCCCGAACT       c.2280
 C  L  E  L  L  I  R  T  G  R  L  P  E  A  A  F  L  A  R  T         p.760

          .         .    | 19    .         .         .         .    g.35539
 TACTTACCCAGTCAGGTTTCAAG | GGTAGTGAAACTCTGGAGAGAGAATCTCTCAAAAGTC    c.2340
 Y  L  P  S  Q  V  S  R  |  V  V  K  L  W  R  E  N  L  S  K  V      p.780

          .         .         .         .         .         .       g.35599
 AATCAGAAAGCAGCAGAATCCCTTGCTGACCCAACAGAGTATGAAAACCTGTTCCCTGGA       c.2400
 N  Q  K  A  A  E  S  L  A  D  P  T  E  Y  E  N  L  F  P  G         p.800

          .         .         .         .         .         .       g.35659
 TTAAAAGAAGCCTTTGTTGTTGAAGAATGGGTGAAGGAAACACATGCTGATCTGTGGCCA       c.2460
 L  K  E  A  F  V  V  E  E  W  V  K  E  T  H  A  D  L  W  P         p.820

          .         .     | 20   .         .         .         .    g.35904
 GCCAAACAATACCCACTTGTCACG | CCAAATGAAGAGAGAAATGTCATGGAAGAGGGAAAA    c.2520
 A  K  Q  Y  P  L  V  T   | P  N  E  E  R  N  V  M  E  E  G  K      p.840

          .         .         .    | 21    .         .         .    g.36436
 GACTTTCAGCCCTCAAGATCTACAGCTCAACAG | GAACTTGATGGGAAACCTGCTTCTCCT    c.2580
 D  F  Q  P  S  R  S  T  A  Q  Q   | E  L  D  G  K  P  A  S  P      p.860

          .         .         .         .      | 22  .         .    g.36737
 ACTCCGGTTATTGTGGCCTCCCACACAGCCAACAAAGAAGAAAAG | AGTTTACTCGAACTA    c.2640
 T  P  V  I  V  A  S  H  T  A  N  K  E  E  K   | S  L  L  E  L      p.880

          .         .         .         .         .         .       g.36797
 GAAGTAGATTTGGATAATTTGGAATTAGAAGATATTGACACAACAGATATCAATCTGGAT       c.2700
 E  V  D  L  D  N  L  E  L  E  D  I  D  T  T  D  I  N  L  D         p.900

          .         .                                               g.36818
 GAAGATATTTTGGATGATTGA                                              c.2721
 E  D  I  L  D  D  X                                                p.906

          .         .         .         .         .         .       g.36878
 ctgtaatgctttccatttacctgactaaacagatcattattatatataggtattgattgc       c.*60

          .         .         .         .         .         .       g.36938
 taccctgaccacagtgctttggactatgagaaacttcttagatttttatatgtaaatgct       c.*120

          .         .         .         .         .         .       g.36998
 gtggaccactgggagcacaatgcccacatcatcttaagaagagtttatgtgcagcattta       c.*180

          .         .         .         .         .         .       g.37058
 aatcactgtgttttccttgttaactaaaacagacatgggctttgatttttttcatactat       c.*240

          .         .         .                                     g.37090
 tagaccatatctcataaaaccttttgaattaa                                   c.*272

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Coatomer protein complex, subunit beta 2 (beta prime) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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