corin, serine peptidase (CORIN) - coding DNA reference sequence

(used for variant description)

(last modified August 11, 2017)


This file was created to facilitate the description of sequence variants on transcript NM_006587.3 in the CORIN gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_032679.1, covering CORIN transcript NM_006587.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                               .         .         .                g.4973
                        agagcagacaaaatatggggcccctggcgcttaaagt       c.-121

 .         .         .         .         .         .                g.5033
 tcagtttgtctctcttgagcttggagaaaatcatccgtagtgcctccccgggggacacgt       c.-61

 .         .         .         .         .         .                g.5093
 agaggagagaaaagcgaccaagataaaagtggacagaagaataagcgagactttttatcc       c.-1

          .         .         .         .         .         .       g.5153
 ATGAAACAGTCTCCTGCCCTCGCTCCGGAAGAGCGCTGCCGCAGAGCCGGGTCCCCAAAG       c.60
 M  K  Q  S  P  A  L  A  P  E  E  R  C  R  R  A  G  S  P  K         p.20

     | 02    .         .         .         .         .         .    g.36052
 CCG | GTCTTGAGAGCTGATGACAATAACATGGGCAATGGCTGCTCTCAGAAGCTGGCGACT    c.120
 P   | V  L  R  A  D  D  N  N  M  G  N  G  C  S  Q  K  L  A  T      p.40

          .         .         .         .         .         .       g.36112
 GCTAACCTCCTCCGGTTCCTATTGCTGGTCCTGATTCCATGTATCTGTGCTCTCGTTCTC       c.180
 A  N  L  L  R  F  L  L  L  V  L  I  P  C  I  C  A  L  V  L         p.60

          .         .         | 03         .         .         .    g.56149
 TTGCTGGTGATCCTGCTTTCCTATGTTG | GAACATTACAAAAGGTCTATTTTAAATCAAAT    c.240
 L  L  V  I  L  L  S  Y  V  G |   T  L  Q  K  V  Y  F  K  S  N      p.80

          .         .         .         .         .         .       g.56209
 GGGAGTGAACCTTTGGTCACTGATGGTGAAATCCAAGGGTCCGATGTTATTCTTACAAAT       c.300
 G  S  E  P  L  V  T  D  G  E  I  Q  G  S  D  V  I  L  T  N         p.100

          .         .         .         .         .         .       g.56269
 ACAATTTATAACCAGAGCACTGTGGTGTCTACTGCACATCCCGACCAACACGTTCCAGCC       c.360
 T  I  Y  N  Q  S  T  V  V  S  T  A  H  P  D  Q  H  V  P  A         p.120

          .         .         .         .          | 04        .    g.79467
 TGGACTACGGATGCTTCTCTCCCAGGGGACCAAAGTCACAGGAATACAA | GTGCCTGTATG    c.420
 W  T  T  D  A  S  L  P  G  D  Q  S  H  R  N  T  S |   A  C  M      p.140

          .         .         .         .         .         .       g.79527
 AACATCACCCACAGCCAGTGTCAGATGCTGCCCTACCACGCCACGCTGACACCTCTCCTC       c.480
 N  I  T  H  S  Q  C  Q  M  L  P  Y  H  A  T  L  T  P  L  L         p.160

          .         .         .         .         .         .       g.79587
 TCAGTTGTCAGAAACATGGAAATGGAAAAGTTCCTCAAGTTTTTCACATATCTCCATCGC       c.540
 S  V  V  R  N  M  E  M  E  K  F  L  K  F  F  T  Y  L  H  R         p.180

          .         .         .         .         .         .       g.79647
 CTCAGTTGCTATCAACATATCATGCTGTTTGGCTGTACCCTCGCCTTCCCTGAGTGCATC       c.600
 L  S  C  Y  Q  H  I  M  L  F  G  C  T  L  A  F  P  E  C  I         p.200

          .        | 05.         .         .         .         .    g.98502
 ATTGATGGCGATGACAG | TCATGGACTCCTGCCCTGTAGGTCCTTCTGTGAGGCTGCAAAA    c.660
 I  D  G  D  D  S  |  H  G  L  L  P  C  R  S  F  C  E  A  A  K      p.220

          .         .         .         .         .         .       g.98562
 GAAGGCTGTGAATCAGTCCTGGGGATGGTGAATTACTCCTGGCCGGATTTCCTCAGATGC       c.720
 E  G  C  E  S  V  L  G  M  V  N  Y  S  W  P  D  F  L  R  C         p.240

          .         .         .         .         .         .       g.98622
 TCCCAGTTTAGAAACCAAACTGAAAGCAGCAATGTCAGCAGAATTTGCTTCTCACCTCAG       c.780
 S  Q  F  R  N  Q  T  E  S  S  N  V  S  R  I  C  F  S  P  Q         p.260

          .          | 06        .         .         .         .    g.150000
 CAGGAAAACGGAAAGCAAT | TGCTCTGTGGAAGGGGTGAGAACTTTCTGTGTGCCAGTGGA    c.840
 Q  E  N  G  K  Q  L |   L  C  G  R  G  E  N  F  L  C  A  S  G      p.280

          .         .         .         .         .         .       g.150060
 ATCTGCATCCCCGGGAAACTGCAATGTAATGGCTACAACGACTGTGACGACTGGAGTGAC       c.900
 I  C  I  P  G  K  L  Q  C  N  G  Y  N  D  C  D  D  W  S  D         p.300

          .    | 07    .         .         .         .         .    g.159251
 GAGGCTCATTGCA | ACTGCAGCGAGAATCTGTTTCACTGTCACACAGGCAAGTGCCTTAAT    c.960
 E  A  H  C  N |   C  S  E  N  L  F  H  C  H  T  G  K  C  L  N      p.320

          .         .         .         .         .         .       g.159311
 TACAGCCTTGTGTGTGATGGATATGATGACTGTGGGGATTTGAGTGATGAGCAAAACTGT       c.1020
 Y  S  L  V  C  D  G  Y  D  D  C  G  D  L  S  D  E  Q  N  C         p.340

   | 08      .         .         .         .         .         .    g.162850
 G | ATTGCAATCCCACAACAGAGCATCGCTGCGGGGACGGGCGCTGCATCGCCATGGAGTGG    c.1080
 D |   C  N  P  T  T  E  H  R  C  G  D  G  R  C  I  A  M  E  W      p.360

          .         .         .         .         .   | 09     .    g.164996
 GTGTGTGATGGTGACCACGACTGTGTGGATAAGTCTGACGAGGTCAACTGCT | CCTGTCAC    c.1140
 V  C  D  G  D  H  D  C  V  D  K  S  D  E  V  N  C  S |   C  H      p.380

          .         .         .         .         .         .       g.165056
 AGCCAGGGTCTGGTGGAATGCAGAAATGGACAATGTATCCCCAGCACGTTTCAATGTGAT       c.1200
 S  Q  G  L  V  E  C  R  N  G  Q  C  I  P  S  T  F  Q  C  D         p.400

          .         .         .         .          | 10        .    g.168553
 GGTGACGAGGACTGCAAGGATGGGAGTGATGAGGAGAACTGCAGCGTCA | TTCAGACTTCA    c.1260
 G  D  E  D  C  K  D  G  S  D  E  E  N  C  S  V  I |   Q  T  S      p.420

          .         .         .         .         .         .       g.168613
 TGTCAAGAAGGAGACCAAAGATGCCTCTACAATCCCTGCCTTGATTCATGTGGTGGTAGC       c.1320
 C  Q  E  G  D  Q  R  C  L  Y  N  P  C  L  D  S  C  G  G  S         p.440

          .         .         .        | 11.         .         .    g.177802
 TCTCTCTGTGACCCGAACAACAGTCTGAATAACTGTA | GTCAATGTGAACCAATTACATTG    c.1380
 S  L  C  D  P  N  N  S  L  N  N  C  S |   Q  C  E  P  I  T  L      p.460

          .         .         .         .         .         .       g.177862
 GAACTCTGCATGAATTTGCCCTACAACAGTACAAGTTATCCAAATTATTTTGGCCACAGG       c.1440
 E  L  C  M  N  L  P  Y  N  S  T  S  Y  P  N  Y  F  G  H  R         p.480

          .         .         .         .         .         .       g.177922
 ACTCAAAAGGAAGCATCCATCAGCTGGGAGTCTTCTCTTTTCCCTGCACTTGTTCAAACC       c.1500
 T  Q  K  E  A  S  I  S  W  E  S  S  L  F  P  A  L  V  Q  T         p.500

          .         .         .         .         .         .       g.177982
 AACTGTTATAAATACCTCATGTTCTTTTCTTGCACCATTTTGGTACCAAAATGTGATGTG       c.1560
 N  C  Y  K  Y  L  M  F  F  S  C  T  I  L  V  P  K  C  D  V         p.520

          .         .          | 12        .         .         .    g.181217
 AATACAGGCGAGCATATCCCTCCTTGCAG | GGCATTGTGTGAACACTCTAAAGAACGCTGT    c.1620
 N  T  G  E  H  I  P  P  C  R  |  A  L  C  E  H  S  K  E  R  C      p.540

          .         .         .         .         .         .       g.181277
 GAGTCTGTTCTTGGGATTGTGGGCCTACAGTGGCCTGAAGACACAGATTGCAGTCAATTT       c.1680
 E  S  V  L  G  I  V  G  L  Q  W  P  E  D  T  D  C  S  Q  F         p.560

          .         .         .         .         .      | 13  .    g.189387
 CCAGAGGAAAATTCAGACAATCAAACCTGCCTGATGCCTGATGAATATGTGGAAG | AATGC    c.1740
 P  E  E  N  S  D  N  Q  T  C  L  M  P  D  E  Y  V  E  E |   C      p.580

          .         .         .         .         .         .       g.189447
 TCACCTAGTCATTTCAAGTGCCGCTCAGGACAGTGTGTTCTGGCTTCCAGAAGATGTGAT       c.1800
 S  P  S  H  F  K  C  R  S  G  Q  C  V  L  A  S  R  R  C  D         p.600

          .         .         .         .    | 14    .         .    g.197865
 GGCCAGGCCGACTGTGACGATGACAGTGATGAGGAAAACTGTG | GTTGTAAAGAGAGAGAT    c.1860
 G  Q  A  D  C  D  D  D  S  D  E  E  N  C  G |   C  K  E  R  D      p.620

          .         .         .         .         .         .       g.197925
 CTTTGGGAATGTCCATCCAATAAACAATGTTTGAAGCACACAGTGATCTGCGATGGGTTC       c.1920
 L  W  E  C  P  S  N  K  Q  C  L  K  H  T  V  I  C  D  G  F         p.640

          .         .         .        | 15.         .         .    g.199809
 CCAGACTGCCCTGATTACATGGACGAGAAAAACTGCT | CATTTTGCCAAGATGATGAGCTG    c.1980
 P  D  C  P  D  Y  M  D  E  K  N  C  S |   F  C  Q  D  D  E  L      p.660

          .         .         .         .         .         .       g.199869
 GAATGTGCAAACCATGCGTGTGTGTCACGTGACCTGTGGTGTGATGGTGAAGCCGACTGC       c.2040
 E  C  A  N  H  A  C  V  S  R  D  L  W  C  D  G  E  A  D  C         p.680

          .         .         | 16         .         .         .    g.201025
 TCAGACAGTTCAGATGAATGGGACTGTG | TGACCCTCTCTATAAATGTGAACTCCTCTTCC    c.2100
 S  D  S  S  D  E  W  D  C  V |   T  L  S  I  N  V  N  S  S  S      p.700

          .         .         .         .         .         .       g.201085
 TTTCTGATGGTTCACAGAGCTGCCACAGAACACCATGTGTGTGCAGATGGCTGGCAGGAG       c.2160
 F  L  M  V  H  R  A  A  T  E  H  H  V  C  A  D  G  W  Q  E         p.720

          .         .         .         | 17         .         .    g.216543
 ATATTGAGTCAGCTGGCCTGCAAGCAGATGGGTTTAGG | AGAACCATCTGTGACCAAATTG    c.2220
 I  L  S  Q  L  A  C  K  Q  M  G  L  G  |  E  P  S  V  T  K  L      p.740

          .         .         .         .         .         .       g.216603
 ATACAGGAACAGGAGAAAGAGCCGCGGTGGCTGACATTACACTCCAACTGGGAGAGCCTC       c.2280
 I  Q  E  Q  E  K  E  P  R  W  L  T  L  H  S  N  W  E  S  L         p.760

          .         .         .      | 18  .         .         .    g.219119
 AATGGGACCACTTTACATGAACTTCTAGTAAATGG | GCAGTCTTGTGAGAGCAGAAGTAAA    c.2340
 N  G  T  T  L  H  E  L  L  V  N  G  |  Q  S  C  E  S  R  S  K      p.780

          .         .      | 19  .         .         .         .    g.219332
 ATTTCTCTTCTGTGTACTAAACAAG | ACTGTGGGCGCCGCCCTGCTGCCCGAATGAACAAA    c.2400
 I  S  L  L  C  T  K  Q  D |   C  G  R  R  P  A  A  R  M  N  K      p.800

          .         .         .         .         .         .       g.219392
 AGGATCCTTGGAGGTCGGACGAGTCGCCCTGGAAGGTGGCCATGGCAGTGTTCTCTGCAG       c.2460
 R  I  L  G  G  R  T  S  R  P  G  R  W  P  W  Q  C  S  L  Q         p.820

          .         .         .         .         .         .       g.219452
 AGTGAACCCAGTGGACATATCTGTGGCTGTGTCCTCATTGCCAAGAAGTGGGTTCTGACA       c.2520
 S  E  P  S  G  H  I  C  G  C  V  L  I  A  K  K  W  V  L  T         p.840

          .         . | 20       .         .         .         .    g.239414
 GTTGCCCACTGCTTCGAGGG | GAGAGAGAATGCTGCAGTTTGGAAAGTGGTGCTTGGCATC    c.2580
 V  A  H  C  F  E  G  |  R  E  N  A  A  V  W  K  V  V  L  G  I      p.860

          .         .         .         .         .         .       g.239474
 AACAATCTAGACCATCCATCAGTGTTCATGCAGACACGCTTTGTGAAGACCATCATCCTG       c.2640
 N  N  L  D  H  P  S  V  F  M  Q  T  R  F  V  K  T  I  I  L         p.880

          .         .         .         .         .         .       g.239534
 CATCCCCGCTACAGTCGAGCAGTGGTGGACTATGACATCAGCATCGTTGAGCTGAGTGAA       c.2700
 H  P  R  Y  S  R  A  V  V  D  Y  D  I  S  I  V  E  L  S  E         p.900

          .         .         .         .         .         .       g.239594
 GACATCAGTGAGACTGGCTACGTCCGGCCTGTCTGCTTGCCCAACCCGGAGCAGTGGCTA       c.2760
 D  I  S  E  T  G  Y  V  R  P  V  C  L  P  N  P  E  Q  W  L         p.920

          .         .         .         .         .   | 21     .    g.242703
 GAGCCTGACACGTACTGCTATATCACAGGCTGGGGCCACATGGGCAATAAAA | TGCCATTT    c.2820
 E  P  D  T  Y  C  Y  I  T  G  W  G  H  M  G  N  K  M |   P  F      p.940

          .         .         .         .         .         .       g.242763
 AAGCTGCAAGAGGGAGAGGTCCGCATTATTTCTCTGGAACATTGTCAGTCCTACTTTGAC       c.2880
 K  L  Q  E  G  E  V  R  I  I  S  L  E  H  C  Q  S  Y  F  D         p.960

          .         .         .         .         .         .       g.242823
 ATGAAGACCATCACCACTCGGATGATATGTGCTGGCTATGAGTCTGGCACAGTTGATTCA       c.2940
 M  K  T  I  T  T  R  M  I  C  A  G  Y  E  S  G  T  V  D  S         p.980

        | 22 .         .         .         .         .         .    g.247193
 TGCATG | GGTGACAGCGGTGGGCCTCTTGTTTGTGAGAAGCCTGGAGGACGGTGGACATTA    c.3000
 C  M   | G  D  S  G  G  P  L  V  C  E  K  P  G  G  R  W  T  L      p.1000

          .         .         .         .         .         .       g.247253
 TTTGGATTAACTTCATGGGGCTCCGTCTGCTTTTCCAAAGTCCTGGGGCCTGGCGTTTAT       c.3060
 F  G  L  T  S  W  G  S  V  C  F  S  K  V  L  G  P  G  V  Y         p.1020

          .         .         .         .         .         .       g.247313
 AGTAATGTGTCATATTTCGTCGAATGGATTAAAAGACAGATTTACATCCAGACCTTTCTC       c.3120
 S  N  V  S  Y  F  V  E  W  I  K  R  Q  I  Y  I  Q  T  F  L         p.1040

                                                                    g.247322
 CTAAACTAA                                                          c.3129
 L  N  X                                                            p.1042

          .         .         .         .         .         .       g.247382
 ttataaggatgatcagagacttttgccagctacactaaaagaaaatggccttcttgactg       c.*60

          .         .         .         .         .         .       g.247442
 tgaagagctgcctgcagagagctgtacagaagcacttttcatggacagaaatgctcaatc       c.*120

          .         .         .         .         .         .       g.247502
 gtgcactgcaaatttgcatgtttgttttggactaatttttttcaatttattttttcacct       c.*180

          .         .         .         .         .         .       g.247562
 tcatttttctcttatttcaagttcaatgaaagactttacaaaagcaaacaaagcagactt       c.*240

          .         .         .         .         .         .       g.247622
 tgtccttttgccaggcctaaccatgactgcagcacaaaattatcgactctggcgagattt       c.*300

          .         .         .         .         .         .       g.247682
 aaaatcaggtgctacagtaacaggttatggaatggtctcttttatcctatcacaaaaaaa       c.*360

          .         .         .         .         .         .       g.247742
 gacatagatatttaggctgattaattatctctaccagtttttgtttctcaagctcagtgc       c.*420

          .         .         .         .         .         .       g.247802
 atagtggtaaatttcagtgttaacattggagacttgcttttctttttctttttttatacc       c.*480

          .         .         .         .         .         .       g.247862
 ccacaattcttttttattacacttcgaattttagggtacacgagcacaacgtgcaggtta       c.*540

          .         .         .         .         .         .       g.247922
 gttacatatgtatacatgtgccatgttggtgtgctgaacccagtaactcgtcatttgatt       c.*600

          .         .         .         .         .         .       g.247982
 tattaaaagccaagataatttacatgtttaaagtatttactattacccccttctaatgtt       c.*660

          .         .         .         .         .         .       g.248042
 tgcataattctgagaactgataaaagacagcaataaaagaccagtgtcatccatttaggt       c.*720

          .         .         .         .         .         .       g.248102
 agcaagacatattgaatgcaaagttctttagatatcaatattaacacttgacattattgg       c.*780

          .         .         .         .         .         .       g.248162
 accccccattctggatgtatatcaagatcataattttatagaagagtctctatagaactg       c.*840

          .         .         .         .         .         .       g.248222
 tcctcatagctgggtttgttcaggatatatgagttggctgattgagactgcaacaactac       c.*900

          .         .         .         .         .         .       g.248282
 atctatatttatgggcaatattttgttttacttatgtggcaaagaactggatattaaact       c.*960

          .         .         .         .         .         .       g.248342
 ttgcaaaagagaatttagatgagagatgcaattttttaaaaagaaaattaatttgcatcc       c.*1020

          .         .         .         .         .         .       g.248402
 ctcgtttaattaaatttatttttcagttttcttgcgttcatccataccaacaaagtcata       c.*1080

          .         .         .         .         .         .       g.248462
 aagagcatattttagagcacagtaagactttgcatggagtaaaacattttgtaattttcc       c.*1140

          .         .         .         .         .         .       g.248522
 tcaaaagatgtttaatatctggtttcttctcattggtaattaaaattttagaaatgattt       c.*1200

          .         .         .         .         .         .       g.248582
 ttagctctaggccactttacgcaactcaatttctgaagcaattagtggtaaaaagtattt       c.*1260

          .         .         .         .         .         .       g.248642
 ttccccactaaaaaactttaaaacacaaatcttcatatatacttaatttaattagtcagg       c.*1320

          .         .         .         .         .         .       g.248702
 catccattttgccttttaaacaactaggattccctactaacctccaccagcaacctggac       c.*1380

          .         .         .         .         .         .       g.248762
 tgcctcagcattccaaatagatactacctgcaattttatacatgtatttttgtatctttt       c.*1440

          .         .         .         .         .         .       g.248822
 ctgtgtgtaaacatagttgaaattcaaaaagttgtagcaatttctatactattcatctcc       c.*1500

          .         .         .         .         .         .       g.248882
 tgtccttcagtttgtataaacctaaggagagtgtgaaatccagcaactgaattgtggtca       c.*1560

          .         .         .         .         .         .       g.248942
 cgattgtatgaaagttcaagaacatatgtcagttttgttacagttgtagctacatactca       c.*1620

          .         .         .         .         .         .       g.249002
 atgtatcaacttttagcctgctcaacttaggctcagtgaaatatatatattatacttatt       c.*1680

          .         .         .         .                           g.249045
 ttaaataattcttaatacaaataaaatggtaatggtctaatca                        c.*1723

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Corin, serine peptidase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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