coproporphyrinogen oxidase (CPOX) - coding DNA reference sequence

(used for variant description)

(last modified October 25, 2018)


This file was created to facilitate the description of sequence variants on transcript NM_000097.5 in the CPOX gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NG_015994.1, covering CPOX transcript NM_000097.5.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                     .         .         .         .                g.5047
              ctttccgcctgtgcagctcgccggctcaatactccgggggtctgggt       c.-61

 .         .         .         .         .         .                g.5107
 ggggggctcaaacgcagggctctgggacgcaggcactgctccaggtgatagtgcgggaac       c.-1

          .         .         .         .         .         .       g.5167
 ATGGCCTTGCAGCTGGGCAGGCTGAGCTCGGGCCCCTGCTGGCTCGTGGCGCGGGGCGGC       c.60
 M  A  L  Q  L  G  R  L  S  S  G  P  C  W  L  V  A  R  G  G         p.20

          .         .         .         .         .         .       g.5227
 TGCGGAGGGCCCCGCGCCTGGTCCCAGTGCGGCGGCGGAGGGCTCCGAGCCTGGTCCCAG       c.120
 C  G  G  P  R  A  W  S  Q  C  G  G  G  G  L  R  A  W  S  Q         p.40

          .         .         .         .         .         .       g.5287
 CGCAGCGCAGCCGGACGCGTCTGCCGGCCCCCTGGCCCGGCTGGCACGGAGCAGAGCCGC       c.180
 R  S  A  A  G  R  V  C  R  P  P  G  P  A  G  T  E  Q  S  R         p.60

          .         .         .         .         .         .       g.5347
 GGGCTGGGGCACGGCTCGACGTCGAGAGGCGGCCCCTGGGTGGGGACAGGGCTGGCCGCG       c.240
 G  L  G  H  G  S  T  S  R  G  G  P  W  V  G  T  G  L  A  A         p.80

          .         .         .         .         .         .       g.5407
 GCGCTGGCGGGGTTGGTGGGGCTGGCCACCGCCGCCTTCGGGCATGTGCAGCGGGCGGAG       c.300
 A  L  A  G  L  V  G  L  A  T  A  A  F  G  H  V  Q  R  A  E         p.100

          .         .         .         .         .         .       g.5467
 ATGTTGCCTAAGACCTCGGGGACGCGGGCCACTTCGCTGGGGAGGCCGGAGGAGGAGGAG       c.360
 M  L  P  K  T  S  G  T  R  A  T  S  L  G  R  P  E  E  E  E         p.120

          .         .         .         .         .         .       g.5527
 GATGAGCTGGCCCACCGCTGCAGCAGCTTCATGGCCCCGCCTGTGACCGACCTGGGCGAG       c.420
 D  E  L  A  H  R  C  S  S  F  M  A  P  P  V  T  D  L  G  E         p.140

          .         .         .         .         .         .       g.5587
 CTGCGAAGGAGGCCGGGCGACATGAAGACCAAGATGGAGCTGCTGATTCTGGAGACCCAG       c.480
 L  R  R  R  P  G  D  M  K  T  K  M  E  L  L  I  L  E  T  Q         p.160

          .         .         .         .         .         .       g.5647
 GCCCAGGTGTGCCAGGCTCTGGCACAGGTAGACGGGGGCGCCAACTTTTCTGTGGACCGG       c.540
 A  Q  V  C  Q  A  L  A  Q  V  D  G  G  A  N  F  S  V  D  R         p.180

          .       | 02 .         .         .         .         .    g.7500
 TGGGAGAGGAAGGAAG | GAGGTGGCGGCATCAGCTGTGTACTTCAAGATGGGTGTGTTTTC    c.600
 W  E  R  K  E  G |   G  G  G  I  S  C  V  L  Q  D  G  C  V  F      p.200

          .         .         .         .         .         .       g.7560
 GAAAAGGCTGGGGTGAGCATTTCTGTTGTTCATGGAAATCTTTCAGAGGAAGCTGCAAAA       c.660
 E  K  A  G  V  S  I  S  V  V  H  G  N  L  S  E  E  A  A  K         p.220

          .         .         .         . | 03       .         .    g.7889
 CAAATGAGAAGCAGAGGAAAAGTTCTGAAGACTAAAGATG | GTAAATTGCCATTTTGTGCT    c.720
 Q  M  R  S  R  G  K  V  L  K  T  K  D  G |   K  L  P  F  C  A      p.240

          .         .         .         .         .         .       g.7949
 ATGGGCGTGAGCTCTGTTATCCACCCCAAGAATCCTCATGCTCCTACTATCCATTTCAAC       c.780
 M  G  V  S  S  V  I  H  P  K  N  P  H  A  P  T  I  H  F  N         p.260

          .         .         .  | 04      .         .         .    g.9786
 TACAGATACTTTGAAGTAGAAGAAGCTGATG | GCAACAAGCAGTGGTGGTTTGGTGGTGGA    c.840
 Y  R  Y  F  E  V  E  E  A  D  G |   N  K  Q  W  W  F  G  G  G      p.280

          .         .         .         .         .         .       g.9846
 TGTGACCTCACTCCAACATACTTGAATCAAGAAGACGCTGTCCATTTTCACAGAACTCTG       c.900
 C  D  L  T  P  T  Y  L  N  Q  E  D  A  V  H  F  H  R  T  L         p.300

          .         .         .         .         .    | 05    .    g.12959
 AAGGAGGCTTGTGACCAGCATGGTCCAGATCTCTACCCCAAATTTAAAAAATG | GTGTGAT    c.960
 K  E  A  C  D  Q  H  G  P  D  L  Y  P  K  F  K  K  W  |  C  D      p.320

          .         .         .         .         .         .       g.13019
 GATTACTTCTTTATAGCCCATCGTGGAGAACGGCGGGGCATTGGTGGTATCTTTTTTGAT       c.1020
 D  Y  F  F  I  A  H  R  G  E  R  R  G  I  G  G  I  F  F  D         p.340

          .         .         .         .         .         .       g.13079
 GATCTTGACTCTCCGTCCAAGGAGGAGGTGTTTCGCTTTGTACAGAGCTGTGCCAGGGCT       c.1080
 D  L  D  S  P  S  K  E  E  V  F  R  F  V  Q  S  C  A  R  A         p.360

          .         .         .         .         .         .       g.13139
 GTAGTTCCTTCTTACATTCCCCTTGTGAAAAAGCACTGTGATGACTCATTCACCCCCCAG       c.1140
 V  V  P  S  Y  I  P  L  V  K  K  H  C  D  D  S  F  T  P  Q         p.380

          .         .         .   | 06     .         .         .    g.17128
 GAGAAGCTGTGGCAGCAGCTCAGAAGAGGACG | GTATGTAGAATTTAATCTGCTGTATGAT    c.1200
 E  K  L  W  Q  Q  L  R  R  G  R  |  Y  V  E  F  N  L  L  Y  D      p.400

          .         .         .         .         .         .       g.17188
 CGGGGCACAAAGTTTGGCCTCTTCACTCCAGGATCCAGAATTGAAAGTATCTTGATGTCT       c.1260
 R  G  T  K  F  G  L  F  T  P  G  S  R  I  E  S  I  L  M  S         p.420

          .        | 07.         .         .         .         .    g.17884
 TTACCTCTAACTGCCCG | ATGGGAGTACATGCATTCACCCTCAGAGAATTCCAAAGAAGCT    c.1320
 L  P  L  T  A  R  |  W  E  Y  M  H  S  P  S  E  N  S  K  E  A      p.440

          .         .         .         .                           g.17929
 GAAATTCTGGAAGTTCTACGCCATCCAAGGGACTGGGTGCGTTGA                      c.1365
 E  I  L  E  V  L  R  H  P  R  D  W  V  R  X                        p.454

          .         .         .         .         .         .       g.17989
 tgcaggcagaatggctgtgcaggggtttggagggcacacgatgtgtgctccccatgccac       c.*60

          .         .         .         .         .         .       g.18049
 tggtcggcactttgccactgtgtggcagttacccgtgccttagtcttctccactctgcac       c.*120

          .         .         .         .         .         .       g.18109
 cctacctcgtgggcagatgataacatgttttggatgctgtcagtgatgaatggtgagatg       c.*180

          .         .         .         .         .         .       g.18169
 gcagattgtcagagtcaattgattaaacctcatttatacttctagtgtcattttatatga       c.*240

          .         .         .         .         .         .       g.18229
 ctagtttacaaaataggacattgagtttccaagtattgagataagggaatataaatagta       c.*300

          .         .         .         .         .         .       g.18289
 ttatatgtatcaggaaatctctcatcttgtttttgtttcatgtattttttaaagttttca       c.*360

          .         .         .         .         .         .       g.18349
 tttgtgccacaaaaatctgtcgtggaatatattttattttcattaattcagtgaagttga       c.*420

          .         .         .         .         .         .       g.18409
 gacttcatagtaattttagaatgcaacttgaaggtaaaaattttactttgtcaatactga       c.*480

          .         .         .         .         .         .       g.18469
 agtctctgctgtaatccttatatatctttctccagagaacataatattgtcaaatagata       c.*540

          .         .         .         .         .         .       g.18529
 cacatttttctaataggtatttagaagcacttgaaataatctctgcatgtgttacaattc       c.*600

          .         .         .         .         .         .       g.18589
 agttatttctgtagtttgtaaactctaaagtgacattactattattttagagatgtctaa       c.*660

          .         .         .         .         .         .       g.18649
 gttgtaattttgatttttgtggaaccattgtttgttaatgttgggattctctgcactttt       c.*720

          .         .         .         .         .         .       g.18709
 gaatgtgaaagcttatatccctgaattctgatacttaagagttttctatttcagacatct       c.*780

          .         .         .         .         .         .       g.18769
 ctgtgtggaagttgagactaagaataatcctagggatgtcatgaatttaggcaatgtttc       c.*840

          .         .         .         .         .         .       g.18829
 tcatttggaaaatgaaatgagaaataatttccttctttaaagcaagtatatatagtatga       c.*900

          .         .         .         .         .         .       g.18889
 gaaacttggaggcatttcatacacacgtttcttaggaaaatggacacattgaaaatgtcc       c.*960

          .         .         .         .         .         .       g.18949
 tcttttttatattagagattctgcagctctttgctcttaagagcaaatcacaacaggatt       c.*1020

          .         .         .         .         .         .       g.19009
 cttaatgtatgatttctttgttcatatattatgaatgtattattttatttgcttcgtaat       c.*1080

          .         .         .         .         .         .       g.19069
 aaagtttataaggaagagcatctcatacatatcattatcgtggaacacgttgaatgtttg       c.*1140

          .         .         .         .         .         .       g.19129
 tgattctgtgtggcctttttggggctggaaaatgtatgaattcttcaactgtcttacaag       c.*1200

          .         .         .                                     g.19166
 agatctgctaataaattttattattaaataagactaa                              c.*1237

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Coproporphyrinogen oxidase protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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