ceruloplasmin (ferroxidase) (CP) - coding DNA reference sequence

(used for variant description)

(last modified April 24, 2013)


This file was created to facilitate the description of sequence variants on transcript NM_000096.3 in the CP gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000003.11, covering CP transcript NM_000096.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
                                                   .                g.5013
                                                acaccctaatgcc       c.-241

 .         .         .         .         .         .                g.5073
 tccaacaataactgttgactttttattttcagtcagagaagcctggcaaccaagaactgt       c.-181

 .         .         .         .         .         .                g.5133
 ttttttggtggtttacgagaacttaactgaattggaaaatatttgctttaatgaaacaat       c.-121

 .         .         .         .         .         .                g.5193
 ttactcttgtgcaacactaaattgtgtcaatcaagcaaataaggaagaaagtcttattta       c.-61

 .         .         .         .         .         .                g.5253
 taaaattgcctgctcctgattttacttcatttcttctcaggctccaagaaggggaaaaaa       c.-1

          .         .         .         .         .         .       g.5313
 ATGAAGATTTTGATACTTGGTATTTTTCTGTTTTTATGTAGTACCCCAGCCTGGGCGAAA       c.60
 M  K  I  L  I  L  G  I  F  L  F  L  C  S  T  P  A  W  A  K         p.20

          .         .         .         .         .         .       g.5373
 GAAAAGCATTATTACATTGGAATTATTGAAACGACTTGGGATTATGCCTCTGACCATGGG       c.120
 E  K  H  Y  Y  I  G  I  I  E  T  T  W  D  Y  A  S  D  H  G         p.40

          .         .       | 02 .         .         .         .    g.14381
 GAAAAGAAACTTATTTCTGTTGACAC | GGAACATTCCAATATCTATCTTCAAAATGGCCCA    c.180
 E  K  K  L  I  S  V  D  T  |  E  H  S  N  I  Y  L  Q  N  G  P      p.60

          .         .         .         .         .         .       g.14441
 GATAGAATTGGGAGACTATATAAGAAGGCCCTTTATCTTCAGTACACAGATGAAACCTTT       c.240
 D  R  I  G  R  L  Y  K  K  A  L  Y  L  Q  Y  T  D  E  T  F         p.80

          .         .         .         .         .         .       g.14501
 AGGACAACTATAGAAAAACCGGTCTGGCTTGGGTTTTTAGGCCCTATTATCAAAGCTGAA       c.300
 R  T  T  I  E  K  P  V  W  L  G  F  L  G  P  I  I  K  A  E         p.100

          .         .         .         .         .         .       g.14561
 ACTGGAGATAAAGTTTATGTACACTTAAAAAACCTTGCCTCTAGGCCCTACACCTTTCAT       c.360
 T  G  D  K  V  Y  V  H  L  K  N  L  A  S  R  P  Y  T  F  H         p.120

          .         .         .     | 03   .         .         .    g.16692
 TCACATGGAATAACTTACTATAAGGAACATGAGG | GGGCCATCTACCCTGATAACACCACA    c.420
 S  H  G  I  T  Y  Y  K  E  H  E  G |   A  I  Y  P  D  N  T  T      p.140

          .         .         .         .         .         .       g.16752
 GATTTTCAAAGAGCAGATGACAAAGTATATCCAGGAGAGCAGTATACATACATGTTGCTT       c.480
 D  F  Q  R  A  D  D  K  V  Y  P  G  E  Q  Y  T  Y  M  L  L         p.160

          .         .         .         .         .         .       g.16812
 GCCACTGAAGAACAAAGTCCTGGGGAAGGAGATGGCAATTGTGTGACTAGGATTTACCAT       c.540
 A  T  E  E  Q  S  P  G  E  G  D  G  N  C  V  T  R  I  Y  H         p.180

          .         .         .         .         .         .       g.16872
 TCCCACATTGATGCTCCAAAAGATATTGCCTCAGGACTCATCGGACCTTTAATAATCTGT       c.600
 S  H  I  D  A  P  K  D  I  A  S  G  L  I  G  P  L  I  I  C         p.200

         | 04.         .         .         .         .         .    g.17714
 AAAAAAG | ATTCTCTAGATAAAGAAAAAGAAAAACATATTGACCGAGAATTTGTGGTGATG    c.660
 K  K  D |   S  L  D  K  E  K  E  K  H  I  D  R  E  F  V  V  M      p.220

          .         .         .         .         .         .       g.17774
 TTTTCTGTGGTGGATGAAAATTTCAGCTGGTACCTAGAAGACAACATTAAAACCTACTGC       c.720
 F  S  V  V  D  E  N  F  S  W  Y  L  E  D  N  I  K  T  Y  C         p.240

          .         .         .         .         .         .       g.17834
 TCAGAACCAGAGAAAGTTGACAAAGACAACGAAGACTTCCAGGAGAGTAACAGAATGTAT       c.780
 S  E  P  E  K  V  D  K  D  N  E  D  F  Q  E  S  N  R  M  Y         p.260

   | 05      .         .         .         .         .         .    g.19487
 T | CTGTGAATGGATACACTTTTGGAAGTCTCCCAGGACTCTCCATGTGTGCTGAAGACAGA    c.840
 S |   V  N  G  Y  T  F  G  S  L  P  G  L  S  M  C  A  E  D  R      p.280

          .         .         .         .         .         .       g.19547
 GTAAAATGGTACCTTTTTGGTATGGGTAATGAAGTTGATGTGCACGCAGCTTTCTTTCAC       c.900
 V  K  W  Y  L  F  G  M  G  N  E  V  D  V  H  A  A  F  F  H         p.300

          .         .         .         .         .         .       g.19607
 GGGCAAGCACTGACTAACAAGAACTACCGTATTGACACAATCAACCTCTTTCCTGCTACC       c.960
 G  Q  A  L  T  N  K  N  Y  R  I  D  T  I  N  L  F  P  A  T         p.320

          .         .         .         .         .         .       g.19667
 CTGTTTGATGCTTATATGGTGGCCCAGAACCCTGGAGAATGGATGCTCAGCTGTCAGAAT       c.1020
 L  F  D  A  Y  M  V  A  Q  N  P  G  E  W  M  L  S  C  Q  N         p.340

          .       | 06 .         .         .         .         .    g.20750
 CTAAACCATCTGAAAG | CCGGTTTGCAAGCCTTTTTCCAGGTCCAGGAGTGTAACAAGTCT    c.1080
 L  N  H  L  K  A |   G  L  Q  A  F  F  Q  V  Q  E  C  N  K  S      p.360

          .         .         .         .         .         .       g.20810
 TCATCAAAGGATAATATCCGTGGGAAGCATGTTAGACACTACTACATTGCCGCTGAGGAA       c.1140
 S  S  K  D  N  I  R  G  K  H  V  R  H  Y  Y  I  A  A  E  E         p.380

          .         .         .         .         .         .       g.20870
 ATCATCTGGAACTATGCTCCCTCTGGTATAGACATCTTCACTAAAGAAAACTTAACAGCA       c.1200
 I  I  W  N  Y  A  P  S  G  I  D  I  F  T  K  E  N  L  T  A         p.400

          | 07         .         .         .         .         .    g.24856
 CCTGGAAG | TGACTCAGCGGTGTTTTTTGAACAAGGTACCACAAGAATTGGAGGCTCTTAT    c.1260
 P  G  S  |  D  S  A  V  F  F  E  Q  G  T  T  R  I  G  G  S  Y      p.420

          .         .         .         .         .         .       g.24916
 AAAAAGCTGGTTTATCGTGAGTACACAGATGCCTCCTTCACAAATCGAAAGGAGAGAGGC       c.1320
 K  K  L  V  Y  R  E  Y  T  D  A  S  F  T  N  R  K  E  R  G         p.440

          .         .         | 08         .         .         .    g.27213
 CCTGAAGAAGAGCATCTTGGCATCCTGG | GTCCTGTCATTTGGGCAGAGGTGGGAGACACC    c.1380
 P  E  E  E  H  L  G  I  L  G |   P  V  I  W  A  E  V  G  D  T      p.460

          .         .         .         .         .         .       g.27273
 ATCAGAGTAACCTTCCATAACAAAGGAGCATATCCCCTCAGTATTGAGCCGATTGGGGTG       c.1440
 I  R  V  T  F  H  N  K  G  A  Y  P  L  S  I  E  P  I  G  V         p.480

          .         .         .         .         .         .       g.27333
 AGATTCAATAAGAACAACGAGGGCACATACTATTCCCCAAATTACAACCCCCAGAGCAGA       c.1500
 R  F  N  K  N  N  E  G  T  Y  Y  S  P  N  Y  N  P  Q  S  R         p.500

   | 09      .         .         .         .         .         .    g.28526
 A | GTGTGCCTCCTTCAGCCTCCCATGTGGCACCCACAGAAACATTCACCTATGAATGGACT    c.1560
 S |   V  P  P  S  A  S  H  V  A  P  T  E  T  F  T  Y  E  W  T      p.520

          .         .         .         .         .         .       g.28586
 GTCCCCAAAGAAGTAGGACCCACTAATGCAGATCCTGTGTGTCTAGCTAAGATGTATTAT       c.1620
 V  P  K  E  V  G  P  T  N  A  D  P  V  C  L  A  K  M  Y  Y         p.540

          .         .         .         .         .         .       g.28646
 TCTGCTGTGGAACCCACTAAAGATATATTCACTGGGCTTATTGGGCCAATGAAAATATGC       c.1680
 S  A  V  E  P  T  K  D  I  F  T  G  L  I  G  P  M  K  I  C         p.560

          .         .         .    | 10    .         .         .    g.38870
 AAGAAAGGAAGTTTACATGCAAATGGGAGACAG | AAAGATGTAGACAAGGAATTCTATTTG    c.1740
 K  K  G  S  L  H  A  N  G  R  Q   | K  D  V  D  K  E  F  Y  L      p.580

          .         .         .         .         .         .       g.38930
 TTTCCTACAGTATTTGATGAGAATGAGAGTTTACTCCTGGAAGATAATATTAGAATGTTT       c.1800
 F  P  T  V  F  D  E  N  E  S  L  L  L  E  D  N  I  R  M  F         p.600

          .         .         .         .         .         .       g.38990
 ACAACTGCACCTGATCAGGTGGATAAGGAAGATGAAGACTTTCAGGAATCTAATAAAATG       c.1860
 T  T  A  P  D  Q  V  D  K  E  D  E  D  F  Q  E  S  N  K  M         p.620

      | 11   .         .         .         .         .         .    g.40369
 CACT | CCATGAATGGATTCATGTATGGGAATCAGCCGGGTCTCACTATGTGCAAAGGAGAT    c.1920
 H  S |   M  N  G  F  M  Y  G  N  Q  P  G  L  T  M  C  K  G  D      p.640

          .         .         .         .         .         .       g.40429
 TCGGTCGTGTGGTACTTATTCAGCGCCGGAAATGAGGCCGATGTACATGGAATATACTTT       c.1980
 S  V  V  W  Y  L  F  S  A  G  N  E  A  D  V  H  G  I  Y  F         p.660

          .         .         .         .         .         .       g.40489
 TCAGGAAACACATATCTGTGGAGAGGAGAACGGAGAGACACAGCAAACCTCTTCCCTCAA       c.2040
 S  G  N  T  Y  L  W  R  G  E  R  R  D  T  A  N  L  F  P  Q         p.680

          .         .         .        | 12.         .         .    g.41622
 ACAAGTCTTACGCTCCACATGTGGCCTGACACAGAGG | GGACTTTTAATGTTGAATGCCTT    c.2100
 T  S  L  T  L  H  M  W  P  D  T  E  G |   T  F  N  V  E  C  L      p.700

          .         .         .         .         .         .       g.41682
 ACAACTGATCATTACACAGGCGGCATGAAGCAAAAATATACTGTGAACCAATGCAGGCGG       c.2160
 T  T  D  H  Y  T  G  G  M  K  Q  K  Y  T  V  N  Q  C  R  R         p.720

          .         .         .         .         .         .       g.41742
 CAGTCTGAGGATTCCACCTTCTACCTGGGAGAGAGGACATACTATATCGCAGCAGTGGAG       c.2220
 Q  S  E  D  S  T  F  Y  L  G  E  R  T  Y  Y  I  A  A  V  E         p.740

          .         .         .         .         .         .       g.41802
 GTGGAATGGGATTATTCCCCACAAAGGGAGTGGGAAAAGGAGCTGCATCATTTACAAGAG       c.2280
 V  E  W  D  Y  S  P  Q  R  E  W  E  K  E  L  H  H  L  Q  E         p.760

       | 13  .         .         .         .         .         .    g.43495
 CAGAA | TGTTTCAAATGCATTTTTAGATAAGGGAGAGTTTTACATAGGCTCAAAGTACAAG    c.2340
 Q  N  |  V  S  N  A  F  L  D  K  G  E  F  Y  I  G  S  K  Y  K      p.780

          .         .         .         .         .         .       g.43555
 AAAGTTGTGTATCGGCAGTATACTGATAGCACATTCCGTGTTCCAGTGGAGAGAAAAGCT       c.2400
 K  V  V  Y  R  Q  Y  T  D  S  T  F  R  V  P  V  E  R  K  A         p.800

          .         .      | 14  .         .         .         .    g.44947
 GAAGAAGAACATCTGGGAATTCTAG | GTCCACAACTTCATGCAGATGTTGGAGACAAAGTC    c.2460
 E  E  E  H  L  G  I  L  G |   P  Q  L  H  A  D  V  G  D  K  V      p.820

          .         .         .         .         .         .       g.45007
 AAAATTATCTTTAAAAACATGGCCACAAGGCCCTACTCAATACATGCCCATGGGGTACAA       c.2520
 K  I  I  F  K  N  M  A  T  R  P  Y  S  I  H  A  H  G  V  Q         p.840

          .         .         .     | 15   .         .         .    g.47409
 ACAGAGAGTTCTACAGTTACTCCAACATTACCAG | GTGAAACTCTCACTTACGTATGGAAA    c.2580
 T  E  S  S  T  V  T  P  T  L  P  G |   E  T  L  T  Y  V  W  K      p.860

          .         .         .         .         .         .       g.47469
 ATCCCAGAAAGATCTGGAGCTGGAACAGAGGATTCTGCTTGTATTCCATGGGCTTATTAT       c.2640
 I  P  E  R  S  G  A  G  T  E  D  S  A  C  I  P  W  A  Y  Y         p.880

          .         .  | 16      .         .         .         .    g.48453
 TCAACTGTGGATCAAGTTAAG | GACCTCTACAGTGGATTAATTGGCCCCCTGATTGTTTGT    c.2700
 S  T  V  D  Q  V  K   | D  L  Y  S  G  L  I  G  P  L  I  V  C      p.900

          .         .         .         .         .         .       g.48513
 CGAAGACCTTACTTGAAAGTATTCAATCCCAGAAGGAAACTGGAATTTGCCCTTCTGTTT       c.2760
 R  R  P  Y  L  K  V  F  N  P  R  R  K  L  E  F  A  L  L  F         p.920

          .         .         .         .         .         .       g.48573
 CTAGTTTTTGATGAGAATGAATCTTGGTACTTAGATGACAACATCAAAACATACTCTGAT       c.2820
 L  V  F  D  E  N  E  S  W  Y  L  D  D  N  I  K  T  Y  S  D         p.940

          .         .         .         .         .         | 17    g.49068
 CACCCCGAGAAAGTAAACAAAGATGATGAGGAATTCATAGAAAGCAATAAAATGCATG | CT    c.2880
 H  P  E  K  V  N  K  D  D  E  E  F  I  E  S  N  K  M  H  A |       p.960

          .         .         .         .         .         .       g.49128
 ATTAATGGAAGAATGTTTGGAAACCTACAAGGCCTCACAATGCACGTGGGAGATGAAGTC       c.2940
 I  N  G  R  M  F  G  N  L  Q  G  L  T  M  H  V  G  D  E  V         p.980

          .         .         .         .         .         .       g.49188
 AACTGGTATCTGATGGGAATGGGCAATGAAATAGACTTACACACTGTACATTTTCACGGC       c.3000
 N  W  Y  L  M  G  M  G  N  E  I  D  L  H  T  V  H  F  H  G         p.1000

          .         | 18         .         .         .         .    g.50675
 CATAGCTTCCAATACAAG | CACAGGGGAGTTTATAGTTCTGATGTCTTTGACATTTTCCCT    c.3060
 H  S  F  Q  Y  K   | H  R  G  V  Y  S  S  D  V  F  D  I  F  P      p.1020

          .         .         .         .         .         .       g.50735
 GGAACATACCAAACCCTAGAAATGTTTCCAAGAACACCTGGAATTTGGTTACTCCACTGC       c.3120
 G  T  Y  Q  T  L  E  M  F  P  R  T  P  G  I  W  L  L  H  C         p.1040

          .         .         .         .         .         .       g.50795
 CATGTGACCGACCACATTCATGCTGGAATGGAAACCACTTACACCGTTCTACAAAATGAA       c.3180
 H  V  T  D  H  I  H  A  G  M  E  T  T  Y  T  V  L  Q  N  E         p.1060

   | 19      .                                                      g.53374
 G | ACACCAAATCTGGCTGA                                              c.3198
 D |   T  K  S  G  X                                                p.1065

          .         .         .         .         .         .       g.53434
 atgaaataaattggtgataagtggaaaaaagagaaaaaccaatgattcataacaatgtat       c.*60

          .         .         .         .         .         .       g.53494
 gtgaaagtgtaaaatagaatgttactttggaatgactataaacattaaaagaagactgga       c.*120

          .         .         .         .         .         .       g.53554
 agcatacaactttgtacatttgtgggggaaaactattaattttttgcaaatggaaagatc       c.*180

          .         .         .         .         .         .       g.53614
 aacagactatataatgatacatgactgacacttgtacactaggtaataaaactgattcat       c.*240

          .         .         .         .         .         .       g.53674
 acagtctaatgatatcaccgctgttagggttttataaaactgcatttaaaaaaagatcta       c.*300

          .         .         .         .         .         .       g.53734
 tgaccagatattctcctgggtgctcctcaaaggaacactattaaggttcattgaaatgtt       c.*360

          .         .         .         .         .         .       g.53794
 ttcaatcattgccttcccattgatccttctaacatgctgttgacatcacacctaatattc       c.*420

          .         .         .         .         .         .       g.53854
 agagggaatgggcaaggtatgagggaaggaaataaaaaataaaataaataaaatagaatg       c.*480

          .         .         .         .         .         .       g.53914
 acacaaatttgagttttgtgaacccctgaacagatggtcttaaggacgttatctggaact       c.*540

          .         .         .         .         .         .       g.53974
 ggagaaaagcagagttgagagacaattctatagattaaatcctggtaaggacaaacattg       c.*600

          .         .         .         .         .         .       g.54034
 ccattagaagaaaagcttcaaaatagacctgtggcagatgtcacatgagtagaatttctg       c.*660

          .         .         .         .         .         .       g.54094
 cccagccttaactgcattcagaggataatatcaatgaactaaacttgaactaaaaatttt       c.*720

          .         .         .         .         .         .       g.54154
 ttaaacaaaaagttataaatgaagacacatggttgtgaatacaatgatgtatttctttat       c.*780

          .         .         .         .         .         .       g.54214
 tttcacatacactctagctaaaagagcaagagtacacatcaacaaaaatggaaacaaggc       c.*840

          .         .         .         .         .         .       g.54274
 tttggctgaaaaaaacatgcatttgacaaatcatgttaatagctagacaagaagaaagtt       c.*900

          .         .         .         .         .         .       g.54334
 agctttgtaaacttctacttcatttgattcagagaaacagagcatgagttttcttaaaag       c.*960

          .         .         .         .         .         .       g.54394
 taacaagaaaaggaacaaaaaaaatgaggtttgaaatcttttaccatggcaaaacattaa       c.*1020

          .         .         .         .         .         .       g.54454
 catctttctcaaaaacatagagaaatctggaaaaatcaagaagataaaattctggaccag       c.*1080

          .         .         .         .         .         .       g.54514
 ttagtgacattctttcaagcatacttgtaaaatgtttccttaaagtgttcttgggatgaa       c.*1140

          .         .         .         .         .         .       g.54574
 aatgattgtcatgtctccaacaacagtgaactgatgttgttccttggaataaaagtcaat       c.*1200

          .                                                         g.54589
 ccccaccttaaaaaa                                                    c.*1215

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The Ceruloplasmin (ferroxidase) protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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