cAMP responsive element binding protein 3-like 1 (CREB3L1) - coding DNA reference sequence

(used for variant description)

(last modified May 11, 2021)


This file was created to facilitate the description of sequence variants on transcript NM_052854.3 in the CREB3L1 gene based on a coding DNA reference sequence following the HGVS recommendations.

The sequence was taken from NC_000011.9, covering CREB3L1 transcript NM_052854.3.


Please note that introns are available by clicking on the exon numbers above the sequence.
 (upstream sequence)
           .         .         .         .         .                g.5015
       ccagccaggggttcccggtttcacagagaggaaagtgacagaagacgtgcggag       c.-421

 .         .         .         .         .         .                g.5075
 ggagacgcagagacagaggagaggccggcagccacccagtctcgggggagcacttagctc       c.-361

 .         .         .         .         .         .                g.5135
 ccccgccccggctcccaccctgtccggggggctcctgaagccctcagccccaaccccggg       c.-301

 .         .         .         .         .         .                g.5195
 ctccccatggaagccagctgtgccccaggaggagcaggaggaggtggagtcggctgaatg       c.-241

 .         .         .         .         .         .                g.5255
 cccacggtgcgcccggggcccctgagcccatcccgctcctagccgctgccctaaggcccc       c.-181

 .         .         .         .         .         .                g.5315
 cgcgcgccccgcgccccccacccggggccgcgccgcctccgtccgcccctcccccggggc       c.-121

 .         .         .         .         .         .                g.5375
 ttcgccccggacctgccccccgcccgtttgccagcgctcaggcaggagctctggactggg       c.-61

 .         .         .         .         .         .                g.5435
 cgcgccgccgccctggagtgagggaagcccagtggaagggggtcccgggagccggctgcg       c.-1

          .         .         .         .         .         .       g.5495
 ATGGACGCCGTCTTGGAACCCTTCCCGGCCGACAGGCTGTTCCCCGGATCCAGCTTCCTG       c.60
 M  D  A  V  L  E  P  F  P  A  D  R  L  F  P  G  S  S  F  L         p.20

          .         .         .         .   | 02     .         .    g.27276
 GACTTGGGGGATCTGAACGAGTCGGACTTCCTCAACAATGCG | CACTTTCCTGAGCACCTG    c.120
 D  L  G  D  L  N  E  S  D  F  L  N  N  A   | H  F  P  E  H  L      p.40

          .         .         .         .         .         .       g.27336
 GACCACTTTACGGAGAACATGGAGGACTTCTCCAATGACCTGTTCAGCAGCTTCTTTGAT       c.180
 D  H  F  T  E  N  M  E  D  F  S  N  D  L  F  S  S  F  F  D         p.60

          .         .         .         .         .         .       g.27396
 GACCCTGTGCTGGATGAGAAGAGCCCTCTATTGGACATGGAACTGGACTCCCCTACGCCA       c.240
 D  P  V  L  D  E  K  S  P  L  L  D  M  E  L  D  S  P  T  P         p.80

          .         .         .         .         .         .       g.27456
 GGCATCCAGGCGGAGCACAGCTACTCCCTGAGCGGCGACTCAGCGCCCCAGAGCCCCCTT       c.300
 G  I  Q  A  E  H  S  Y  S  L  S  G  D  S  A  P  Q  S  P  L         p.100

          .         .         .  | 03      .         .         .    g.35168
 GTGCCCATCAAGATGGAGGACACCACCCAAG | ATGCAGAGCATGGAGCATGGGCGCTGGGA    c.360
 V  P  I  K  M  E  D  T  T  Q  D |   A  E  H  G  A  W  A  L  G      p.120

          .         .         .         .         .         .       g.35228
 CACAAACTGTGCTCCATCATGGTGAAGCAGGAGCAGAGCCCGGAGCTGCCCGTGGACCCT       c.420
 H  K  L  C  S  I  M  V  K  Q  E  Q  S  P  E  L  P  V  D  P         p.140

          .         .         .         .         .         .       g.35288
 CTGGCTGCCCCCTCGGCCATGGCTGCCGCGGCCGCCATGGCCACCACCCCGCTGCTGGGC       c.480
 L  A  A  P  S  A  M  A  A  A  A  A  M  A  T  T  P  L  L  G         p.160

          .         .         .       | 04 .         .         .    g.37336
 CTCAGCCCCTTGTCCAGGCTGCCCATCCCCCACCAG | GCCCCGGGAGAGATGACTCAGCTG    c.540
 L  S  P  L  S  R  L  P  I  P  H  Q   | A  P  G  E  M  T  Q  L      p.180

          .         .         .         .         .      | 05  .    g.38360
 CCAGTGATCAAAGCAGAGCCTCTGGAGGTGAACCAGTTCCTCAAAGTGACACCGG | AGGAC    c.600
 P  V  I  K  A  E  P  L  E  V  N  Q  F  L  K  V  T  P  E |   D      p.200

          .         .         .         .         .         .       g.38420
 CTGGTGCAGATGCCTCCGACGCCCCCCAGCAGCCATGGCAGTGACAGCGACGGCTCCCAG       c.660
 L  V  Q  M  P  P  T  P  P  S  S  H  G  S  D  S  D  G  S  Q         p.220

          .         .         .         .         .         .       g.38480
 AGTCCCCGCTCTCTGCCCCCCTCCAGCCCTGTCAGGCCCATGGCGCGCTCCTCCACGGCC       c.720
 S  P  R  S  L  P  P  S  S  P  V  R  P  M  A  R  S  S  T  A         p.240

          .         .         .    | 06    .         .         .    g.39675
 ATCTCCACCTCCCCACTCCTCACTGCCCCTCAC | AAATTACAGGGGACATCAGGGCCACTG    c.780
 I  S  T  S  P  L  L  T  A  P  H   | K  L  Q  G  T  S  G  P  L      p.260

          .         .         .         .         .         .       g.39735
 CTCCTGACAGAGGAGGAGAAGCGGACCCTGATTGCTGAGGGCTACCCCATCCCCACAAAA       c.840
 L  L  T  E  E  E  K  R  T  L  I  A  E  G  Y  P  I  P  T  K         p.280

          .         .         .         .         .         .       g.39795
 CTCCCCCTCACCAAAGCCGAGGAGAAGGCCTTGAAGAGAGTCCGGAGGAAAATCAAGAAC       c.900
 L  P  L  T  K  A  E  E  K  A  L  K  R  V  R  R  K  I  K  N         p.300

     | 07    .         .         .         .         .         .    g.39992
 AAG | ATCTCAGCCCAGGAGAGCCGTCGTAAGAAGAAGGAGTATGTGGAGTGTCTAGAAAAG    c.960
 K   | I  S  A  Q  E  S  R  R  K  K  K  E  Y  V  E  C  L  E  K      p.320

    | 08     .         .         .         .         .         .    g.40232
 AA | GGTGGAGACATTTACATCTGAGAACAATGAACTGTGGAAGAAGGTGGAGACCCTGGAG    c.1020
 K  |  V  E  T  F  T  S  E  N  N  E  L  W  K  K  V  E  T  L  E      p.340

          .  | 09      .         .         .         .         .    g.43658
 AATGCCAACAG | GACCCTGCTCCAGCAGCTGCAGAAACTCCAGACTCTGGTCACCAACAAG    c.1080
 N  A  N  R  |  T  L  L  Q  Q  L  Q  K  L  Q  T  L  V  T  N  K      p.360

          .         .         .         .         .  | 10      .    g.44693
 ATCTCCAGACCTTACAAGATGGCCGCCACCCAGACTGGGACCTGCCTCATG | GTGGCAGCC    c.1140
 I  S  R  P  Y  K  M  A  A  T  Q  T  G  T  C  L  M   | V  A  A      p.380

          .         .         .         .         .         .       g.44753
 TTGTGCTTTGTTCTGGTGCTGGGCTCCCTCGTGCCCTGCCTTCCCGAGTTCTCCTCCGGC       c.1200
 L  C  F  V  L  V  L  G  S  L  V  P  C  L  P  E  F  S  S  G         p.400

          .         .         .         .         .         | 11    g.47589
 TCCCAGACTGTGAAGGAAGACCCCCTGGCCGCAGACGGCGTCTACACGGCCAGCCAGA | TG    c.1260
 S  Q  T  V  K  E  D  P  L  A  A  D  G  V  Y  T  A  S  Q  M |       p.420

          .         .         .         .         .         .       g.47649
 CCCTCCCGAAGCCTCCTATTCTACGATGACGGGGCAGGCTTATGGGAAGATGGCCGCAGC       c.1320
 P  S  R  S  L  L  F  Y  D  D  G  A  G  L  W  E  D  G  R  S         p.440

          .         .         .         .         .         .       g.47709
 ACCCTGCTGCCCATGGAGCCCCCAGATGGCTGGGAAATCAACCCCGGGGGGCCGGCAGAG       c.1380
 T  L  L  P  M  E  P  P  D  G  W  E  I  N  P  G  G  P  A  E         p.460

          .         .         .         .         .         .       g.47769
 CAGCGGCCCCGGGACCACCTGCAGCATGATCACCTGGACAGCACCCACGAGACCACCAAG       c.1440
 Q  R  P  R  D  H  L  Q  H  D  H  L  D  S  T  H  E  T  T  K         p.480

          .         .         .         .         .         .       g.47829
 TACCTGAGTGAGGCCTGGCCTAAAGACGGTGGAAACGGCACCAGCCCCGACTTCTCCCAC       c.1500
 Y  L  S  E  A  W  P  K  D  G  G  N  G  T  S  P  D  F  S  H         p.500

          .         .    | 12    .         .         .         .    g.48069
 TCCAAGGAGTGGTTCCACGACAG | GGATCTGGGCCCCAACACCACCATCAAACTCTCCTAG    c.1560
 S  K  E  W  F  H  D  R  |  D  L  G  P  N  T  T  I  K  L  S  X      p.519

          .         .         .         .         .         .       g.48129
 gccatgccaagacccaggacataggacggacccctggtacccagaagaggagttcttgct       c.*60

          .         .         .         .         .         .       g.48189
 cactaacccggatccgcctcgtgcccctgcctcctggagcttcccattccaggagaaaag       c.*120

          .         .         .         .         .         .       g.48249
 gctccacttcccagcccttccttgcccctgacatttggactcttcccttgggccgaccac       c.*180

          .         .         .         .         .         .       g.48309
 tctgttctcattctccttcccaccaacatccatccgtccttctcagacaaaccactcact       c.*240

          .         .         .         .         .         .       g.48369
 gggtaccccacctcctctctcatatgcccaacacgaccactgcctccctgcccccacacc       c.*300

          .         .         .         .         .         .       g.48429
 tgcacccaaacagacacatcaacgcaccccactcacagacaccccttaccccacccccac       c.*360

          .         .         .         .         .         .       g.48489
 tgtacagagaccaagaacagaaattgtttgtaaataatgaaccttattttttattattgc       c.*420

          .         .         .         .         .         .       g.48549
 caatcccctaagatattgtattttacaaatctccctcttcccttcgcccctcccttgttt       c.*480

          .         .         .         .         .         .       g.48609
 tatattttatgaagttagtgcgggctttgctgctccctggcccaggaaagagggactacc       c.*540

          .         .         .         .         .         .       g.48669
 tgaccctcacctggcacccccctgctgctgcccaagccgctgggcctttttaattgccaa       c.*600

          .         .         .         .         .         .       g.48729
 actgctctcttcatcagctcagcacatgctttaagaaagcaaaaccaaaaaaaaaaaaaa       c.*660

          .                                                         g.48745
 aaagatgcagcatcaa                                                   c.*676

 (downstream sequence)
Legend:
Nucleotide numbering (following the rules of the HGVS for a 'Coding DNA Reference Sequence') is indicated at the right of the sequence, counting the A of the ATG translation initiating Methionine as 1. Every 10th nucleotide is indicated by a "." above the sequence. The CAMP responsive element binding protein 3-like 1 protein sequence is shown below the coding DNA sequence, with numbering indicated at the right starting with 1 for the translation initiating Methionine. Every 10th amino acid is shown in bold. The position of introns is indicated by a vertical line, splitting the two exons. The start of the first exon (transcription initiation site) is indicated by a '\', the end of the last exon (poly-A addition site) by a '/'. The exon number is indicated above the first nucleotide(s) of the exon. To aid the description of frame shift variants, all stop codons in the +1 frame are shown in bold while all stop codons in the +2 frame are underlined.

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